Coexpression cluster:C2633

Full id: C2633_smallcell_Hep2_gall_cervical_splenic_mesothelioma_serous

Phase1 CAGE Peaks

Hg19::chr21:43816105..43816116,-	p3@TMPRSS3
Hg19::chr21:43816124..43816151,-	p2@TMPRSS3
Hg19::chr21:43816152..43816182,-	p1@TMPRSS3
Hg19::chr21:43816226..43816231,-	p4@TMPRSS3

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

---

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

---

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br>disease_data<br>

---

Uber Anatomy

Ontology term	p-value	n
adult organism	3.37e-34	115
neural tube	1.34e-24	57
neural rod	1.34e-24	57
future spinal cord	1.34e-24	57
neural keel	1.34e-24	57
regional part of brain	5.58e-21	59
brain	1.21e-19	69
future brain	1.21e-19	69
anterior neural tube	2.57e-19	42
regional part of forebrain	1.22e-18	41
forebrain	1.22e-18	41
future forebrain	1.22e-18	41
central nervous system	1.06e-17	82
gray matter	2.34e-16	34
brain grey matter	2.34e-16	34
neural plate	3.65e-16	86
presumptive neural plate	3.65e-16	86
cerebral hemisphere	7.46e-15	32
neurectoderm	8.12e-15	90
telencephalon	9.19e-15	34
regional part of nervous system	2.92e-14	94
nervous system	2.92e-14	94
regional part of telencephalon	5.21e-14	33
anterior region of body	3.03e-13	129
craniocervical region	3.03e-13	129
larynx	3.50e-13	9
pre-chordal neural plate	4.11e-12	61
head	8.77e-12	123
regional part of cerebral cortex	4.97e-11	22
neocortex	6.85e-11	20
organ part	2.54e-10	219
basal ganglion	7.53e-10	9
nuclear complex of neuraxis	7.53e-10	9
aggregate regional part of brain	7.53e-10	9
collection of basal ganglia	7.53e-10	9
cerebral subcortex	7.53e-10	9
nucleus of brain	7.97e-10	9
neural nucleus	7.97e-10	9
anatomical cluster	1.06e-09	286
cerebral cortex	3.61e-09	25
pallium	3.61e-09	25
upper respiratory tract	3.92e-09	19
foregut	8.65e-09	98
biliary system	1.89e-08	7
biliary tree	1.89e-08	7
biliary bud	1.89e-08	7
multi-tissue structure	3.03e-08	347
brainstem	4.19e-08	8
telencephalic nucleus	5.82e-08	7
digestive system	6.53e-08	155
digestive tract	6.53e-08	155
primitive gut	6.53e-08	155
mixed endoderm/mesoderm-derived structure	7.45e-08	130
organ	9.07e-08	511
respiratory primordium	2.79e-07	38
endoderm of foregut	2.79e-07	38
gyrus	3.38e-07	6
subdivision of digestive tract	5.09e-07	129
endodermal part of digestive tract	5.09e-07	129
endoderm-derived structure	5.19e-07	169
endoderm	5.19e-07	169
presumptive endoderm	5.19e-07	169

Disease

Ontology term	p-value	n
carcinoma	2.23e-19	106
cell type cancer	1.86e-12	143
adenocarcinoma	2.06e-09	25
cancer	5.40e-09	235
disease of cellular proliferation	2.06e-08	239

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

---

Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

---

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF	#promoters	Enrichment	p-value	q-value
CEBPB#1051	4	7.97114762582482	0.000247638578809083	0.00268289683944417
STAT1#6772	4	20.7065874971992	5.43610708103893e-06	0.000165474085525102
STAT3#6774	4	10.5194649971542	8.16377768286615e-05	0.00123263955099155
TBP#6908	4	3.70677068709639	0.00529637781478435	0.0244561147138678
TFAP2A#7020	4	16.518634373045	1.34240829060362e-05	0.00032688220905188
TFAP2C#7022	4	10.8092286098602	7.32289634782688e-05	0.001146792580103

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

---

This analysis result is provided for C0 - C305 clusters.