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{{Coexpression_clusters
{
|coexpression_dpi_cluster_scores_median=0,0,0,0

Latest revision as of 10:20, 17 September 2013


Full id: C57_Neutrophils_Eosinophils_Whole_CD4_CD8_CD19_Natural



Phase1 CAGE Peaks

Hg19::chr10:103880002..103880070,-p4@LDB1
Hg19::chr10:11207401..11207410,+p10@CELF2
Hg19::chr10:11207415..11207422,+p7@CELF2
Hg19::chr10:112631976..112632038,-p1@ENST00000420367
Hg19::chr10:26727088..26727109,+p7@APBB1IP
Hg19::chr10:26727647..26727722,+p2@APBB1IP
Hg19::chr11:108093656..108093698,+p3@ATM
Hg19::chr11:108093699..108093710,+p7@ATM
Hg19::chr11:108094132..108094180,+p4@ATM
Hg19::chr11:118095718..118095753,-p1@AMICA1
Hg19::chr11:128563948..128564003,+p1@FLI1
Hg19::chr11:3875828..3875866,+p1@ENST00000430222
Hg19::chr11:3877214..3877237,+p1@MIR4687
Hg19::chr11:64107610..64107648,-p@chr11:64107610..64107648
-
Hg19::chr11:64107663..64107703,+p1@CCDC88B
Hg19::chr11:64107705..64107718,+p2@CCDC88B
Hg19::chr11:64511575..64511629,-p1@RASGRP2
Hg19::chr11:64511908..64511923,-p13@RASGRP2
Hg19::chr11:64578188..64578223,-p3@MEN1
Hg19::chr11:65150103..65150148,-p1@SLC25A45
Hg19::chr11:65405556..65405623,+p1@SIPA1
Hg19::chr11:65407251..65407280,+p7@SIPA1
Hg19::chr11:65837549..65837593,+p3@PACS1
Hg19::chr11:66610804..66610835,-p1@CU688443
Hg19::chr11:67171358..67171385,+p2@TBC1D10C
Hg19::chr11:67171391..67171468,+p1@TBC1D10C
Hg19::chr11:67171471..67171484,+p5@TBC1D10C
Hg19::chr11:67203349..67203358,-p1@ENST00000535922
Hg19::chr11:67203630..67203643,-p2@PTPRCAP
Hg19::chr11:67204754..67204767,+p@chr11:67204754..67204767
+
Hg19::chr11:67204769..67204797,+p@chr11:67204769..67204797
+
Hg19::chr11:67205141..67205160,-p1@PTPRCAP
Hg19::chr11:67205245..67205270,+p@chr11:67205245..67205270
+
Hg19::chr11:6767644..6767655,-p2@GVINP1
Hg19::chr11:6767657..6767736,-p1@GVINP1
Hg19::chr11:72525425..72525486,+p1@ATG16L2
Hg19::chr12:109491750..109491794,-p1@LOC100131733
Hg19::chr12:110434073..110434090,-p5@GIT2
Hg19::chr12:110434100..110434139,-p2@GIT2
Hg19::chr12:118797475..118797527,-p3@TAOK3
Hg19::chr12:15114492..15114565,-p1@ARHGDIB
Hg19::chr12:47610202..47610253,-p1@LOC100233209
Hg19::chr12:51717922..51717943,-p2@BIN2
Hg19::chr12:56326402..56326424,-p5@WIBG
Hg19::chr12:57871162..57871177,+p@chr12:57871162..57871177
+
Hg19::chr12:57871591..57871612,-p3@ARHGAP9
Hg19::chr12:57871620..57871659,-p1@ARHGAP9
Hg19::chr12:57871661..57871676,-p5@ARHGAP9
Hg19::chr12:57871853..57871879,-p6@ARHGAP9
Hg19::chr12:58135903..58135974,-p1@AGAP2
Hg19::chr13:114898016..114898113,-p1@RASA3
Hg19::chr14:58740722..58740736,-p1@ENST00000556225
Hg19::chr14:86400995..86401031,+p2@ENST00000557195
Hg19::chr14:86401039..86401083,+p1@ENST00000557195
Hg19::chr14:91581011..91581044,+p6@C14orf159
Hg19::chr14:91883897..91883910,-p6@CCDC88C
Hg19::chr14:91883918..91883957,-p3@CCDC88C
Hg19::chr14:91884129..91884141,-p2@CCDC88C
Hg19::chr14:93117860..93117876,+p9@RIN3
Hg19::chr14:93117883..93117929,+p2@RIN3
Hg19::chr15:40600115..40600166,-p1@PLCB2
Hg19::chr15:75074839..75074866,+p4@CSK
Hg19::chr15:77287457..77287487,+p1@PSTPIP1
Hg19::chr15:77287491..77287507,+p4@PSTPIP1
Hg19::chr15:81589254..81589272,+p2@IL16
Hg19::chr15:81589277..81589337,+p1@IL16
