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{{Coexpression_clusters
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|full_id=C4087_Mesenchymal_Adipocyte_Alveolar_Hair_Renal_Fibroblast_Pericytes
|id=C4087
|ontology_enrichment_celltype=CL:0002321!7.50e-26!248;CL:0000220!1.33e-25!246;CL:0000548!2.56e-22!679;CL:0000004!2.56e-22!679;CL:0000255!2.56e-22!679;CL:0000012!4.33e-21!682;CL:0000055!5.17e-20!180;CL:0000183!1.88e-18!59;CL:0000144!3.93e-18!625;CL:0002371!9.88e-18!591;CL:0000222!8.40e-17!119;CL:0000187!5.98e-16!54;CL:0000680!6.17e-16!57;CL:0000056!6.17e-16!57;CL:0000355!6.17e-16!57;CL:0000066!1.06e-15!254;CL:0000393!3.11e-15!60;CL:0000211!3.11e-15!60;CL:0000192!5.09e-15!42;CL:0000514!5.09e-15!42;CL:0000359!4.22e-11!32;CL:0000003!1.71e-10!722;CL:0000325!2.43e-10!39;CL:1000449!1.65e-08!16;CL:1000497!1.36e-07!18;CL:0002518!1.36e-07!18;CL:1000507!3.62e-07!12;CL:1000494!3.62e-07!12;CL:0000136!4.42e-07!15;CL:0002681!4.48e-07!13;CL:0002584!4.48e-07!13;CL:0000057!8.48e-07!75
|ontology_enrichment_disease=
|ontology_enrichment_uberon=UBERON:0005256!7.29e-25!143;UBERON:0002100!8.88e-22!216;UBERON:0003104!4.29e-19!238;UBERON:0009142!4.29e-19!238;UBERON:0000914!7.90e-18!83;UBERON:0002329!7.90e-18!83;UBERON:0003077!7.90e-18!83;UBERON:0003059!7.90e-18!83;UBERON:0007282!7.90e-18!83;UBERON:0009618!7.90e-18!83;UBERON:0007285!7.90e-18!83;UBERON:0003914!8.17e-18!118;UBERON:0000486!2.76e-16!82;UBERON:0004290!2.89e-16!70;UBERON:0000481!3.56e-16!347;UBERON:0000490!3.05e-15!138;UBERON:0002049!2.24e-13!79;UBERON:0007798!2.24e-13!79;UBERON:0001134!8.11e-13!61;UBERON:0002036!8.11e-13!61;UBERON:0003082!8.11e-13!61;UBERON:0002385!8.58e-13!63;UBERON:0001015!8.58e-13!63;UBERON:0000383!8.58e-13!63;UBERON:0000475!8.86e-13!365;UBERON:0000119!1.23e-12!312;UBERON:0000483!3.10e-12!309;UBERON:0009569!3.73e-10!113;UBERON:0004872!5.29e-10!84;UBERON:0001981!3.03e-09!60;UBERON:0007500!3.03e-09!60;UBERON:0004537!3.03e-09!60;UBERON:0006965!3.03e-09!60;UBERON:0000055!3.05e-09!69;UBERON:0000477!4.99e-09!286;UBERON:0004211!1.65e-08!16;UBERON:0001285!1.65e-08!16;UBERON:0007684!1.65e-08!16;UBERON:0003220!1.65e-08!16;UBERON:0004208!1.65e-08!16;UBERON:0001637!2.40e-08!42;UBERON:0003509!2.40e-08!42;UBERON:0004572!2.40e-08!42;UBERON:0002417!3.78e-08!61;UBERON:0000916!3.78e-08!61;UBERON:0006555!5.91e-08!17;UBERON:0005103!5.91e-08!17;UBERON:0000083!5.91e-08!17;UBERON:0009201!5.91e-08!17;UBERON:0004819!5.91e-08!17;UBERON:0006553!5.91e-08!17;UBERON:0003074!5.91e-08!17;UBERON:0003060!5.91e-08!17;UBERON:0000080!2.23e-07!18;UBERON:0002120!2.23e-07!18;UBERON:0004875!2.23e-07!18;UBERON:0005721!2.23e-07!18;UBERON:0005754!2.23e-07!18;UBERON:0007297!2.23e-07!18;UBERON:0005172!2.27e-07!55;UBERON:0005173!2.27e-07!55;UBERON:0006554!3.05e-07!44;UBERON:0004535!3.19e-07!110;UBERON:0009773!3.62e-07!12;UBERON:0001231!3.62e-07!12;UBERON:0004810!3.62e-07!12;UBERON:0001048!4.30e-07!168;UBERON:0001225!4.48e-07!13;UBERON:0008987!4.48e-07!13;UBERON:0005085!5.56e-07!29;UBERON:0001008!5.63e-07!45;UBERON:0004119!7.47e-07!169;UBERON:0000925!7.47e-07!169;UBERON:0006595!7.47e-07!169;UBERON:0004876!8.48e-07!20
}}

