FF:10534-107G3: Difference between revisions
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{{f5samples | {{f5samples | ||
| | |DRA_sample_Accession=CAGE@SAMD00005931 | ||
| | |accession_numbers=CAGE;DRX007798;DRR008670;DRZ000095;DRZ001480;DRZ011445;DRZ012830 | ||
| | |ancestors_in_anatomy_facet= | ||
| | |ancestors_in_cell_lineage_facet=CL:0000000,CL:0000003,CL:0000988,CL:0000548,CL:0002371,CL:0000542,CL:0000219,CL:0000945,CL:0000738,CL:0002087,CL:0002242,CL:0000255,CL:0000236,CL:0000817 | ||
|ancestors_in_disease_facet=DOID:4,DOID:0050686,DOID:162,DOID:2531,DOID:14566,DOID:0060083,DOID:1240 | |||
|ancestors_in_ff_facet=FF:0000102,FF:0000003,FF:0000210,FF:0000101,FF:0000001,FF:0100737,FF:0102144,FF:0101035,FF:0100741,FF:0100773,FF:0100739,FF:0100603,FF:0103288 | |||
|comment= | |||
|created_by= | |||
|creation_date= | |||
| | |data_phase=2 | ||
|datafreeze_phase=2 | |||
| | |def= | ||
|expression_enrichment_score=chr11:111249993..111250006,-!p1@POU2AF1!2.13!134.75!POU2AF1;;chr6:391743..391759,+!p1@IRF4!2.13!133.59!IRF4;;chr4:109090075..109090095,-!p2@LEF1!1.83!67.23!LEF1;;chr1:23857698..23857733,-!p1@E2F2!1.76!100.99!E2F2;;chr19:50922187..50922204,+!p1@SPIB!1.72!51.79!SPIB;;chr21:39870339..39870443,-!p1@ERG!1.72!51.22!ERG;;chr6:135502408..135502459,+!p2@MYB!1.68!53.52!MYB;;chr6:135502501..135502546,+!p1@MYB!1.64!50.93!MYB;;chr4:109089901..109089930,-!p3@LEF1!1.63!41.84!LEF1;;chr11:47400078..47400106,-!p1@SPI1!1.62!40.83!SPI1;;chr9:37034186..37034216,-!p2@PAX5!1.54!33.76!PAX5;;chr8:10588010..10588030,-!p1@SOX7!1.53!32.60!SOX7;;chr6:91006518..91006570,-!p1@BACH2!1.51!69.68!BACH2;;chr5:158526917..158526932,-!p1@EBF1!1.49!72.71!EBF1;;chr7:50348268..50348366,+!p4@IKZF1!1.47!28.57!IKZF1;;chr2:100759010..100759035,-!p1@AFF3!1.46!27.84!AFF3;;chr18:53089538..53089578,-!p14@TCF4!1.46!27.70!TCF4;;chr18:53089453..53089482,-!p11@TCF4!1.45!27.27!TCF4;;chr2:100759037..100759058,-!p2@AFF3!1.44!26.69!AFF3;;chr18:53089521..53089533,-!p22@TCF4!1.43!25.82!TCF4;;chr9:37034469..37034474,-!p1@PAX5!1.39!23.37!PAX5;;chr6:91006575..91006602,-!p2@BACH2!1.35!31.31!BACH2;;chr2:214015111..214015179,-!p1@IKZF2!1.33!36.07!IKZF2;;chr5:3595977..3595999,+!p1@IRX1!1.33!20.20!IRX1;;chr18:53089493..53089517,-!p15@TCF4!1.31!19.48!TCF4;;chr5:124082580..124082603,-!p4@ZNF608!1.28!20.49!ZNF608;;chr5:158527104..158527135,-!p4@EBF1!1.24!16.30!EBF1;;chr2:60780607..60780624,-!p2@BCL11A!1.23!48.33!BCL11A;;chrX:131624056..131624069,-!p2@MBNL3!1.22!21.35!MBNL3;;chr13:41593425..41593480,-!p1@ELF1!1.20!93.34!ELF1;;chr20:42295713..42295738,+!p2@MYBL2!1.20!86.71!MYBL2;;chr1:23857674..23857685,-!p3@E2F2!1.20!14.72!E2F2;;chr5:88178983..88179012,-!p1@MEF2C!1.18!107.34!MEF2C;;chr5:158526756..158526797,-!p3@EBF1!1.18!14.14!EBF1;;chr2:60778035..60778060,-!p4@BCL11A!1.17!16.45!BCL11A;;chr7:64126535..64126559,+!p2@ZNF107!1.16!28.71!ZNF107;;chr1:167298300..167298319,+!p2@POU2F1!1.16!13.42!POU2F1;;chr7:44143925..44143970,+!p1@AEBP1!1.15!292.15!AEBP1;;chr20:42295745..42295765,+!p1@MYBL2!1.14!209.05!MYBL2;;chr5:158524625..158524669,-!p6@EBF1!1.14!12.84!EBF1;;chr7:44143978..44143989,+!p2@AEBP1!1.13!22.79!AEBP1;;chr18:53257001..53257015,-!p5@TCF4!1.11!20.49!TCF4;;chr10:135122868..135122893,+!p3@ZNF511!1.10!11.69!ZNF511;;chr2:214014959..214015006,-!p4@IKZF2!1.10!11.54!IKZF2;;chr8:128748308..128748324,+!p2@MYC!1.09!312.92!MYC;;chr7:28610099..28610113,+!p5@CREB5!1.07!10.82!CREB5;;chr5:124082548..124082571,-!p9@ZNF608!1.07!10.68!ZNF608;;chr5:3595934..3595957,+!p2@IRX1!1.05!10.24!IRX1;;chr19:50432453..50432468,+!p1@ATF5!1.03!546.49!ATF5;;chr4:146403912..146403972,+!p5@SMAD1!1.03!12.70!SMAD1;;chr4:109090106..109090124,-!p10@LEF1!1.03!9.67!LEF1;;chr5:124082470..124082483,-!p8@ZNF608!1.03!9.67!ZNF608;;chr2:214013461..214013517,-!p6@IKZF2!1.02!9.38!IKZF2;;chr4:109090408..109090441,-!p21@LEF1!1.00!8.94!LEF1;;chr9:37034147..37034157,-!p7@PAX5!1.00!8.94!PAX5;;chr9:37034258..37034270,-!p3@PAX5!1.00!8.94!PAX5;;chr4:109090054..109090073,-!p7@LEF1!0.98!8.66!LEF1;;chr4:109087445..109087463,-!p1@LEF1!0.98!8.51!LEF1;;chr4:109089996..109090012,-!p5@LEF1!0.98!8.51!LEF1;;chr13:41593493..41593506,-!p8@ELF1!0.96!8.08!ELF1;;chr21:36421535..36421610,-!p2@RUNX1!0.95!29.43!RUNX1;;chr11:19263192..19263222,-!p2@E2F8!0.95!9.81!E2F8;;chr2:145277640..145277771,-!p1@ZEB2!0.94!107.77!ZEB2;;chr10:135122906..135122921,+!p4@ZNF511!0.94!7.79!ZNF511;;chr1:167298384..167298412,+!p3@POU2F1!0.94!7.79!POU2F1;;chr4:146404160..146404186,+!p13@SMAD1!0.94!7.65!SMAD1;;chr20:32274179..32274213,-!p1@E2F1!0.93!51.65!E2F1;;chr5:124082525..124082536,-!p10@ZNF608!0.93!7.50!ZNF608;;chr5:158527020..158527029,-!p13@EBF1!0.93!7.50!EBF1;;chr3:141747459..141747475,-!p1@TFDP2!0.92!63.48!TFDP2;;chr19:45579725..45579743,-!p1@ZNF296!0.92!34.19!ZNF296;;chr2:100758991..100759009,-!p3@AFF3!0.91!7.21!AFF3;;chr2:214015343..214015366,-!p3@IKZF2!0.91!7.21!IKZF2;;chr11:19262421..19262455,-!p3@E2F8!0.91!7.21!E2F8;;chr5:124084493..124084524,-!p2@ZNF608!0.90!16.01!ZNF608;;chr2:200323414..200323455,-!p1@SATB2!0.90!15.44!SATB2;;chr19:13213704..13213726,-!p3@LYL1!0.90!9.23!LYL1;;chr11:19262486..19262512,-!p4@E2F8!0.90!8.66!E2F8;;chr19:44124019..44124030,-!p2@ZNF428!0.90!8.08!ZNF428;;chr7:64838786..64838809,+!p2@ZNF92!0.89!40.68!ZNF92;;chr6:20402102..20402152,+!p1@E2F3!0.89!28.85!E2F3;;chr1:41827095..41827155,+!p1@FOXO6!0.89!9.38!FOXO6;;chr6:135502472..135502489,+!p3@MYB!0.88!6.64!MYB;;chr6:21597765..21597779,+!p2@SOX4!0.87!54.53!SOX4;;chr17:41277372..41277418,-!p1@BRCA1!0.87!24.53!BRCA1;;chr7:44143997..44144008,+!p3@AEBP1!0.87!8.22!AEBP1;;chr11:19262461..19262476,-!p5@E2F8!0.87!6.49!E2F8;;chr21:39870648..39870655,-!p8@ERG!0.87!6.49!ERG;;chr5:3595961..3595975,+!p3@IRX1!0.87!6.35!IRX1;;chr5:176738887..176738934,-!p1@MXD3!0.86!44.29!MXD3;;chr5:124082322..124082364,-!p1@ZNF608!0.86!16.59!ZNF608;;chr18:53255415..53255491,-!p1@TCF4!0.85!55.11!TCF4;;chr17:38020392..38020477,-!p1@IKZF3!0.85!6.06!IKZF3;;chr6:21593973..21593988,+!p1@SOX4!0.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!ZNF608;;chr5:142779999..142780026,-!p20@NR3C1!0.20!0.58!NR3C1;;chr5:142783987..142783998,-!p29@NR3C1!0.20!0.58!NR3C1;;chr6:15245752..15245767,+!p14@JARID2!0.20!0.58!JARID2;;chr6:27440529..27440553,-!p5@ZNF184!0.20!0.58!ZNF184;;chr6:91006309..91006314,-!p10@BACH2!0.20!0.58!BACH2;;chr6:91006740..91006751,-!p6@BACH2!0.20!0.58!BACH2;;chr7:64363682..64363692,+!p4@ZNF273!0.20!0.58!ZNF273;;chr8:42698383..42698394,-!p5@THAP1!0.20!0.58!THAP1;;chr8:81398538..81398549,+!p14@ZBTB10!0.20!0.58!ZBTB10;;chr1:93811438..93811548,+!p1@DR1!0.19!73.87!DR1;;chr2:220094514..220094599,+!p1@ANKZF1!0.19!40.40!ANKZF1;;chr7:104654623..104654669,+!p1@MLL5!0.19!37.22!MLL5;;chr2:169312725..169312810,+!p1@CERS6!0.19!33.76!CERS6;;chr6:41040678..41040722,+!p1@NFYA!0.19!27.99!NFYA;;chr15:57210818..57210930,+!p1@TCF12!0.19!24.53!TCF12;;chr16:67876180..67876242,+!p1@THAP11!0.19!23.23!THAP11;;chr5:138629349..138629386,+!p3@MATR3!0.19!22.36!MATR3;;chr3:101395963..101395993,-!p1@ZBTB11!0.19!20.49!ZBTB11;;chr16:29817665..29817719,+!p3@MAZ!0.19!20.49!MAZ;;chr17:61920023..61920110,-!p1@SMARCD2!0.19!19.04!SMARCD2;;chr8:42698433..42698486,-!p1@THAP1!0.19!16.74!THAP1;;chr19:19496728..19496813,+!p2@GATAD2A!0.19!16.45!GATAD2A;;chr17:35766967..35767022,+!p1@TADA2A!0.19!14.72!TADA2A;;chr14:58765217..58765301,+!p1@ARID4A!0.19!11.97!ARID4A;;chr4:106068026..106068084,+!p1@TET2!0.19!11.97!TET2;;chr14:100705200..100705237,+!p3@YY1!0.19!10.10!YY1;;chr14:74318611..74318682,+!p1@PTGR2,p2@ZNF410!0.19!8.94!ZNF410;;chr22:24093267..24093327,-!p1@ZNF70!0.19!8.94!ZNF70;;chr17:17740330..17740349,-!p3@SREBF1!0.19!8.66!SREBF1;;chr19:49140609..49140643,-!p1@DBP!0.19!7.21!DBP;;chr5:43120995..43121052,+!p1@ZNF131!0.19!6.35!ZNF131;;chr16:69419794..69419830,-!p3@TERF2!0.19!5.92!TERF2;;chr10:21823243..21823290,+!p2@MLLT10!0.19!5.48!MLLT10;;chr7:99156212..99156244,+!p3@ZNF655!0.19!4.62!ZNF655;;chr4:95129061..95129085,+!p3@SMARCAD1!0.19!4.33!SMARCAD1;;chr9:3525867..3525902,-!p3@RFX3!0.19!4.04!RFX3;;chr3:71632864..71632885,-!p4@FOXP1!0.19!4.04!FOXP1;;chr16:29817433..29817468,+!p8@MAZ!0.19!3.61!MAZ;;chr19:36980429..36980448,-!p1@ZNF566!0.19!3.17!ZNF566;;chr20:3388207..3388236,-!p4@C20orf194!0.19!2.60!C20orf194;;chr17:61920246..61920272,-!p4@SMARCD2!0.19!2.31!SMARCD2;;chr6:151712800..151712835,-!p2@ZBTB2!0.19!2.31!ZBTB2;;chr11:47270436..47270464,+!p2@NR1H3!0.19!2.16!NR1H3;;chr19:6280007..6280019,-!p3@MLLT1!0.19!1.88!MLLT1;;chr1:151431674..151431685,-!p4@POGZ!0.19!1.15!POGZ;;chr19:39390652..39390663,+!p3@NFKBIB!0.19!1.01!NFKBIB;;chr4:1873216..1873238,+!p5@WHSC1!0.19!1.01!WHSC1;;chr6:157099113..157099126,+!p9@ARID1B!0.19!0.87!ARID1B;;chr7:127032262..127032294,-!p5@ZNF800!0.19!0.87!ZNF800;;chr5:43121586..43121601,+!p10@ZNF131!0.19!0.72!ZNF131;;chr9:128509857..128509872,+!p6@PBX3!0.19!0.72!PBX3;;chr19:21579964..21579975,+!p2@ZNF493!0.19!0.72!ZNF493;;chr18:32924372..32924430,-!p1@ZNF24!0.18!41.41!ZNF24;;chr1:41157363..41157416,+!p1@NFYC!0.18!25.25!NFYC;;chr18:45457192..45457278,-!p1@SMAD2!0.18!22.51!SMAD2;;chr19:58331088..58331106,+!p1@ZNF587!0.18!18.75!ZNF587;;chr1:27022485..27022543,+!p1@ARID1A!0.18!18.47!ARID1A;;chr19:36208877..36208919,+!p1@MLL4!0.18!16.88!MLL4;;chr12:498415..498492,-!p1@KDM5A!0.18!14.72!KDM5A;;chr12:19592405..19592492,+!p2@AEBP2!0.18!11.11!AEBP2;;chr19:37019136..37019178,-!p1@ZNF260!0.18!10.53!ZNF260;;chr1:8877692..8877732,-!p1@RERE!0.18!10.39!RERE;;chr12:51157744..51157796,+!p2@ATF1!0.18!8.66!ATF1;;chr13:27998831..27998851,+!p2@GTF3A!0.18!7.50!GTF3A;;chr6:7107999..7108031,+!p2@RREB1!0.18!6.49!RREB1;;chr2:61108650..61108687,+!p2@REL!0.18!6.06!REL;;chr19:38210622..38210681,-!p1@ZNF607!0.18!4.33!ZNF607;;chr14:74353576..74353589,+!p3@ZNF410!0.18!3.90!ZNF410;; | |||
|ffid_belonging_in_development=CL:0000134,CL:0000051 | |||
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| | |||