Hg19::chr15:86233140..86233178,+p2@AKAP13
Hg19::chr15:93458175..93458196,+p@chr15:93458175..93458196
+
Hg19::chr16:29756562..29756583,+p1@ENST00000501801
p1@uc002dtq.1
Hg19::chr16:29757272..29757347,-p1@C16orf54
Hg19::chr16:29757348..29757359,-p3@C16orf54
Hg19::chr16:29757389..29757400,-p2@C16orf54
Hg19::chr16:30483962..30484018,+p2@ITGAL
Hg19::chr16:30484021..30484047,+p3@ITGAL
Hg19::chr16:3313774..3313790,+p1@FLJ39639
Hg19::chr16:3313791..3313834,+p2@ZNF263
Hg19::chr16:3627360..3627373,-p2@NLRC3
Hg19::chr16:3627377..3627431,-p1@NLRC3
Hg19::chr16:50300440..50300485,+p1@ADCY7
Hg19::chr16:53468342..53468414,+p1@RBL2
Hg19::chr16:58033455..58033483,+p@chr16:58033455..58033483
+
Hg19::chr16:66586461..66586567,+p1@CKLF-CMTM1
p1@CKLF
Hg19::chr16:67679007..67679059,+p3@RLTPR
Hg19::chr16:68033371..68033398,-p1@DPEP2
Hg19::chr16:68320188..68320208,-p@chr16:68320188..68320208
-
Hg19::chr16:88770019..88770033,-p3@RNF166
Hg19::chr16:88772761..88772839,-p1@RNF166
Hg19::chr16:89787937..89787971,+p1@ZNF276
Hg19::chr16:89788671..89788686,+p1@AF354755
p1@AF354756
Hg19::chr16:89788687..89788698,+p2@AF354755
p2@AF354756
Hg19::chr17:2699697..2699769,+p1@RAP1GAP2
Hg19::chr17:28088355..28088367,-p4@SSH2
Hg19::chr17:38020481..38020506,-p7@IKZF3
Hg19::chr17:3867722..3867748,-p1@ATP2A3
Hg19::chr17:3867752..3867764,-p2@ATP2A3
Hg19::chr17:3867766..3867778,-p3@ATP2A3
Hg19::chr17:43299130..43299151,-p1@ENST00000498986
p1@uc002iil.3
Hg19::chr17:43299168..43299177,-p2@ENST00000498986
p2@uc002iil.3
Hg19::chr17:43487780..43487792,-p5@ARHGAP27
Hg19::chr17:43487793..43487803,-p8@ARHGAP27
Hg19::chr17:4843654..4843674,+p10@RNF167
Hg19::chr17:4843679..4843703,+p5@RNF167
Hg19::chr17:54910566..54910612,+p@chr17:54910566..54910612
+
Hg19::chr17:56409871..56409890,-p1@AX721088
Hg19::chr17:56414556..56414572,+p1@LOC100506779
Hg19::chr17:56414584..56414610,+p1@uc002ivz.2
p1@uc010dcv.1
Hg19::chr17:56414635..56414648,+p3@uc002iwa.2
p3@uc002iwb.2
p3@uc002iwc.2
Hg19::chr17:56414657..56414675,+p2@uc002iwa.2
p2@uc002iwb.2
p2@uc002iwc.2
Hg19::chr17:56414688..56414711,+p1@uc002iwa.2
p1@uc002iwb.2
p1@uc002iwc.2
Hg19::chr17:61777459..61777502,-p1@LIMD2
Hg19::chr17:7239821..7239902,+p1@ACAP1
Hg19::chr17:7239904..7239915,+p2@ACAP1
Hg19::chr17:75369167..75369178,+p17@SEPT9
Hg19::chr17:75447533..75447595,+p3@SEPT9
Hg19::chr17:75450099..75450128,+p13@SEPT9
Hg19::chr17:76126828..76126839,+p3@TMC8
Hg19::chr17:76126842..76126896,+p1@TMC8
Hg19::chr17:76128159..76128188,-p@chr17:76128159..76128188
-
Hg19::chr17:76778339..76778413,-p1@CYTH1
Hg19::chr17:80817460..80817512,+p@chr17:80817460..80817512
+
Hg19::chr18:11908297..11908323,-p1@MPPE1
Hg19::chr18:2636728..2636753,-p@chr18:2636728..2636753
-
Hg19::chr18:29598769..29598776,+p3@RNF125
Hg19::chr18:5295679..5295734,-p2@ZFP161
Hg19::chr18:72166564..72166620,+p5@CNDP2
Hg19::chr19:10450287..10450324,-p1@ICAM3
Hg19::chr19:10450328..10450351,-p2@ICAM3
Hg19::chr19:1066984..1067041,+p3@HMHA1
Hg19::chr19:1067144..1067190,+p2@HMHA1
Hg19::chr19:1067256..1067270,+p4@HMHA1
Hg19::chr19:1067271..1067335,+p1@HMHA1
Hg19::chr19:1067342..1067353,+p8@HMHA1
Hg19::chr19:10714098..10714112,-p@chr19:10714098..10714112
-
Hg19::chr19:14492217..14492241,+p2@CD97
