Coexpression cluster:C586

Full id: C586_cerebellum_brain_occipital_middle_parietal_medial_amygdala

Phase1 CAGE Peaks

Hg19::chr11:132807611..132807618,-	p@chr11:132807611..132807618 -
Hg19::chr11:132814188..132814199,-	p@chr11:132814188..132814199 -
Hg19::chr13:102746160..102746164,-	p@chr13:102746160..102746164 -
Hg19::chr16:6493692..6493697,+	p@chr16:6493692..6493697 +
Hg19::chr17:884354..884374,-	p@chr17:884354..884374 -
Hg19::chr19:13317729..13317738,-	p@chr19:13317729..13317738 -
Hg19::chr1:18433873..18433888,+	p8@IGSF21
Hg19::chr20:33815160..33815166,-	p@chr20:33815160..33815166 -
Hg19::chr22:51158914..51158921,+	p13@SHANK3
Hg19::chr5:160820302..160820306,-	p@chr5:160820302..160820306 -
Hg19::chr5:176256892..176256896,+	p@chr5:176256892..176256896 +
Hg19::chr7:153634554..153634556,+	p@chr7:153634554..153634556 +
Hg19::chr7:36561860..36561869,-	p@chr7:36561860..36561869 -
Hg19::chr8:9776684..9776691,-	p@chr8:9776684..9776691 -
Hg19::chr9:114312975..114312986,+	p@chr9:114312975..114312986 +

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0001838	embryonic epithelial tube formation	0.0187743671962285
GO:0016331	morphogenesis of embryonic epithelium	0.0187743671962285
GO:0002009	morphogenesis of an epithelium	0.0304695680059167
GO:0035239	tube morphogenesis	0.0304695680059167
GO:0048598	embryonic morphogenesis	0.0304695680059167
GO:0035295	tube development	0.0304695680059167
GO:0045211	postsynaptic membrane	0.0304695680059167
GO:0000165	MAPKKK cascade	0.0304695680059167
GO:0044456	synapse part	0.0304695680059167
GO:0009790	embryonic development	0.0399830940917626

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
regional part of nervous system	4.19e-72	53
regional part of brain	4.19e-72	53
neural tube	4.24e-68	56
neural rod	4.24e-68	56
future spinal cord	4.24e-68	56
neural keel	4.24e-68	56
brain	7.62e-65	68
future brain	7.62e-65	68
cerebral hemisphere	2.35e-59	32
telencephalon	8.74e-56	34
brain grey matter	9.70e-56	34
gray matter	9.70e-56	34
central nervous system	4.85e-54	81
regional part of telencephalon	2.04e-52	32
regional part of forebrain	9.30e-52	41
forebrain	9.30e-52	41
anterior neural tube	9.30e-52	41
future forebrain	9.30e-52	41
regional part of cerebral cortex	2.09e-50	22
nervous system	2.40e-48	89
neocortex	4.47e-47	20
neural plate	1.68e-45	82
presumptive neural plate	1.68e-45	82
cerebral cortex	2.54e-44	25
pallium	2.54e-44	25
neurectoderm	3.20e-43	86
ecto-epithelium	4.17e-35	104
adult organism	6.22e-35	114
pre-chordal neural plate	5.59e-34	61
gyrus	9.77e-30	6
structure with developmental contribution from neural crest	1.91e-29	132
ectoderm-derived structure	1.52e-23	171
ectoderm	1.52e-23	171
presumptive ectoderm	1.52e-23	171
segmental subdivision of hindbrain	4.67e-21	12
hindbrain	4.67e-21	12
presumptive hindbrain	4.67e-21	12
segmental subdivision of nervous system	2.10e-19	13
brainstem	7.00e-19	6
organ system subdivision	1.09e-18	223
tube	3.59e-17	192
temporal lobe	7.79e-17	6
posterior neural tube	9.33e-17	15
chordal neural plate	9.33e-17	15
corpus striatum	1.92e-16	4
striatum	1.92e-16	4
ventral part of telencephalon	1.92e-16	4
future corpus striatum	1.92e-16	4
middle temporal gyrus	2.08e-15	2
limbic system	1.07e-13	5
parietal lobe	2.03e-13	5
organ part	3.69e-13	218
regional part of metencephalon	3.89e-13	9
metencephalon	3.89e-13	9
future metencephalon	3.89e-13	9
basal ganglion	6.42e-13	9
nuclear complex of neuraxis	6.42e-13	9
aggregate regional part of brain	6.42e-13	9
collection of basal ganglia	6.42e-13	9
cerebral subcortex	6.42e-13	9
anatomical conduit	6.90e-13	240
neural nucleus	9.32e-13	9
nucleus of brain	9.32e-13	9
frontal cortex	1.22e-10	3
caudate-putamen	2.38e-10	3
dorsal striatum	2.38e-10	3
medulla oblongata	2.49e-10	3
myelencephalon	2.49e-10	3
future myelencephalon	2.49e-10	3
pons	2.88e-10	3
telencephalic nucleus	1.25e-09	7
anatomical cluster	2.01e-09	373
epithelium	3.61e-09	306
cell layer	4.89e-09	309
olfactory region	1.02e-08	1
primary subdivision of skull	1.02e-08	1
cranium	1.02e-08	1
neurocranium	1.02e-08	1
chondrocranium	1.02e-08	1
cartilaginous neurocranium	1.02e-08	1
head paraxial mesoderm	1.02e-08	1
multi-tissue structure	1.15e-08	342
insula	1.18e-08	1
paracentral gyrus	1.59e-08	1
putamen	1.84e-08	1
nucleus accumbens	2.13e-08	1
ventral striatum	2.13e-08	1
occipital pole	3.06e-08	1
pole of cerebral hemisphere	3.06e-08	1
postcentral gyrus	3.53e-08	1

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.