|fonse_cell_line=FF:0101035 | |fonse_cell_line=FF:0101035 | ||
|fonse_cell_line_closure=FF:0101035 | |fonse_cell_line_closure=FF:0101035 | ||
Line 66: | Line 40: | ||
|fonse_treatment= | |fonse_treatment= | ||
|fonse_treatment_closure= | |fonse_treatment_closure= | ||
|has_quality= | |has_quality= | ||
|is_a=EFO:0002091;;FF: | |hg19bam=http://fantom.gsc.riken.jp/5/datafiles/latest/basic/human.cell_line.hCAGE/acute%2520lymphoblastic%2520leukemia%2520%2528B-ALL%2529%2520cell%2520line%253aNALM-6.CNhs11282.10534-107G3.hg19.nobarcode.bam | ||
|hg19ctss=http://fantom.gsc.riken.jp/5/datafiles/latest/basic/human.cell_line.hCAGE/acute%2520lymphoblastic%2520leukemia%2520%2528B-ALL%2529%2520cell%2520line%253aNALM-6.CNhs11282.10534-107G3.hg19.ctss.bed.gz | |||
|hg19fasta=http://fantom.gsc.riken.jp/5/datafiles/latest/basic/human.cell_line.hCAGE/acute%2520lymphoblastic%2520leukemia%2520%2528B-ALL%2529%2520cell%2520line%253aNALM-6.CNhs11282.10534-107G3.hg19.nobarcode.rdna.fa.gz | |||
|hg38bam=http://fantom.gsc.riken.jp/5/datafiles/reprocessed/hg38_v2/basic/human.cell_line.hCAGE/acute%2520lymphoblastic%2520leukemia%2520%2528B-ALL%2529%2520cell%2520line%253aNALM-6.CNhs11282.10534-107G3.hg38.nobarcode.bam | |||
|hg38ctss=http://fantom.gsc.riken.jp/5/datafiles/reprocessed/hg38_v2/basic/human.cell_line.hCAGE/acute%2520lymphoblastic%2520leukemia%2520%2528B-ALL%2529%2520cell%2520line%253aNALM-6.CNhs11282.10534-107G3.hg38.nobarcode.ctss.bed.gz | |||
|id=FF:10534-107G3 | |||
|is_a=EFO:0002091;;FF:0000210;;FF:0103288 | |||
|is_obsolete= | |||
|library_id=CNhs11282 | |||
|library_id_phase_based=2:CNhs11282 | |||
|microRNAs= | |||
|microRNAs_nn= | |||
|microRNAs_nonnovel_cage=http://fantom.gsc.riken.jp/5/suppl/De_Rie_et_al_2017/vis_viewer/#/human#cage;sample;10534 | |||
|microRNAs_novel_cage=http://fantom.gsc.riken.jp/5/suppl/De_Rie_et_al_2017/vis_viewer_novel/#/human#cage;sample;10534 | |||
|name=acute lymphoblastic leukemia (B-ALL) cell line:NALM-6 | |||
|namespace=FANTOM5 | |namespace=FANTOM5 | ||
|part_of= | |part_of= | ||
|profile_cagescan=,,, | |||
|profile_hcage=CNhs11282,LSID759,release008,COMPLETED | |||
|profile_rnaseq= | |||
|profile_srnaseq=,,, | |||
|refex=http://refex.dbcls.jp/genelist.php?lang | |||
|repeat_enrich_byfamily=0,0,0,0,0,0,0,-0.00413014182384891,0,-0.277362132193514,-0.282403560576942,0,0,0,0,0,0,0,0,0,0,0,0,0,-0.153323010348428,0,0,0,0.0292641066146016,0.436358362479358,-0.0979578962680575,0,0,-0.132956589778862,0,0,0,0,0,0,0,0,0,0,0,0,-0.182617433918447,0,0,0,0,0,0,0,0,-0.0242150211128343,0,0,0,0,0,-0.0179258226336657,0,-0.0384641480134018,0,0,0.205827471782318,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-0.081639998609673,0.0989264286382515,0,0,0.0440150210493521,-0.112270974057618,0.0585282132292033,0,0.0292641066146016,0.197852857276503,-0.0395071380085031,-0.0799489875716919,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-0.0671094873078595,0.110097374326945,0,0,-0.174472769623376,-0.473343820032671,0,0,0,0,0,0 | |||
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| |||
|rna_box=107 | |||
|rna_catalog_number= | |||
|rna_concentration=2.34348 | |||
|rna_extraction_protocol=OP-RNA-extraction-totalRNA-miRNeasy_Mini-v1.0 | |||
|rna_lot_number= | |||
|rna_od260/230=2.11 | |||
|rna_od260/280=2.07 | |||
|rna_position=G3 | |||
|rna_rin= | |||
|rna_sample_type=total RNA | |||
|rna_tube_id=107G3 | |||
|rna_weight_ug=82.0218 | |||
|sample_age= | |||
|sample_category=cell lines | |||
|sample_cell_catalog=RCB1933 | |||
|sample_cell_line=NALM-6 | |||
|sample_cell_lot= | |||
|sample_cell_type=b cell | |||
|sample_collaboration=Yukio Nakamura (RIKEN BRC) | |||
|sample_company=RIKEN Bioresource centre | |||
|sample_description= | |||
|sample_dev_stage= | |||
|sample_disease=acute lymphoblastic leukemia (B-ALL) | |||
|sample_donor(cell lot)= | |||
|sample_ethnicity= | |||
|sample_experimental_condition= | |||
|sample_gostat=GO:0044464;cell part;0!GO:0005622;intracellular;0!GO:0044424;intracellular part;6.18066701191055e-278!GO:0043227;membrane-bound organelle;1.63086975650185e-246!GO:0043231;intracellular membrane-bound organelle;3.07504500071075e-246!GO:0043226;organelle;2.47063379616637e-236!GO:0043229;intracellular organelle;6.60423817441967e-236!GO:0044422;organelle part;9.27252421880698e-179!GO:0044446;intracellular organelle part;5.99079243139567e-177!GO:0005737;cytoplasm;4.17790358936054e-154!GO:0005634;nucleus;7.07754072405437e-141!GO:0032991;macromolecular complex;7.90968828657084e-141!GO:0044237;cellular metabolic process;3.06252263975023e-126!GO:0044238;primary metabolic process;1.08242816079881e-122!GO:0044428;nuclear part;1.3214566004754e-120!GO:0043170;macromolecule metabolic process;7.85140880364973e-117!GO:0030529;ribonucleoprotein complex;5.4461623208545e-113!GO:0044444;cytoplasmic part;2.6075171554426e-108!GO:0043233;organelle lumen;1.82870101217341e-106!GO:0031974;membrane-enclosed lumen;1.82870101217341e-106!GO:0003723;RNA binding;4.03218134832067e-104!GO:0005739;mitochondrion;1.33489190723027e-80!GO:0006139;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;1.06810700077916e-79!GO:0043283;biopolymer metabolic process;3.91212472541936e-79!GO:0006396;RNA processing;2.45150823531577e-78!GO:0031981;nuclear lumen;6.32834201018616e-74!GO:0043234;protein complex;1.62632996657523e-72!GO:0010467;gene expression;1.80739798090969e-70!GO:0006259;DNA metabolic process;5.45287982163837e-66!GO:0006412;translation;7.13269615093783e-62!GO:0016071;mRNA metabolic process;1.7617484963821e-60!GO:0005840;ribosome;2.96020963614325e-60!GO:0005515;protein binding;1.54182969156954e-59!GO:0044429;mitochondrial part;4.13463154134377e-56!GO:0003676;nucleic acid binding;2.89826039858183e-54!GO:0008380;RNA splicing;4.00940501287906e-52!GO:0006397;mRNA processing;6.1346774275646e-52!GO:0003735;structural constituent of ribosome;2.3163445577551e-51!GO:0019538;protein metabolic process;2.45210173467359e-49!GO:0031967;organelle envelope;6.2796764906347e-49!GO:0031975;envelope;1.5305918774107e-48!GO:0044249;cellular biosynthetic process;7.68905535658456e-47!GO:0005654;nucleoplasm;1.19788005535258e-46!GO:0022613;ribonucleoprotein complex biogenesis and assembly;3.83171851180034e-46!GO:0044267;cellular protein metabolic process;5.28206181710043e-45!GO:0033279;ribosomal subunit;1.02939786794717e-44!GO:0044260;cellular macromolecule metabolic process;2.70368276520945e-44!GO:0006996;organelle organization and biogenesis;1.6353758128165e-43!GO:0009059;macromolecule biosynthetic process;4.10009936848485e-43!GO:0009058;biosynthetic process;6.82900500526289e-43!GO:0016043;cellular component organization and biogenesis;1.19628372618975e-42!GO:0043228;non-membrane-bound organelle;2.29361254853515e-42!GO:0043232;intracellular non-membrane-bound organelle;2.29361254853515e-42!GO:0007049;cell cycle;4.76474749070404e-42!GO:0031090;organelle membrane;9.70505467803306e-42!GO:0006974;response to DNA damage stimulus;2.87539174633504e-41!GO:0033036;macromolecule localization;4.82480470082896e-39!GO:0005681;spliceosome;1.70020299163384e-38!GO:0015031;protein transport;7.11824858932663e-38!GO:0065003;macromolecular complex assembly;8.55467591443437e-38!GO:0006281;DNA repair;1.95811484661706e-37!GO:0016070;RNA metabolic process;2.03611856887284e-37!GO:0005694;chromosome;3.85172092299517e-37!GO:0000166;nucleotide binding;4.41075309111446e-37!GO:0044451;nucleoplasm part;6.13769924299105e-37!GO:0005829;cytosol;7.54694131567119e-35!GO:0045184;establishment of protein localization;1.79143368638144e-34!GO:0008104;protein localization;4.39735186712725e-34!GO:0000278;mitotic cell cycle;8.11518538187961e-34!GO:0022607;cellular component assembly;1.0572457768903e-33!GO:0005740;mitochondrial envelope;1.62376490348076e-33!GO:0022402;cell cycle process;2.29573166138234e-33!GO:0046907;intracellular transport;3.64264335111505e-33!GO:0005830;cytosolic ribosome (sensu Eukaryota);2.64475367114994e-32!GO:0019866;organelle inner membrane;1.38651892548591e-31!GO:0031966;mitochondrial membrane;3.57275657476474e-31!GO:0044427;chromosomal part;3.05398659422067e-30!GO:0022403;cell cycle phase;4.2910217557165e-30!GO:0006886;intracellular protein transport;4.49686073574664e-29!GO:0000087;M phase of mitotic cell cycle;5.21684750673562e-29!GO:0005743;mitochondrial inner membrane;5.58049550259196e-29!GO:0044445;cytosolic part;6.24577251920227e-29!GO:0051276;chromosome organization and biogenesis;6.66781982469255e-29!GO:0009719;response to endogenous stimulus;1.28531008744129e-28!GO:0007067;mitosis;2.46047926362553e-28!GO:0005730;nucleolus;4.01547980444073e-28!GO:0006260;DNA replication;2.17757666007698e-27!GO:0005524;ATP binding;2.51239462691379e-27!GO:0032553;ribonucleotide binding;6.38461258669608e-27!GO:0032555;purine ribonucleotide binding;6.38461258669608e-27!GO:0031980;mitochondrial lumen;6.78444152020494e-27!GO:0005759;mitochondrial matrix;6.78444152020494e-27!GO:0032559;adenyl ribonucleotide binding;1.14395818386251e-26!GO:0000279;M phase;3.14243293750798e-26!GO:0016462;pyrophosphatase activity;3.5717858928357e-26!GO:0016818;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;3.69963443604476e-26!GO:0016817;hydrolase activity, acting on acid anhydrides;4.4057380925677e-26!GO:0017076;purine nucleotide binding;1.07895876514508e-25!GO:0017111;nucleoside-triphosphatase activity;1.3632196123648e-25!GO:0051301;cell division;2.20491763640914e-25!GO:0030554;adenyl nucleotide binding;4.93804273149288e-25!GO:0022618;protein-RNA complex assembly;1.08894625588226e-24!GO:0015935;small ribosomal subunit;1.18497273733915e-23!GO:0006119;oxidative phosphorylation;3.40030918872619e-23!GO:0016874;ligase activity;4.94048003393902e-23!GO:0044455;mitochondrial membrane part;9.29578763101026e-23!GO:0051649;establishment