Hg19::chr19:14551066..14551097,+p2@PKN1
Hg19::chr19:15575340..15575367,-p1@RASAL3
Hg19::chr19:15575369..15575386,-p2@RASAL3
Hg19::chr19:17862274..17862335,+p2@FCHO1
Hg19::chr19:17958771..17958829,-p1@JAK3
Hg19::chr19:17958832..17958861,-p2@JAK3
Hg19::chr19:18111927..18111988,+p2@ARRDC2
Hg19::chr19:18197714..18197750,-p1@IL12RB1
Hg19::chr19:18197799..18197815,-p2@IL12RB1
Hg19::chr19:18414444..18414500,+p@chr19:18414444..18414500
+
Hg19::chr19:1942102..1942130,-p@chr19:1942102..1942130
-
Hg19::chr19:19887364..19887438,+p@chr19:19887364..19887438
+
Hg19::chr19:3178754..3178779,+p1@S1PR4
Hg19::chr19:36235552..36235619,-p2@U2AF1L4
Hg19::chr19:36393354..36393363,+p4@HCST
Hg19::chr19:36393367..36393387,+p3@HCST
Hg19::chr19:36393388..36393421,+p2@HCST
Hg19::chr19:36393422..36393439,+p1@HCST
Hg19::chr19:39826639..39826719,-p1@GMFG
Hg19::chr19:42061692..42061699,+p@chr19:42061692..42061699
+
Hg19::chr19:42387240..42387310,+p1@ARHGEF1
Hg19::chr19:4916794..4916840,-p1@AK097879
Hg19::chr19:49838878..49838904,-p@chr19:49838878..49838904
-
Hg19::chr19:6481759..6481771,-p2@DENND1C
Hg19::chr19:6481776..6481815,-p1@DENND1C
Hg19::chr1:111217410..111217472,-p2@KCNA3
Hg19::chr1:151032040..151032115,-p1@CDC42SE1
Hg19::chr1:160492994..160493057,-p1@SLAMF6
Hg19::chr1:160493058..160493069,-p2@SLAMF6
Hg19::chr1:160765947..160765976,+p1@LY9
Hg19::chr1:161039647..161039744,-p1@ARHGAP30
Hg19::chr1:169680745..169680771,-p1@SELL
Hg19::chr1:1711945..1711970,-p6@NADK
Hg19::chr1:179851893..179851995,+p1@TOR1AIP1
Hg19::chr1:209929388..209929412,+p3@TRAF3IP3
Hg19::chr1:209929446..209929490,+p1@TRAF3IP3
Hg19::chr1:209929494..209929523,+p5@TRAF3IP3
Hg19::chr1:209941889..209941928,+p2@TRAF3IP3
Hg19::chr1:26872304..26872315,+p4@RPS6KA1
Hg19::chr1:27668505..27668582,+p1@SYTL1
Hg19::chr1:39680895..39680915,+p7@MACF1
Hg19::chr1:39680927..39680954,+p2@MACF1
Hg19::chr1:53098820..53098860,+p1@FAM159A
Hg19::chr1:84609944..84609964,+p3@PRKACB
Hg19::chr1:84609965..84610025,+p2@PRKACB
Hg19::chr1:84610949..84610971,+p@chr1:84610949..84610971
+
Hg19::chr1:9711781..9711813,+p1@PIK3CD
Hg19::chr1:9711821..9711832,+p2@PIK3CD
Hg19::chr1:9712538..9712576,-p@chr1:9712538..9712576
-
Hg19::chr20:25039008..25039028,-p3@ACSS1
Hg19::chr20:34078776..34078819,-p1@ENST00000453914
Hg19::chr20:34078866..34078891,+p@chr20:34078866..34078891
+
Hg19::chr20:34078894..34078909,+p@chr20:34078894..34078909
+
Hg19::chr20:35274548..35274622,-p1@SLA2
Hg19::chr20:45318230..45318303,-p2@TP53RK
Hg19::chr20:56195525..56195556,-p2@ZBP1
Hg19::chr21:38739289..38739363,+p2@DYRK1A
Hg19::chr21:43346790..43346823,-p4@C2CD2
Hg19::chr21:45559983..45560006,+p@chr21:45559983..45560006
+
Hg19::chr22:24551765..24551817,+p5@CABIN1
Hg19::chr22:24823491..24823509,-p@chr22:24823491..24823509
-
Hg19::chr22:27068766..27068794,+p1@ENST00000435162
p1@ENST00000437071
p1@ENST00000440816
Hg19::chr22:27068859..27068915,+p3@MIAT
Hg19::chr22:31892159..31892189,+p2@SFI1
Hg19::chr22:36556821..36556864,-p2@APOL3
Hg19::chr22:38073284..38073329,-p@chr22:38073284..38073329
-
Hg19::chr22:39147797..39147812,-p15@SUN2
Hg19::chr22:39150947..39150977,-p4@SUN2
Hg19::chr22:39540626..39540653,+p@chr22:39540626..39540653
+
Hg19::chr22:50628999..50629023,+p2@TRABD
