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MCL coexpression mm9:1034

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Phase1 CAGE Peaks

 Short description
Mm9::chr10:62523378..62523405,+p2@Pbld1
Mm9::chr12:33987111..33987131,+p10@Atxn7l1
Mm9::chr12:74968671..74968675,+p@chr12:74968671..74968675
+
Mm9::chr17:43804437..43804461,+p2@Cyp39a1
Mm9::chr6:139535719..139535751,+p1@Pik3c2g
Mm9::chr6:139845232..139845235,+p@chr6:139845232..139845235
+
Mm9::chr8:108659441..108659470,+p2@ENSMUST00000140509


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:003378224-hydroxycholesterol 7alpha-hydroxylase activity0.00442654832323127
GO:0008387steroid 7-alpha-hydroxylase activity0.00442654832323127
GO:0030573bile acid catabolic process0.00442654832323127
GO:0008396oxysterol 7-alpha-hydroxylase activity0.00442654832323127
GO:0035005phosphatidylinositol-4-phosphate 3-kinase activity0.00442654832323127
GO:0006707cholesterol catabolic process0.00553197275074394
GO:0016127sterol catabolic process0.00553197275074394
GO:0006699bile acid biosynthetic process0.00553197275074394
GO:0046395carboxylic acid catabolic process0.00553197275074394
GO:0006706steroid catabolic process0.00553197275074394
GO:0016054organic acid catabolic process0.00553197275074394
GO:0044255cellular lipid metabolic process0.00553197275074394
GO:0046854phosphoinositide phosphorylation0.00553197275074394
GO:0035004phosphoinositide 3-kinase activity0.00553197275074394
GO:00163031-phosphatidylinositol-3-kinase activity0.00553197275074394
GO:0006629lipid metabolic process0.00553197275074394
GO:0005942phosphoinositide 3-kinase complex0.00553197275074394
GO:0016307phosphatidylinositol phosphate kinase activity0.00553197275074394
GO:0046834lipid phosphorylation0.00553197275074394
GO:0008395steroid hydroxylase activity0.00553197275074394
GO:0008206bile acid metabolic process0.00579524122475263
GO:0001727lipid kinase activity0.0105578556728842
GO:0016709oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen0.0105794246050111
GO:0030258lipid modification0.0105991708625171
GO:0044242cellular lipid catabolic process0.0119091415279413
GO:0004428inositol or phosphatidylinositol kinase activity0.0119091415279413
GO:0007586digestion0.0163775564470731
GO:0048015phosphoinositide-mediated signaling0.0167710368873478
GO:0030384phosphoinositide metabolic process0.0167710368873478
GO:0006650glycerophospholipid metabolic process0.0213621610797628
GO:0008203cholesterol metabolic process0.0228078961176848
GO:0006694steroid biosynthetic process0.0230363935280724
GO:0016125sterol metabolic process0.0230363935280724
GO:0016053organic acid biosynthetic process0.0230363935280724
GO:0046394carboxylic acid biosynthetic process0.0230363935280724
GO:0016042lipid catabolic process0.0280437053928451
GO:0044445cytosolic part0.0280437053928451
GO:0020037heme binding0.0314025432472364
GO:0046906tetrapyrrole binding0.0314025432472364
GO:0006644phospholipid metabolic process0.0319922495485837
GO:0019932second-messenger-mediated signaling0.0320612840675953
GO:0004497monooxygenase activity0.0320612840675953
GO:0016705oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen0.0320612840675953
GO:0008202steroid metabolic process0.0350780635844419
GO:0006643membrane lipid metabolic process0.0366554511166649
GO:0005792microsome0.0366554511166649
GO:0042598vesicular fraction0.0368094199443403
GO:0035091phosphoinositide binding0.0376422993612194
GO:0005543phospholipid binding0.0449238549794652
GO:0032787monocarboxylic acid metabolic process0.0468702382571968



Relative expression of the co-expression cluster over median <br>Analyst:




Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

Uber Anatomy
Ontology termp-valuen
trunk region element6.06e-2179
trunk1.40e-1790
immaterial anatomical entity6.31e-1779
liver1.77e-1422
epithelial sac1.77e-1422
digestive gland1.77e-1422
epithelium of foregut-midgut junction1.77e-1422
anatomical boundary1.77e-1422
hepatobiliary system1.77e-1422
foregut-midgut junction1.77e-1422
hepatic diverticulum1.77e-1422
liver primordium1.77e-1422
septum transversum1.77e-1422
liver bud1.77e-1422
digestive tract diverticulum1.76e-1323
sac1.76e-1323
exocrine gland2.04e-1325
exocrine system2.04e-1325
subdivision of trunk1.27e-1266
abdomen element1.99e-1049
abdominal segment element1.99e-1049
abdominal segment of trunk1.99e-1049
abdomen1.99e-1049
pancreas8.68e-1012
trunk mesenchyme5.85e-0945
foregut1.27e-0780
mesenchyme2.73e-0761
entire embryonic mesenchyme2.73e-0761
viscus4.22e-0719
subdivision of digestive tract8.38e-07114
digestive system8.99e-07116
digestive tract8.99e-07116
primitive gut8.99e-07116


TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs




JASPAR motifs


Motifs-log10(p-value)
MA0003.10.0286946
MA0004.10.481116
MA0006.10.311391
MA0007.10.465969
MA0009.10.92425
MA0014.10.0200028
MA0017.10.337808
MA0019.10.740036
MA0024.10.880057
MA0025.11.15921
MA0027.12.57545
MA0028.10.321735
MA0029.11.99617
MA0030.10.864739
MA0031.11.93597
MA0038.10.62758
MA0040.10.936879
MA0041.11.04397
MA0042.11.79544
MA0043.11.02178
MA0046.12.20556
MA0048.10.40238
MA0050.10.520357
MA0051.10.636645
MA0052.10.945011
MA0055.10.0406078
MA0056.10
MA0057.10.117936
MA0058.10.384683
MA0059.10.397033
MA0060.10.656954
MA0061.10.724575
MA0063.10
MA0066.10.616444
MA0067.11.27078
MA0068.10.385183
MA0069.10.945354
MA0070.10.93557
MA0071.10.519509
MA0072.10.927016
MA0073.10.00223012
MA0074.10.580087
MA0076.10.356883
MA0077.10.905143
MA0078.11.60783
MA0081.10.420276
MA0083.11.02098
MA0084.11.59945
MA0087.10.977537
MA0088.10.0841779
MA0089.10
MA0090.11.1347
MA0091.10.494398
MA0092.10.446857
MA0093.10.879104
MA0095.10
MA0098.10
MA0100.10.568369
MA0101.10.406019
MA0103.10.920496
MA0105.10.162418
MA0106.10.677988
MA0107.10.342432
MA0108.20.763162
MA0109.10
MA0111.10.460823
MA0113.10.649407
MA0114.10.719313
MA0115.11.0246
MA0116.10.836994
MA0117.10.992087
MA0119.11.04809
MA0122.11.01209
MA0124.11.21735
MA0125.11.14291
MA0130.10
MA0131.10.735438
MA0132.10
MA0133.10
MA0135.11.05845
MA0136.10.600242
MA0139.10.202522
MA0140.10.568252
MA0141.10.964041
MA0142.10.814115
MA0143.10.665982
MA0144.10.72625
MA0145.11.05551
MA0146.10.108739
MA0147.10.274511
MA0148.11.24416
MA0149.10.411562
MA0062.20.167299
MA0035.21.40435
MA0039.20.113749
MA0138.20.727395
MA0002.20.205289
MA0137.20.957645
MA0104.20.624968
MA0047.20.626803
MA0112.20.0910939
MA0065.20.633155
MA0150.10.465855
MA0151.10
MA0152.10.626912
MA0153.11.07519
MA0154.10.126143
MA0155.10.687925
MA0156.10.356017
MA0157.11.83902
MA0158.10
MA0159.10.284457
MA0160.10.50056
MA0161.10
MA0162.10.0312493
MA0163.10.0280055
MA0164.11.46244
MA0080.20.343316
MA0018.20.610433
MA0099.20.721008
MA0079.20.105858
MA0102.21.65195
MA0258.10.246285
MA0259.10.26402
MA0442.10
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