of cellular localization;1.09085639132214e-22!GO:0016887;ATPase activity;1.58983523930864e-22!GO:0006512;ubiquitin cycle;2.11862883634645e-22!GO:0042623;ATPase activity, coupled;2.46215349603331e-22!GO:0015934;large ribosomal subunit;3.34688195640525e-22!GO:0051641;cellular localization;4.83972963930876e-22!GO:0042254;ribosome biogenesis and assembly;7.34602431030894e-22!GO:0044265;cellular macromolecule catabolic process;1.18016336173436e-21!GO:0006325;establishment and/or maintenance of chromatin architecture;1.12603251923056e-20!GO:0006323;DNA packaging;5.58000862528492e-20!GO:0008135;translation factor activity, nucleic acid binding;1.78587173274921e-19!GO:0004386;helicase activity;2.54089036044749e-19!GO:0016604;nuclear body;3.87721748460434e-19!GO:0051603;proteolysis involved in cellular protein catabolic process;7.09167511428538e-19!GO:0019941;modification-dependent protein catabolic process;7.54895748948014e-19!GO:0043632;modification-dependent macromolecule catabolic process;7.54895748948014e-19!GO:0006511;ubiquitin-dependent protein catabolic process;8.60578414962414e-19!GO:0043285;biopolymer catabolic process;8.97872611951064e-19!GO:0006457;protein folding;1.19045600429036e-18!GO:0000398;nuclear mRNA splicing, via spliceosome;1.49625043983843e-18!GO:0000375;RNA splicing, via transesterification reactions;1.49625043983843e-18!GO:0000377;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile;1.49625043983843e-18!GO:0044257;cellular protein catabolic process;1.7897499115419e-18!GO:0005746;mitochondrial respiratory chain;3.29259713004348e-18!GO:0000502;proteasome complex (sensu Eukaryota);1.22511982897868e-17!GO:0009057;macromolecule catabolic process;1.29913425320352e-17!GO:0044453;nuclear membrane part;2.14954216329794e-17!GO:0008134;transcription factor binding;2.17607317558622e-17!GO:0031965;nuclear membrane;3.07176447586302e-17!GO:0005761;mitochondrial ribosome;3.42572952474174e-17!GO:0000313;organellar ribosome;3.42572952474174e-17!GO:0005843;cytosolic small ribosomal subunit (sensu Eukaryota);3.51779668862245e-17!GO:0016568;chromatin modification;5.65943199085672e-17!GO:0008026;ATP-dependent helicase activity;6.16689855488486e-17!GO:0043412;biopolymer modification;1.96694753613358e-16!GO:0006399;tRNA metabolic process;2.47409139135805e-16!GO:0005635;nuclear envelope;3.13675413148721e-16!GO:0044248;cellular catabolic process;3.40774028643683e-16!GO:0006605;protein targeting;5.73812244233158e-16!GO:0006413;translational initiation;6.50159443859525e-16!GO:0050136;NADH dehydrogenase (quinone) activity;8.55905015579998e-16!GO:0003954;NADH dehydrogenase activity;8.55905015579998e-16!GO:0008137;NADH dehydrogenase (ubiquinone) activity;8.55905015579998e-16!GO:0016655;oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor;1.07557545640248e-15!GO:0005842;cytosolic large ribosomal subunit (sensu Eukaryota);1.13891326543554e-15!GO:0050657;nucleic acid transport;1.21147159797248e-15!GO:0051236;establishment of RNA localization;1.21147159797248e-15!GO:0050658;RNA transport;1.21147159797248e-15!GO:0006403;RNA localization;1.422914448979e-15!GO:0005643;nuclear pore;2.17613449476207e-15!GO:0003743;translation initiation factor activity;2.94766555985917e-15!GO:0006364;rRNA processing;3.12463115502107e-15!GO:0016072;rRNA metabolic process;6.68102211363969e-15!GO:0012505;endomembrane system;8.10248148533698e-15!GO:0016607;nuclear speck;1.24128301739815e-14!GO:0006261;DNA-dependent DNA replication;1.42734419182277e-14!GO:0051726;regulation of cell cycle;1.89164963439318e-14!GO:0042775;organelle ATP synthesis coupled electron transport;2.37659389500841e-14!GO:0042773;ATP synthesis coupled electron transport;2.37659389500841e-14!GO:0000074;regulation of progression through cell cycle;2.73320806494041e-14!GO:0006446;regulation of translational initiation;5.04651897856254e-14!GO:0030163;protein catabolic process;7.22715417406827e-14!GO:0030964;NADH dehydrogenase complex (quinone);7.48578729949438e-14!GO:0045271;respiratory chain complex I;7.48578729949438e-14!GO:0005747;mitochondrial respiratory chain complex I;7.48578729949438e-14!GO:0051082;unfolded protein binding;1.67286055461784e-13!GO:0006120;mitochondrial electron transport, NADH to ubiquinone;1.72721703884918e-13!GO:0016779;nucleotidyltransferase activity;2.02427356739899e-13!GO:0051028;mRNA transport;3.28764634479382e-13!GO:0043687;post-translational protein modification;4.12784975367864e-13!GO:0000785;chromatin;4.40555483925357e-13!GO:0046930;pore complex;4.52061022302111e-13!GO:0006464;protein modification process;4.59906800156703e-13!GO:0065002;intracellular protein transport across a membrane;5.81161377018128e-13!GO:0051186;cofactor metabolic process;6.30858527116345e-13!GO:0000775;chromosome, pericentric region;6.60101271105029e-13!GO:0009259;ribonucleotide metabolic process;7.29339433746663e-13!GO:0015931;nucleobase, nucleoside, nucleotide and nucleic acid transport;7.43777465197789e-13!GO:0016591;DNA-directed RNA polymerase II, holoenzyme;1.56808778092036e-12!GO:0006163;purine nucleotide metabolic process;1.79022139738851e-12!GO:0065004;protein-DNA complex assembly;5.29635575961268e-12!GO:0006913;nucleocytoplasmic transport;5.33299688664099e-12!GO:0006333;chromatin assembly or disassembly;5.33299688664099e-12!GO:0016651;oxidoreductase activity, acting on NADH or NADPH;9.76531727014205e-12!GO:0051169;nuclear transport;1.2184670937118e-11!GO:0016879;ligase activity, forming carbon-nitrogen bonds;1.84853456798307e-11!GO:0006164;purine nucleotide biosynthetic process;2.0078517813382e-11!GO:0006310;DNA recombination;2.33163321000396e-11!GO:0043566;structure-specific DNA binding;2.86045188651965e-11!GO:0048770;pigment granule;2.87320180162432e-11!GO:0042470;melanosome;2.87320180162432e-11!GO:0009260;ribonucleotide biosynthetic process;3.01051712775025e-11!GO:0009150;purine ribonucleotide metabolic process;3.24116424290098e-11!GO:0003712;transcription cofactor activity;5.24746299696369e-11!GO:0008639;small protein conjugating enzyme activity;6.91173376117067e-11!GO:0030532;small nuclear ribonucleoprotein complex;6.91173376117067e-11!GO:0003697;single-stranded DNA binding;6.94543232111636e-11!GO:0044432;endoplasmic reticulum part;7.24578303023154e-11!GO:0016876;ligase activity, forming aminoacyl-tRNA and related compounds;8.27816375989656e-11!GO:0004812;aminoacyl-tRNA ligase activity;8.27816375989656e-11!GO:0016875;ligase activity, forming carbon-oxygen bonds;8.27816375989656e-11!GO:0016740;transferase activity;8.7488351581977e-11!GO:0043038;amino acid activation;1.52516368592042e-10!GO:0006418;tRNA aminoacylation for protein translation;1.52516368592042e-10!GO:0043039;tRNA aminoacylation;1.52516368592042e-10!GO:0006732;coenzyme metabolic process;1.86246953817033e-10!GO:0004842;ubiquitin-protein ligase activity;1.91745750558198e-10!GO:0008565;protein transporter activity;2.20882452898305e-10!GO:0005819;spindle;2.25732002998009e-10!GO:0009152;purine ribonucleotide biosynthetic process;3.53728386939999e-10!GO:0019787;small conjugating protein ligase activity;3.56000975605636e-10!GO:0000075;cell cycle checkpoint;3.57429593471115e-10!GO:0019222;regulation of metabolic process;4.09517513329167e-10!GO:0005657;replication fork;4.48260440186388e-10!GO:0005783;endoplasmic reticulum;5.75744653174425e-10!GO:0005667;transcription factor complex;5.83201187862482e-10!GO:0009055;electron carrier activity;5.90842375952582e-10!GO:0051329;interphase of mitotic cell cycle;1.67810101546184e-09!GO:0048193;Golgi vesicle transport;1.70557529438984e-09!GO:0008094;DNA-dependent ATPase activity;1.73459435018347e-09!GO:0051325;interphase;1.73459435018347e-09!GO:0046961;hydrogen ion transporting ATPase activity, rotational mechanism;1.7449855650227e-09!GO:0009141;nucleoside triphosphate metabolic process;2.11985056058962e-09!GO:0009199;ribonucleoside triphosphate metabolic process;2.13808387217402e-09!GO:0003899;DNA-directed RNA polymerase activity;2.13808387217402e-09!GO:0042175;nuclear envelope-endoplasmic reticulum network;2.68971236610533e-09!GO:0016787;hydrolase activity;2.83471422330592e-09!GO:0017038;protein import;4.08288424130625e-09!GO:0015630;microtubule cytoskeleton;4.84291539295332e-09!GO:0009205;purine ribonucleoside triphosphate metabolic process;5.66941893204795e-09!GO:0009144;purine nucleoside triphosphate metabolic process;5.66941893204795e-09!GO:0005789;endoplasmic reticulum membrane;6.08059228661525e-09!GO:0046933;hydrogen ion transporting ATP synthase activity, rotational mechanism;6.84236875526368e-09!GO:0006461;protein complex assembly;7.1355857822262e-09!GO:0016881;acid-amino acid ligase activity;7.44676046807945e-09!GO:0050794;regulation of cellular process;7.61439666535039e-09!GO:0019829;cation-transporting ATPase activity;1.02078584952398e-08!GO:0012501;programmed cell death;1.04959646938882e-08!GO:0009142;nucleoside triphosphate biosynthetic process;1.14643142601288e-08!GO:0009201;ribonucleoside triphosphate biosynthetic process;1.14643142601288e-08!GO:0006302;double-strand break repair;1.18860627737382e-08!GO:0006366;transcription from RNA polymerase II promoter;1.20117887672733e-08!GO:0005813;centrosome;1.23838633970855e-08!GO:0006915;apoptosis;1.35181975494897e-08!GO:0009056;catabolic process;1.54730916439168e-08!GO:0055086;nucleobase, nucleoside and nucleotide metabolic process;1.65315680678548e-08!GO:0007051;spindle organization and biogenesis;1.65455448970997e-08!GO:0005815;microtubule organizing center;1.71006054357005e-08!GO:0000245;spliceosome assembly;2.70522229916925e-08!GO:0007005;mitochondrion organization and biogenesis;2.9427213986638e-08!GO:0051246;regulation of protein metabolic process;2.94590476814704e-08!GO:0015986;ATP synthesis coupled proton transport;3.02888406206767e-08!GO:0015985;energy