MCL coexpression mm9:36
From FANTOM5_SSTAR
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
| GO ID | GO name | FDR corrected p-value |
|---|---|---|
| GO:0030695 | GTPase regulator activity | 9.60069024222695e-12 |
| GO:0007242 | intracellular signaling cascade | 4.96592236326085e-11 |
| GO:0006796 | phosphate metabolic process | 5.69007184886453e-10 |
| GO:0006793 | phosphorus metabolic process | 5.69007184886453e-10 |
| GO:0043687 | post-translational protein modification | 1.01105146402042e-09 |
| GO:0006468 | protein amino acid phosphorylation | 1.34747850057329e-08 |
| GO:0016310 | phosphorylation | 3.31022314463866e-08 |
| GO:0012501 | programmed cell death | 3.31022314463866e-08 |
| GO:0002376 | immune system process | 3.35392106398924e-08 |
| GO:0005083 | small GTPase regulator activity | 6.40931428681538e-08 |
| GO:0005096 | GTPase activator activity | 6.40931428681538e-08 |
| GO:0008219 | cell death | 8.26760275788842e-08 |
| GO:0016265 | death | 8.47959355115573e-08 |
| GO:0043412 | biopolymer modification | 1.14620597334351e-07 |
| GO:0006464 | protein modification process | 1.47646668890361e-07 |
| GO:0008047 | enzyme activator activity | 1.6401587268654e-07 |
| GO:0009966 | regulation of signal transduction | 2.73279874345622e-07 |
| GO:0006915 | apoptosis | 2.03030169218078e-06 |
| GO:0016301 | kinase activity | 3.53536775124329e-06 |
| GO:0046649 | lymphocyte activation | 5.04201234038593e-06 |
| GO:0005085 | guanyl-nucleotide exchange factor activity | 5.0568969853915e-06 |
| GO:0019992 | diacylglycerol binding | 5.46288007224109e-06 |
| GO:0005515 | protein binding | 8.39525602692427e-06 |
| GO:0048523 | negative regulation of cellular process | 8.7075393766611e-06 |
| GO:0046578 | regulation of Ras protein signal transduction | 9.14159752996105e-06 |
| GO:0045321 | leukocyte activation | 9.91185560266736e-06 |
| GO:0001775 | cell activation | 2.02662945382274e-05 |
| GO:0035023 | regulation of Rho protein signal transduction | 2.02662945382274e-05 |
| GO:0050794 | regulation of cellular process | 2.39086718383889e-05 |
| GO:0007265 | Ras protein signal transduction | 2.63517434722423e-05 |
| GO:0005088 | Ras guanyl-nucleotide exchange factor activity | 2.63517434722423e-05 |
| GO:0042110 | T cell activation | 2.94314319555051e-05 |
| GO:0048519 | negative regulation of biological process | 4.40466049838481e-05 |
| GO:0051056 | regulation of small GTPase mediated signal transduction | 4.5010971385828e-05 |
| GO:0016772 | transferase activity, transferring phosphorus-containing groups | 8.01877965651401e-05 |
| GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 0.000101808172616602 |
| GO:0032943 | mononuclear cell proliferation | 0.000101808172616602 |
| GO:0046651 | lymphocyte proliferation | 0.000101808172616602 |
| GO:0050789 | regulation of biological process | 0.000145453800378097 |
| GO:0007266 | Rho protein signal transduction | 0.000163529718410785 |
| GO:0005089 | Rho guanyl-nucleotide exchange factor activity | 0.000168802833046338 |
| GO:0007264 | small GTPase mediated signal transduction | 0.000195429195080487 |
| GO:0042098 | T cell proliferation | 0.000200383817706704 |
| GO:0030029 | actin filament-based process | 0.000339895051862783 |
| GO:0004674 | protein serine/threonine kinase activity | 0.000348324167385986 |
| GO:0065007 | biological regulation | 0.000677743312153398 |
| GO:0048534 | hemopoietic or lymphoid organ development | 0.000809440398580939 |
