MCL coexpression mm9:1820
From FANTOM5_SSTAR
Phase1 CAGE Peaks
| Short description | |
|---|---|
| Mm9::chr6:124789985..124790034,- | p1@Gnb3 |
| Mm9::chr7:130174860..130174906,+ | p1@uc009jpa.1 |
| Mm9::chr8:28479265..28479279,+ | p1@Chrnb3 |
| Mm9::chr8:28524351..28524364,- | p1@Chrna6 |
| Mm9::chr8:28524409..28524418,- | p2@Chrna6 |
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
| GO ID | GO name | FDR corrected p-value |
|---|---|---|
| GO:0007271 | synaptic transmission, cholinergic | 8.6003638539287e-05 |
| GO:0004889 | nicotinic acetylcholine-activated cation-selective channel activity | 8.6003638539287e-05 |
| GO:0005231 | excitatory extracellular ligand-gated ion channel activity | 0.000541929406359434 |
| GO:0005230 | extracellular ligand-gated ion channel activity | 0.000902009987176167 |
| GO:0015276 | ligand-gated ion channel activity | 0.000902009987176167 |
| GO:0022834 | ligand-gated channel activity | 0.000902009987176167 |
| GO:0030594 | neurotransmitter receptor activity | 0.000902009987176167 |
| GO:0042165 | neurotransmitter binding | 0.000902009987176167 |
| GO:0045211 | postsynaptic membrane | 0.00123189256685554 |
| GO:0044456 | synapse part | 0.0013669119896086 |
| GO:0007268 | synaptic transmission | 0.00306546162485347 |
| GO:0019226 | transmission of nerve impulse | 0.00390432643555917 |
| GO:0044459 | plasma membrane part | 0.00390432643555917 |
| GO:0005261 | cation channel activity | 0.00390432643555917 |
| GO:0022836 | gated channel activity | 0.00417251402309012 |
| GO:0046873 | metal ion transmembrane transporter activity | 0.00466767539808082 |
| GO:0014059 | regulation of dopamine secretion | 0.0047926820287058 |
| GO:0014046 | dopamine secretion | 0.0047926820287058 |
| GO:0007267 | cell-cell signaling | 0.00497758359007022 |
| GO:0050433 | regulation of catecholamine secretion | 0.00497758359007022 |
| GO:0005216 | ion channel activity | 0.00497758359007022 |
| GO:0005886 | plasma membrane | 0.00497758359007022 |
| GO:0022838 | substrate specific channel activity | 0.00497758359007022 |
| GO:0050432 | catecholamine secretion | 0.00497758359007022 |
| GO:0022803 | passive transmembrane transporter activity | 0.00497758359007022 |
| GO:0015267 | channel activity | 0.00497758359007022 |
| GO:0030054 | cell junction | 0.0050521666090356 |
| GO:0005892 | nicotinic acetylcholine-gated receptor-channel complex | 0.00594790648019933 |
| GO:0003993 | acid phosphatase activity | 0.00594790648019933 |
| GO:0008324 | cation transmembrane transporter activity | 0.00643070053725156 |
| GO:0051899 | membrane depolarization | 0.00945546203797659 |
| GO:0046928 | regulation of neurotransmitter secretion | 0.00969826959635346 |
| GO:0015075 | ion transmembrane transporter activity | 0.0107477629438982 |
| GO:0004890 | GABA-A receptor activity | 0.0123374528278361 |
| GO:0006811 | ion transport | 0.0123374528278361 |
| GO:0060089 | molecular transducer activity | 0.0123374528278361 |
| GO:0004871 | signal transducer activity | 0.0123374528278361 |
| GO:0022891 | substrate-specific transmembrane transporter activity | 0.0123374528278361 |
| GO:0016917 | GABA receptor activity | 0.0123716352329554 |
| GO:0005834 | heterotrimeric G-protein complex | 0.0142124383203555 |
| GO:0022857 | transmembrane transporter activity | 0.0152784281800477 |
| GO:0046879 | hormone secretion | 0.0168096521810302 |
| GO:0042391 | regulation of membrane potential | 0.0168182646960398 |
| GO:0022892 | substrate-specific transporter activity | 0.017037543320729 |
| GO:0019897 | extrinsic to plasma membrane | 0.0187752593651088 |
| GO:0007269 | neurotransmitter secretion | 0.0187752593651088 |
| GO:0051046 | regulation of secretion | 0.0187752593651088 |
| GO:0007154 | cell communication | 0.0187752593651088 |
| GO:0045055 | regulated secretory pathway | 0.0224626122373204 |
| GO:0019898 | extrinsic to membrane | 0.0237266452172607 |
| GO:0043235 | receptor complex | 0.0242687884136653 |
| GO:0003001 | generation of a signal involved in cell-cell signaling | 0.0285174909041151 |