Hg19::chr22:50629033..50629048,+p3@TRABD
Hg19::chr2:113931513..113931583,+p1@PSD4
Hg19::chr2:127839445..127839462,-p5@BIN1
Hg19::chr2:131129793..131129812,+p1@PTPN18
Hg19::chr2:143886877..143886888,+p5@ARHGAP15
Hg19::chr2:143886890..143886904,+p4@ARHGAP15
Hg19::chr2:143886909..143886922,+p2@ARHGAP15
Hg19::chr2:143886927..143886938,+p3@ARHGAP15
Hg19::chr2:143886949..143886997,+p1@ARHGAP15
Hg19::chr2:175462523..175462539,-p2@WIPF1
Hg19::chr2:182321734..182321748,+p11@ITGA4
Hg19::chr2:198174475..198174519,+p@chr2:198174475..198174519
+
Hg19::chr2:198175375..198175440,-p2@ANKRD44
Hg19::chr2:198175527..198175542,-p4@ANKRD44
Hg19::chr2:198175544..198175567,-p3@ANKRD44
Hg19::chr2:202098203..202098256,+p3@CASP8
Hg19::chr2:202125162..202125180,-p@chr2:202125162..202125180
-
Hg19::chr2:202125219..202125230,+p9@CASP8
Hg19::chr2:202125233..202125266,+p4@CASP8
Hg19::chr2:202125267..202125292,+p1@CASP8
Hg19::chr2:233925038..233925062,+p1@INPP5D
Hg19::chr2:233925064..233925090,+p2@INPP5D
Hg19::chr2:30455229..30455276,+p3@LBH
Hg19::chr2:43446411..43446479,+p@chr2:43446411..43446479
+
Hg19::chr2:45795145..45795174,-p3@SRBD1
Hg19::chr2:70322412..70322438,-p1@ENST00000424748
Hg19::chr2:85555061..85555081,-p2@TGOLN2
Hg19::chr3:113251358..113251423,+p1@SIDT1
Hg19::chr3:130745571..130745677,-p1@ASTE1
Hg19::chr3:16926441..16926463,+p2@PLCL2
Hg19::chr3:16926484..16926502,+p1@PLCL2
Hg19::chr3:195163803..195163826,-p2@ACAP2
Hg19::chr3:48520915..48520952,-p11@SHISA5
Hg19::chr3:52279908..52279919,+p3@PPM1M
Hg19::chr3:52321827..52321859,+p1@GLYCTK
Hg19::chr4:153457523..153457575,+p1@MIR4453
Hg19::chr4:15683260..15683337,+p4@FAM200B
Hg19::chr4:1725231..1725273,+p2@TACC3
Hg19::chr4:37892682..37892757,+p2@TBC1D1
Hg19::chr5:118604439..118604502,+p1@TNFAIP8
Hg19::chr5:131746575..131746682,+p1@C5orf56
Hg19::chr5:169064245..169064303,+p1@DOCK2
Hg19::chr5:171615315..171615383,-p2@STK10
Hg19::chr5:175963588..175963604,-p11@RNF44
Hg19::chr5:175963631..175963657,-p4@RNF44
Hg19::chr5:175964366..175964429,-p2@RNF44
Hg19::chr5:175968683..175968713,+p@chr5:175968683..175968713
+
Hg19::chr5:176797664..176797668,+p6@RGS14
Hg19::chr5:176853669..176853701,+p1@GRK6
Hg19::chr5:42992912..42992938,-p4@uc003jnb.1
Hg19::chr5:42992944..42992958,-p7@uc003jnb.1
Hg19::chr5:43040442..43040486,-p2@C5orf39
Hg19::chr6:144665273..144665349,+p1@UTRN
Hg19::chr6:159463364..159463398,-p4@TAGAP
Hg19::chr6:26365404..26365440,+p2@BTN3A2
Hg19::chr6:26365443..26365493,+p1@BTN3A2
Hg19::chr6:26402472..26402512,+p1@BTN3A1
Hg19::chr6:26440710..26440788,+p1@BTN3A3
Hg19::chr6:26458152..26458164,+p2@BTN2A1
Hg19::chr6:30029008..30029055,+p2@ZNRD1
Hg19::chr6:32160622..32160719,-p2@GPSM3
Hg19::chr6:32821599..32821615,-p4@TAP1
Hg19::chr6:35265586..35265641,+p1@DEF6
Hg19::chr6:42531930..42531953,+p3@UBR2
Hg19::chr6:42714708..42714748,+p2@KIAA0240
Hg19::chr7:100183742..100183781,-p1@LRCH4
Hg19::chr7:142495131..142495159,+p1@TRBJ2-7
Hg19::chr7:150382781..150382815,+p1@GIMAP1
p1@GIMAP2
Hg19::chr7:150382818..150382821,+p2@GIMAP2
Hg19::chr7:44613618..44613631,+p@chr7:44613618..44613631
+
Hg19::chr7:50343478..50343494,+p9@IKZF1
Hg19::chr7:50343510..50343521,+p11@IKZF1
Hg19::chr7:50343536..50343545,+p12@IKZF1
