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{{Coexpression_clusters
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|full_id=C1812_Mast_granulocyte_acute_Eosinophils_chronic_Basophils_CD133
|id=C1812
|ontology_enrichment_celltype=CL:0000037!3.10e-53!172;CL:0000566!3.10e-53!172;CL:0000763!7.74e-53!112;CL:0000049!7.74e-53!112;CL:0002032!7.30e-50!165;CL:0000837!7.30e-50!165;CL:0000988!2.22e-47!182;CL:0000738!1.30e-36!140;CL:0000766!3.71e-36!76;CL:0000557!8.77e-32!71;CL:0000839!2.47e-31!70;CL:0002031!4.28e-30!124;CL:0002009!4.12e-27!65;CL:0002057!2.68e-26!42;CL:0002194!2.91e-26!63;CL:0000576!2.91e-26!63;CL:0000040!2.91e-26!63;CL:0000559!2.91e-26!63;CL:0002087!6.50e-26!119;CL:0000860!4.24e-23!45;CL:0000134!7.77e-09!358;CL:0002320!2.81e-08!365;CL:0000094!1.70e-07!8;CL:0002393!5.13e-07!9;CL:0002397!5.13e-07!9
|ontology_enrichment_disease=DOID:8692!6.88e-15!31;DOID:1240!1.62e-12!39;DOID:2531!3.06e-09!51;DOID:0060083!3.06e-09!51
|ontology_enrichment_uberon=UBERON:0002390!2.34e-33!102;UBERON:0003061!2.34e-33!102;UBERON:0002193!1.27e-29!112;UBERON:0002371!3.18e-27!80;UBERON:0001474!1.97e-24!86;UBERON:0002405!4.65e-23!115;UBERON:0004765!1.96e-17!101;UBERON:0001434!1.96e-17!101;UBERON:0007023!6.46e-13!115;UBERON:0003081!7.60e-08!216;UBERON:0002384!1.06e-07!375;UBERON:0000178!1.75e-07!15;UBERON:0000179!1.75e-07!15;UBERON:0000463!1.75e-07!15
|tf_chipseq_enrich=MYC#4609;4:4.17782549728752:0.00569196903682344:0.0256820993751589
|tfbs_overrepresentation=0.23317,0.0958562,0.877965,0.078254,0.310241,0.43203,0.0706464,0.0615998,0.0539364,0.0424746,0.221396,0.346629,0.294377,0.201017,0.235304,0.101024,0.223746,0.158251,0.0865245,0.0160113,0.29418,0.211047,0.13286,0.153106,0.0683222,0.332688,0.324018,0.146582,0.227906,0.150721,0.31768,0.182756,0.0298713,0.322378,0.108398,0.136785,0.132604,0.070583,0.192426,0.108683,0.155571,0.0406818,0.222325,0.287476,0.193292,0.0596699,0.0625547,0.28382,0.178503,0.193726,0.243359,0.0886583,0.114185,0.150136,0.308837,0.0632035,0.172598,0.328738,0.127101,0.169687,0.0485674,0.236408,0.174369,0.00794097,0.0892839,0.0827236,0.164127,0.0980005,0.139298,0.262613,0.547889,0.110232,0.143944,0.190944,0.012429,0.0283664,0.155593,0.0717582,0.0613084,0.0120583,0.154245,0.348799,0.0698251,0.183986,0.436695,0.38341,0.104918,0.323505,0.790836,0.102375,0.138802,0.0812726,0.153861,0.0777027,0.138224,0.184264,0.769004,0.242703,0.149747,0.413729,0.0939617,0.416542,0.225088,0.0610111,0.337778,0.0672793,0.109136,0.497282,0.228612,0.407248,0.285407,0.0560173,0.23661,0.0293017,0.162943,0.0556189,0.0336673,0.0926302,0.00214876,0.13579,0.0378196,0.331577,0.222452,0.138843,0.164723,0.277102,0.146529,0.0245339,0.136609,0.0248804,0.0973103,0.121587,0.0935301,0.0376876,0.200735,0.173595,0.105753,0.0905147,0.0544577,0.0065834,0.037671,0.203496,0.00690137,0.246229,0.446477,0.112838,0.159217,0.1364,0.0640569,0.193163,0.311509,0.227801,0.282656,0.0439093,0.070163,0.188135,0.121467,0.350865,0.0846706,0.0555742,0.349932,0.153706,0.186743,0.23397,0.412853,0.183121,0.065826,0.203135,0.0663482,0.463935,0.281162,0.218835,0.646289,0.0885874,0.129639,0.145577,0.22277,0.284267,0.27935,0.0586816,0.250461,0.195671,0.0452583,0.185103,0.11983