Latest revision as of 12:39, 17 September 2013


Full id: C4087_Mesenchymal_Adipocyte_Alveolar_Hair_Renal_Fibroblast_Pericytes



Phase1 CAGE Peaks

Hg19::chr22:19166235..19166238,-p4@SLC25A1
Hg19::chr22:19166241..19166257,-p1@SLC25A1
Hg19::chr22:19166269..19166306,-p2@SLC25A1


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Uber Anatomy
Ontology termp-valuen
mesenchyme1.06e-20160
entire embryonic mesenchyme1.06e-20160
organism subdivision4.41e-20264
epithelial vesicle3.84e-1978
trunk mesenchyme4.54e-18122
unilaminar epithelium9.29e-18148
trunk2.93e-17199
epithelial tube3.01e-17117
somite3.83e-1671
presomitic mesoderm3.83e-1671
presumptive segmental plate3.83e-1671
dermomyotome3.83e-1671
trunk paraxial mesoderm3.83e-1671
multilaminar epithelium8.30e-1683
paraxial mesoderm2.03e-1572
presumptive paraxial mesoderm2.03e-1572
dense mesenchyme tissue2.08e-1573
vasculature1.13e-1378
vascular system1.13e-1378
multi-tissue structure4.49e-13342
muscle tissue7.13e-1364
musculature7.13e-1364
musculature of body7.13e-1364
skeletal muscle tissue8.93e-1362
striated muscle tissue8.93e-1362
myotome8.93e-1362
cell layer3.19e-11309
splanchnic layer of lateral plate mesoderm6.83e-1183
epithelium8.36e-11306
epithelial tube open at both ends8.76e-1059
blood vessel8.76e-1059
blood vasculature8.76e-1059
vascular cord8.76e-1059
vessel1.11e-0968
anatomical cluster5.64e-09373
artery1.38e-0842
arterial blood vessel1.38e-0842
arterial system1.38e-0842
subdivision of trunk1.45e-08112
nephron epithelium1.86e-0815
renal tubule1.86e-0815
nephron tubule1.86e-0815
nephron1.86e-0815
uriniferous tubule1.86e-0815
nephrogenic mesenchyme1.86e-0815
excretory tube7.84e-0816
kidney epithelium7.84e-0816
abdominal segment of trunk1.23e-0760
abdomen1.23e-0760
cardiovascular system1.76e-07109
urinary system structure3.64e-0747
ectodermal placode4.10e-0731
primordium4.43e-07160
abdomen element6.19e-0754
abdominal segment element6.19e-0754
renal system6.69e-0748
cortex of kidney6.96e-0712
renal parenchyma6.96e-0712
endoderm-derived structure7.43e-07160
endoderm7.43e-07160
presumptive endoderm7.43e-07160
circulatory system8.28e-07112
systemic artery9.54e-0733
systemic arterial system9.54e-0733


