Coexpression cluster:C2

Full id: C2_Eosinophils_Neutrophils_CD14_Whole_Basophils_Peripheral_Mast

Phase1 CAGE Peaks

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Hg19::chr10:104154066..104154118,-	p@chr10:104154066..104154118 -
Hg19::chr10:104154246..104154347,+	p3@NFKB2
Hg19::chr10:104154415..104154434,+	p5@NFKB2
Hg19::chr10:104154935..104154948,-	p@chr10:104154935..104154948 -
Hg19::chr10:104154951..104154972,-	p@chr10:104154951..104154972 -
Hg19::chr10:104155012..104155023,-	p@chr10:104155012..104155023 -
Hg19::chr10:104155480..104155534,+	p2@NFKB2
Hg19::chr10:104402213..104402251,+	p@chr10:104402213..104402251 +
Hg19::chr10:104405799..104405813,-	p@chr10:104405799..104405813 -
Hg19::chr10:106082606..106082621,+	p@chr10:106082606..106082621 +
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Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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p.value	FDR	nGenes	nPathway	Name
0.000970340307810119	0.0093064456794516	4	22	Glycosaminoglycan biosynthesis - chondroitin sulfate (KEGG):00532
4.65243803465159e-05	0.000718291042910843	17	268	MAPK signaling pathway (KEGG):04010
0.0012974158667898	0.0117323463382564	14	265	Cytokine-cytokine receptor interaction (KEGG):04060
1.54556235118358e-08	9.78340968299204e-07	19	189	Chemokine signaling pathway (KEGG):04062
7.05806799987445e-05	0.000971251531287072	9	86	Apoptosis (KEGG):04210
0.00560489145848038	0.0385640901436748	8	130	Axon guidance (KEGG):04360
9.53279137564679e-09	7.54282117598052e-07	16	128	Osteoclast differentiation (KEGG):04380
0.00297793893602976	0.0227112692350222	6	69	Complement and coagulation cascades (KEGG):04610
0.00124408104351538	0.0114130913122498	8	102	Toll-like receptor signaling pathway (KEGG):04620
3.23218703486014e-07	1.13665244059248e-05	10	59	NOD-like receptor signaling pathway (KEGG):04621
2.16010784423818e-07	8.0432250906045e-06	11	71	RIG-I-like receptor signaling pathway (KEGG):04622
0.00056399576137951	0.00575821478956822	10	137	Natural killer cell mediated cytotoxicity (KEGG):04650
2.41260800961241e-06	6.36325362535272e-05	12	108	T cell receptor signaling pathway (KEGG):04660
3.17485654046503e-06	8.03873676045745e-05	10	75	B cell receptor signaling pathway (KEGG):04662
5.12612718515944e-06	0.000111890983041584	10	79	Fc epsilon RI signaling pathway (KEGG):04664
2.67933247547575e-05	0.000472945725325111	10	95	Fc gamma R-mediated phagocytosis (KEGG):04666
0.000722949550586345	0.00715042289876807	9	117	Leukocyte transendothelial migration (KEGG):04670
2.34935311162699e-06	6.36325362535272e-05	13	127	Neurotrophin signaling pathway (KEGG):04722
0.00493451687970843	0.0349360353873404	7	101	GnRH signaling pathway (KEGG):04912
0.00297793893602976	0.0227112692350222	6	69	Adipocytokine signaling pathway (KEGG):04920
0.000751793538402944	0.00732131245860098	6	53	Amyotrophic lateral sclerosis (ALS) (KEGG):05014
7.70966769921315e-05	0.00103457480411096	8	68	Epithelial cell signaling in Helicobacter pylori infection (KEGG):05120
4.82141295271982e-06	0.000108998371395416	9	62	Shigellosis (KEGG):05131
3.05774469648286e-08	1.75959308443059e-06	12	73	Leishmaniasis (KEGG):05140
5.86750511288341e-05	0.000844120621921636	10	104	Chagas disease (American trypanosomiasis) (KEGG):05142
0.000610564574659582	0.00613472025015104	6	51	Malaria (KEGG):05144
0.000101033887833748	0.00127908901997525	11	133	Toxoplasmosis (KEGG):05145
0.00586709168027053	0.0399340756302284	5	56	Staphylococcus aureus infection (KEGG):05150
1.37107190052063e-09	1.44648085504927e-07	20	182	Tuberculosis (KEGG):05152
0.00187990545709692	0.0163010980046897	9	134	Measles (KEGG):05162
7.84511699799779e-05	0.00103457480411096	13	176	Influenza A (KEGG):05164
0.00135386157892107	0.0120703433726344	16	327	Pathways in cancer (KEGG):05200