coupled proton transport, down electrochemical gradient;3.02888406206767e-08!GO:0009206;purine ribonucleoside triphosphate biosynthetic process;3.06101418603948e-08!GO:0009145;purine nucleoside triphosphate biosynthetic process;3.06101418603948e-08!GO:0006793;phosphorus metabolic process;3.59456404395445e-08!GO:0006796;phosphate metabolic process;3.59456404395445e-08!GO:0016741;transferase activity, transferring one-carbon groups;3.70780788520078e-08!GO:0005839;proteasome core complex (sensu Eukaryota);3.79317230582033e-08!GO:0016772;transferase activity, transferring phosphorus-containing groups;3.98838353819461e-08!GO:0009060;aerobic respiration;4.02515022275783e-08!GO:0046034;ATP metabolic process;4.30479962666985e-08!GO:0031202;RNA splicing factor activity, transesterification mechanism;5.4785735483695e-08!GO:0031323;regulation of cellular metabolic process;5.59685904793061e-08!GO:0007059;chromosome segregation;5.94006470872779e-08!GO:0016363;nuclear matrix;7.11811077142027e-08!GO:0008168;methyltransferase activity;7.19080756226843e-08!GO:0045333;cellular respiration;7.19080756226843e-08!GO:0051188;cofactor biosynthetic process;7.47418896578641e-08!GO:0015078;hydrogen ion transmembrane transporter activity;8.02291739675102e-08!GO:0016310;phosphorylation;8.25206109411401e-08!GO:0004518;nuclease activity;1.09188862719188e-07!GO:0032446;protein modification by small protein conjugation;1.40831597720646e-07!GO:0003724;RNA helicase activity;1.43528140686798e-07!GO:0004298;threonine endopeptidase activity;1.4396201375885e-07!GO:0003682;chromatin binding;1.63588404732848e-07!GO:0006754;ATP biosynthetic process;2.06421701497294e-07!GO:0006753;nucleoside phosphate metabolic process;2.06421701497294e-07!GO:0009117;nucleotide metabolic process;2.2882908192318e-07!GO:0008219;cell death;2.69250168568148e-07!GO:0016265;death;2.69250168568148e-07!GO:0006888;ER to Golgi vesicle-mediated transport;2.88719451596024e-07!GO:0044452;nucleolar part;3.04779315206013e-07!GO:0006752;group transfer coenzyme metabolic process;3.73164267067707e-07!GO:0016567;protein ubiquitination;3.78728321567435e-07!GO:0031497;chromatin assembly;3.91099796936225e-07!GO:0008033;tRNA processing;4.26663113405826e-07!GO:0006350;transcription;5.7265507792669e-07!GO:0003713;transcription coactivator activity;5.94471892816252e-07!GO:0051052;regulation of DNA metabolic process;6.14868612625155e-07!GO:0016192;vesicle-mediated transport;6.68967807667398e-07!GO:0007088;regulation of mitosis;6.97092781203831e-07!GO:0051168;nuclear export;7.01829862089331e-07!GO:0045259;proton-transporting ATP synthase complex;7.27313906395254e-07!GO:0003678;DNA helicase activity;7.74199714080238e-07!GO:0000151;ubiquitin ligase complex;8.01030122716444e-07!GO:0006334;nucleosome assembly;8.01034229757992e-07!GO:0000776;kinetochore;8.38730682695169e-07!GO:0003690;double-stranded DNA binding;9.190270894144e-07!GO:0015077;monovalent inorganic cation transmembrane transporter activity;1.09991184183358e-06!GO:0006401;RNA catabolic process;1.13646756053411e-06!GO:0016469;proton-transporting two-sector ATPase complex;1.16691782272314e-06!GO:0003684;damaged DNA binding;1.73148681848937e-06!GO:0006402;mRNA catabolic process;1.83871218189271e-06!GO:0009108;coenzyme biosynthetic process;2.03199294517004e-06!GO:0006084;acetyl-CoA metabolic process;2.31713666637854e-06!GO:0005793;ER-Golgi intermediate compartment;2.84952785706644e-06!GO:0006099;tricarboxylic acid cycle;2.96452924533725e-06!GO:0046356;acetyl-CoA catabolic process;2.96452924533725e-06!GO:0006613;cotranslational protein targeting to membrane;3.72726352259149e-06!GO:0006352;transcription initiation;4.39854718418225e-06!GO:0016563;transcription activator activity;4.87489062838416e-06!GO:0048475;coated membrane;5.03760402262633e-06!GO:0030117;membrane coat;5.03760402262633e-06!GO:0003677;DNA binding;5.65552383043894e-06!GO:0004527;exonuclease activity;6.08301270545257e-06!GO:0030880;RNA polymerase complex;6.13669081809575e-06!GO:0030120;vesicle coat;7.5089924966601e-06!GO:0030662;coated vesicle membrane;7.5089924966601e-06!GO:0015405;P-P-bond-hydrolysis-driven transmembrane transporter activity;9.30065608794512e-06!GO:0015399;primary active transmembrane transporter activity;9.30065608794512e-06!GO:0006612;protein targeting to membrane;9.46202953986321e-06!GO:0010468;regulation of gene expression;1.02745187036452e-05!GO:0003729;mRNA binding;1.0302620024086e-05!GO:0016251;general RNA polymerase II transcription factor activity;1.08177715844434e-05!GO:0005762;mitochondrial large ribosomal subunit;1.08381880116266e-05!GO:0000315;organellar large ribosomal subunit;1.08381880116266e-05!GO:0019219;regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;1.25528392516605e-05!GO:0008186;RNA-dependent ATPase activity;1.31658893981696e-05!GO:0006383;transcription from RNA polymerase III promoter;1.36944454142237e-05!GO:0006606;protein import into nucleus;1.37158923596008e-05!GO:0007093;mitotic cell cycle checkpoint;1.38794746797407e-05!GO:0051170;nuclear import;1.39005024000339e-05!GO:0032508;DNA duplex unwinding;1.55599223583525e-05!GO:0032392;DNA geometric change;1.55599223583525e-05!GO:0000228;nuclear chromosome;1.6080492760331e-05!GO:0000314;organellar small ribosomal subunit;1.62658507386174e-05!GO:0005763;mitochondrial small ribosomal subunit;1.62658507386174e-05!GO:0055029;nuclear DNA-directed RNA polymerase complex;1.66483365090215e-05!GO:0000428;DNA-directed RNA polymerase complex;1.66483365090215e-05!GO:0042625;ATPase activity, coupled to transmembrane movement of ions;1.6806957492984e-05!GO:0043623;cellular protein complex assembly;1.79419149242839e-05!GO:0030530;heterogeneous nuclear ribonucleoprotein complex;1.89965195144641e-05!GO:0009165;nucleotide biosynthetic process;2.23514670261218e-05!GO:0009109;coenzyme catabolic process;2.23514670261218e-05!GO:0031324;negative regulation of cellular metabolic process;2.59812773559309e-05!GO:0051427;hormone receptor binding;2.61400634508645e-05!GO:0050789;regulation of biological process;3.00515124808418e-05!GO:0016564;transcription repressor activity;3.28664922726732e-05!GO:0043021;ribonucleoprotein binding;4.00447138143954e-05!GO:0004004;ATP-dependent RNA helicase activity;4.14455129678231e-05!GO:0043681;protein import into mitochondrion;4.255108078488e-05!GO:0006091;generation of precursor metabolites and energy;4.43172014464013e-05!GO:0005794;Golgi apparatus;4.49043634645232e-05!GO:0042981;regulation of apoptosis;4.79077539596689e-05!GO:0016853;isomerase activity;4.81714808181439e-05!GO:0045934;negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;4.92728212948108e-05!GO:0006268;DNA unwinding during replication;4.98657624112092e-05!GO:0035257;nuclear hormone receptor binding;5.5825637568507e-05!GO:0000819;sister chromatid segregation;5.86609678778516e-05!GO:0043067;regulation of programmed cell death;6.01081746298109e-05!GO:0000070;mitotic sister chromatid segregation;6.01172097521175e-05!GO:0006405;RNA export from nucleus;6.73012555963277e-05!GO:0045786;negative regulation of progression through cell cycle;8.62857260413847e-05!GO:0007052;mitotic spindle organization and biogenesis;8.83767126211222e-05!GO:0032200;telomere organization and biogenesis;9.21285912005064e-05!GO:0000723;telomere maintenance;9.21285912005064e-05!GO:0043492;ATPase activity, coupled to movement of substances;9.30568143294901e-05!GO:0051187;cofactor catabolic process;9.4769733539459e-05!GO:0031570;DNA integrity checkpoint;0.000102644582266448!GO:0032774;RNA biosynthetic process;0.000110114281652779!GO:0006414;translational elongation;0.000110617972966127!GO:0006839;mitochondrial transport;0.000113687148746193!GO:0000049;tRNA binding;0.000125171202189161!GO:0000922;spindle pole;0.0001372939370423!GO:0006626;protein targeting to mitochondrion;0.000139194189266768!GO:0009892;negative regulation of metabolic process;0.000140661918150422!GO:0042626;ATPase activity, coupled to transmembrane movement of substances;0.000149031473110812!GO:0006351;transcription, DNA-dependent;0.000149423785254284!GO:0009451;RNA modification;0.000158806152272306!GO:0005798;Golgi-associated vesicle;0.000166428355819327!GO:0016820;hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances;0.000170969787129872!GO:0016281;eukaryotic translation initiation factor 4F complex;0.000184632922947944!GO:0006270;DNA replication initiation;0.00018549796240133!GO:0048523;negative regulation of cellular process;0.000192380689273904!GO:0005753;mitochondrial proton-transporting ATP synthase complex;0.000194815481159916!GO:0043596;nuclear replication fork;0.000198603678745901!GO:0000079;regulation of cyclin-dependent protein kinase activity;0.000210814937442219!GO:0003755;peptidyl-prolyl cis-trans isomerase activity;0.000211178335757057!GO:0000184;mRNA catabolic process, nonsense-mediated decay;0.00022357035052006!GO:0004674;protein serine/threonine kinase activity;0.00022801369258419!GO:0016859;cis-trans isomerase activity;0.000243010632284209!GO:0000059;protein import into nucleus, docking;0.000251680903505358!GO:0000226;microtubule cytoskeleton organization and biogenesis;0.000254413094666392!GO:0005684;U2-dependent spliceosome;0.000259248543970618!GO:0006367;transcription initiation from RNA polymerase II promoter;0.000273813427413343!GO:0006275;regulation of DNA replication;0.000273813427413343!GO:0008757;S-adenosylmethionine-dependent methyltransferase activity;0.000273816832927759!GO:0005770;late endosome;0.000274484327087909!GO:0007006;mitochondrial membrane organization and biogenesis;0.000294526884540559!GO:0006284;base-excision repair;0.000297686634325444!GO:0016491;oxidoreductase activity;0.000330549534874377!GO:0004003;ATP-dependent DNA helicase activity;0.000331939686021107!GO:0051252;regulation