MCL coexpression mm9:162
From FANTOM5_SSTAR
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
| GO ID | GO name | FDR corrected p-value |
|---|---|---|
| GO:0006629 | lipid metabolic process | 0.0277682095850798 |
| GO:0031529 | ruffle organization and biogenesis | 0.0277682095850798 |
| GO:0030948 | negative regulation of vascular endothelial growth factor receptor signaling pathway | 0.0277682095850798 |
| GO:0009966 | regulation of signal transduction | 0.0277682095850798 |
| GO:0032868 | response to insulin stimulus | 0.0277682095850798 |
| GO:0043434 | response to peptide hormone stimulus | 0.0277682095850798 |
| GO:0032870 | cellular response to hormone stimulus | 0.0277682095850798 |
| GO:0032869 | cellular response to insulin stimulus | 0.0277682095850798 |
| GO:0042579 | microbody | 0.0277682095850798 |
| GO:0005777 | peroxisome | 0.0277682095850798 |
| GO:0031532 | actin cytoskeleton reorganization | 0.0371242313547847 |
| GO:0005085 | guanyl-nucleotide exchange factor activity | 0.039670377237159 |
| GO:0003997 | acyl-CoA oxidase activity | 0.039670377237159 |
| GO:0051056 | regulation of small GTPase mediated signal transduction | 0.039670377237159 |
| GO:0044255 | cellular lipid metabolic process | 0.0425148821081574 |
| GO:0030947 | regulation of vascular endothelial growth factor receptor signaling pathway | 0.0425148821081574 |
| GO:0008195 | phosphatidate phosphatase activity | 0.048003657065088 |
Relative expression of the co-expression cluster over median <br>Analyst:
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>
| Ontology term | p-value | n |
|---|---|---|
| metabolising cell | 2.48e-24 | 5 |
| endopolyploid cell | 2.48e-24 | 5 |
| parenchymal cell | 2.48e-24 | 5 |
| polyploid cell | 2.48e-24 | 5 |
| hepatocyte | 2.48e-24 | 5 |
| fibroblast | 7.41e-09 | 1 |
| hepatic stellate cell | 7.41e-09 | 1 |
| Ontology term | p-value | n |
|---|---|---|
| liver | 1.33e-32 | 22 |
| epithelial sac | 1.33e-32 | 22 |
| digestive gland | 1.33e-32 | 22 |
| epithelium of foregut-midgut junction | 1.33e-32 | 22 |
| anatomical boundary | 1.33e-32 | 22 |
| hepatobiliary system | 1.33e-32 | 22 |
| foregut-midgut junction | 1.33e-32 | 22 |
| hepatic diverticulum | 1.33e-32 | 22 |
| liver primordium | 1.33e-32 | 22 |
| septum transversum | 1.33e-32 | 22 |
| liver bud | 1.33e-32 | 22 |
| digestive tract diverticulum | 3.71e-31 | 23 |
| sac | 3.71e-31 | 23 |
| exocrine gland | 1.30e-28 | 25 |
| exocrine system | 1.30e-28 | 25 |
| trunk mesenchyme | 1.44e-15 | 45 |
| epithelial tube | 7.19e-15 | 47 |
| abdomen element | 3.14e-14 | 49 |
| abdominal segment element | 3.14e-14 | 49 |
| abdominal segment of trunk | 3.14e-14 | 49 |
| abdomen | 3.14e-14 | 49 |
| gut epithelium | 1.39e-12 | 55 |
| endocrine gland | 1.83e-11 | 60 |
| mesenchyme | 2.92e-11 | 61 |
| entire embryonic mesenchyme | 2.92e-11 | 61 |
| gland | 1.64e-10 | 65 |
| unilaminar epithelium | 2.44e-10 | 66 |
| subdivision of trunk | 2.44e-10 | 66 |
| endo-epithelium | 7.53e-10 | 69 |
| endocrine system | 2.12e-09 | 72 |
| immaterial anatomical entity | 1.75e-08 | 79 |