Hg19::chr7:50343634..50343717,+p2@IKZF1
Hg19::chr7:50344144..50344157,+p6@IKZF1
Hg19::chr7:644239..644302,+p@chr7:644239..644302
+
Hg19::chr7:86849025..86849059,-p1@C7orf23
Hg19::chr8:133772856..133772863,-p3@TMEM71
Hg19::chr8:134511563..134511586,-p5@ST3GAL1
Hg19::chr8:23101142..23101156,+p2@CHMP7
Hg19::chr8:38644957..38645020,+p4@TACC1
Hg19::chr8:71564073..71564104,+p@chr8:71564073..71564104
+
Hg19::chr9:117150254..117150271,-p1@AKNA
Hg19::chr9:117150303..117150312,-p3@AKNA
Hg19::chr9:117160738..117160782,-p2@AKNA
Hg19::chr9:123691281..123691362,-p2@TRAF1
Hg19::chr9:130541017..130541032,-p6@SH2D3C
Hg19::chr9:134145898..134145952,-p4@FAM78A
Hg19::chr9:2017676..2017700,+p@chr9:2017676..2017700
+
Hg19::chr9:272886..272918,+p6@DOCK8
Hg19::chr9:272921..272937,+p8@DOCK8
Hg19::chr9:273026..273037,+p5@DOCK8
Hg19::chr9:273038..273076,+p2@DOCK8
Hg19::chr9:32526299..32526346,-p2@DDX58
Hg19::chr9:91992875..91992889,-p@chr9:91992875..91992889
-
Hg19::chr9:92112972..92113048,-p1@SEMA4D
Hg19::chr9:98638233..98638306,-p1@LINC00476
Hg19::chrX:10066426..10066458,+p2@WWC3
Hg19::chrX:117629595..117629640,+p2@DOCK11
Hg19::chrX:118827113..118827140,-p1@SEPT6
Hg19::chrX:128913906..128913957,+p1@SASH3
Hg19::chrX:129220847..129220883,-p@chrX:129220847..129220883
-
Hg19::chrX:129220902..129220913,-p@chrX:129220902..129220913
-
Hg19::chrX:153192292..153192326,-p4@ARHGAP4
Hg19::chrX:70331410..70331436,-p1@IL2RG
Hg19::chrX:70418030..70418054,-p1@ENST00000450860


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

p.valueFDRnGenesnPathwayName
1.66393622232006e-060.0001504673755326579189Chemokine signaling pathway (KEGG):04062
2.6083048043839e-050.001500960855613648204Endocytosis (KEGG):04144
0.001083404149888460.0403408721693763335Primary immunodeficiency (KEGG):05340
0.0005220199156641870.0206524129134644464IL-4 signaling Pathway (Wikipathways):WP395
8.36232923303133e-050.00441112867042403440G13 Signaling Pathway (Wikipathways):WP524
3.53351911337367e-101.11835879938277e-0711133T Cell Receptor Signaling Pathway (Wikipathways):WP69
6.41276890061639e-078.11856542818034e-05785Integrin cell surface interactions (Reactome):REACT_13552
1.55851378778502e-109.86539227667916e-0819511Signaling in Immune system (Reactome):REACT_6900
3.47160198084761e-060.00027469050673456713466Hemostasis (Reactome):REACT_604
5.43343015399396e-078.11856542818034e-058121Signaling by Rho GTPases (Reactome):REACT_11044
1.28207912517131e-060.00013525934770557311295IL-2 down reg. targets (Netpath):NetPath_14
4.65649974928251e-060.0003275071490328712406{GRB2,414} (Static Module):NA
3.55175527931001e-087.49420363934413e-06517{HCLS1,17} (Static Module):NA
0.0002176374581123590.00984032221322309451{HLA-A,53} (Static Module):NA
1.22010885576084e-050.0007723289056966137132{RAC1,133} (Static Module):NA
0.0002693570178085110.0113668661515192322{RAP1A,22} (Static Module):NA
0.0002010947834562660.00979176907137047320{SEPT2,21} (Static Module):NA



Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0030695GTPase regulator activity6.69754590003444e-11
GO:0005515protein binding2.96276810717286e-08
GO:0007165signal transduction2.96276810717286e-08
GO:0005096GTPase activator activity3.44757962320888e-07
