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{{Coexpression_clusters
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|coexpression_dpi_cluster_scores_median=-0.

Latest revision as of 14:14, 17 September 2013


Full id: C4509_CD14_renal_Whole_serous_signet_small_optic



Phase1 CAGE Peaks

Hg19::chr5:60140009..60140050,-p2@ELOVL7
Hg19::chr5:60140059..60140075,-p3@ELOVL7
Hg19::chr5:60140089..60140118,-p1@ELOVL7


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>


Cell Type
Ontology termp-valuen
epithelial cell1.38e-08253
endo-epithelial cell7.83e-0842
endodermal cell1.34e-0758
Uber Anatomy
Ontology termp-valuen
adult organism1.20e-37114
neural tube1.17e-2156
neural rod1.17e-2156
future spinal cord1.17e-2156
neural keel1.17e-2156
regional part of nervous system5.03e-2053
regional part of brain5.03e-2053
ecto-epithelium1.74e-19104
neural plate2.34e-1782
presumptive neural plate2.34e-1782
regional part of forebrain3.56e-1741
forebrain3.56e-1741
anterior neural tube3.56e-1741
future forebrain3.56e-1741
central nervous system1.90e-1681
neurectoderm2.65e-1686
organ3.61e-16503
brain5.72e-1668
future brain5.72e-1668
nervous system6.06e-1589
pre-chordal neural plate1.32e-1461
brain grey matter2.95e-1434
gray matter2.95e-1434
telencephalon3.32e-1434
regional part of telencephalon4.30e-1332
cerebral hemisphere5.24e-1332
organ system subdivision1.55e-12223
embryo2.23e-12592
ectoderm-derived structure2.41e-12171
ectoderm2.41e-12171
presumptive ectoderm2.41e-12171
developing anatomical structure2.54e-11581
regional part of cerebral cortex2.13e-1022
cerebral cortex2.10e-0925
pallium2.10e-0925
neocortex2.45e-0920
multi-cellular organism3.50e-09656
structure with developmental contribution from neural crest3.25e-08132
anatomical system4.98e-08624
anatomical group7.37e-08625
embryonic structure9.69e-08564
germ layer4.23e-07560
germ layer / neural crest4.23e-07560
embryonic tissue4.23e-07560
presumptive structure4.23e-07560
germ layer / neural crest derived structure4.23e-07560
epiblast (generic)4.23e-07560
organ part8.13e-07218
Disease
Ontology termp-valuen
carcinoma5.00e-11106
cell type cancer2.70e-08143


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.16.06693
MA0004.10.826076
MA0006.11.5435
MA0007.11.88666
MA0009.11.3275
MA0014.13.90467
MA0017.10.686276
MA0019.10.990656
MA0024.11.21731
MA0025.11.46617
MA0027.12.95767
MA0028.10.658629
MA0029.11.23771
MA0030.11.22561
MA0031.11.15713
MA0038.10.94098
MA0040.11.24388
MA0041.10.847069
MA0042.10.810843
MA0043.11.32783
MA0046.11.31611
MA0048.10.904546
MA0050.10.81185
MA0051.10.936307
MA0052.11.24796
MA0055.10.190716
MA0056.10
MA0057.11.59304
MA0058.10.716037
MA0059.10.714521
MA0060.10.492218
MA0061.10.456531
MA0063.10
MA0066.10.941452
MA0067.11.65513
MA0068.10.405474
MA0069.11.31207
MA0070.11.30033
MA0071.10.897953
MA0072.11.29561
MA0073.10.0185922
MA0074.10.935474
MA0076.10.734647
MA0077.11.28751
MA0078.11.04495
MA0081.10.714712
MA0083.11.33535
MA0084.11.84562
MA0087.11.29304
MA0088.10.257905
MA0089.10
MA0090.10.751469
MA0091.10.829044
MA0092.10.785956
MA0093.10.642957
MA0095.10
MA0098.10
MA0100.10.956299
MA0101.10.646932
MA0103.11.52002
MA0105.10.31555
MA0106.10.986396
MA0107.10.556367
MA0108.21.15387
MA0109.10
MA0111.10.767139
MA0113.11.00436
MA0114.11.35563
MA0115.11.57693
MA0116.10.560723
MA0117.11.36676
MA0119.10.695578
MA0122.11.39371
MA0124.11.53432
MA0125.11.44766
MA0130.10
MA0131.11.06461
MA0132.10
MA0133.10
MA0135.11.35921
MA0136.10.948776
MA0139.18.84824
MA0140.10.894983
MA0141.10.712476
MA0142.11.12317
MA0143.11.00455
MA0144.10.531867
MA0145.10.273764
MA0146.11.70974
MA0147.10.565108
MA0148.10.854239
MA0149.10.884158
MA0062.20.449458
MA0035.20.894194
MA0039.20.757898
MA0138.21.04628
MA0002.20.476938
MA0137.20.666381
MA0104.22.13189
MA0047.20.973066
MA0112.20.731309
MA0065.22.13692
MA0150.10.744617
MA0151.10
MA0152.10.902317
MA0153.11.43021
MA0154.10.312019
MA0155.12.83144
MA0156.10.669101
MA0157.11.09377
MA0158.10
MA0159.10.565904
MA0160.10.871361
MA0161.10
MA0162.12.05956
MA0163.11.2663
MA0164.11.01792
MA0080.20.643061
MA0018.20.987913
MA0099.20.902716
MA0079.25.16052
MA0102.21.88331
MA0258.10.519674
MA0259.10.575594
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CCNT2#90536.336201576962630.003930750035764890.0190896816082422
CTCF#1066435.360256373075030.0064925092527670.0280937675608938
E2F1#186934.907389214879320.008460985347239390.0327195485866751
E2F6#187635.017155731697390.00791769806886330.0323937974933997
FOSL1#8061339.7135797163731.59554825631833e-050.000372291028466556
GATA3#2625327.2365163572064.94721007899563e-050.000853737067812664
HMGN3#932438.178547723350590.001827766942164210.0109080086670108
JUN#3725312.51282919233630.0005103313992726250.00445937926779064
JUND#372736.994663941871030.002921845042734990.0157458500731785
MYC#460935.22228187160940.007020843755740150.0295712978305269
PAX5#507936.669565531177830.003370290999677260.0173547885669704
RAD21#5885310.35503389545630.0009004912073565420.00667469135593398
SMC3#9126315.04493284493280.0002935825420371870.00310432996940586
TCF12#6938310.63446490218640.0008313523990202070.00631459005100155
USF1#739136.361499277207960.00388404057290560.0190981785966896
ZBTB7A#5134137.35190930787590.002516255860282270.014075803202572
ZEB1#6935316.88843201754390.0002075486917327580.00243579928260226
ZNF143#7702313.50087655222790.0004062804962997170.0039035445035001



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.