| trunk region element | 1.75e-08 | 79 |
| foregut | 2.30e-08 | 80 |
| trunk | 2.52e-07 | 90 |
TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
| Motifs | -log10(p-value) |
|---|---|
| MA0003.1 | 1.38858e-12 |
| MA0004.1 | 1.025 |
| MA0006.1 | 0.0545783 |
| MA0007.1 | 0.245853 |
| MA0009.1 | 0.46576 |
| MA0014.1 | 6.60087e-08 |
| MA0017.1 | 1.41868 |
| MA0019.1 | 0.519556 |
| MA0024.1 | 0.12989 |
| MA0025.1 | 2.26713 |
| MA0027.1 | 1.59941 |
| MA0028.1 | 0.000883268 |
| MA0029.1 | 0.118998 |
| MA0030.1 | 0.775333 |
| MA0031.1 | 1.15283 |
| MA0038.1 | 0.925152 |
| MA0040.1 | 0.483091 |
| MA0041.1 | 0.459147 |
| MA0042.1 | 0.254235 |
| MA0043.1 | 1.13973 |
| MA0046.1 | 0.992857 |
| MA0048.1 | 0.122836 |
| MA0050.1 | 0.580263 |
| MA0051.1 | 0.956711 |
| MA0052.1 | 0.494368 |
| MA0055.1 | 0.0220108 |
| MA0056.1 | 0 |
| MA0057.1 | 0.000945085 |
| MA0058.1 | 0.398282 |
| MA0059.1 | 0.0620265 |
| MA0060.1 | 0.641135 |
| MA0061.1 | 0.456037 |
| MA0063.1 | 0 |
| MA0066.1 | 0.560747 |
| MA0067.1 | 0.387388 |
| MA0068.1 | 0.102868 |
| MA0069.1 | 0.164922 |
| MA0070.1 | 0.934729 |
| MA0071.1 | 0.868643 |
| MA0072.1 | 0.469536 |
| MA0073.1 | 0.0142121 |
| MA0074.1 | 0.474988 |
| MA0076.1 | 0.00170201 |
| MA0077.1 | 0.142892 |
| MA0078.1 | 0.174236 |
| MA0081.1 | 0.17383 |
| MA0083.1 | 0.210065 |
| MA0084.1 | 0.664822 |
| MA0087.1 | 0.183562 |
| MA0088.1 | 0.0733481 |
| MA0089.1 | 0 |
| MA0090.1 | 1.53357 |
| MA0091.1 | 0.146366 |
| MA0092.1 | 0.380367 |
| MA0093.1 | 1.06324 |
| MA0095.1 | 0 |
| MA0098.1 | 0 |
| MA0100.1 | 0.236549 |
| MA0101.1 | 0.463214 |
| MA0103.1 | 0.463373 |
| MA0105.1 | 0.17048 |
| MA0106.1 | 0.717683 |
| MA0107.1 | 0.0808299 |
| MA0108.2 | 0.266897 |
| MA0109.1 | 0 |
| MA0111.1 | 0.112742 |
| MA0113.1 | 0.358538 |
| MA0114.1 | 2.25916 |
| MA0115.1 | 1.14661 |
| MA0116.1 | 0.00530013 |
| MA0117.1 | 0.192271 |
| MA0119.1 | 0.286362 |
| MA0122.1 | 0.204518 |
| MA0124.1 | 0.346379 |
| MA0125.1 | 0.793271 |
| MA0130.1 | 0 |
| MA0131.1 | 0.237396 |
| MA0132.1 | 0 |
| MA0133.1 | 0 |
| MA0135.1 | 1.23006 |
| MA0136.1 | 0.521849 |
| MA0139.1 | 0.0184675 |
| MA0140.1 | 1.06816 |
| MA0141.1 | 1.67225 |
| MA0142.1 | 0.667303 |
| MA0143.1 | 0.68599 |
| MA0144.1 | 1.95706 |
| MA0145.1 | 0.0100079 |
| MA0146.1 | 5.69442e-05 |
| MA0147.1 | 0.230754 |
| MA0148.1 | 1.8881 |
| MA0149.1 | 0.0039909 |
| MA0062.2 | 0.000564861 |
| MA0035.2 | 2.44148 |
| MA0039.2 | 6.99506e-09 |
| MA0138.2 | 0.0641537 |
| MA0002.2 | 0.229976 |
| MA0137.2 | 2.01645 |
| MA0104.2 | 0.107492 |
| MA0047.2 | 1.7827 |
| MA0112.2 | 0.010006 |
| MA0065.2 | 0.741795 |
| MA0150.1 | 0.245658 |
| MA0151.1 | 0 |
| MA0152.1 | 0.922839 |
| MA0153.1 | 0.68621 |
| MA0154.1 | 0.0101745 |
| MA0155.1 | 0.00842769 |
| MA0156.1 | 0.038486 |
| MA0157.1 | 1.50123 |
| MA0158.1 | 0 |
| MA0159.1 | 0.564224 |
| MA0160.1 | 0.153045 |
| MA0161.1 | 0 |
| MA0162.1 | 2.26037e-05 |
| MA0163.1 | 3.42301e-05 |
| MA0164.1 | 0.282353 |
| MA0080.2 | 0.0816674 |
| MA0018.2 | 0.124921 |
| MA0099.2 | 0.48382 |
| MA0079.2 | 0 |
| MA0102.2 | 0.712096 |
| MA0258.1 | 0.0451601 |
| MA0259.1 | 0.0605653 |
| MA0442.1 | 0 |