GO:0007154cell communication6.34812840990484e-07
GO:0008047enzyme activator activity6.34812840990484e-07
GO:0007242intracellular signaling cascade1.00556473591337e-06
GO:0044464cell part1.37047040346379e-05
GO:0009966regulation of signal transduction7.39182975357727e-05
GO:0005737cytoplasm0.000224555448856817
GO:0048523negative regulation of cellular process0.000224555448856817
GO:0005622intracellular0.000224555448856817
GO:0006793phosphorus metabolic process0.000224555448856817
GO:0006796phosphate metabolic process0.000224555448856817
GO:0005085guanyl-nucleotide exchange factor activity0.000249065636103417
GO:0048519negative regulation of biological process0.000271166935493937
GO:0005083small GTPase regulator activity0.00105457326875663
GO:0043687post-translational protein modification0.00279701940806723
GO:0016310phosphorylation0.00475609600344279
GO:0016773phosphotransferase activity, alcohol group as acceptor0.00480933041583784
GO:0051056regulation of small GTPase mediated signal transduction0.00501149392782198
GO:0007264small GTPase mediated signal transduction0.00788346418871303
GO:0006468protein amino acid phosphorylation0.00888485381338819
GO:0044424intracellular part0.00888485381338819
GO:0045786negative regulation of progression through cell cycle0.0098002953816129
GO:0050794regulation of cellular process0.00985184691038585
GO:0065007biological regulation0.0105433643864069
GO:0007265Ras protein signal transduction0.0105433643864069
GO:0050789regulation of biological process0.0105433643864069
GO:0008277regulation of G-protein coupled receptor protein signaling pathway0.0109549788468241
GO:0004691cAMP-dependent protein kinase activity0.0114286417244299
GO:0043412biopolymer modification0.0117317148626051
GO:0004674protein serine/threonine kinase activity0.0128423856255069
GO:0002376immune system process0.0128423856255069
GO:0004715non-membrane spanning protein tyrosine kinase activity0.0128423856255069
GO:0051020GTPase binding0.0143246460336337
GO:0043621protein self-association0.0149288019354728
GO:0006464protein modification process0.0149288019354728
GO:0007498mesoderm development0.0152699367873361
GO:0005070SH3/SH2 adaptor activity0.020155545189995
GO:0004690cyclic nucleotide-dependent protein kinase activity0.020155545189995
GO:0035004phosphoinositide 3-kinase activity0.0300857148965339
GO:00163031-phosphatidylinositol-3-kinase activity0.0300857148965339
GO:0031410cytoplasmic vesicle0.0300857148965339
GO:0022610biological adhesion0.0300857148965339
GO:0007155cell adhesion0.0300857148965339
GO:0060090molecular adaptor activity0.0308849183944295
GO:0031982vesicle0.0308849183944295
GO:0007254JNK cascade0.0377042552840043
GO:0016301kinase activity0.0382960047285508
GO:0004672protein kinase activity0.0388422829624299
GO:0031098stress-activated protein kinase signaling pathway0.0404099427357716
GO:0000074regulation of progression through cell cycle0.0466701585089559
GO:0051726regulation of cell cycle0.0497445654238121



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

Cell Type
Ontology termp-valuen
hematopoietic stem cell5.86e-93168
angioblastic mesenchymal cell5.86e-93168
hematopoietic cell1.16e-88177
