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{{Coexpression_clusters
{
|coexpression_dpi_cluster_scores_median=0,0,

Latest revision as of 11:36, 17 September 2013


Full id: C1032_Mast_Natural_CD4_CD8_CD19_Basophils_CD14



Phase1 CAGE Peaks

Hg19::chr14:50101931..50101969,-p4@DNAAF2
Hg19::chr15:86250415..86250426,-p@chr15:86250415..86250426
-
Hg19::chr16:27247011..27247032,+p@chr16:27247011..27247032
+
Hg19::chr19:16435987..16435993,+p@chr19:16435987..16435993
+
Hg19::chr19:18415466..18415480,-p@chr19:18415466..18415480
-
Hg19::chr2:25195104..25195126,+p5@DNAJC27-AS1
Hg19::chr8:38243836..38243862,+p10@LETM2
Hg19::chr9:129485649..129485680,-p@chr9:129485649..129485680
-


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Cell Type
Ontology termp-valuen
leukocyte1.30e-30136
nongranular leukocyte2.82e-25115
hematopoietic lineage restricted progenitor cell3.11e-25120
hematopoietic cell2.16e-23177
hematopoietic stem cell4.19e-23168
angioblastic mesenchymal cell4.19e-23168
mature alpha-beta T cell1.57e-2218
alpha-beta T cell1.57e-2218
immature T cell1.57e-2218
mature T cell1.57e-2218
immature alpha-beta T cell1.57e-2218
hematopoietic oligopotent progenitor cell4.99e-21161
hematopoietic multipotent progenitor cell4.99e-21161
T cell1.35e-1925
pro-T cell1.35e-1925
lymphoid lineage restricted progenitor cell4.44e-1952
intermediate monocyte6.55e-199
CD14-positive, CD16-positive monocyte6.55e-199
lymphocyte1.39e-1853
common lymphoid progenitor1.39e-1853
nucleate cell1.18e-1755
CD4-positive, alpha-beta T cell1.35e-146
CD8-positive, alpha-beta T cell4.56e-1211
myeloid leukocyte6.27e-1272
classical monocyte2.34e-1042
CD14-positive, CD16-negative classical monocyte2.34e-1042
circulating cell3.97e-096
myeloid lineage restricted progenitor cell9.73e-0966
defensive cell1.52e-0848
phagocyte1.52e-0848
granulocyte monocyte progenitor cell1.56e-0867
natural killer cell1.61e-083
pro-NK cell1.61e-083
naive T cell4.74e-083
histamine secreting cell7.07e-085
biogenic amine secreting cell7.07e-085
granulocytopoietic cell7.07e-085
mast cell7.07e-085
mast cell progenitor7.07e-085
basophil mast progenitor cell7.07e-085
basophil7.32e-083
single nucleate cell1.23e-073
mononuclear cell1.23e-073
non-classical monocyte2.38e-073
CD14-low, CD16-positive monocyte2.38e-073
Uber Anatomy
Ontology termp-valuen
hematopoietic system1.82e-1098
blood island1.82e-1098
hemolymphoid system7.68e-09108
bone marrow5.94e-0776


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.797136
MA0004.10.455723
MA0006.10.812175
MA0007.10.437331
MA0009.10.918715
MA0014.10.727045
MA0017.10.337901
MA0019.10.602411
MA0024.10.813542
MA0025.11.05265
MA0027.12.5321
MA0028.10.315574
MA0029.10.832916
MA0030.10.821423
MA0031.10.756713
MA0038.10.557409
MA0040.10.838784
MA0041.10.474018
MA0042.10.442535
MA0043.10.919032
MA0046.10.90778
MA0048.10.0955945
MA0050.10.443405
MA0051.10.553205
MA0052.10.842664
MA0055.10.028436
MA0056.10
MA0057.10.0912556
MA0058.11.69448
MA0059.10.948176
MA0060.10.190336
MA0061.10.165998
MA0063.10
MA0066.10.557833
MA0067.11.23721
MA0068.10.415214
MA0069.10.903908
MA0070.10.892666
MA0071.10.518907
MA0072.10.888148
MA0073.10.326687
MA0074.11.36092
MA0076.10.377799
MA0077.10.880402
MA0078.10.652193
MA0081.10.361233
MA0083.10.926258
MA0084.11.42483
MA0087.10.885691
MA0088.10.441522
MA0089.10
MA0090.11.01596
MA0091.10.458301
MA0092.10.421159
MA0093.10.818737
MA0095.10
MA0098.10
MA0100.10.571227
MA0101.10.30624
MA0103.10.291333
MA0105.10.586268
MA0106.10.59853
MA0107.10.236528
MA0108.20.753643
MA0109.10
MA0111.10.405141
MA0113.10.614917
MA0114.10.655057
MA0115.11.1606
MA0116.10.239768
MA0117.10.956472
MA0119.10.913661
MA0122.10.982472
MA0124.11.11898
MA0125.11.0347
MA0130.10
MA0131.10.670358
MA0132.10
MA0133.10
MA0135.10.949204
MA0136.10.564434
MA0139.10.470675
MA0140.10.516266
MA0141.10.359385
MA0142.10.724856
MA0143.10.615094
MA0144.11.82745
MA0145.10.220937
MA0146.11.26525
MA0147.11.26392
MA0148.10.480298
MA0149.10.506665
MA0062.20.485915
MA0035.20.515566
MA0039.20.0817047
MA0138.20.653421
MA0002.20.531206
MA0137.20.86081
MA0104.21.05746
MA0047.20.586412
MA0112.20.458158
MA0065.20.844872
MA0150.10.386144
MA0151.10
MA0152.10.52279
MA0153.11.01778
MA0154.10.0799828
MA0155.10.43752
MA0156.10.323987
MA0157.10.697424
MA0158.10
MA0159.10.243637
MA0160.10.495355
MA0161.10
MA0162.10.93331
MA0163.11.06699
MA0164.10.627336
MA0080.20.303167
MA0018.21.46097
MA0099.20.523145
MA0079.20.754308
MA0102.21.46209
MA0258.11.13653
MA0259.10.25092
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
E2F6#187653.135722332310870.01024880501420960.0381486544614384
POLR2A#543082.147453176558070.002210725788971910.0127174877815718



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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