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Coexpression cluster:C1184

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Full id: C1184_Natural_Basophils_blood_NK_Peripheral_Whole_CD8



Phase1 CAGE Peaks

Hg19::chr12:9795420..9795436,+p@chr12:9795420..9795436
+
Hg19::chr12:9795452..9795469,+p@chr12:9795452..9795469
+
Hg19::chr14:22918081..22918089,+p1@TRDD3
Hg19::chr14:22918107..22918130,+p1@uc001wdw.2
Hg19::chr19:10226741..10226769,-p@chr19:10226741..10226769
-
Hg19::chr19:55417499..55417521,+p1@NCR1
Hg19::chr2:8464726..8464731,-p3@LINC00299


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0042269regulation of natural killer cell mediated cytotoxicity0.00393951881941991
GO:0016514SWI/SNF complex0.00393951881941991
GO:0001910regulation of leukocyte mediated cytotoxicity0.00393951881941991
GO:0031341regulation of cell killing0.00393951881941991
GO:0042267natural killer cell mediated cytotoxicity0.00393951881941991
GO:0002228natural killer cell mediated immunity0.00393951881941991
GO:0001909leukocyte mediated cytotoxicity0.00429765689391263
GO:0001906cell killing0.00429765689391263
GO:0030101natural killer cell activation0.00429765689391263
GO:0016585chromatin remodeling complex0.0088101966325209
GO:0006968cellular defense response0.0128929706817379
GO:0002449lymphocyte mediated immunity0.0128929706817379
GO:0002443leukocyte mediated immunity0.0128929706817379
GO:0002252immune effector process0.016331096196868
GO:0045087innate immune response0.016331096196868
GO:0046649lymphocyte activation0.0208167755798893
GO:0005057receptor signaling protein activity0.0214882844695632
GO:0045321leukocyte activation0.0214882844695632
GO:0001775cell activation0.0217952599619855
GO:0006917induction of apoptosis0.0217952599619855
GO:0012502induction of programmed cell death0.0217952599619855
GO:0043065positive regulation of apoptosis0.024104249535423
GO:0043068positive regulation of programmed cell death0.024104249535423
GO:0044451nucleoplasm part0.0404696024176773
GO:0005654nucleoplasm0.0446096785588131
GO:0042981regulation of apoptosis0.0448184218936603
GO:0043067regulation of programmed cell death0.0448184218936603
GO:0006952defense response0.0448184218936603



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Uber Anatomy
Ontology termp-valuen
blood1.38e-3115
haemolymphatic fluid1.38e-3115
organism substance1.38e-3115
hemolymphoid system8.57e-12108
hemopoietic organ1.52e-117
immune organ1.52e-117
hematopoietic system4.27e-1198
blood island4.27e-1198
adult organism2.21e-08114
thymus7.13e-084
hemolymphoid system gland7.13e-084
thymic region7.13e-084
pharyngeal gland7.13e-084
thymus primordium7.13e-084


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.0137961
MA0004.10.502801
MA0006.10.341337
MA0007.10.483857
MA0009.10.973289
MA0014.10.0156227
MA0017.10.380797
MA0019.10.652951
MA0024.10.867125
MA0025.11.10816
MA0027.12.59001
MA0028.10.35747
MA0029.10.886702
MA0030.10.875089
MA0031.10.809638
MA0038.10.60704
MA0040.10.892629
MA0041.10.521615
MA0042.10.48922
MA0043.10.973609
MA0046.10.962263
MA0048.10.120314
MA0050.10.490116
MA0051.10.602745
MA0052.10.896548
MA0055.10.158296
MA0056.10
MA0057.10.115382
MA0058.11.04727
MA0059.10.404929
MA0060.10.224688
MA0061.10.198335
MA0063.10
MA0066.10.607474
MA0067.11.29359
MA0068.10.162298
MA0069.10.958358
MA0070.10.947018
MA0071.10.567661
MA0072.10.942461
MA0073.10.000265001
MA0074.10.60198
MA0076.10.422297
MA0077.12.1528
MA0078.10.703614
MA0081.10.405093
MA0083.10.980893
MA0084.11.48179
MA0087.10.939982
MA0088.10.0723293
MA0089.10
MA0090.10.436918
MA0091.14.34752
MA0092.10.467172
MA0093.10.344385
MA0095.10
MA0098.10
MA0100.11.50553
MA0101.10.347695
MA0103.10.88373
MA0105.10.340955
MA0106.10.648997
MA0107.10.274127
MA0108.20.806528
MA0109.10
MA0111.10.45062
MA0113.10.665691
MA0114.10.269076
MA0115.11.21667
MA0116.10.277571
MA0117.11.01134
MA0119.10.388712
MA0122.11.03753
MA0124.11.17486
MA0125.11.0901
MA0130.10
MA0131.10.722072
MA0132.10
MA0133.10
MA0135.11.00402
MA0136.10.614215
MA0139.10.186511
MA0140.10.564957
MA0141.10.403171
MA0142.10.777365
MA0143.11.59899
MA0144.10.254954
MA0145.10.276317
MA0146.10.0610556
MA0147.10.281049
MA0148.10.528066
MA0149.10.555119
MA0062.20.193221
MA0035.20.564239
MA0039.20.00276064
MA0138.20.704862
MA0002.20.611548
MA0137.20.36398
MA0104.20.223944
MA0047.20.636643
MA0112.21.41281
MA0065.20.282161
MA0150.10.430951
MA0151.10
MA0152.10.571637
MA0153.11.07307
MA0154.10.335384
MA0155.10.250175
MA0156.10.36627
MA0157.11.77267
MA0158.10
MA0159.10.281681
MA0160.10.543522
MA0161.10
MA0162.10.0249953
MA0163.10.0765396
MA0164.10.678332
MA0080.20.911393
MA0018.20.650405
MA0099.20.572
MA0079.20.0109305
MA0102.21.51913
MA0258.11.27333
MA0259.10.289405
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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