,0.190123,0.286036,0.00223156,0.134265,0.272191,0.172119,0.292239,0.196376,0.0706236,0.18064,0.0772176,0.126988,0.0984435,0.110187,0.176022,0.144361,0.0986228,0.0508565,0.0989516,0.21691,0.393782,0.100282,0.240045,0.057597,0.279218,0.0752697,0.167805,0.193654,0.180992,0.130092,0.265567,0.258402,0.162511,0.102771,0.165687,0.225173,0.540012,0.246322,0.0353118,0.120044,0.201982,0.220536,0.139142,0.0987108,0.09782,0.0543538,0.554981,0.0687568,0.124225,0.1547,0.150448,0.0774663,0.398789,0.257365,0.331711,0.285222,0.511,0.158559,0.134615,0.186192,0.217494,0.132125,0.179065,0.540443,0.187334,0.250769,0.0465383,0.0468257,0.157983,0.158078,0.251693,0.172268,0.313249,0.113261,0.766691,0.101058,0.274448,0.25718,0.204241,0.0568578,0.131428,0.131579,0.148683,0.00130932,0.00785145,0.0179186,0.103245,0.387442,0.00345857,0.14011,0.0626022,0.2074,0.769028,0.875285,0.921608,0.238493,0.748392,0.784283,0.75925,0.493893,0.0268346,0.396701,0.0776041,0.541514,0.127393,0.310815,0.0305032,0.205616,0.144209,0.0406603,0.0233572,0.0991209,0.114025,0.0576112,0.569955,0.00382346,0.780281,0.292173,0.528152,0.284119,0.234606,0.176507,0.030558,0.336705,0.0148976,0.545464,0.0872037,0.824163,0.356237,0.0360622,0.537972,0.225841,0.100468,0.0134523,0.417358,0.450485,0.665656,0.470142,0.0674365,0.00689628,0.201404,0.426591,0.467379,0.420732,0.437202,0.0184191,0.761311,0.00233032,0.438692,0.660225,0.619033,0.0446353,0.0579174,0.790857,0.285074,0.870229,0.5469,0.0833105,0.415372,0.362164,0.289863,0.0351913,0.721501,0.409489,0.0258909,0.113112,0.699429,0.1272,0.0831446,0.423719,0.00476875,0.256985,0.109234,0.11883,0.288602,0.779806,0.69124,0.0598994,0.0608018,0.0404974,0.379957,0.386101,0.260733,0.337121,0.130279,0.317914,0.0740433,0.121457,0.351733,0.256178,0.00422416,0.687274,0.115972,0.503865,0.0958387,0.111787,0.483295,0.570706,0.418989,0.517568,0.606622,0.0701899,0.495024,0.307173,0.246694,0.165722,0.231945,0.0992734,0.597346,0.34136,0.632906,0.493489,0.229501,0.230597,0.195392,0.544572,0.0781633,0.641833,0.383956,0.241286,0.0764074,0.025678,0.393543,0.214395,0.158849,0.146799,0.439833,0.427746,0.156494,0.125252,0.455709,0.0698698,0.00688487,0.0367334,0.108356,0.0925073,0.524026,0.347879,0.58021,0.593219,0.174576,0.0882021,0.903142,0.319495,0.711229,0.827435,0.248788,0.407113,0.498776,0.152069,0.105985,0.224914,0.268941,0.0359783,0.251608,0.365107,0.539805,0.356278,0.0487212,0.144104,0.0972855,0.710825,0.80526,0.159658,0.370345,0.161968,0.0238753,0.214417,0.00813996,0.0270368,0.469232,0.113555,0.0910724,0.299839,0.126587,0.0940929,0.22877,0.343849,0.315824,0.0757554,0.0751409,0.29873,0.179502,0.111889,0.0715061,0.452515,0.201779,0.214491,0.171725,0.412647,0.102448,0.550877,0.029672,0.453305,0.421335,0.0510705,0.0762646,0.266371,0.183582,0.168118,0.145381,0.140277,0.251925,0.172066,0.0720324,0.00647589,0.19738,0.205854,0.0598573,0.301472,0.507714,0.0818982,0.134306,0.108669,0.284804,0.178494,0.338195,0.490571,0.0518509,0.210475,0.0483057,0.0790025,0.310539,0.0577178,0.203728,0.275452,0.288155,0.265827,0.141761,0.153627,0.0186891,0.342497,0.171961,0.415228,0.00800917,0.00423094,0.223952,0.327153,0.0496113,0.20949,0.0730994,0.0857377,0.323267,0.0319907,0.129