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{{Coexpression_clusters
{
|full_id=C4006_immature_CD4_embryonic_Natural_CD19_hepatoblastoma_CD8

Latest revision as of 12:37, 17 September 2013


Full id: C4006_immature_CD4_embryonic_Natural_CD19_hepatoblastoma_CD8



Phase1 CAGE Peaks

Hg19::chr1:91487774..91487802,-p2@ZNF644
Hg19::chr1:91487806..91487826,-p5@ZNF644
Hg19::chr1:91487836..91487854,-p3@ZNF644


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Cell Type
Ontology termp-valuen
leukocyte1.38e-33136
hematopoietic stem cell2.73e-30168
angioblastic mesenchymal cell2.73e-30168
hematopoietic cell1.43e-28177
hematopoietic oligopotent progenitor cell6.48e-27161
hematopoietic multipotent progenitor cell6.48e-27161
nongranular leukocyte6.00e-25115
hematopoietic lineage restricted progenitor cell6.54e-25120
nucleate cell1.45e-1555
lymphocyte1.71e-1553
common lymphoid progenitor1.71e-1553
lymphoid lineage restricted progenitor cell3.98e-1552
classical monocyte1.02e-1442
CD14-positive, CD16-negative classical monocyte1.02e-1442
myeloid leukocyte9.46e-1372
myeloid cell2.95e-12108
common myeloid progenitor2.95e-12108
granulocyte monocyte progenitor cell7.11e-1167
defensive cell5.14e-1048
phagocyte5.14e-1048
macrophage dendritic cell progenitor8.35e-1061
myeloid lineage restricted progenitor cell1.16e-0966
mature alpha-beta T cell1.67e-0918
alpha-beta T cell1.67e-0918
immature T cell1.67e-0918
mature T cell1.67e-0918
immature alpha-beta T cell1.67e-0918
monopoietic cell6.93e-0959
monocyte6.93e-0959
monoblast6.93e-0959
promonocyte6.93e-0959
T cell1.04e-0825
pro-T cell1.04e-0825
B cell9.36e-0814
CD8-positive, alpha-beta T cell9.86e-0711
Uber Anatomy
Ontology termp-valuen
hematopoietic system3.10e-1098
blood island3.10e-1098
hemolymphoid system8.14e-09108
bone element2.46e-0882
skeletal element6.11e-0890
bone marrow2.30e-0776
immune system2.94e-0793


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.401049
MA0004.10.826076
MA0006.10.639288
MA0007.10.804807
MA0009.11.3275
MA0014.10.118426
MA0017.10.686276
MA0019.10.990656
MA0024.11.21731
MA0025.11.46617
MA0027.12.95767
MA0028.10.658629
MA0029.11.23771
MA0030.11.22561
MA0031.11.15713
MA0038.10.94098
MA0040.11.24388
MA0041.10.847069
MA0042.10.810843
MA0043.11.32783
MA0046.11.31611
MA0048.10.341392
MA0050.10.81185
MA0051.10.936307
MA0052.11.24796
MA0055.10.190716
MA0056.10
MA0057.10.333427
MA0058.10.716037
MA0059.10.714521
MA0060.10.492218
MA0061.10.456531
MA0063.10
MA0066.10.941452
MA0067.11.65513
MA0068.10.405474
MA0069.11.31207
MA0070.11.30033
MA0071.13.42881
MA0072.11.29561
MA0073.10.0185922
MA0074.10.935474
MA0076.10.734647
MA0077.11.28751
MA0078.11.04495
MA0081.11.70054
MA0083.12.96495
MA0084.11.84562
MA0087.11.29304
MA0088.10.715722
MA0089.10
MA0090.10.751469
MA0091.10.829044
MA0092.10.785956
MA0093.10.642957
MA0095.10
MA0098.10
MA0100.10.956299
MA0101.10.646932
MA0103.10.628063
MA0105.10.31555
MA0106.10.986396
MA0107.10.556367
MA0108.21.15387
MA0109.10
MA0111.10.767139
MA0113.11.00436
MA0114.10.549955
MA0115.11.57693
MA0116.10.560723
MA0117.11.36676
MA0119.10.695578
MA0122.11.39371
MA0124.11.53432
MA0125.13.19113
MA0130.10
MA0131.11.06461
MA0132.10
MA0133.10
MA0135.11.35921
MA0136.10.948776
MA0139.10.440097
MA0140.10.894983
MA0141.11.6959
MA0142.11.12317
MA0143.11.00455
MA0144.11.31729
MA0145.10.273764
MA0146.10.707589
MA0147.10.565108
MA0148.10.854239
MA0149.10.884158
MA0062.20.449458
MA0035.20.894194
MA0039.20.0526989
MA0138.21.04628
MA0002.20.476938
MA0137.20.666381
MA0104.20.491226
MA0047.20.973066
MA0112.20.264678
MA0065.20.277623
MA0150.10.744617
MA0151.10
MA0152.10.902317
MA0153.11.43021
MA0154.10.312019
MA0155.10.256269
MA0156.10.669101
MA0157.11.09377
MA0158.10
MA0159.10.565904
MA0160.12.02335
MA0161.10
MA0162.10.455568
MA0163.10.387745
MA0164.11.01792
MA0080.20.643061
MA0018.20.987913
MA0099.20.902716
MA0079.20.0373086
MA0102.21.88331
MA0258.11.29138
MA0259.10.575594
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CCNT2#90536.336201576962630.003930750035764890.0190268633196723
CEBPB#105137.971147625824820.001974187055288560.0115320835542973
E2F1#186934.907389214879320.008460985347239390.0325784120587057
E2F4#1874312.66806031528440.0004917987006298980.00437690366383349
E2F6#187635.017155731697390.00791769806886330.0322711703330477
EBF1#187938.9064668465690.00141523283560980.00915884881139251
EGR1#195834.988179094810140.008056488137383440.0321075923292448
ELF1#199734.258097958807540.01295179875054610.0462911231548641
ESR1#2099330.76860329615453.43136389821584e-050.00067693278081935
GABPB1#255337.067683836182170.002832212825417420.0154300195760965
GTF2F1#2962312.73966087675770.0004835525047438590.0043453570850924
JUND#372736.994663941871030.002921845042734990.0156956369930151
MAX#414936.452555509007120.003721913834265510.0186782451077245
NFKB1#479035.488063424193840.006049381815655430.0269869457710152
NRF1#4899312.21027944771090.0005492172401020010.00471552937676857
RFX5#5993312.04791082719510.0005717246050312580.00485095020106098
SETDB1#9869340.32002617801051.52461559299059e-050.00035927194926973
SP1#666735.69838137814090.005403962701712170.0246854944934662
SRF#6722313.79717826216780.0003806615025800190.00375480795881702
TAF7#6879311.43306940492390.0006690181981945830.00543832437743182
TFAP2C#7022310.80922860986020.0007916746575753130.00616429654532976
USF1#739136.361499277207960.00388404057290560.0190542211185912
WRNIP1#568973109.8199643493767.53682839543883e-073.32687582752002e-05
YY1#752834.911170749853860.008441455341808260.0329798426770579
ZNF143#7702313.50087655222790.0004062804962997170.00389530237336327



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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