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.11.54338
MA0004.10.826076
MA0006.11.5435
MA0007.11.88666
MA0009.11.3275
MA0014.13.14798
MA0017.10.686276
MA0019.10.990656
MA0024.11.21731
MA0025.11.46617
MA0027.12.95767
MA0028.10.658629
MA0029.11.23771
MA0030.11.22561
MA0031.11.15713
MA0038.10.94098
MA0040.11.24388
MA0041.10.847069
MA0042.10.810843
MA0043.11.32783
MA0046.11.31611
MA0048.10.341392
MA0050.10.81185
MA0051.10.936307
MA0052.11.24796
MA0055.10.190716
MA0056.10
MA0057.10.886807
MA0058.11.70328
MA0059.10.714521
MA0060.12.13518
MA0061.10.456531
MA0063.10
MA0066.13.5636
MA0067.11.65513
MA0068.10.405474
MA0069.11.31207
MA0070.11.30033
MA0071.10.897953
MA0072.12.8848
MA0073.11.36698
MA0074.10.935474
MA0076.10.734647
MA0077.11.28751
MA0078.11.04495
MA0081.10.714712
MA0083.11.33535
MA0084.11.84562
MA0087.11.29304
MA0088.10.257905
MA0089.10
MA0090.10.751469
MA0091.10.829044
MA0092.10.785956
MA0093.10.642957
MA0095.10
MA0098.10
MA0100.10.956299
MA0101.10.646932
MA0103.10.628063
MA0105.10.31555
MA0106.10.986396
MA0107.10.556367
MA0108.21.15387
MA0109.10
MA0111.10.767139
MA0113.11.00436
MA0114.14.59872
MA0115.11.57693
MA0116.10.560723
MA0117.13.02823
MA0119.10.695578
MA0122.11.39371
MA0124.11.53432
MA0125.11.44766
MA0130.10
MA0131.11.06461
MA0132.10
MA0133.10
MA0135.11.35921
MA0136.10.948776
MA0139.10.440097
MA0140.10.894983
MA0141.10.712476
MA0142.11.12317
MA0143.11.00455
MA0144.10.531867
MA0145.12.11725
MA0146.15.33893
MA0147.11.38767
MA0148.10.854239
MA0149.10.884158
MA0062.20.449458
MA0035.20.894194
MA0039.211.588
MA0138.21.04628
MA0002.20.476938
MA0137.20.666381
MA0104.23.15214
MA0047.20.973066
MA0112.22.88736
MA0065.23.88385
MA0150.10.744617
MA0151.10
MA0152.10.902317
MA0153.11.43021
MA0154.11.51687
MA0155.12.02721
MA0156.10.669101
MA0157.11.09377
MA0158.10
MA0159.10.565904
MA0160.10.871361
MA0161.10
MA0162.14.34338
MA0163.10.776149
MA0164.11.01792
MA0080.20.643061
MA0018.20.987913
MA0099.20.902716
MA0079.29.48295
MA0102.21.88331
MA0258.11.29138
MA0259.10.575594
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CHD2#1106310.34402283411690.0009033701102746880.00661203104260832
E2F1#186934.907389214879320.008460985347239390.0325976408691285
E2F6#187635.017155731697390.00791769806886330.0322938556828092
EBF1#187938.9064668465690.00141523283560980.00916452766110196
ELF1#199734.258097958807540.01295179875054610.0463212420282269
ESR1#2099330.76860329615453.43136389821584e-050.000677829041357601
HDAC2#3066313.41562023662630.0004140761399857210.00391895767865598
HNF4A#3172323.13229036295378.07584663437677e-050.00122931547390712
HNF4G#3174328.75342252644684.20470658818262e-050.00075765243506419
IRF1#365937.63716375356390.002244692747297240.0128323096959317
MXI1#460139.96157162875930.001011470541259020.00721169933496388
NANOG#79923329.24477848101273.99627955670032e-050.000738311410971564
RXRA#6256320.07461713913330.0001235730348432220.00165417126198299
SIN3A#2594235.408884726815140.006318961977991520.0277299915971031
SP1#666735.69838137814090.005403962701712170.0246984578619805
SREBF1#6720347.00584944048839.62099323994382e-060.000254897745557203
USF1#739136.361499277207960.00388404057290560.0190658635736834
YY1#752834.911170749853860.008441455341808260.0329971238282474



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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