414,0.157037,0.0349321,0.0208825,0.146467,0.0912686,0.106866,0.0351178,0.218241,0.0242146,0.10708,0.327369,0.339826,0.12998,0.123097,0.254847,0.300809,0.0898207,0.126545,0.0918749,0.0686325,0.0569043,0.0639461,0.387306,0.267408,0.312064,0.080156,0.274185,0.53753,0.0545112,0.510703,0.33844,0.0649137,0.0974216,0.0137454,0.195675,0.174786,0.176557,0.0917509,0.0472148,0.14949,0.229138,0.0639045,0.141461,0.0900204,0.228387,0.0864965,0.334921,0.296227,0.208788,0.0525834,0.36304,0.430936,0.123626,0.270619,0.132705,0.285556,0.493429,0.233835,0.224471,0.262929,0.223204,0.143824,0.127678,0.431098,0.0775891,0.153079,0.0771804,0.211515,0.125701,0.175283,0.204954,0.209341,0.576888,0.629422,0.084895,0.160115,0.0819954,0.10091,0.122658,0.151161,0.228398,0.056055,0.120552,0.102815,0.893893,0.529713,0.335207,0.434016,0.190688,0.0502346,0.278645,0.148202,0.0940982,0.0780533,0.564811,0.0993772,0.274769,0.448923,0.11602,0.344528,0.113233,0.0585992,0.20045,0.274438,0.98236,0.672453,0.319826,0.0643195,0.0160761,0.109708,0.174594,0.0809806,0.0126171,0.318794,0.122767,0.0749261,0.176858,0.114361,0.347759,0.242462,0.0620267,0.211111,0.0738743,0.0882327,0.183058,0.150073,0.00413644,0.16872,0.341388,0.0934526,0.0739908,0.123404,0.0196604,0.0316547,0.0515122,0.336623,0.163542,0.142089,0.27134,0.500871,0.239667,0.10226,0.29809,0.0301117,0.689826,0.245965,0.116923,0.148426,0.0983658,0.228743,0.238223,0.156976,0.244789,0.267391,0.301441,0.21807,0.350528,0.382904,0.110951,0.190404,0.135865,0.0307173,0.18137,0.0173914,0.291283,0.0415219,0.0123556,0.0935746,0.0834173,0.22307,0.160699,0.391307,0.166736,0.181253,0.0422294,0.263877,0.146486,0.431348,0.262486,0.294204,0.131936,0.288826,0.246621,0.1295,0.335656,0.0965376,0.377203,0.279263,0.0643411,0.0101164,0.581771,0.800557,0.0594155,0.0127582,0.208795,0.0713793,0.212621,0.594469,0.53612,0.261842,0.0583216,0.355154,0.145569,0.619037,0.537088,0.0671798,0.261576,0.306963,0.206759,0.526495,0.580285,0.191067,0.178116,0.0309224,0.610475,0.167927,0.561689,0.672416,0.685628,0.623136,0.349408,0.96913,0.445257,0.349068,0.0353848,0.476117,0.196345,0.427789,0.326931,0.386595,0.371114,0.433702,0.0367004,0.277222,0.432123,0.0565478,0.295122,0.494975,0.651196,0.392155,0.626931,0.371758,0.91821,0.0513067,0.890566,0.128028,0.254547,0.673352,0.0969507,0.0289617,0.931136,0.183869,0.922893,0.660884,0.922144,0.666904,0.446908,0.315485,0.311289,0.318577,0.4488,0.088424,0.603509,0.511254,0.193221,0.246387,0.224252,0.587237,0.155054,0.466978,0.0379309,0.257848,0.353942,0.192234,0.427276,0.00295893,0.466967,0.283682,0.424668,0.7175,0.797471,0.0587897,0.0347497,0.477016,0.530902,0.498956,0.209091,0.197115,0.708394,0.50651,0.723248,0.000916334,0.592696,0.592314,0.27725,0.89036,0.177129,0.317485,0.01922,0.220564,0.119459,0.262394,0.307462,0.135076,0.469588,0.0251525,0.274593,0.490712,0.541363,0.128394,0.0589911,0.176255,0.137231,0.0512684,0.174119,0.361524,0.0560593,0.0169552,0.54408,0.62698,0.0367094,0.415367,0.0918421,0.124718,0.36864,0.181824,0.456862,0.0234438,0.680686,0.557093,0.693441,0.382214,0.553161,0.639572,0.00701689,0.339393,0.694478,0.306231,0.298354,0.278436,0.453817,0.457741,0.0206327,0.426239,0.00300615,0.656093,0.572