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Coexpression cluster:C3444

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Full id: C3444_Neutrophils_CD8_Natural_Whole_CD4_Eosinophils_Peripheral



Phase1 CAGE Peaks

Hg19::chr14:65170917..65170935,+p5@PLEKHG3
Hg19::chr14:65170938..65170956,+p4@PLEKHG3
Hg19::chr14:65170966..65170990,+p6@PLEKHG3


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
hematopoietic stem cell8.49e-17172
angioblastic mesenchymal cell8.49e-17172
hematopoietic oligopotent progenitor cell1.60e-16165
hematopoietic multipotent progenitor cell1.60e-16165
hematopoietic cell1.96e-14182
myeloid cell6.72e-14112
common myeloid progenitor6.72e-14112
leukocyte1.65e-13140
mature alpha-beta T cell1.66e-1218
alpha-beta T cell1.66e-1218
immature T cell1.66e-1218
mature T cell1.66e-1218
immature alpha-beta T cell1.66e-1218
myeloid leukocyte1.57e-1176
nongranular leukocyte6.98e-10119
CD8-positive, alpha-beta T cell7.93e-1011
classical monocyte8.02e-1045
CD14-positive, CD16-negative classical monocyte8.91e-1042
hematopoietic lineage restricted progenitor cell1.74e-09124
granulocyte4.60e-088
granulocyte monocyte progenitor cell4.79e-0771
myeloid lineage restricted progenitor cell6.60e-0770
T cell6.73e-0725
pro-T cell6.73e-0725
Uber Anatomy
Ontology termp-valuen
adult organism5.63e-12115
hematopoietic system2.24e-09102
blood island2.24e-09102
hemolymphoid system7.39e-08112
blood1.00e-0715
haemolymphatic fluid1.00e-0715
organism substance1.00e-0715


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
E2F1#186934.907389214879320.008460985347239390.0324408696604257
MAX#414936.452555509007120.003721913834265510.0186147380009987
NANOG#79923329.24477848101273.99627955670032e-050.000736487454777175
TFAP2C#7022310.80922860986020.0007916746575753130.0061414030723099
ZNF263#1012738.221841637010680.001799043925565870.010913705189485



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.