| GO:0001505 | regulation of neurotransmitter levels | 0.0285174909041151 |
| GO:0043234 | protein complex | 0.0400603620266142 |
| GO:0003924 | GTPase activity | 0.041739751496872 |
| GO:0055082 | cellular chemical homeostasis | 0.0437631748158408 |
| GO:0006873 | cellular ion homeostasis | 0.0437631748158408 |
| GO:0050877 | neurological system process | 0.0437631748158408 |
| GO:0005083 | small GTPase regulator activity | 0.0438053474380967 |
| GO:0050801 | ion homeostasis | 0.0473152438728316 |
| GO:0003008 | system process | 0.0482476081683852 |
| GO:0045045 | secretory pathway | 0.0482476081683852 |
Relative expression of the co-expression cluster over median <br>Analyst:
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>
| Ontology term | p-value | n |
|---|---|---|
| CNS neuron (sensu Vertebrata) | 2.22e-10 | 23 |
| neuroblast (sensu Vertebrata) | 2.22e-10 | 23 |
| neuron of the substantia nigra | 1.44e-07 | 3 |
| neuron | 1.47e-07 | 33 |
| neuronal stem cell | 1.47e-07 | 33 |
| neuroblast | 1.47e-07 | 33 |
| electrically signaling cell | 1.47e-07 | 33 |
| raphe nuclei neuron | 2.02e-07 | 3 |
TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
| Motifs | -log10(p-value) |
|---|---|
| MA0003.1 | 0.0185483 |
| MA0004.1 | 0.603793 |
| MA0006.1 | 0.419915 |
| MA0007.1 | 0.587678 |
| MA0009.1 | 1.06266 |
| MA0014.1 | 0.187732 |
| MA0017.1 | 0.449113 |
| MA0019.1 | 0.874061 |
| MA0024.1 | 1.01759 |
| MA0025.1 | 1.30092 |
| MA0027.1 | 2.72141 |
| MA0028.1 | 0.43138 |
| MA0029.1 | 0.995171 |
| MA0030.1 | 1.00195 |
| MA0031.1 | 0.965177 |
| MA0038.1 | 0.757669 |
| MA0040.1 | 1.07552 |
| MA0041.1 | 0.522007 |
| MA0042.1 | 0.507715 |
| MA0043.1 | 1.1618 |
| MA0046.1 | 1.09955 |
| MA0048.1 | 0.593503 |
| MA0050.1 | 0.645342 |
| MA0051.1 | 0.767098 |
| MA0052.1 | 1.08379 |
| MA0055.1 | 0.0851423 |
| MA0056.1 | 0 |
| MA0057.1 | 1.06992 |
| MA0058.1 | 0.50032 |
| MA0059.1 | 0.513699 |
| MA0060.1 | 0.330907 |
| MA0061.1 | 0.955135 |
| MA0063.1 | 0 |
| MA0066.1 | 0.746072 |
| MA0067.1 | 1.41352 |
| MA0068.1 | 4.059 |
| MA0069.1 | 1.08414 |
| MA0070.1 | 1.07418 |
| MA0071.1 | 0.644448 |
| MA0072.1 | 1.06547 |
| MA0073.1 | 2.46751 |
| MA0074.1 | 0.708108 |
| MA0076.1 | 0.470037 |
| MA0077.1 | 1.04318 |
| MA0078.1 | 0.801834 |
| MA0081.1 | 0.53877 |
| MA0083.1 | 1.16099 |
| MA0084.1 | 1.74401 |
| MA0087.1 | 1.11687 |
| MA0088.1 | 0.148348 |
| MA0089.1 | 0 |
| MA0090.1 | 0.566938 |
| MA0091.1 | 0.617887 |
| MA0092.1 | 0.567278 |
| MA0093.1 | 0.440484 |
| MA0095.1 | 0 |
| MA0098.1 | 0 |
| MA0100.1 | 0.695835 |
| MA0101.1 | 0.523409 |
| MA0103.1 | 0.460936 |
| MA0105.1 | 0.248108 |
| MA0106.1 | 0.809991 |
| MA0107.1 | 0.454197 |
| MA0108.2 | 0.897859 |
| MA0109.1 | 0 |
| MA0111.1 | 2.43013 |
| MA0113.1 | 0.780358 |
| MA0114.1 | 0.361633 |
| MA0115.1 | 1.16466 |
| MA0116.1 | 0.419688 |
| MA0117.1 | 1.13165 |
| MA0119.1 | 0.524046 |
| MA0122.1 | 1.15196 |
| MA0124.1 | 1.35963 |
| MA0125.1 | 1.28445 |
| MA0130.1 | 0 |
| MA0131.1 | 0.869325 |
| MA0132.1 | 0 |
| MA0133.1 | 0 |
| MA0135.1 | 1.19898 |
| MA0136.1 | 0.729175 |
| MA0139.1 | 0.295945 |
| MA0140.1 | 0.695713 |
| MA0141.1 | 0.482463 |
| MA0142.1 | 0.950155 |
| MA0143.1 | 0.797553 |
| MA0144.1 | 0.365053 |
| MA0145.1 | 0.157686 |
| MA0146.1 | 0.475727 |
| MA0147.1 | 0.378658 |
| MA0148.1 | 1.50563 |
| MA0149.1 | 0.529387 |
| MA0062.2 | 0.254018 |
| MA0035.2 | 0.700704 |
| MA0039.2 | 0.489701 |
| MA0138.2 | 0.861035 |
| MA0002.2 | 0.299191 |
| MA0137.2 | 0.479301 |
| MA0104.2 | 0.315156 |
| MA0047.2 | 1.78778 |
| MA0112.2 | 0.47695 |
| MA0065.2 | 0.477991 |
| MA0150.1 | 0.587557 |
| MA0151.1 | 0 |
| MA0152.1 | 0.756973 |
| MA0153.1 | 1.21594 |
| MA0154.1 | 0.587595 |
| MA0155.1 | 0.173445 |
| MA0156.1 | 0.469089 |
| MA0157.1 | 0.91689 |
| MA0158.1 | 0 |
| MA0159.1 | 0.389847 |
| MA0160.1 | 0.624415 |
| MA0161.1 | 0 |
| MA0162.1 | 0.0699535 |
| MA0163.1 | 0.497328 |
| MA0164.1 | 0.729558 |
| MA0080.2 | 0.455167 |
| MA0018.2 | 0.739807 |
| MA0099.2 | 0.854449 |
| MA0079.2 | 3.01303 |
| MA0102.2 | 1.79669 |
| MA0258.1 | 0.346619 |
| MA0259.1 | 0.366802 |
| MA0442.1 | 0 |