of RNA metabolic process;0.00033856432575265!GO:0045454;cell redox homeostasis;0.00035722561915213!GO:0005852;eukaryotic translation initiation factor 3 complex;0.000380344980447198!GO:0006338;chromatin remodeling;0.000380344980447198!GO:0008276;protein methyltransferase activity;0.00039577509356963!GO:0000725;recombinational repair;0.000409402014100163!GO:0000724;double-strand break repair via homologous recombination;0.000409402014100163!GO:0033178;proton-transporting two-sector ATPase complex, catalytic domain;0.000422625088346125!GO:0065009;regulation of a molecular function;0.000429539942899854!GO:0031072;heat shock protein binding;0.000448596382493004!GO:0019752;carboxylic acid metabolic process;0.000460031837349509!GO:0003714;transcription corepressor activity;0.000464575435084655!GO:0015992;proton transport;0.000464575435084655!GO:0000793;condensed chromosome;0.000468414499513099!GO:0006818;hydrogen transport;0.00047387741898813!GO:0006082;organic acid metabolic process;0.000480871530999324!GO:0000082;G1/S transition of mitotic cell cycle;0.000494466129741484!GO:0045261;proton-transporting ATP synthase complex, catalytic core F(1);0.000497113811011901!GO:0003887;DNA-directed DNA polymerase activity;0.000514420607861437!GO:0005885;Arp2/3 protein complex;0.00055200964446201!GO:0000077;DNA damage checkpoint;0.000563577790806998!GO:0000781;chromosome, telomeric region;0.000569652922293799!GO:0006950;response to stress;0.000580247687186273!GO:0015631;tubulin binding;0.000604732817971859!GO:0000287;magnesium ion binding;0.000633038271200114!GO:0031124;mRNA 3'-end processing;0.000639020345120979!GO:0006289;nucleotide-excision repair;0.000639683329886803!GO:0019899;enzyme binding;0.000644958290957077!GO:0045449;regulation of transcription;0.000676954445700596!GO:0006520;amino acid metabolic process;0.000724284736817254!GO:0031968;organelle outer membrane;0.000795395036645252!GO:0016679;oxidoreductase activity, acting on diphenols and related substances as donors;0.00079733271503444!GO:0016681;oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor;0.00079733271503444!GO:0008121;ubiquinol-cytochrome-c reductase activity;0.00079733271503444!GO:0016272;prefoldin complex;0.000798036772164894!GO:0019867;outer membrane;0.000830273849873276!GO:0009112;nucleobase metabolic process;0.000876691356108987!GO:0043601;nuclear replisome;0.000884660427803145!GO:0030894;replisome;0.000884660427803145!GO:0019843;rRNA binding;0.000907346149482453!GO:0048500;signal recognition particle;0.000954415838329781!GO:0005669;transcription factor TFIID complex;0.000987206518632254!GO:0006417;regulation of translation;0.00104954452294812!GO:0016891;endoribonuclease activity, producing 5'-phosphomonoesters;0.00105844396567674!GO:0003711;transcription elongation regulator activity;0.00106911295271381!GO:0000910;cytokinesis;0.00109364944790797!GO:0008312;7S RNA binding;0.00109868450211998!GO:0015980;energy derivation by oxidation of organic compounds;0.00110049858172394!GO:0006144;purine base metabolic process;0.00117190684672711!GO:0005637;nuclear inner membrane;0.0011747884289778!GO:0016481;negative regulation of transcription;0.00117699263360458!GO:0042770;DNA damage response, signal transduction;0.00118544881875424!GO:0005876;spindle microtubule;0.00119034943998323!GO:0005768;endosome;0.00120013326568824!GO:0005838;proteasome regulatory particle (sensu Eukaryota);0.00126727276364351!GO:0008654;phospholipid biosynthetic process;0.00127823899449204!GO:0006611;protein export from nucleus;0.00134118099484876!GO:0006357;regulation of transcription from RNA polymerase II promoter;0.00137459649351529!GO:0009124;nucleoside monophosphate biosynthetic process;0.00143549393911752!GO:0009123;nucleoside monophosphate metabolic process;0.00143549393911752!GO:0031123;RNA 3'-end processing;0.00144357298285619!GO:0051053;negative regulation of DNA metabolic process;0.00147289426559891!GO:0005048;signal sequence binding;0.00156239949989283!GO:0000726;non-recombinational repair;0.00157002010892833!GO:0016796;exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters;0.00159077343133666!GO:0008408;3'-5' exonuclease activity;0.00164200653503282!GO:0046483;heterocycle metabolic process;0.00165389269014625!GO:0007017;microtubule-based process;0.00165389269014625!GO:0030384;phosphoinositide metabolic process;0.0016757161260768!GO:0000786;nucleosome;0.00167948876294479!GO:0005741;mitochondrial outer membrane;0.00168414727595593!GO:0043069;negative regulation of programmed cell death;0.00171769867241185!GO:0042393;histone binding;0.00174302952557232!GO:0006400;tRNA modification;0.00176265654946746!GO:0045263;proton-transporting ATP synthase complex, coupling factor F(o);0.00176265654946746!GO:0033177;proton-transporting two-sector ATPase complex, proton-transporting domain;0.00176265654946746!GO:0046966;thyroid hormone receptor binding;0.00177773349608607!GO:0046489;phosphoinositide biosynthetic process;0.0017848793056697!GO:0048519;negative regulation of biological process;0.00180667696130577!GO:0016893;endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters;0.00186257651705895!GO:0000118;histone deacetylase complex;0.00189343069211683!GO:0022890;inorganic cation transmembrane transporter activity;0.00191024588100671!GO:0000178;exosome (RNase complex);0.00194631912002495!GO:0006614;SRP-dependent cotranslational protein targeting to membrane;0.00207398072461663!GO:0045047;protein targeting to ER;0.00207398072461663!GO:0043066;negative regulation of apoptosis;0.00208616288663481!GO:0044450;microtubule organizing center part;0.00230547498562137!GO:0005758;mitochondrial intermembrane space;0.00237976133356584!GO:0005665;DNA-directed RNA polymerase II, core complex;0.00241419344173789!GO:0043488;regulation of mRNA stability;0.00248791991126011!GO:0043487;regulation of RNA stability;0.00248791991126011!GO:0005786;signal recognition particle, endoplasmic reticulum targeting;0.0024912097892074!GO:0051540;metal cluster binding;0.00255578350504226!GO:0051536;iron-sulfur cluster binding;0.00255578350504226!GO:0047485;protein N-terminus binding;0.00255944683460292!GO:0051539;4 iron, 4 sulfur cluster binding;0.00267282239704786!GO:0051920;peroxiredoxin activity;0.00273669510127456!GO:0004532;exoribonuclease activity;0.0027581063805185!GO:0016896;exoribonuclease activity, producing 5'-phosphomonoesters;0.0027581063805185!GO:0030521;androgen receptor signaling pathway;0.00284167489832447!GO:0031326;regulation of cellular biosynthetic process;0.00289087288679078!GO:0032259;methylation;0.00301959348052474!GO:0031577;spindle checkpoint;0.00301959348052474!GO:0006650;glycerophospholipid metabolic process;0.0030863749566546!GO:0004722;protein serine/threonine phosphatase activity;0.00309403628595518!GO:0016676;oxidoreductase activity, acting on heme group of donors, oxygen as acceptor;0.00309403628595518!GO:0015002;heme-copper terminal oxidase activity;0.00309403628595518!GO:0016675;oxidoreductase activity, acting on heme group of donors;0.00309403628595518!GO:0004129;cytochrome-c oxidase activity;0.00309403628595518!GO:0008022;protein C-terminus binding;0.00316069942473611!GO:0000339;RNA cap binding;0.00324611374648842!GO:0003746;translation elongation factor activity;0.00330403769777379!GO:0008632;apoptotic program;0.00331980575614616!GO:0006891;intra-Golgi vesicle-mediated transport;0.00331980575614616!GO:0003924;GTPase activity;0.0036295903453444!GO:0051320;S phase;0.00364405089424294!GO:0009161;ribonucleoside monophosphate metabolic process;0.00364405089424294!GO:0009156;ribonucleoside monophosphate biosynthetic process;0.00364405089424294!GO:0043414;biopolymer methylation;0.0039497220887478!GO:0030663;COPI coated vesicle membrane;0.0039497220887478!GO:0030126;COPI vesicle coat;0.0039497220887478!GO:0033116;ER-Golgi intermediate compartment membrane;0.00395605715312093!GO:0000152;nuclear ubiquitin ligase complex;0.00399276587321053!GO:0042054;histone methyltransferase activity;0.00412079297492976!GO:0005663;DNA replication factor C complex;0.00424468141551421!GO:0006916;anti-apoptosis;0.00426076641515349!GO:0006595;polyamine metabolic process;0.00426252780441682!GO:0008139;nuclear localization sequence binding;0.00426376033959202!GO:0046474;glycerophospholipid biosynthetic process;0.00427118148774021!GO:0005525;GTP binding;0.0045494921524187!GO:0043161;proteasomal ubiquitin-dependent protein catabolic process;0.00455002341436097!GO:0007004;telomere maintenance via telomerase;0.00455349865396918!GO:0003725;double-stranded RNA binding;0.0046226175129781!GO:0019783;small conjugating protein-specific protease activity;0.00475572633088295!GO:0045947;negative regulation of translational initiation;0.0048707261688571!GO:0043284;biopolymer biosynthetic process;0.00489504660312118!GO:0006220;pyrimidine nucleotide metabolic process;0.00499803970852138!GO:0030518;steroid hormone receptor signaling pathway;0.00518908251764321!GO:0008017;microtubule binding;0.00523130731951558!GO:0009303;rRNA transcription;0.00587254014271428!GO:0004843;ubiquitin-specific protease activity;0.00591823140054486!GO:0051297;centrosome organization and biogenesis;0.00591823140054486!GO:0031023;microtubule organizing center organization and biogenesis;0.00591823140054486!GO:0006378;mRNA polyadenylation;0.00591823140054486!GO:0030658;transport vesicle membrane;0.00611478843611342!GO:0044454;nuclear chromosome part;0.0061251226095533!GO:0008234;cysteine-type peptidase activity;0.00633216556502962!GO:0008652;amino acid biosynthetic process;0.00634142369105353!GO:0006519;amino acid and derivative metabolic process;0.00646355803741231!GO:0016584;nucleosome positioning;0.00658839347937599!GO:0051656;establishment of organelle