661,0.100067,0.534679,0.41502,0.19449,0.66153,0.523749,0.499347,0.307426,0.462582,0.557732,0.490527,0.132075,0.44799,0.813041,0.318338,0.00443315,0.126433,0.417412,0.318174,0.0555558,0.295666,0.393022,0.293641,0.116969,0.0941346,0.0359836,0.297663,0.256708,0.338258,0.322052,0.145568,0.153833,0.261242,0.38389,0.0463258,0.388459,0.0582761,0.0780866,0.280757,0.301366,0.340343,0.00093263,0.0337506,0.462092,0.336254,0.053444,0.291523,0.19697,0.309816,0.0537285,0.15063,0.198077,0.281455,0.348739,0.419895,0.138495,0.208834,0.32256,0.082459,0.342366,0.109684,0.322704,0.403482,0.181288,0.230841,0.352328,0.255358,0.351665,0.265112,0.0633313,0.10772,0.0854747,0.0747609,0.0968383,0.0550411,0.0063138,0.244656,0.192188,0.158985,0.174153,0.0972854,0.00822058,0.249919,0.0655592,0.0516568,0.0211134,0.0144647,0.126349,0.282501,0.252005,0.390891,0.238377,0.334983,0.197875,0.287909,0.289389,0.117618,0.014271,0.396962,0.316002,0.0618069,0.321404,0.225079,0.300542,0.379651,0.185715,0.345505,0.375521,0.271405,0.311201,0.221943,0.306427,0.367733,0.246925,0.208775,0.0886961,0.0670191,0.270094,0.0424726,0.156279,0.313647,0.461742,0.422872,0.336468,0.13327,0.313545,0.17149,0.0877361,0.0880065,0.238969,0.126615,0.0669467,0.0879453,0.474066,0.396935,0.326779,0.292869,0.358198,0.29552,0.131776,0.158116,0.00567261,0.00144253,0.104167,0.168186,0.108081,0.123829,0.205215,0.175247,0.0724304,0.109077,0.144842,0.0604892,0.214671,0.056553,0.442567,0.430541,0.0354176,0.224871,0.398887,0.389061,0.310732,0.349611,0.445995,0.385709,0.278202,0.426488,0.0938069,0.209809,0.0351523,0.319519,0.309489,0.430805,0.362154,0.480785,0.185476,0.336314,0.344469,0.184651,0.303359,0.297596,0.42392,0.425912,0.380826,0.259046,0.345068,0.151046,0.483953,0.347171,0.321735,0.15463,0.13907,0.470121,0.0400826,0.250466,0.409882,0.115686,0.408975,0.162633,0.342661,0.27567,0.248127,0.33299,0.384731,0.00711361,0.526476
}}

Latest revision as of 11:52, 17 September 2013


Full id: C1812_Mast_granulocyte_acute_Eosinophils_chronic_Basophils_CD133



Phase1 CAGE Peaks

Hg19::chr19:18391340..18391345,-p8@BC169275
Hg19::chr20:1448319..1448351,-p3@NSFL1C
Hg19::chr6:36665587..36665612,+p1@uc010jwl.1
Hg19::chr6:36665624..36665632,+p2@uc010jwl.1
Hg19::chr8:145516154..145516162,-p@chr8:145516154..145516162
-


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

Cell Type
Ontology termp-valuen
myeloid cell1.12e-56108
common myeloid progenitor1.12e-56108
hematopoietic stem cell8.80e-40168
angioblastic mesenchymal cell8.80e-40168
myeloid leukocyte8.25e-3772
hematopoietic cell1.21e-36177
hematopoietic oligopotent progenitor cell1.22e-36161
hematopoietic multipotent progenitor cell1.22e-36161
myeloid lineage restricted progenitor cell5.41e-3066
granulocyte monocyte progenitor cell5.08e-2867
classical monocyte3.65e-2642
CD14-positive, CD16-negative classical monocyte3.65e-2642
defensive cell9.09e-2248
phagocyte9.09e-2248
monopoietic cell1.20e-2159
monocyte1.20e-2159
monoblast1.20e-2159
promonocyte1.20e-2159
macrophage dendritic cell progenitor1.26e-2061
leukocyte5.50e-20136
hematopoietic lineage restricted progenitor cell6.17e-15120
granulocyte1.01e-118
nongranular leukocyte3.14e-11115
