Coexpression cluster:C1584

Full id: C1584_Endothelial_prostate_Gingival_Prostate_lens_Urothelial_Mallassezderived

Phase1 CAGE Peaks

Hg19::chr10:4720273..4720297,-	p1@LOC100216001
Hg19::chr10:4720301..4720325,-	p1@ENST00000449712
Hg19::chr10:4720333..4720350,-	p3@ENST00000430998
Hg19::chr10:4720356..4720386,-	p2@ENST00000430998
Hg19::chr10:4720389..4720416,-	p1@ENST00000430998

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
endothelial cell of vascular tree	2.79e-29	24
endothelial cell	2.16e-25	36
blood vessel endothelial cell	7.44e-23	18
embryonic blood vessel endothelial progenitor cell	7.44e-23	18
meso-epithelial cell	5.11e-21	45
epithelial cell	4.90e-16	253
lining cell	7.42e-16	58
barrier cell	7.42e-16	58
squamous epithelial cell	1.65e-12	63
endothelial cell of artery	2.22e-12	9
embryonic cell	6.96e-12	250
mesodermal cell	9.39e-10	121
animal cell	4.88e-09	679
eukaryotic cell	4.88e-09	679
vein endothelial cell	6.35e-09	6
aortic endothelial cell	7.23e-09	6
lymphangioblast	5.65e-08	6
endothelial cell of lymphatic vessel	5.65e-08	6
vascular lymphangioblast	5.65e-08	6
endo-epithelial cell	8.06e-08	42
somatic cell	1.40e-07	588
endodermal cell	5.63e-07	58

Uber Anatomy

Ontology term	p-value	n
blood vessel endothelium	7.44e-23	18
endothelium	7.44e-23	18
cardiovascular system endothelium	7.44e-23	18
simple squamous epithelium	5.98e-22	22
squamous epithelium	2.30e-18	25
vessel	6.33e-16	68
epithelial tube open at both ends	1.22e-12	59
blood vessel	1.22e-12	59
blood vasculature	1.22e-12	59
vascular cord	1.22e-12	59
endothelial tube	2.22e-12	9
arterial system endothelium	2.22e-12	9
endothelium of artery	2.22e-12	9
vasculature	2.75e-12	78
vascular system	2.75e-12	78
splanchnic layer of lateral plate mesoderm	1.44e-11	83
epithelial tube	5.04e-11	117
unilaminar epithelium	5.78e-10	148
cardiovascular system	6.70e-09	109
circulatory system	2.43e-08	112
artery	6.87e-08	42
arterial blood vessel	6.87e-08	42
arterial system	6.87e-08	42
multi-cellular organism	1.71e-07	656
anatomical system	2.65e-07	624
aorta	2.71e-07	21
aortic system	2.71e-07	21
anatomical group	3.14e-07	625
surface structure	3.49e-07	99
anatomical conduit	4.81e-07	240
systemic artery	7.16e-07	33
systemic arterial system	7.16e-07	33

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF	#promoters	Enrichment	p-value	q-value
EP300#2033	5	6.7739417262232	7.00901578206049e-05	0.00110643077276695
FOS#2353	5	8.9979553088944	1.69470025615156e-05	0.000388397630134327
FOSL2#2355	5	16.9302006045617	7.18315284751475e-07	3.20461896728575e-05
FOXA1#3169	5	11.0814197493855	5.98116883436141e-06	0.000178680575483945
GATA2#2624	5	12.744931733554	2.9719152914525e-06	0.000100970677008461
GATA3#2625	3	16.3419098143236	0.000467886519508923	0.00430117069016745
JUN#3725	5	12.5128291923363	3.25800591331781e-06	0.00010898875066656
JUND#3727	5	6.99466394187103	5.97069468343598e-05	0.000982934082666094
MAFF#23764	5	56.3153564899452	1.76021388477016e-09	1.53965643141968e-07
MAFK#7975	5	27.1007331378299	6.83095404221442e-08	4.14777912334205e-06
NR3C1#2908	5	14.973023331173	1.32777388277837e-06	5.23485755166062e-05
STAT3#6774	5	10.5194649971542	7.759040745861e-06	0.000220083230976908
TCF7L2#6934	5	10.7701765631373	6.89693748574565e-06	0.00019936597123548

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.