Coexpression cluster:C2826
From FANTOM5_SSTAR
Full id: C2826_Mast_medial_frontal_occipital_parietal_brain_olfactory
Phase1 CAGE Peaks
| Hg19::chr5:67586544..67586558,+ | p7@PIK3R1 |
| Hg19::chr5:67588391..67588411,+ | p13@PIK3R1 |
| Hg19::chr5:67588419..67588430,+ | p29@PIK3R1 |
| Hg19::chr6:147453079..147453129,- | p1@ENST00000431143 p1@uc003qlv.2 |
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
| p.value | FDR | nGenes | nPathway | Name |
|---|---|---|---|---|
| 0.00304771246409304 | 0.049893154907868 | 1 | 87 | ErbB signaling pathway (KEGG):04012 |
| 0.00273243186435928 | 0.049893154907868 | 1 | 78 | Phosphatidylinositol signaling system (KEGG):04070 |
| 0.00182162124290619 | 0.049893154907868 | 1 | 52 | mTOR signaling pathway (KEGG):04150 |
| 0.00301268128634485 | 0.049893154907868 | 1 | 86 | Apoptosis (KEGG):04210 |
| 0.00266236950886289 | 0.049893154907868 | 1 | 76 | VEGF signaling pathway (KEGG):04370 |
| 0.00357318013031598 | 0.049893154907868 | 1 | 102 | Toll-like receptor signaling pathway (KEGG):04620 |
| 0.00378336719680516 | 0.049893154907868 | 1 | 108 | T cell receptor signaling pathway (KEGG):04660 |
| 0.00262733833111469 | 0.049893154907868 | 1 | 75 | B cell receptor signaling pathway (KEGG):04662 |
| 0.00276746304210748 | 0.049893154907868 | 1 | 79 | Fc epsilon RI signaling pathway (KEGG):04664 |
| 0.00332796188607861 | 0.049893154907868 | 1 | 95 | Fc gamma R-mediated phagocytosis (KEGG):04666 |
| 0.00304771246409304 | 0.049893154907868 | 1 | 87 | Progesterone-mediated oocyte maturation (KEGG):04914 |
| 0.0016814965319134 | 0.049893154907868 | 1 | 48 | Type II diabetes mellitus (KEGG):04930 |
| 0.00147130946542423 | 0.049893154907868 | 1 | 42 | Aldosterone-regulated sodium reabsorption (KEGG):04960 |
| 0.00154137182092062 | 0.049893154907868 | 1 | 44 | Carbohydrate digestion and absorption (KEGG):04973 |
| 0.00248721362012191 | 0.049893154907868 | 1 | 71 | Bacterial invasion of epithelial cells (KEGG):05100 |
| 0.00364324248581237 | 0.049893154907868 | 1 | 104 | Chagas disease (American trypanosomiasis) (KEGG):05142 |
| 0.00371330484130877 | 0.049893154907868 | 1 | 106 | Amoebiasis (KEGG):05146 |
| 0.00217193302038814 | 0.049893154907868 | 1 | 62 | Colorectal cancer (KEGG):05210 |
| 0.00245218244237371 | 0.049893154907868 | 1 | 70 | Renal cell carcinoma (KEGG):05211 |
| 0.00245218244237371 | 0.049893154907868 | 1 | 70 | Pancreatic cancer (KEGG):05212 |
| 0.00182162124290619 | 0.049893154907868 | 1 | 52 | Endometrial cancer (KEGG):05213 |
| 0.00227702655363273 | 0.049893154907868 | 1 | 65 | Glioma (KEGG):05214 |
| 0.00311777481958943 | 0.049893154907868 | 1 | 89 | Prostate cancer (KEGG):05215 |
| 0.00248721362012191 | 0.049893154907868 | 1 | 71 | Melanoma (KEGG):05218 |
| 0.0025572759756183 | 0.049893154907868 | 1 | 73 | Chronic myeloid leukemia (KEGG):05220 |
| 0.00203180830939536 | 0.049893154907868 | 1 | 58 | Acute myeloid leukemia (KEGG):05221 |
| 0.00297765010859665 | 0.049893154907868 | 1 | 85 | Small cell lung cancer (KEGG):05222 |
| 0.00189168359840258 | 0.049893154907868 | 1 | 54 | Non-small cell lung cancer (KEGG):05223 |
| 0.00241715126462552 | 0.049893154907868 | 1 | 69 | IL-5 Signaling Pathway (Wikipathways):WP127 |
| 0.0025572759756183 | 0.049893154907868 | 1 | 73 | AMPK signaling (Wikipathways):WP1403 |
| 0.00304771246409304 | 0.049893154907868 | 1 | 87 | MicroRNAs in cardiomyocyte hypertrophy (Wikipathways):WP1544 |
| 0.00154137182092062 | 0.049893154907868 | 1 | 44 | IL-7 Signaling Pathway (Wikipathways):WP205 |
| 0.000840748265956701 | 0.049893154907868 | 1 | 24 | IL-9 Signaling Pathway (Wikipathways):WP22 |
| 0.00241715126462552 | 0.049893154907868 | 1 | 69 | Alpha6-Beta4 Integrin Signaling Pathway (Wikipathways):WP244 |
| 0.00297765010859665 | 0.049893154907868 | 1 | 85 | Apoptosis (Wikipathways):WP254 |
| 0.00357318013031598 | 0.049893154907868 | 1 | 102 | IL-3 Signaling Pathway (Wikipathways):WP286 |
| 0.00241715126462552 | 0.049893154907868 | 1 | 69 | Kit Receptor Signaling Pathway (Wikipathways):WP304 |
| 0.00346808659707139 | 0.049893154907868 | 1 | 99 | IL-6 Signaling Pathway (Wikipathways):WP364 |
