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{{Coexpression_clusters
{
|coexpression_dpi_cluster_scores_median=-0.336488352117295

Latest revision as of 12:18, 17 September 2013


Full id: C3059_thyroid_Renal_Smooth_Hepatic_acute_CD34_Endothelial



Phase1 CAGE Peaks

Hg19::chr10:94449649..94449664,+p3@HHEX
Hg19::chr10:94449675..94449694,+p2@HHEX
Hg19::chr10:94449703..94449718,+p1@HHEX


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

Cell Type
Ontology termp-valuen
myeloid cell1.23e-25108
common myeloid progenitor1.23e-25108
hematopoietic stem cell1.52e-20168
angioblastic mesenchymal cell1.52e-20168
hematopoietic oligopotent progenitor cell7.29e-19161
hematopoietic multipotent progenitor cell7.29e-19161
hematopoietic cell1.10e-18177
endothelial cell2.12e-1536
myeloid leukocyte1.96e-1472
endothelial cell of vascular tree1.31e-1224
granulocyte monocyte progenitor cell2.22e-1267
meso-epithelial cell8.30e-1245
myeloid lineage restricted progenitor cell5.15e-1166
macrophage dendritic cell progenitor8.24e-1161
monopoietic cell2.01e-1059
monocyte2.01e-1059
monoblast2.01e-1059
promonocyte2.01e-1059
blood vessel endothelial cell3.44e-1018
embryonic blood vessel endothelial progenitor cell3.44e-1018
leukocyte4.65e-10136
defensive cell8.35e-0948
phagocyte8.35e-0948
B cell9.23e-0914
hematopoietic lineage restricted progenitor cell3.02e-07120
classical monocyte3.26e-0742
CD14-positive, CD16-negative classical monocyte3.26e-0742
nongranular leukocyte3.57e-07115
Uber Anatomy
Ontology termp-valuen
lateral plate mesoderm1.15e-21203
epithelial tube1.01e-15117
cardiovascular system1.48e-15109
vessel1.52e-1568
circulatory system1.54e-15112
epithelial tube open at both ends3.49e-1459
blood vessel3.49e-1459
blood vasculature3.49e-1459
vascular cord3.49e-1459
hemolymphoid system1.75e-13108
vasculature1.88e-1378
vascular system1.88e-1378
splanchnic layer of lateral plate mesoderm1.62e-1283
immune system2.52e-1193
hematopoietic system6.37e-1198
blood island6.37e-1198
blood vessel endothelium3.44e-1018
endothelium3.44e-1018
cardiovascular system endothelium3.44e-1018
bone marrow1.53e-0976
bone element3.04e-0982
tube4.20e-09192
artery4.50e-0942
arterial blood vessel4.50e-0942
arterial system4.50e-0942
simple squamous epithelium7.63e-0922
mesoderm1.32e-08315
mesoderm-derived structure1.32e-08315
presumptive mesoderm1.32e-08315
anatomical conduit5.34e-08240
systemic artery9.08e-0733
systemic arterial system9.08e-0733
Disease
Ontology termp-valuen
myeloid leukemia5.83e-1531
leukemia1.03e-1039
hematologic cancer1.16e-0751
immune system cancer1.16e-0751


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.115.1495
MA0004.10.826076
MA0006.10.639288
MA0007.10.804807
MA0009.11.3275
MA0014.110.356
MA0017.10.686276
MA0019.10.990656
MA0024.11.21731
MA0025.11.46617
MA0027.12.95767
MA0028.10.658629
MA0029.11.23771
MA0030.11.22561
MA0031.11.15713
MA0038.10.94098
MA0040.11.24388
MA0041.10.847069
MA0042.10.810843
MA0043.11.32783
MA0046.11.31611
MA0048.10.341392
MA0050.10.81185
MA0051.10.936307
MA0052.11.24796
MA0055.10.190716
MA0056.10
MA0057.10.333427
MA0058.10.716037
MA0059.10.714521
MA0060.12.13518
MA0061.10.456531
MA0063.10
MA0066.10.941452
MA0067.11.65513
MA0068.11.84332
MA0069.11.31207
MA0070.11.30033
MA0071.10.897953
MA0072.11.29561
MA0073.13.923
MA0074.10.935474
MA0076.10.734647
MA0077.11.28751
MA0078.11.04495
MA0081.10.714712
MA0083.11.33535
MA0084.11.84562
MA0087.11.29304
MA0088.11.31954
MA0089.10
MA0090.10.751469
MA0091.10.829044
MA0092.10.785956
MA0093.10.642957
MA0095.10
MA0098.10
MA0100.10.956299
MA0101.10.646932
MA0103.10.628063
MA0105.10.31555
MA0106.10.986396
MA0107.10.556367
MA0108.21.15387
MA0109.10
MA0111.10.767139
MA0113.11.00436
MA0114.10.549955
MA0115.11.57693
MA0116.10.560723
MA0117.11.36676
MA0119.11.66081
MA0122.11.39371
MA0124.11.53432
MA0125.11.44766
MA0130.10
MA0131.11.06461
MA0132.10
MA0133.10
MA0135.11.35921
MA0136.10.948776
MA0139.11.96087
MA0140.10.894983
MA0141.10.712476
MA0142.11.12317
MA0143.11.00455
MA0144.10.531867
MA0145.10.752137
MA0146.11.70974
MA0147.10.565108
MA0148.10.854239
MA0149.10.884158
MA0062.21.141
MA0035.20.894194
MA0039.24.04548
MA0138.21.04628
MA0002.20.476938
MA0137.20.666381
MA0104.20.491226
MA0047.20.973066
MA0112.20.264678
MA0065.20.277623
MA0150.10.744617
MA0151.10
MA0152.10.902317
MA0153.11.43021
MA0154.14.15415
MA0155.12.02721
MA0156.10.669101
MA0157.11.09377
MA0158.10
MA0159.10.565904
MA0160.10.871361
MA0161.10
MA0162.12.76014
MA0163.10.776149
MA0164.11.01792
MA0080.20.643061
MA0018.20.987913
MA0099.20.902716
MA0079.24.62164
MA0102.21.88331
MA0258.10.519674
MA0259.10.575594
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CCNT2#90536.336201576962630.003930750035764890.0189094243659719
E2F1#186934.907389214879320.008460985347239390.0323506076763805
E2F4#1874312.66806031528440.0004917987006298980.00435279360127847
E2F6#187635.017155731697390.00791769806886330.0320324024254896
EGR1#195834.988179094810140.008056488137383440.0319006507650966
ELF1#199734.258097958807540.01295179875054610.0459983306596485
GABPB1#255337.067683836182170.002832212825417420.0153627025695321
HMGN3#932438.178547723350590.001827766942164210.0108281894419813
SIN3A#2594235.408884726815140.006318961977991520.027534465538195
SUZ12#23512350.11578091106297.93834897779404e-060.000221145166415533



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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