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{{Coexpression_clusters
{
|coexpression_dpi_cluster_scores_median=-0.113826763725245

Latest revision as of 12:03, 17 September 2013


Full id: C2322_Mast_Neutrophils_Eosinophils_granulocyte_cerebellum_Whole_CD4



Phase1 CAGE Peaks

Hg19::chr14:91526905..91526916,-p3@RPS6KA5
Hg19::chr14:91526922..91527001,-p1@RPS6KA5
Hg19::chr14:91527015..91527034,-p2@RPS6KA5
Hg19::chr17:38278209..38278250,+p2@MSL1


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0016572histone phosphorylation0.00488637701636642
GO:0007173epidermal growth factor receptor signaling pathway0.0305398563522901
GO:0016570histone modification0.0305398563522901
GO:0016569covalent chromatin modification0.0305398563522901



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Uber Anatomy
Ontology termp-valuen
adult organism7.74e-31114
neural tube6.10e-1556
neural rod6.10e-1556
future spinal cord6.10e-1556
neural keel6.10e-1556
regional part of nervous system6.83e-1453
regional part of brain6.83e-1453
regional part of forebrain2.24e-1141
forebrain2.24e-1141
anterior neural tube2.24e-1141
future forebrain2.24e-1141
brain2.76e-1168
future brain2.76e-1168
central nervous system5.42e-1181
nervous system2.14e-1089
telencephalon1.36e-0934
brain grey matter1.63e-0934
gray matter1.63e-0934
hematopoietic system7.62e-0998
blood island7.62e-0998
regional part of telencephalon8.34e-0932
cerebral hemisphere1.02e-0832
regional part of cerebral cortex5.49e-0822
neocortex2.07e-0720
blood3.53e-0715
haemolymphatic fluid3.53e-0715
organism substance3.53e-0715
neurectoderm3.62e-0786
hemolymphoid system4.24e-07108
neural plate5.29e-0782
presumptive neural plate5.29e-0782


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.233555
MA0004.10.71247
MA0006.10.532262
MA0007.10.6918
MA0009.11.20602
MA0014.11.34758
MA0017.10.577281
MA0019.10.873355
MA0024.11.09684
MA0025.11.34373
MA0027.12.83281
MA0028.10.550763
MA0029.11.11704
MA0030.11.10506
MA0031.11.03735
MA0038.11.92746
MA0040.11.12314
MA0041.10.732902
MA0042.10.697662
MA0043.11.20635
MA0046.11.19471
MA0048.10.25531
MA0050.10.69864
MA0051.10.820063
MA0052.11.12718
MA0055.10.396851
MA0056.10
MA0057.11.98521
MA0058.10.605914
MA0059.10.604454
MA0060.14.7631
MA0061.10.360128
MA0063.10
MA0066.10.825101
MA0067.11.53181
MA0068.10.313194
MA0069.11.19071
MA0070.11.17908
MA0071.10.782546
MA0072.11.1744
MA0073.10.599068
MA0074.10.819248
MA0076.10.623864
MA0077.11.16637
MA0078.10.926725
MA0081.10.604638
MA0083.11.21381
MA0084.11.72172
MA0087.11.17185
MA0088.10.182167
MA0089.10
MA0090.10.640115
MA0091.10.715356
MA0092.10.673508
MA0093.10.535768
MA0095.10
MA0098.10
MA0100.10.83965
MA0101.10.539569
MA0103.10.521546
MA0105.10.232357
MA0106.10.869173
MA0107.10.453492
MA0108.21.03412
MA0109.10
MA0111.10.655276
MA0113.10.886811
MA0114.10.447443
MA0115.11.45393
MA0116.10.457606
MA0117.11.24497
MA0119.11.43218
MA0122.11.27173
MA0124.11.41151
MA0125.11.32534
MA0130.10
MA0131.10.94608
MA0132.10
MA0133.10
MA0135.11.23748
MA0136.10.832277
MA0139.10.344952
MA0140.10.779643
MA0141.10.602484
MA0142.11.00381
MA0143.10.887001
MA0144.10.430413
MA0145.10.569905
MA0146.11.25938
MA0147.10.46175
MA0148.10.739888
MA0149.10.769072
MA0062.20.353589
MA0035.20.778873
MA0039.21.5472
MA0138.20.928035
MA0002.20.98779
MA0137.20.558189
MA0104.20.392359
MA0047.20.856092
MA0112.20.187982
MA0065.21.09513
MA0150.10.633493
MA0151.10
MA0152.10.78681
MA0153.11.30799
MA0154.10.229241
MA0155.11.61785
MA0156.10.560797
MA0157.10.97481
MA0158.10
MA0159.10.462502
MA0160.10.756582
MA0161.10
MA0162.11.57817
MA0163.11.37853
MA0164.10.90014
MA0080.20.535868
MA0018.20.870662
MA0099.20.7872
MA0079.24.91669
MA0102.21.75932
MA0258.10.418966
MA0259.10.471671
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
E2F1#186944.907389214879320.001724022357361790.0106384148289813
E2F4#187439.501045236463330.001850751034728270.0109253101580367
E2F6#187645.017155731697390.00157802193473060.0099605362529511
EGR1#195844.988179094810140.001615011500076050.0101352112760752
FOS#235336.74846648167080.005032452776317940.0234604443827107
FOXA2#3170212.31523187633260.009361916285467240.0353386285578254
HEY1#2346244.040111043105710.00375304636917980.0185773927556173
IRF1#365935.727872815172930.008097114790333330.0319996432280479
IRF3#3661335.23646415861723.79279212646878e-050.000719686440581891
NFYB#4801312.56984494015230.000811456397697350.00618596311818347
NRF1#4899412.21027944771094.49717228915276e-050.00079284297215872
PBX3#5090316.43588451505810.0003669431395554610.00365714042866999
RFX5#599339.035933120396320.002144561191324070.0123832490883339
SMARCB1#6598313.68953683586810.0006305783409379340.00518110072765454
SP2#6668319.61514787038350.0002171004269245340.00248533941549615
TAF1#687243.343046285745290.008005664898701650.0321726810972565
TBP#690843.706770687096390.005296377814784350.0243817341472325
ZNF143#7702310.12565741417090.001534861610688180.0097624489499795
ZNF263#1012748.221841637010680.0002187871180958320.00248422568241037



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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