hematopoietic oligopotent progenitor cell7.74e-87161
hematopoietic multipotent progenitor cell7.74e-87161
leukocyte1.02e-84136
hematopoietic lineage restricted progenitor cell6.53e-71120
nongranular leukocyte1.81e-70115
myeloid cell5.94e-45108
common myeloid progenitor5.94e-45108
nucleate cell1.24e-3755
lymphocyte2.14e-3753
common lymphoid progenitor2.14e-3753
myeloid leukocyte2.55e-3772
lymphoid lineage restricted progenitor cell5.88e-3752
granulocyte monocyte progenitor cell4.28e-3267
myeloid lineage restricted progenitor cell2.69e-3166
macrophage dendritic cell progenitor4.56e-2961
monopoietic cell1.40e-2859
monocyte1.40e-2859
monoblast1.40e-2859
promonocyte1.40e-2859
defensive cell4.54e-2648
phagocyte4.54e-2648
classical monocyte2.32e-2542
CD14-positive, CD16-negative classical monocyte2.32e-2542
T cell3.75e-2025
pro-T cell3.75e-2025
mature alpha-beta T cell2.02e-1718
alpha-beta T cell2.02e-1718
immature T cell2.02e-1718
mature T cell2.02e-1718
immature alpha-beta T cell2.02e-1718
lymphocyte of B lineage2.76e-1524
pro-B cell2.76e-1524
mesenchymal cell4.79e-15354
connective tissue cell6.96e-14361
CD8-positive, alpha-beta T cell1.12e-1111
B cell8.31e-1114
motile cell5.59e-10386
granulocyte7.29e-088
intermediate monocyte1.44e-079
CD14-positive, CD16-positive monocyte1.44e-079
stuff accumulating cell2.78e-0787
Uber Anatomy
Ontology termp-valuen
hematopoietic system2.53e-4398
blood island2.53e-4398
hemolymphoid system6.82e-39108
immune system1.59e-2893
bone marrow8.59e-2876
bone element5.36e-2482
skeletal element8.36e-2090
skeletal system3.33e-16100
adult organism8.74e-15114
connective tissue1.07e-12371
blood5.92e-1215
haemolymphatic fluid5.92e-1215
organism substance5.92e-1215
lateral plate mesoderm4.91e-10203
Disease
Ontology termp-valuen
hematologic cancer1.46e-1351
immune system cancer1.46e-1351
leukemia1.06e-1039
myeloid leukemia2.75e-0731


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.113.0705
MA0004.10.612289
MA0006.10.716611
MA0007.11.05818
MA0009.10.0179945
MA0014.12.56642
MA0017.10.538635
MA0019.10.0149403
MA0024.10.685017
MA0025.10.0119608
MA0027.10.966386
MA0028.13.7176
MA0029.10.0635187
MA0030.10.345925
MA0031.10.121066
MA0038.10.0143063
MA0040.10.245431
MA0041.10.00462943
MA0042.10.0836955
MA0043.10.0581805
MA0046.10.0160244
MA0048.11.77776
MA0050.18.49777
MA0051.17.59055
MA0052.10.0271889
MA0055.13.66176
MA0056.10
MA0057.12.19243
MA0058.10.63442
MA0059.11.52544
MA0060.10.0357955
MA0061.13.58456
MA0063.10
MA0066.10.307927
MA0067.10.171618
MA0068.12.34706
MA0069.10.119521
MA0070.10.0456289
MA0071.10.0498777
MA0072.10.0436826
MA0073.16.21169
MA0074.10.289911
MA0076.15.38387
MA0077.10.193194
MA0078.10.118709
MA0081.14.22718
MA0083.10.141956
MA0084.10.110928
MA0087.10.102969
MA0088.11.20389
MA0089.10
MA0090.10.100731
MA0091.10.225775
MA0092.11.23258
MA0093.10.536997
MA0095.10
MA0098.10
MA0100.10.175099
MA0101.10.669983
MA0103.10.437258
MA0105.14.03039
MA0106.10.341745
MA0107.10.692674
MA0108.20.117418
MA0109.10
MA0111.11.05184
MA0113.10.878377
MA0114.10.387382
MA0115.10.278604
MA0116.14.68994
MA0117.10.176055
MA0119.10.146499
MA0122.11.16015
MA0124.10.226764
MA0125.10.139357
MA0130.10
MA0131.10.635636
MA0132.10
MA0133.10
MA0135.10.00423351