0.00394772178271287	0.0287230791776695	6	73	Chronic myeloid leukemia (KEGG):05220
0.00294173554509008	0.0227112692350222	7	92	Rheumatoid arthritis (KEGG):05323
1.59686223955026e-07	7.22009855453797e-06	11	69	IL-5 Signaling Pathway (Wikipathways):WP127
0.0028095001695359	0.0225282609957947	8	116	Androgen Receptor Signaling Pathway (Wikipathways):WP138
3.47523886287376e-08	1.83318850016591e-06	16	140	Regulation of toll-like receptor signaling pathway (Wikipathways):WP1449
4.38535543828732e-05	0.000693982498108968	9	81	Apoptosis Modulation and Signaling (Wikipathways):WP1772
0.00166512315533981	0.0146392077406958	3	12	IL-1 Signaling Pathway (Wikipathways):WP195
0.00204013856806717	0.017218769514487	5	44	IL-7 Signaling Pathway (Wikipathways):WP205
1.52141726275597e-10	1.92611425464906e-08	20	161	B Cell Receptor Signaling Pathway (Wikipathways):WP23
4.05992976265879e-07	1.35259765250685e-05	17	188	TNF-alpha/NF-kB Signaling Pathway (Wikipathways):WP231
8.24393176446049e-07	2.48495657471595e-05	14	135	Adipogenesis (Wikipathways):WP236
6.43535237978491e-05	0.000905239568089744	9	85	Apoptosis (Wikipathways):WP254
4.96725732573373e-05	0.000748636639807012	10	102	IL-3 Signaling Pathway (Wikipathways):WP286
0.00496720882284461	0.0349360353873404	9	155	Myometrial Relaxation and Contraction Pathways (Wikipathways):WP289
0.00297793893602976	0.0227112692350222	6	69	Kit Receptor Signaling Pathway (Wikipathways):WP304
0.00117672405999836	0.0109539166173377	5	39	FAS pathway and Stress induction of HSP regulation (Wikipathways):WP314
3.83850065111146e-05	0.000656694841122583	10	99	IL-6 Signaling Pathway (Wikipathways):WP364
7.18490455338091e-06	0.000142126393196566	14	162	MAPK signaling pathway (Wikipathways):WP382
0.00506296573549221	0.0352182122040282	4	34	p38 MAPK Signaling Pathway (Wikipathways):WP400
0.00281158391574689	0.0225282609957947	4	29	MAPK Cascade (Wikipathways):WP422
2.01207644187443e-07	7.9602774231657e-06	17	179	EGFR1 Signaling Pathway (Wikipathways):WP437
0.00306696130254474	0.0231117441013193	13	260	GPCRs, Class A Rhodopsin-like (Wikipathways):WP455
7.18490455338091e-06	0.000142126393196566	14	162	Insulin Signaling (Wikipathways):WP481
5.04216976617355e-07	1.59584673099393e-05	11	77	IL-2 Signaling Pathway (Wikipathways):WP49
0.0038389684395675	0.0282565932819328	9	149	Calcium Regulation in the Cardiac Cell (Wikipathways):WP536
4.18748060656859e-05	0.000693982498108968	10	100	Senescence and Autophagy (Wikipathways):WP615
3.74521509285015e-11	5.92680288443537e-09	19	133	T Cell Receptor Signaling Pathway (Wikipathways):WP69
0.00454012897115326	0.0326579731675002	4	33	Serotonin HTR1 Group and FOS Pathway (Wikipathways):WP722
0.000262964690315585	0.00286994222361665	9	102	Toll-like receptor signaling pathway (Wikipathways):WP75
3.10611034979892e-16	1.96616785142271e-13	45	511	Signaling in Immune system (Reactome):REACT_6900
1.75767438366783e-07	7.41738589907823e-06	19	220	Signalling by NGF (Reactome):REACT_11061
3.66610659740041e-09	3.3152078230778e-07	32	466	Hemostasis (Reactome):REACT_604
0.00734271248841417	0.0489256526859597	13	289	Metabolism of lipids and lipoproteins (Reactome):REACT_22258
0.00197047930519973	0.0168555864890734	33	932	Signaling by GPCR (Reactome):REACT_14797
0.00351131175466853	0.0261489451847668	9	147	Apoptosis (Reactome):REACT_578
7.94824055889127e-06	0.000152461705266005	12	121	Signaling by Rho GTPases (Reactome):REACT_11044
0.000346352469068364	0.00371595106644533	6	46	Interactions of the immunoglobulin superfamily (IgSF) member proteins (Reactome):REACT_23853
6.59401064705715e-08	3.2107759535286e-06	42	816	TGF beta receptor up reg. targets (Netpath):NetPath_7
0.000382646869233026	0.00403692447040842	30	740	TGF beta receptor down reg. targets (Netpath):NetPath_7
3.85687004363391e-06	9.04221754674173e-05	35	728	TNF alpha/NF-kB up reg. targets (Netpath):NetPath_9
