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Coexpression cluster:C2598

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Full id: C2598_anaplastic_substantia_thalamus_globus_locus_corpus_spinal



Phase1 CAGE Peaks

Hg19::chr1:66458072..66458109,+p7@PDE4B
Hg19::chr1:66628017..66628018,+p@chr1:66628017..66628018
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Hg19::chr1:66738486..66738490,+p@chr1:66738486..66738490
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Hg19::chr5:135211849..135211853,+p@chr5:135211849..135211853
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Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>


Uber Anatomy
Ontology termp-valuen
neural tube3.92e-7556
neural rod3.92e-7556
future spinal cord3.92e-7556
neural keel3.92e-7556
regional part of nervous system1.50e-6953
regional part of brain1.50e-6953
regional part of forebrain7.32e-6241
forebrain7.32e-6241
anterior neural tube7.32e-6241
future forebrain7.32e-6241
central nervous system1.34e-6181
brain grey matter8.54e-6134
gray matter8.54e-6134
telencephalon1.70e-6034
nervous system1.99e-6089
brain1.03e-5968
future brain1.03e-5968
neural plate6.82e-5982
presumptive neural plate6.82e-5982
neurectoderm1.89e-5786
regional part of telencephalon4.78e-5732
cerebral hemisphere1.12e-5632
pre-chordal neural plate1.57e-4861
ecto-epithelium6.99e-48104
cerebral cortex1.37e-4425
pallium1.37e-4425
adult organism3.77e-42114
regional part of cerebral cortex2.17e-4022
ectoderm-derived structure9.82e-37171
ectoderm9.82e-37171
presumptive ectoderm9.82e-37171
neocortex1.23e-3620
structure with developmental contribution from neural crest9.95e-33132
organ system subdivision1.18e-26223
basal ganglion2.52e-179
nuclear complex of neuraxis2.52e-179
aggregate regional part of brain2.52e-179
collection of basal ganglia2.52e-179
cerebral subcortex2.52e-179
neural nucleus2.77e-179
nucleus of brain2.77e-179
tube1.67e-15192
posterior neural tube2.36e-1415
chordal neural plate2.36e-1415
organ part8.93e-14218
telencephalic nucleus1.07e-137
temporal lobe2.00e-136
brainstem2.71e-126
anatomical cluster4.16e-12373
anatomical conduit8.21e-12240
gyrus1.37e-116
segmental subdivision of nervous system3.86e-1113
limbic system1.49e-105
parietal lobe3.83e-105
occipital lobe1.13e-095
segmental subdivision of hindbrain1.20e-0912
hindbrain1.20e-0912
presumptive hindbrain1.20e-0912
epithelium8.06e-09306
cell layer1.40e-08309
organ1.51e-08503
multi-tissue structure3.06e-08342
corpus striatum4.98e-084
striatum4.98e-084
ventral part of telencephalon4.98e-084
future corpus striatum4.98e-084
pons5.08e-073
spinal cord5.70e-073
dorsal region element5.70e-073
dorsum5.70e-073
medulla oblongata6.40e-073
myelencephalon6.40e-073
future myelencephalon6.40e-073


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.