| GO:0044260 | cellular macromolecule metabolic process | 0.00123912007359184 |
| GO:0030036 | actin cytoskeleton organization and biogenesis | 0.00129140879918011 |
| GO:0048468 | cell development | 0.00129140879918011 |
| GO:0002520 | immune system development | 0.00132825258429391 |
| GO:0030097 | hemopoiesis | 0.00173751321311094 |
| GO:0044267 | cellular protein metabolic process | 0.00187866405307808 |
| GO:0042981 | regulation of apoptosis | 0.00197248803086623 |
| GO:0043067 | regulation of programmed cell death | 0.00214206907025535 |
| GO:0019538 | protein metabolic process | 0.00222873526476404 |
| GO:0009968 | negative regulation of signal transduction | 0.00249147798168532 |
| GO:0046633 | alpha-beta T cell proliferation | 0.0025156128344762 |
| GO:0046631 | alpha-beta T cell activation | 0.00263704908738666 |
| GO:0005100 | Rho GTPase activator activity | 0.00397512038399187 |
| GO:0030048 | actin filament-based movement | 0.00485794791326106 |
| GO:0032502 | developmental process | 0.00492126764024058 |
| GO:0005622 | intracellular | 0.00513077301497887 |
| GO:0043066 | negative regulation of apoptosis | 0.00541938545713187 |
| GO:0043069 | negative regulation of programmed cell death | 0.00578747949642075 |
| GO:0004672 | protein kinase activity | 0.00651331911466173 |
| GO:0002700 | regulation of production of molecular mediator of immune response | 0.00723065494077095 |
| GO:0046934 | phosphatidylinositol-4,5-bisphosphate 3-kinase activity | 0.00723065494077095 |
| GO:0007165 | signal transduction | 0.00738857755339257 |
| GO:0007010 | cytoskeleton organization and biogenesis | 0.00801713170672124 |
| GO:0002697 | regulation of immune effector process | 0.00868666014703643 |
| GO:0005856 | cytoskeleton | 0.00882837652689101 |
| GO:0030155 | regulation of cell adhesion | 0.00922143752294149 |
| GO:0000902 | cell morphogenesis | 0.00964369539040416 |
| GO:0032989 | cellular structure morphogenesis | 0.00964369539040416 |
| GO:0008283 | cell proliferation | 0.00988716708871266 |
| GO:0043283 | biopolymer metabolic process | 0.00995170648567971 |
| GO:0008270 | zinc ion binding | 0.00995170648567971 |
| GO:0005099 | Ras GTPase activator activity | 0.00995170648567971 |
| GO:0005938 | cell cortex | 0.00995170648567971 |
| GO:0048266 | behavioral response to pain | 0.0100832160563066 |
| GO:0002521 | leukocyte differentiation | 0.011142112896585 |
| GO:0008284 | positive regulation of cell proliferation | 0.0113481232832344 |
| GO:0043524 | negative regulation of neuron apoptosis | 0.0131131461614718 |
| GO:0045123 | cellular extravasation | 0.0140139519494546 |
| GO:0004703 | G-protein coupled receptor kinase activity | 0.0140139519494546 |
| GO:0005522 | profilin binding | 0.0140139519494546 |
| GO:0050670 | regulation of lymphocyte proliferation | 0.0141286118102255 |
| GO:0032944 | regulation of mononuclear cell proliferation | 0.0141286118102255 |
| GO:0030098 | lymphocyte differentiation | 0.0149602667540727 |
| GO:0018108 | peptidyl-tyrosine phosphorylation | 0.016811276372801 |
| GO:0018212 | peptidyl-tyrosine modification | 0.016811276372801 |
| GO:0030675 | Rac GTPase activator activity | 0.0180712628993188 |
| GO:0002467 | germinal center formation | 0.0180712628993188 |
| GO:0042127 | regulation of cell proliferation | 0.0205048809554274 |
| GO:0030217 | T cell differentiation | 0.0221531625874148 |
| GO:0004727 | prenylated protein tyrosine phosphatase activity | 0.0232256146258054 |
| GO:0050863 | regulation of T cell activation | 0.0239706495900613 |