localization;0.00662297017991315!GO:0006278;RNA-dependent DNA replication;0.00699849443906594!GO:0031970;organelle envelope lumen;0.00702382243683366!GO:0005874;microtubule;0.00703230008327323!GO:0016279;protein-lysine N-methyltransferase activity;0.00704272665281429!GO:0018024;histone-lysine N-methyltransferase activity;0.00704272665281429!GO:0016278;lysine N-methyltransferase activity;0.00704272665281429!GO:0044431;Golgi apparatus part;0.00748766033618991!GO:0005832;chaperonin-containing T-complex;0.00773636826801491!GO:0006266;DNA ligation;0.00794321499387813!GO:0051087;chaperone binding;0.00801751818729481!GO:0006355;regulation of transcription, DNA-dependent;0.00808619945265242!GO:0016407;acetyltransferase activity;0.00814121970610197!GO:0006007;glucose catabolic process;0.00816098167433485!GO:0008156;negative regulation of DNA replication;0.00836623755990263!GO:0004519;endonuclease activity;0.00844891505140415!GO:0016408;C-acyltransferase activity;0.00851514753775766!GO:0050790;regulation of catalytic activity;0.0085857459456386!GO:0022411;cellular component disassembly;0.00860375168093631!GO:0016569;covalent chromatin modification;0.00867095545339898!GO:0006376;mRNA splice site selection;0.00876149331876255!GO:0000389;nuclear mRNA 3'-splice site recognition;0.00876149331876255!GO:0007007;inner mitochondrial membrane organization and biogenesis;0.00886830200240606!GO:0000018;regulation of DNA recombination;0.00890188091983776!GO:0019205;nucleobase, nucleoside, nucleotide kinase activity;0.00893495737996626!GO:0030137;COPI-coated vesicle;0.00894169970965371!GO:0048471;perinuclear region of cytoplasm;0.00896490979463145!GO:0005788;endoplasmic reticulum lumen;0.00902027271445905!GO:0030433;ER-associated protein catabolic process;0.00904367619165124!GO:0006515;misfolded or incompletely synthesized protein catabolic process;0.00904367619165124!GO:0008180;signalosome;0.00914605383933431!GO:0035267;NuA4 histone acetyltransferase complex;0.00921271094932513!GO:0000792;heterochromatin;0.0093442185345545!GO:0006406;mRNA export from nucleus;0.00979346094363986!GO:0007094;mitotic cell cycle spindle assembly checkpoint;0.00982477775914788!GO:0004221;ubiquitin thiolesterase activity;0.00986442126862808!GO:0016790;thiolester hydrolase activity;0.00986757181565603!GO:0043189;H4/H2A histone acetyltransferase complex;0.00990841166928152!GO:0030118;clathrin coat;0.00990841166928152!GO:0051287;NAD binding;0.00998860556390386!GO:0006730;one-carbon compound metabolic process;0.00999112282558654!GO:0009081;branched chain family amino acid metabolic process;0.0100683362643464!GO:0000119;mediator complex;0.0102211662678988!GO:0000096;sulfur amino acid metabolic process;0.0104246855200318!GO:0009889;regulation of biosynthetic process;0.0105706128343894!GO:0051789;response to protein stimulus;0.0108385002207124!GO:0006986;response to unfolded protein;0.0108385002207124!GO:0009116;nucleoside metabolic process;0.0112317357165661!GO:0045120;pronucleus;0.0113743178744896!GO:0016197;endosome transport;0.0116974632991707!GO:0031647;regulation of protein stability;0.0119405333461175!GO:0004523;ribonuclease H activity;0.0119989336278493!GO:0043624;cellular protein complex disassembly;0.0125763225232555!GO:0006118;electron transport;0.0126168501174396!GO:0035258;steroid hormone receptor binding;0.0127301244877825!GO:0004540;ribonuclease activity;0.012810009611559!GO:0030660;Golgi-associated vesicle membrane;0.0130996227305226!GO:0046112;nucleobase biosynthetic process;0.0131953190454384!GO:0006303;double-strand break repair via nonhomologous end joining;0.0131953190454384!GO:0042809;vitamin D receptor binding;0.0135840410773579!GO:0048487;beta-tubulin binding;0.013600897381114!GO:0051318;G1 phase;0.0137120179061407!GO:0000123;histone acetyltransferase complex;0.0138629409091081!GO:0043022;ribosome binding;0.0148506224335699!GO:0007098;centrosome cycle;0.0149217552254338!GO:0003702;RNA polymerase II transcription factor activity;0.0150919624100455!GO:0051640;organelle localization;0.0155288354592236!GO:0040029;regulation of gene expression, epigenetic;0.015550663642243!GO:0009127;purine nucleoside monophosphate biosynthetic process;0.0156486352355461!GO:0009167;purine ribonucleoside monophosphate metabolic process;0.0156486352355461!GO:0009126;purine nucleoside monophosphate metabolic process;0.0156486352355461!GO:0009168;purine ribonucleoside monophosphate biosynthetic process;0.0156486352355461!GO:0030867;rough endoplasmic reticulum membrane;0.0159613571042128!GO:0032039;integrator complex;0.0159629835736576!GO:0000175;3'-5'-exoribonuclease activity;0.0160289449075628!GO:0033170;DNA-protein loading ATPase activity;0.0160289449075628!GO:0003689;DNA clamp loader activity;0.0160289449075628!GO:0008536;Ran GTPase binding;0.0167220514813483!GO:0007050;cell cycle arrest;0.0167220514813483!GO:0030134;ER to Golgi transport vesicle;0.0167910914783452!GO:0050662;coenzyme binding;0.0172739272345458!GO:0032984;macromolecular complex disassembly;0.0173240831753636!GO:0005869;dynactin complex;0.0178516961451952!GO:0006506;GPI anchor biosynthetic process;0.0178550423692547!GO:0042802;identical protein binding;0.0184662496082898!GO:0000209;protein polyubiquitination;0.0190261817509963!GO:0005658;alpha DNA polymerase:primase complex;0.0190261817509963!GO:0005487;nucleocytoplasmic transporter activity;0.0194434015626163!GO:0000084;S phase of mitotic cell cycle;0.0195551411666779!GO:0065007;biological regulation;0.019688949856739!GO:0016862;intramolecular oxidoreductase activity, interconverting keto- and enol-groups;0.0198519580664435!GO:0001522;pseudouridine synthesis;0.0199579392171134!GO:0030119;AP-type membrane coat adaptor complex;0.0200364269048587!GO:0031902;late endosome membrane;0.0202821296299558!GO:0008538;proteasome activator activity;0.0203666831310453!GO:0005680;anaphase-promoting complex;0.0206802411927937!GO:0008170;N-methyltransferase activity;0.0206983716327458!GO:0005652;nuclear lamina;0.0208512418982546!GO:0004576;oligosaccharyl transferase activity;0.0208768237489101!GO:0005732;small nucleolar ribonucleoprotein complex;0.0210498748018265!GO:0000930;gamma-tubulin complex;0.0211563603197569!GO:0042719;mitochondrial intermembrane space protein transporter complex;0.0213459592421404!GO:0045039;protein import into mitochondrial inner membrane;0.0213459592421404!GO:0006505;GPI anchor metabolic process;0.0216449717150527!GO:0002763;positive regulation of myeloid leukocyte differentiation;0.0218132451212225!GO:0044440;endosomal part;0.0219271837054136!GO:0010008;endosome membrane;0.0219271837054136!GO:0008097;5S rRNA binding;0.0226238833576553!GO:0006541;glutamine metabolic process;0.0226264429025362!GO:0006497;protein amino acid lipidation;0.0227793017825123!GO:0016301;kinase activity;0.0228743255271662!GO:0007021;tubulin folding;0.0230141882069777!GO:0008143;poly(A) binding;0.0230801759943106!GO:0008287;protein serine/threonine phosphatase complex;0.0231064409631155!GO:0043631;RNA polyadenylation;0.0231083122494574!GO:0030127;COPII vesicle coat;0.023163982233669!GO:0012507;ER to Golgi transport vesicle membrane;0.023163982233669!GO:0016765;transferase activity, transferring alkyl or aryl (other than methyl) groups;0.0237161415123442!GO:0005850;eukaryotic translation initiation factor 2 complex;0.0238440422231965!GO:0000307;cyclin-dependent protein kinase holoenzyme complex;0.0239750489923378!GO:0030496;midbody;0.0239991959648873!GO:0050000;chromosome localization;0.0243926788043011!GO:0051303;establishment of chromosome localization;0.0243926788043011!GO:0005666;DNA-directed RNA polymerase III complex;0.0245675195480056!GO:0032561;guanyl ribonucleotide binding;0.0247444289421903!GO:0019001;guanyl nucleotide binding;0.0247444289421903!GO:0004579;dolichyl-diphosphooligosaccharide-protein glycotransferase activity;0.0252883416015276!GO:0007010;cytoskeleton organization and biogenesis;0.0253538406546489!GO:0051338;regulation of transferase activity;0.0254504622984074!GO:0006301;postreplication repair;0.0254921339591766!GO:0019206;nucleoside kinase activity;0.0255164856599988!GO:0030131;clathrin adaptor complex;0.0260224689303235!GO:0008250;oligosaccharyl transferase complex;0.0260780504427334!GO:0001832;blastocyst growth;0.0261631095546143!GO:0017134;fibroblast growth factor binding;0.026557218927911!GO:0030041;actin filament polymerization;0.0267711499199335!GO:0005769;early endosome;0.0267711499199335!GO:0000097;sulfur amino acid biosynthetic process;0.0268528861433098!GO:0009113;purine base biosynthetic process;0.0272897986368345!GO:0030374;ligand-dependent nuclear receptor transcription coactivator activity;0.0275234353347649!GO:0005851;eukaryotic translation initiation factor 2B complex;0.0275238481012905!GO:0005521;lamin binding;0.0276036823970285!GO:0006379;mRNA cleavage;0.0279660500769643!GO:0030522;intracellular receptor-mediated signaling pathway;0.0280539838448531!GO:0000080;G1 phase of mitotic cell cycle;0.0280643136187226!GO:0006356;regulation of transcription from RNA polymerase I promoter;0.0283352801756008!GO:0043241;protein complex disassembly;0.0291008135444961!GO:0045815;positive regulation of gene expression, epigenetic;0.0293973593390931!GO:0030330;DNA damage response, signal transduction by p53 class mediator;0.0296842026455948!GO:0016570;histone modification;0.0303299916632166!GO:0030261;chromosome condensation;0.0309008100822181!GO:0004177;aminopeptidase activity;0.0309008100822181!GO:0008213;protein amino acid alkylation;0.0309008100822181!GO:0006479;protein amino acid methylation;0.0309008100822181!GO:0007346;regulation of progression through mitotic cell cycle;0.0313274708583596!GO:0005092;GDP-dissociation inhibitor activity;0.0316094463277325!GO:0006096;glycolysis;0.0325629330397336!GO:0005773;vacuole;0.0325729998757179!GO:0005784;translocon