MA0136.18.41315
MA0139.10.703011
MA0140.10.0130306
MA0141.10.325525
MA0142.10.0866133
MA0143.10.195407
MA0144.10.226974
MA0145.13.60497
MA0146.110.1604
MA0147.11.14287
MA0148.10.0690119
MA0149.10.418715
MA0062.222.4824
MA0035.20.0128308
MA0039.26.64671
MA0138.20.728933
MA0002.24.53222
MA0137.20.20819
MA0104.20.877116
MA0047.20.138567
MA0112.23.13756
MA0065.21.11388
MA0150.10.0070084
MA0151.10
MA0152.10.00086416
MA0153.10.448391
MA0154.15.40189
MA0155.17.66473
MA0156.118.236
MA0157.10.19315
MA0158.10
MA0159.11.43872
MA0160.10.0318848
MA0161.10
MA0162.11.75339
MA0163.17.88702
MA0164.10.0476019
MA0080.225.5711
MA0018.20.244616
MA0099.20.00680078
MA0079.221.9905
MA0102.20.128041
MA0258.11.15472
MA0259.10.781029
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
BATF#10538251.958022652114440.001217477677190770.0081927932427917
BCL11A#53335252.280502821833370.0001345972344381460.00176442833782924
CCNT2#905691.405781057268240.001859246494707350.0109680210495222
CTCF#10664751.292666327911980.009699995698351970.0364973826688829
E2F6#1876831.338983684022130.002379878885535040.0134796990577794
EBF1#18791243.551131475802431.13785549189177e-386.25455209040447e-36
EGR1#19581342.149247584259032.48862897078138e-206.43341388810486e-18
ELF1#19972283.121692394238327.0546765553469e-778.66803958545735e-74
ETS1#2113672.095906693850664.32096525468803e-093.52560382995596e-07
GABPB1#25531032.340744164394742.15175186185779e-174.52166625152044e-15
GATA1#2623391.700488802598770.0008707027968025490.00649584465999439
HEY1#234621051.364024628701280.0002261713366069920.0024958905562022
IRF4#3662362.536728156664923.83290559628327e-071.87320930074978e-05
MAX#41491012.095524457909077.37544821467009e-141.17064503965339e-11
MEF2A#4205352.109366822628753.00898357121811e-050.000619344176575577
MYC#4609851.427311765552410.0002789360366455510.00296990526365835
NFKB1#47901713.017552557997258.2862295969632e-485.69345745313973e-45
PAX5#50791052.251782574834961.35710136898059e-162.72042821257129e-14
POLR2A#54302942.030068276231752.17317920283812e-752.60878922718632e-72
POU2F2#5452992.898734024811933.79835507507458e-231.12697842524351e-20
SIN3A#25942961.669623581267699.67342133891119e-085.70136823484506e-06
SP1#6667881.612403734007711.91433974329882e-067.04481072763866e-05
SPI1#66881534.036210600655882.58329055838661e-572.2297213440276e-54
SRF#6722421.863284524151288.00107997729139e-050.00122489708552966
STAT1#6772251.664516679839160.009497356047084510.0357774624225025
STAT2#6773153.147770314458550.0001139486758528650.0015601318507338
TAF1#68721821.956380784584061.30182250441192e-254.24878251682113e-23
TBP#69081471.752074890685431.74196730624563e-142.95820038206484e-12
TCF12#6938541.8464987289978.49569769508425e-060.000231424666556313
USF1#7391651.329573803918060.009172777096320750.0346961597610605
USF2#7392522.172328823227071.10462079781917e-076.41632322043585e-06
YY1#75281402.210816414725211.11974543483412e-223.2216279192463e-20
ZBTB7A#51341781.8438872219114.6534295720924e-083.0393966921811e-06
ZEB1#6935372.009234677328374.87850741035938e-050.000846918941872545



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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