| GO:0048869 | cellular developmental process | 0.0239706495900613 |
| GO:0030154 | cell differentiation | 0.0239706495900613 |
| GO:0043087 | regulation of GTPase activity | 0.0249951520417521 |
| GO:0007154 | cell communication | 0.0252958471021514 |
| GO:0050900 | leukocyte migration | 0.0256207315291405 |
| GO:0016485 | protein processing | 0.0262155454216915 |
| GO:0035004 | phosphoinositide 3-kinase activity | 0.0262155454216915 |
| GO:0022407 | regulation of cell-cell adhesion | 0.0262155454216915 |
| GO:0016303 | 1-phosphatidylinositol-3-kinase activity | 0.0262155454216915 |
| GO:0046854 | phosphoinositide phosphorylation | 0.0262155454216915 |
| GO:0051607 | defense response to virus | 0.0262155454216915 |
| GO:0048522 | positive regulation of cellular process | 0.0262962600125354 |
| GO:0046777 | protein amino acid autophosphorylation | 0.0280397816713004 |
| GO:0005737 | cytoplasm | 0.0297839871090428 |
| GO:0043523 | regulation of neuron apoptosis | 0.0297839871090428 |
| GO:0005942 | phosphoinositide 3-kinase complex | 0.029891816505369 |
| GO:0046834 | lipid phosphorylation | 0.029891816505369 |
| GO:0007159 | leukocyte adhesion | 0.029891816505369 |
| GO:0030183 | B cell differentiation | 0.0308061542389952 |
| GO:0016540 | protein autoprocessing | 0.0308061542389952 |
| GO:0050671 | positive regulation of lymphocyte proliferation | 0.0328665834981235 |
| GO:0032946 | positive regulation of mononuclear cell proliferation | 0.0328665834981235 |
| GO:0042802 | identical protein binding | 0.0338538766393764 |
| GO:0016044 | membrane organization and biogenesis | 0.0364866839421309 |
| GO:0006909 | phagocytosis | 0.0371687716551118 |
| GO:0051402 | neuron apoptosis | 0.0371687716551118 |
| GO:0005524 | ATP binding | 0.0388438935630497 |
| GO:0030101 | natural killer cell activation | 0.0388536599643475 |
| GO:0048265 | response to pain | 0.0388536599643475 |
| GO:0007260 | tyrosine phosphorylation of STAT protein | 0.0388536599643475 |
| GO:0045785 | positive regulation of cell adhesion | 0.0388536599643475 |
| GO:0032559 | adenyl ribonucleotide binding | 0.0446661850611836 |
| GO:0050798 | activated T cell proliferation | 0.0449931732158892 |
| GO:0042129 | regulation of T cell proliferation | 0.0464705080131112 |
| GO:0051249 | regulation of lymphocyte activation | 0.04706471371434 |
| GO:0019899 | enzyme binding | 0.0480159975240116 |
Relative expression of the co-expression cluster over median <br>Analyst:
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>
| Ontology term | p-value | n |
|---|---|---|
| hematopoietic cell | 1.07e-11 | 32 |
| hematopoietic oligopotent progenitor cell | 1.07e-11 | 32 |
| hematopoietic stem cell | 1.07e-11 | 32 |
| angioblastic mesenchymal cell | 1.07e-11 | 32 |
| hematopoietic multipotent progenitor cell | 1.07e-11 | 32 |
| hematopoietic lineage restricted progenitor cell | 3.05e-09 | 25 |
| lymphoid lineage restricted progenitor cell | 5.54e-09 | 12 |
| T cell | 2.53e-08 | 11 |
| pro-T cell | 2.53e-08 | 11 |
| lymphocyte | 3.60e-08 | 13 |
| common lymphoid progenitor | 3.60e-08 | 13 |
| leukocyte | 7.73e-08 | 17 |
| nongranular leukocyte | 7.73e-08 | 17 |
| mature alpha-beta T cell | 2.71e-07 | 9 |
| alpha-beta T cell | 2.71e-07 | 9 |
| immature T cell | 2.71e-07 | 9 |
| mature T cell | 2.71e-07 | 9 |
| immature alpha-beta T cell | 2.71e-07 | 9 |
TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
| Motifs | -log10(p-value) |
|---|---|
|
{{{tfbs_overrepresentation_jaspar}}} |