complex;0.0326823285814472!GO:0046365;monosaccharide catabolic process;0.0327621505371591!GO:0006415;translational termination;0.0329782799910666!GO:0032981;mitochondrial respiratory chain complex I assembly;0.0330563928683304!GO:0010257;NADH dehydrogenase complex assembly;0.0330563928683304!GO:0033108;mitochondrial respiratory chain complex assembly;0.0330563928683304!GO:0009067;aspartate family amino acid biosynthetic process;0.0331118466261834!GO:0001824;blastocyst development;0.0334634653889645!GO:0009396;folic acid and derivative biosynthetic process;0.03348253995655!GO:0009083;branched chain family amino acid catabolic process;0.0339668537880376!GO:0030174;regulation of DNA replication initiation;0.0353604508672512!GO:0032040;small subunit processome;0.0356851486622273!GO:0043065;positive regulation of apoptosis;0.0357019504917623!GO:0043549;regulation of kinase activity;0.0357019504917623!GO:0000731;DNA synthesis during DNA repair;0.0358520955908279!GO:0019238;cyclohydrolase activity;0.0363292063819221!GO:0007243;protein kinase cascade;0.036483133103508!GO:0008537;proteasome activator complex;0.0367285732998151!GO:0015036;disulfide oxidoreductase activity;0.0367419693142769!GO:0031371;ubiquitin conjugating enzyme complex;0.0376655748118378!GO:0006740;NADPH regeneration;0.0383975749759647!GO:0006098;pentose-phosphate shunt;0.0383975749759647!GO:0000086;G2/M transition of mitotic cell cycle;0.0388557366678768!GO:0000777;condensed chromosome kinetochore;0.0390477814044539!GO:0000779;condensed chromosome, pericentric region;0.0390477814044539!GO:0009066;aspartate family amino acid metabolic process;0.0395876681230327!GO:0006596;polyamine biosynthetic process;0.0397632948693585!GO:0016627;oxidoreductase activity, acting on the CH-CH group of donors;0.0408043184839178!GO:0004239;methionyl aminopeptidase activity;0.040902151182007!GO:0046164;alcohol catabolic process;0.0409427674617781!GO:0033261;regulation of progression through S phase;0.0414372035361712!GO:0046128;purine ribonucleoside metabolic process;0.0416115418513762!GO:0042278;purine nucleoside metabolic process;0.0416115418513762!GO:0043068;positive regulation of programmed cell death;0.0418335918299696!GO:0042769;DNA damage response, detection of DNA damage;0.0424097434483262!GO:0008320;protein transmembrane transporter activity;0.0424274739739083!GO:0016180;snRNA processing;0.0424274739739083!GO:0016073;snRNA metabolic process;0.0424274739739083!GO:0007076;mitotic chromosome condensation;0.0427995232009638!GO:0030176;integral to endoplasmic reticulum membrane;0.0437069015943925!GO:0004536;deoxyribonuclease activity;0.0437069015943925!GO:0042026;protein refolding;0.0438137893291925!GO:0016126;sterol biosynthetic process;0.044303583311971!GO:0042162;telomeric DNA binding;0.0444231999770757!GO:0005996;monosaccharide metabolic process;0.044453594821717!GO:0032404;mismatch repair complex binding;0.0446069017242796!GO:0005675;holo TFIIH complex;0.0447218470872776!GO:0016585;chromatin remodeling complex;0.0449591662999275!GO:0048037;cofactor binding;0.0449699364302617!GO:0016605;PML body;0.0453116608366255!GO:0030132;clathrin coat of coated pit;0.0465905868948693!GO:0004520;endodeoxyribonuclease activity;0.0468355134963412!GO:0019318;hexose metabolic process;0.0472828736746085!GO:0006221;pyrimidine nucleotide biosynthetic process;0.0473306656125306!GO:0008629;induction of apoptosis by intracellular signals;0.0473306656125306!GO:0045859;regulation of protein kinase activity;0.0478756926281217!GO:0008270;zinc ion binding;0.0480643129166216!GO:0008637;apoptotic mitochondrial changes;0.0488056433227009!GO:0006308;DNA catabolic process;0.0488056433227009!GO:0042158;lipoprotein biosynthetic process;0.0490315204515127!GO:0003893;epsilon DNA polymerase activity;0.0495242561785915 | |||
|sample_id=10534 | |||
|sample_note= | |||
|sample_sex=unknown | |||
|sample_species=Human (Homo sapiens) | |||
|sample_strain= | |||
|sample_tissue=blood | |||
|top_motifs=MYB:2.3740301558;E2F1..5:2.36094457063;PBX1:2.05434538639;POU2F1..3:1.97421656268;NKX2-1,4:1.64368936566;RXR{A,B,G}_{NR1H2,PPAR}dimers:1.58651212195;NFY{A,B,C}:1.55831472998;FOX{I1,J2}:1.50655751035;ZNF143:1.44027475523;BREu{core}:1.38135531735;YY1:1.26383446033;FOXA2:1.23329866945;PDX1:1.21326224764;IKZF2:1.20590515488;HES1:1.1920672689;PAX4:1.08948612389;TFDP1:1.06787392024;PITX1..3:1.05264275582;SOX{8,9,10}:1.01351160331;NRF1:0.966051750502;GFI1:0.948218905844;ELF1,2,4:0.93138890711;ARNT_ARNT2_BHLHB2_MAX_MYC_USF1:0.92348466872;DMAP1_NCOR{1,2}_SMARC:0.893218993955;CDX1,2,4:0.843311731198;BPTF:0.830578341487;POU5F1:0.824008145247;RBPJ:0.772365871375;AR:0.751966436116;NKX2-2,8:0.748997414462;PAX8:0.676738720061;CUX2:0.65896744658;PAX3,7:0.6344908983;ELK1,4_GABP{A,B1}:0.614475414559;OCT4_SOX2{dimer}:0.612430813613;SOX17:0.604648401693;GATA6:0.582600860469;STAT5{A,B}:0.569379045636;NR5A1,2:0.493891426596;NKX6-1,2:0.49225779239;NANOG{mouse}:0.474192091791;T:0.461934695089;SOX5:0.461895513946;FOX{F1,F2,J1}:0.456434100938;IRF1,2:0.451966330671;HAND1,2:0.447745317418;TGIF1:0.44672839648;FOXP1:0.445088202068;EVI1:0.434549449487;NKX2-3_NKX2-5:0.424622996082;NANOG:0.42306519119;TEF:0.415251170846;TOPORS:0.371953239288;FOXP3:0.371432137822;AIRE:0.363640229116;VSX1,2:0.360971578091;SPI1:0.34776200771;ATF5_CREB3:0.341259582187;RUNX1..3:0.335872927972;ALX1:0.295979990903;MYBL2:0.248259805257;FOXQ1:0.230207799879;HOX{A6,A7,B6,B7}:0.225996087356;SPIB:0.215182890144;AHR_ARNT_ARNT2:0.210097584086;PAX6:0.205638178938;ARID5B:0.175830571678;PRRX1,2:0.1704764011;RORA:0.16800796848;DBP:0.162677446647;SOX2:0.154107114997;HOX{A4,D4}:0.145906862118;FOXM1:0.137188324278;CRX:0.123339748555;LMO2:0.117792158655;bHLH_family:0.0980066343576;ZBTB16:0.0959938438806;POU1F1:0.0937163505754;HOX{A5,B5}:0.0718504402029;CREB1:0.0610669556655;FOXN1:0.0583105876738;HNF4A_NR2F1,2:0.0074477707091;MEF2{A,B,C,D}:0.00623854607708;GATA4:0.00147361270686;RXRA_VDR{dimer}:-0.0414687716706;ADNP_IRX_SIX_ZHX:-0.0438190852678;ZEB1:-0.0440427056528;ZNF384:-0.0728980417528;EN1,2:-0.079380986762;ETS1,2:-0.0927958406298;PAX2:-0.112138034747;SNAI1..3:-0.132324546689;NFIL3:-0.137893173962;POU6F1:-0.157488045419;CDC5L:-0.15769804999;PPARG:-0.161543979188;POU3F1..4:-0.161806198959;MTF1:-0.164528232196;KLF4:-0.167643532721;STAT1,3:-0.192647927252;HNF1A:-0.21053893276;FOXD3:-0.216782490821;SMAD1..7,9:-0.22575387517;NFKB1_REL_RELA:-0.255038216698;ZIC1..3:-0.260070567565;LEF1_TCF7_TCF7L1,2:-0.289389339893;FOXO1,3,4:-0.295818393767;HOXA9_MEIS1:-0.296416280875;LHX3,4:-0.308841557517;NKX3-2:-0.35355388743;MYOD1:-0.360356483718;IRF7:-0.369466542393;ZFP161:-0.382980552118;PAX1,9:-0.391099071957;HBP1_HMGB_SSRP1_UBTF:-0.39624811555;HIF1A:-0.397614255609;PRDM1:-0.397900593834;ATF4:-0.426741643632;NFIX:-0.430734224358;NHLH1,2:-0.46280613581;NR1H4:-0.474624496583;ESR1:-0.486023258822;RXR{A,B,G}:-0.492431231666;RFX1:-0.49468123619;FOXL1:-0.496438986025;GFI1B:-0.501958560079;ZNF238:-0.502798165233;TAL1_TCF{3,4,12}:-0.519400794337;ONECUT1,2:-0.527797270682;UFEwm:-0.540902712291;CEBPA,B_DDIT3:-0.542892542794;RFX2..5_RFXANK_RFXAP:-0.545442308998;FOSL2:-0.576873559625;NR6A1:-0.582650359013;RREB1:-0.587778339862;ZNF423:-0.596665897446;FOS_FOS{B,L1}_JUN{B,D}:-0.61972573737;MTE{core}:-0.637136512049;SREBF1,2:-0.63860574273;XBP1:-0.64675009218;TLX2:-0.651925483711;BACH2:-0.667808326277;NFE2:-0.704208170024;TP53:-0.705809386871;ESRRA:-0.713645283205;MZF1:-0.744650310878;GCM1,2:-0.766082427985;HLF:-0.787293798528;NR3C1:-0.792015261077;HSF1,2:-0.819809676444;PATZ1:-0.833939324637;MED-1{core}:-0.89842069169;IKZF1:-0.910793013336;REST:-0.937535534958;MYFfamily:-0.937918246551;SPZ1:-0.947976944681;NFATC1..3:-0.958324806063;GZF1:-0.958898602175;FOX{D1,D2}:-0.97818775494;GTF2A1,2:-0.986867128399;JUN:-0.987123500162;HIC1:-1.02636777771;NFE2L1:-1.02683950659;ALX4:-1.06462961433;PAX5:-1.09113311374;NFE2L2:-1.12803321561;NKX3-1:-1.13043357946;ZNF148:-1.15876644699;HMX1:-1.17908657506;EBF1:-1.18866595898;HMGA1,2:-1.20098603676;GTF2I:-1.20891005899;EP300:-1.20949219184;ATF2:-1.2281895977;XCPE1{core}:-1.23603763616;ZBTB6:-1.25606223767;TBP:-1.27420825653;MAZ:-1.33744579626;STAT2,4,6:-1.36660831676;TEAD1:-1.37184298683;ATF6:-1.38168518163;MAFB:-1.45026821524;SRF:-1.45285840746;TFAP2B:-1.5060466601;EGR1..3:-1.5237666216;TLX1..3_NFIC{dimer}:-1.54185252522;GLI1..3:-1.54749772348;TFAP2{A,C}:-1.54998712769;SP1:-1.62286192005;TFAP4:-1.67115940286;TBX4,5:-1.88677917039;TFCP2:-2.10491771066 | |||
|xref= | |||
|zenbu_report=https://fantom.gsc.riken.jp/zenbu/reports/#miRNA_expression_atlas_human;search_select_hide=table111:FF:10534-107G3;search_select_hide=table117:FF:10534-107G3 | |||
}} | }} |
Latest revision as of 14:28, 3 June 2020
Name: | acute lymphoblastic leukemia (B-ALL) cell line:NALM-6 |
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Species: | Human (Homo sapiens) |
Library ID: | CNhs11282 |
Sample type: | cell lines |
Genomic View: | UCSC |
RefEX: | Specific genes |
CAGEd-oPOSSUM: | link |
ZENBU report : | link |
Additional information | ||||||||||||||||||||||||||||
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Sample information
RNA information
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CAGE Accession numbers | ||||||||||||||||||||||||||||||||||||||||||||||
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Download raw sequence, BAM & CTSS | ||||||||||||||
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Relative expression to median (log10)
Transcription factors with enriched expression in this sampleRanked list of transcription factor promoter expression in this sample relative to the median expression in the FANTOM5 collection is shown. Value is log10 transformed.