| 0.00224199537588454 | 0.049893154907868 | 1 | 64 | IL-4 signaling Pathway (Wikipathways):WP395 |
| 0.00269740068661108 | 0.049893154907868 | 1 | 77 | IL-2 Signaling Pathway (Wikipathways):WP49 |
| 0.00301268128634485 | 0.049893154907868 | 1 | 86 | Delta-Notch Signaling Pathway (Wikipathways):WP61 |
| 0.00357318013031598 | 0.049893154907868 | 1 | 102 | Toll-like receptor signaling pathway (Wikipathways):WP75 |
| 0.00378336719680516 | 0.049893154907868 | 1 | 108 | Signaling by Insulin receptor (Reactome):REACT_498 |
| 0.00182162124290619 | 0.049893154907868 | 1 | 52 | Signaling by EGFR (Reactome):REACT_9417 |
| 0.00227702655363273 | 0.049893154907868 | 1 | 65 | Signaling by PDGF (Reactome):REACT_16888 |
| 0.00157640299866882 | 0.049893154907868 | 1 | 45 | Signaling by FGFR (Reactome):REACT_9470 |
| 0.00161143417641701 | 0.049893154907868 | 1 | 46 | Interactions of the immunoglobulin superfamily (IgSF) member proteins (Reactome):REACT_23853 |
| 0.0025572759756183 | 0.049893154907868 | 1 | 73 | Notch up reg. targets (Netpath):NetPath_3 |
Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data
| GO ID | GO name | FDR corrected p-value |
|---|---|---|
| GO:0035030 | phosphoinositide 3-kinase complex, class IA | 0.00167785234899329 |
| GO:0043559 | insulin binding | 0.00167785234899329 |
| GO:0043125 | ErbB-3 class receptor binding | 0.00209731543624161 |
| GO:0043560 | insulin receptor substrate binding | 0.00209731543624161 |
| GO:0048009 | insulin-like growth factor receptor signaling pathway | 0.00215723873441994 |
| GO:0017046 | peptide hormone binding | 0.00215723873441994 |
| GO:0035014 | phosphoinositide 3-kinase regulator activity | 0.00215723873441994 |
| GO:0005159 | insulin-like growth factor receptor binding | 0.00230704697986577 |
| GO:0019903 | protein phosphatase binding | 0.00272651006711409 |
| GO:0005545 | phosphatidylinositol binding | 0.00272651006711409 |
| GO:0005942 | phosphoinositide 3-kinase complex | 0.00272651006711409 |
| GO:0019902 | phosphatase binding | 0.00272651006711409 |
| GO:0005158 | insulin receptor binding | 0.00272651006711409 |
| GO:0046854 | phosphoinositide phosphorylation | 0.00272651006711409 |
| GO:0042562 | hormone binding | 0.00272651006711409 |
| GO:0046834 | lipid phosphorylation | 0.00272651006711409 |
| GO:0008286 | insulin receptor signaling pathway | 0.00315831030398737 |
| GO:0030258 | lipid modification | 0.00484712900820283 |
| GO:0030384 | phosphoinositide metabolic process | 0.00706464146944542 |
| GO:0006650 | glycerophospholipid metabolic process | 0.00806967082134867 |
| GO:0032403 | protein complex binding | 0.00806967082134867 |
| GO:0019207 | kinase regulator activity | 0.00930445393532642 |
| GO:0044445 | cytosolic part | 0.0138605194047272 |
| GO:0042277 | peptide binding | 0.0138745482705214 |
| GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | 0.0138745482705214 |
| GO:0006644 | phospholipid metabolic process | 0.0138745482705214 |
| GO:0035091 | phosphoinositide binding | 0.0155978125776783 |
| GO:0006643 | membrane lipid metabolic process | 0.0162991371045062 |
| GO:0007167 | enzyme linked receptor protein signaling pathway | 0.0167785234899329 |
| GO:0019899 | enzyme binding | 0.0167785234899329 |
| GO:0005125 | cytokine activity | 0.0167785234899329 |
| GO:0005543 | phospholipid binding | 0.0175125838926175 |
| GO:0005829 | cytosol | 0.0285728385313857 |
| GO:0008289 | lipid binding | 0.0285728385313857 |
| GO:0044255 | cellular lipid metabolic process | 0.036816874400767 |
| GO:0006629 | lipid metabolic process | 0.0440902311707681 |
| GO:0005102 | receptor binding | 0.0470252131325957 |
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>
Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
| Motifs | -log10(p-value) |
|---|---|
|
{{{tfbs_overrepresentation_jaspar}}} |
ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data
No analysis results for this cluster
Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data
This analysis result is provided for C0 - C305 clusters.