intermediate monocyte5.52e-119
CD14-positive, CD16-positive monocyte5.52e-119
histamine secreting cell7.91e-105
biogenic amine secreting cell7.91e-105
granulocytopoietic cell7.91e-105
mast cell7.91e-105
mast cell progenitor7.91e-105
basophil mast progenitor cell7.91e-105
stuff accumulating cell2.22e-0887
mesenchymal cell2.86e-08354
blood cell4.11e-0811
connective tissue cell9.02e-08361
Uber Anatomy
Ontology termp-valuen
hematopoietic system4.71e-3798
blood island4.71e-3798
hemolymphoid system4.17e-32108
bone marrow6.17e-2576
immune system6.48e-2393
bone element3.04e-2282
skeletal element3.16e-1990
skeletal system3.68e-16100
lateral plate mesoderm3.77e-13203
blood3.47e-1115
haemolymphatic fluid3.47e-1115
organism substance3.47e-1115
connective tissue1.69e-07371
adult organism1.70e-07114
Disease
Ontology termp-valuen
myeloid leukemia5.25e-2331
leukemia7.32e-1739
hematologic cancer2.35e-1151
immune system cancer2.35e-1151


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.737422
MA0004.10.626788
MA0006.10.452993
MA0007.10.606704
MA0009.11.11255
MA0014.10.660087
MA0017.10.496101
MA0019.10.784036
MA0024.11.00439
MA0025.11.24931
MA0027.12.73598
MA0028.10.470679
MA0029.11.02437
MA0030.11.01252
MA0031.12.1751
MA0038.10.736268
MA0040.11.03042
MA0041.10.64667
MA0042.10.612397
MA0043.11.11288
MA0046.11.10134
MA0048.10.569896
MA0050.10.613347
MA0051.10.731787
MA0052.11.03442
MA0055.11.5062
MA0056.10
MA0057.10.189508
MA0058.10.523638
MA0059.10.522232
MA0060.13.25531
MA0061.10.291022
MA0063.10
MA0066.10.736721
MA0067.11.43651
MA0068.10.247962
MA0069.11.09737
MA0070.11.08584
MA0071.10.695094
MA0072.11.0812
MA0073.10.0140295
MA0074.10.730989
MA0076.10.540943
MA0077.11.07324
MA0078.10.836493
MA0081.10.522409
MA0083.11.12028
MA0084.11.62584
MA0087.11.07867
MA0088.10.412364
MA0089.10
MA0090.10.556637
MA0091.10.629594
MA0092.10.588959
MA0093.10.456342
MA0095.10
MA0098.10
MA0100.10.750974
MA0101.10.459973
MA0103.10.442769
MA0105.10.175503
MA0106.11.83541
MA0107.10.378225
MA0108.20.94238
MA0109.10
MA0111.10.5713
MA0113.10.797251
MA0114.10.372523
MA0115.11.35895
MA0116.10.382106
MA0117.11.1512
MA0119.10.504689
MA0122.11.17777
MA0124.11.31673
MA0125.11.23103
MA0130.10
MA0131.10.855546
MA0132.10
MA0133.10
MA0135.11.14377
MA0136.10.743749
MA0139.10.759606
MA0140.10.692258
MA0141.10.520334
MA0142.10.912455
MA0143.10.797437
MA0144.10.938075
MA0145.10.868598
MA0146.10.143081
MA0147.10.386018
MA0148.10.653474
MA0149.10.681935
MA0062.20.284987
MA0035.20.691506
MA0039.20.0118463
MA0138.20.837782
MA0002.20.30855
MA0137.20.47779
MA0104.20.320919
MA0047.20.767096
MA0112.21.96224
MA0065.20.146576
MA0150.10.550239
MA0151.10
MA0152.10.69926
MA0153.11.21379
MA0154.10.514087
MA0155.11.3196
MA0156.11.20729
MA0157.10.883854
MA0158.10
MA0159.10.386729
MA0160.10.669748
MA0161.10
MA0162.10.0592265
MA0163.10.0439995
MA0164.10.810347
MA0080.21.15604
MA0018.20.781393
MA0099.20.699641
MA0079.20.00207114
MA0102.21.66336
MA0258.11.63655
MA0259.10.395396
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
MYC#460944.177825497287520.005691969036823440.0256820993751589



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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