Co-expression clusters with enriched expression in this sampleRanked list of co-expression cluster expression in this sample relative to the median expression in the FANTOM5 collection is shown. Value is log10 transformed. <br>Analyst:NA <br><br>link to dataset.<br>data
Repeat families with enriched expression in this sample<b>Summary:</b>Ranked list of repeat family expression in this sample relative tothe median expression in the FANTOM5 collection is shown. Value is log10transformed.<br><b>Analyst:</b>NA<br><br>link to dataset.<br>data
TFBS(DNA)motifs over-represented in proximal region of promoters active in this sample
JASPAR motifs<b>Summary:</b>Association of JASPAR motif to the promoter expression in thissample. Pearson's correlation between the number of TFBSs estimated byusing the position-weight matrix for each promoter and its expression isexpressed as Z-score by taking the ones based on random position-weightmatrix, and the tail probability of the normal distribution correspondingto the Z-score is taken as the resulting P-value. Lower P-value indicatesmore (non-random) association of the motif to promoter expression<br><b>Analyst:</b> Michiel de Hoon <br><br><br>link to dataset.<br>data
library id: CNhs11282
FANTOM5 phase1 novel unique motifs<b>Summary:</b>Association of the 169 novel and unique motifs discovered in FANTOM5 phase1 in this sample. Among the de-novo motifs discovered by DMF, HOMER,ChIPMunk, and ScanAll, only novel motifs are selected after comparison with known motif sets, and their clustering based on MACRO-APE resulted in169 novel and unique motifs. Their association to the promoter expression is evaluated in the same way to the JASPAR motif above<br><b>Analyst:</b> Michiel de Hoon <br><br><br>link to dataset.<br>data
library id: CNhs11282
Novel motif | Logo | P-value |
---|---|---|
1 | 1 | 0.0536 |
10 | 10 | 0.0321 |
100 | 100 | 0.115 |
101 | 101 | 0.602 |
102 | 102 | 0.966 |
103 | 103 | 0.581 |
104 | 104 | 0.769 |
105 | 105 | 0.871 |
106 | 106 | 0.595 |
107 | 107 | 0.172 |
108 | 108 | 0.375 |
109 | 109 | 0.172 |
11 | 11 | 0.168 |
110 | 110 | 0.231 |
111 | 111 | 0.192 |
112 | 112 | 0.35 |
113 | 113 | 0.648 |
114 | 114 | 0.801 |
115 | 115 | 0.53 |
116 | 116 | 0.895 |
117 | 117 | 0.0366 |
118 | 118 | 0.494 |
119 | 119 | 0.913 |
12 | 12 | 0.372 |
120 | 120 | 0.395 |
121 | 121 | 0.957 |
122 | 122 | 0.932 |
123 | 123 | 0.00638 |
124 | 124 | 0.136 |
125 | 125 | 0.306 |
126 | 126 | 0.834 |
127 | 127 | 0.159 |
128 | 128 | 0.314 |
129 | 129 | 0.597 |
13 | 13 | 0.0415 |
130 | 130 | 0.184 |
131 | 131 | 0.0535 |
132 | 132 | 0.503 |
133 | 133 | 0.319 |
134 | 134 | 0.981 |
135 | 135 | 0.212 |
136 | 136 | 0.438 |
137 | 137 | 0.541 |
138 | 138 | 0.227 |
139 | 139 | 0.273 |
14 | 14 | 0.897 |
140 | 140 | 0.742 |
141 | 141 | 0.117 |
142 | 142 | 0.442 |
143 | 143 | 0.709 |
144 | 144 | 0.709 |
145 | 145 | 0.733 |
146 | 146 | 0.729 |
147 | 147 | 0.291 |
148 | 148 | 0.425 |
149 | 149 | 0.243 |
15 | 15 | 0.24 |
150 | 150 | 0.54 |
151 | 151 | 0.398 |
152 | 152 | 0.0162 |
153 | 153 | 0.931 |
154 | 154 | 0.656 |
155 | 155 | 0.0102 |
156 | 156 | 0.817 |
157 | 157 | 0.224 |
158 | 158 | 0.202 |
159 | 159 | 0.535 |
16 | 16 | 0.477 |
160 | 160 | 0.327 |
161 | 161 | 0.183 |
162 | 162 | 0.97 |
163 | 163 | 0.911 |
164 | 164 | 0.464 |
165 | 165 | 0.836 |
166 | 166 | 0.371 |
167 | 167 | 0.0365 |
168 | 168 | 0.47 |
169 | 169 | 0.335 |
17 | 17 | 0.532 |
18 | 18 | 0.958 |
19 | 19 | 0.351 |
2 | 2 | 0.127 |
20 | 20 | 0.283 |
21 | 21 | 0.306 |
22 | 22 | 0.52 |
23 | 23 | 0.00989 |
24 | 24 | 0.81 |
25 | 25 | 0.131 |
26 | 26 | 0.0825 |
27 | 27 | 0.838 |
28 | 28 | 0.865 |
29 | 29 | 0.0296 |
3 | 3 | 0.434 |
30 | 30 | 0.0625 |
31 | 31 | 0.607 |
32 | 32 | 0.0125 |
33 | 33 | 0.689 |
34 | 34 | 0.367 |
35 | 35 | 0.158 |
36 | 36 | 0.0431 |
37 | 37 | 0.844 |
38 | 38 | 0.964 |
39 | 39 | 0.101 |
4 | 4 | 0.13 |
40 | 40 | 0.155 |
41 | 41 | 0.792 |
42 | 42 | 0.28 |
43 | 43 | 0.825 |
44 | 44 | 0.51 |
45 | 45 | 0.182 |
46 | 46 | 0.0998 |
47 | 47 | 0.0709 |
48 | 48 | 0.25 |
49 | 49 | 0.197 |
5 | 5 | 0.919 |
50 | 50 | 0.729 |
51 | 51 | 0.907 |
52 | 52 | 0.139 |
53 | 53 | 0.861 |
54 | 54 | 0.504 |
55 | 55 | 0.133 |
56 | 56 | 0.703 |
57 | 57 | 0.0907 |
58 | 58 | 0.57 |
59 | 59 | 0.488 |
6 | 6 | 0.987 |
60 | 60 | 0.491 |
61 | 61 | 0.0933 |
62 | 62 | 0.499 |
63 | 63 | 0.475 |
64 | 64 | 0.425 |
65 | 65 | 0.279 |
66 | 66 | 0.0133 |
67 | 67 | 0.957 |
68 | 68 | 0.0309 |
69 | 69 | 0.613 |
7 | 7 | 0.149 |
70 | 70 | 0.17 |
71 | 71 | 0.0523 |
72 | 72 | 0.685 |
73 | 73 | 0.18 |
74 | 74 | 0.763 |
75 | 75 | 0.0311 |
76 | 76 | 0.408 |
77 | 77 | 0.367 |
78 | 78 | 0.0601 |
79 | 79 | 0.173 |
8 | 8 | 0.328 |
80 | 80 | 0.716 |
81 | 81 | 0.499 |
82 | 82 | 0.402 |
83 | 83 | 0.59 |
84 | 84 | 0.459 |
85 | 85 | 0.0127 |
86 | 86 | 0.523 |
87 | 87 | 0.604 |
88 | 88 | 0.629 |
89 | 89 | 0.358 |
9 | 9 | 0.379 |
90 | 90 | 0.0231 |
91 | 91 | 0.405 |
92 | 92 | 0.0567 |
93 | 93 | 0.705 |
94 | 94 | 0.525 |
95 | 95 | 0.165 |
96 | 96 | 0.714 |
97 | 97 | 0.359 |
98 | 98 | 0.504 |
99 | 99 | 0.171 |
de novo motifs identified by HOMER in promoters active in this sample<b>Summary:</b>The result of HOMER in this sample is shown.<br><b>Analyst:</b>NA <br>
library id: CNhs11282
FANTOM5 (FF) ontology
Direct parent terms
is_a relathionship
EFO:0002091 biological replicate
FF:0000210 human sample
FF:0103288 NALM-6 cell sample
Ancestor terms (non development)<b>Summary:</b>Connected ontology terms with is_a, part_of or located_in relationship <br><b>Analyst:</b> Hideya Kawaji<br><br>link to source data<br>data
CL: Cell type
0000000 (cell), 0000000 (cell)
0000003 (native cell)
0000988 (hematopoietic cell)
0000548 (animal cell)
0002371 (somatic cell)
0000542 (lymphocyte)
0000219 (motile cell)
0000945 (lymphocyte of B lineage)
0000738 (leukocyte)
0002087 (nongranular leukocyte)
0002242 (nucleate cell)
0000255 (eukaryotic cell)
0000236 (B cell)
0000817 (precursor B cell)
DOID: Disease
4 (disease)
0050686 (organ system cancer)
162 (cancer)
2531 (hematologic cancer)
14566 (disease of cellular proliferation)
0060083 (immune system cancer)
1240 (leukemia)
FF: FANTOM5
0000102 (sample by type)
0000003 (cell line sample)
0000210 (human sample)
0000101 (sample by species)
0000001 (sample)
0100737 (leukemia cell line sample)
0102144 (acute lymphoblastic leukemia cell line sample)
0101035 (hematopoietic cell line sample)
0100741 (lymphocytic leukemia cell line sample)
0100773 (lymphoblastoid cell line sample)
0100739 (lymphoblastic leukemia cell line sample)
0100603 (pre-B acute lymphoblastic leukemia cell line sample)
0103288 (NALM-6 cell sample)
Ancestor terms (development)<b>Summary:</b>Connected ontology terms with develops_from, derives_from or preceded_by relationship <br><b>Analyst:</b> Hideya Kawaji <br><br>link to source data<br>data
CL:0000134 (mesenchymal cell)
CL:0000051 (common lymphoid progenitor)