Coexpression cluster:C1120
From FANTOM5_SSTAR
Full id: C1120_adult_hairy_mycosis_B_plasma_CD4_cord
Phase1 CAGE Peaks
| Hg19::chr10:69513561..69513563,- | p@chr10:69513561..69513563 - |
| Hg19::chr5:95309942..95309984,+ | p@chr5:95309942..95309984 + |
| Hg19::chr7:142494920..142494955,+ | p1@TRBJ2-6 |
| Hg19::chr8:102980193..102980205,- | p@chr8:102980193..102980205 - |
| Hg19::chr8:102987548..102987571,- | p4@NCALD |
| Hg19::chr8:102987581..102987599,- | p5@NCALD |
| Hg19::chr8:103108677..103108680,- | p@chr8:103108677..103108680 - |
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
No results for this coexpression
Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data
| GO ID | GO name | FDR corrected p-value |
|---|---|---|
| GO:0030276 | clathrin binding | 0.00647592134699164 |
| GO:0030130 | clathrin coat of trans-Golgi network vesicle | 0.00647592134699164 |
| GO:0012510 | trans-Golgi network transport vesicle membrane | 0.00647592134699164 |
| GO:0030125 | clathrin vesicle coat | 0.00647592134699164 |
| GO:0030665 | clathrin coated vesicle membrane | 0.00647592134699164 |
| GO:0030140 | trans-Golgi network transport vesicle | 0.00647592134699164 |
| GO:0030658 | transport vesicle membrane | 0.00647592134699164 |
| GO:0030660 | Golgi-associated vesicle membrane | 0.00647592134699164 |
| GO:0030120 | vesicle coat | 0.0079792602311147 |
| GO:0030662 | coated vesicle membrane | 0.0079792602311147 |
| GO:0030133 | transport vesicle | 0.0079792602311147 |
| GO:0030118 | clathrin coat | 0.0079792602311147 |
| GO:0015631 | tubulin binding | 0.0079792602311147 |
| GO:0005798 | Golgi-associated vesicle | 0.0079792602311147 |
| GO:0030659 | cytoplasmic vesicle membrane | 0.00939008595313787 |
| GO:0044433 | cytoplasmic vesicle part | 0.00939008595313787 |
| GO:0012506 | vesicle membrane | 0.00939008595313787 |
| GO:0030136 | clathrin-coated vesicle | 0.00939008595313787 |
| GO:0030117 | membrane coat | 0.00939008595313787 |
| GO:0048475 | coated membrane | 0.00939008595313787 |
| GO:0030135 | coated vesicle | 0.0113328623572354 |
| GO:0016023 | cytoplasmic membrane-bound vesicle | 0.0246219926213745 |
| GO:0031988 | membrane-bound vesicle | 0.0246219926213745 |
| GO:0000139 | Golgi membrane | 0.0246219926213745 |
| GO:0044431 | Golgi apparatus part | 0.0253254781248423 |
| GO:0031410 | cytoplasmic vesicle | 0.0253254781248423 |
| GO:0031982 | vesicle | 0.0253254781248423 |
| GO:0003779 | actin binding | 0.0253254781248423 |
| GO:0005829 | cytosol | 0.031648454324814 |
| GO:0008092 | cytoskeletal protein binding | 0.031648454324814 |
| GO:0016192 | vesicle-mediated transport | 0.031648454324814 |
| GO:0005794 | Golgi apparatus | 0.0351622291887437 |
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>
| Ontology term | p-value | n |
|---|---|---|
| lymphocyte of B lineage | 1.93e-29 | 24 |
| pro-B cell | 1.93e-29 | 24 |
| lymphoid lineage restricted progenitor cell | 1.77e-23 | 52 |
| lymphocyte | 5.32e-23 | 53 |
| common lymphoid progenitor | 5.32e-23 | 53 |
| nucleate cell | 4.28e-22 | 55 |
| circulating cell | 2.39e-14 | 6 |
| antibody secreting cell | 8.14e-11 | 1 |
| plasma cell | 8.14e-11 | 1 |
| plasmablast | 8.14e-11 | 1 |
| nongranular leukocyte | 1.88e-09 | 115 |
| hematopoietic cell | 4.28e-09 | 177 |
| hematopoietic lineage restricted progenitor cell | 5.58e-09 | 120 |
| leukocyte | 1.06e-07 | 136 |
| Ontology term | p-value | n |
|---|---|---|
| hemopoietic organ | 6.77e-12 | 7 |
| immune organ | 6.77e-12 | 7 |
| vermiform appendix | 2.08e-10 | 1 |
| caecum | 2.08e-10 | 1 |
| midgut | 2.08e-10 | 1 |
| tonsil | 2.50e-10 | 1 |
| mucosa-associated lymphoid tissue | 2.50e-10 | 1 |
| lymphoid tissue | 2.50e-10 | 1 |
| tonsillar ring | 2.50e-10 | 1 |
| thymus | 1.12e-09 | 4 |
| hemolymphoid system gland | 1.12e-09 | 4 |
| thymic region | 1.12e-09 | 4 |
| pharyngeal gland | 1.12e-09 | 4 |
| thymus primordium | 1.12e-09 | 4 |
| umbilical cord | 8.05e-09 | 10 |
| blastocyst | 8.05e-09 | 10 |
| blastula | 8.05e-09 | 10 |
| bilaminar disc | 8.05e-09 | 10 |
| inner cell mass | 8.05e-09 | 10 |
| cleaving embryo | 8.05e-09 | 10 |
| connecting stalk | 8.05e-09 | 10 |
| inner cell mass derived epiblast | 8.05e-09 | 10 |
| extraembryonic mesoderm | 8.05e-09 | 10 |
| chordate pharynx | 1.69e-08 | 10 |
| pharyngeal region of foregut | 1.69e-08 | 10 |
| pharynx | 9.03e-08 | 11 |
| pharyngeal epithelium | 9.81e-07 | 6 |
| Ontology term | p-value | n |
|---|---|---|
| lymphoma | 1.45e-43 | 10 |
| non-Hodgkin lymphoma | 7.40e-11 | 1 |
| cutaneous T cell lymphoma | 7.40e-11 | 1 |
| mycosis fungoides | 7.40e-11 | 1 |
| hematologic cancer | 1.97e-10 | 51 |
| immune system cancer | 1.97e-10 | 51 |
| anemia | 3.61e-10 | 1 |
Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
| Motifs | -log10(p-value) |
|---|---|
|
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ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data
(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)
| TF | #promoters | Enrichment | p-value | q-value |
|---|---|---|---|---|
| POU2F2#5452 | 4 | 5.20349946156716 | 0.00386671431017981 | 0.0190605454212899 |
Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data
This analysis result is provided for C0 - C305 clusters.