0.000142565457657669	0.00173546028264047	12	162	TNF alpha/NF-kB down reg. targets (Netpath):NetPath_9
0.0065913605218177	0.0443865022373469	9	162	AR down reg. targets (Netpath):NetPath_2
0.000197233912307263	0.00222944761590174	15	246	B Cell Receptor up reg. targets (Netpath):NetPath_12
2.68973872222812e-05	0.000472945725325111	14	182	B Cell Receptor down reg. targets (Netpath):NetPath_12
0.00276619478071525	0.0225282609957947	6	68	T Cell Receptor down reg. targets (Netpath):NetPath_11
9.36954883482032e-05	0.00121039273723291	12	155	IL-1 up reg. targets (Netpath):NetPath_13
3.66152701679595e-13	7.72582200543945e-11	37	433	IL-2 up reg. targets (Netpath):NetPath_14
1.380321598015e-08	9.70826190603881e-07	24	295	IL-2 down reg. targets (Netpath):NetPath_14
0.00015754639755304	0.00188163905002027	6	40	IL-3 up reg. targets (Netpath):NetPath_15
0.000178526829517874	0.00205468151063299	14	217	IL-4 up reg. targets (Netpath):NetPath_16
1.66271212006162e-05	0.000309557874117355	10	90	IL-4 down reg. targets (Netpath):NetPath_16
3.51478877303396e-14	1.11243064666525e-11	22	131	IL-5 up reg. targets (Netpath):NetPath_17
5.75159782697013e-06	0.00012135871414907	10	80	IL-6 up reg. targets (Netpath):NetPath_18
0.000164491806646958	0.00192820951125045	7	57	IL-7 up reg. targets (Netpath):NetPath_19
0.00267179014727005	0.0222531995160782	3	14	IL-7 down reg. targets (Netpath):NetPath_19
0.000241983421003513	0.00268728957009164	5	28	{C5,29} (Static Module):NA
0.00117672405999836	0.0109539166173377	5	39	{CASP3,41} (Static Module):NA
4.28872827565316e-05	0.000693982498108968	22	406	{GRB2,414} (Static Module):NA
5.64386248953368e-05	0.000830829059505772	5	21	{HRAS,27} (Static Module):NA
9.22054542637176e-07	2.65300238858788e-05	13	117	{MAPK14,123} (Static Module):NA
0.000536858715792336	0.00557100929666473	5	33	{NFKB1,33} (Static Module):NA
3.62352483161167e-06	8.82188930157764e-05	13	132	{RAC1,133} (Static Module):NA
0.00013081130018214	0.00162359907873127	7	55	{TRAF6,55} (Static Module):NA

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0005515	protein binding	2.74509374464167e-32
GO:0007243	protein kinase cascade	2.39783232829899e-28
GO:0009611	response to wounding	5.51958463244479e-26
GO:0006952	defense response	5.51958463244479e-26
GO:0009605	response to external stimulus	5.51958463244479e-26
GO:0006915	apoptosis	1.17843262725126e-22
GO:0012501	programmed cell death	2.11084753531072e-22
GO:0007242	intracellular signaling cascade	5.27788377827644e-22
GO:0008219	cell death	8.20352805547855e-22
GO:0016265	death	8.20352805547855e-22
GO:0007165	signal transduction	4.30487153438062e-20
GO:0006950	response to stress	1.380317756955e-19
GO:0048519	negative regulation of biological process	8.19828682175533e-19
GO:0007154	cell communication	7.3823854543091e-18
GO:0044464	cell part	1.85889022129786e-17
GO:0048523	negative regulation of cellular process	3.05233528151365e-17
GO:0005737	cytoplasm	2.27341334624827e-15
GO:0048468	cell development	2.27341334624827e-15
GO:0065007	biological regulation	2.27341334624827e-15
GO:0044424	intracellular part	3.22784694763059e-15
GO:0006954	inflammatory response	8.51939799247491e-15
GO:0042981	regulation of apoptosis	4.00924270229385e-14
GO:0043067	regulation of programmed cell death	6.96819389499938e-14
GO:0050789	regulation of biological process	4.88089431682367e-13
GO:0005622	intracellular	6.98197252593015e-13
GO:0065009	regulation of a molecular function	1.34127106441045e-12
GO:0002376	immune system process	2.85711686506574e-12
GO:0048518	positive regulation of biological process	4.65452164150995e-12
GO:0048869	cellular developmental process	7.53085136080446e-12
GO:0030154	cell differentiation	7.53085136080446e-12
GO:0032502	developmental process	1.42944481668252e-11
GO:0043227	membrane-bound organelle	6.62026845184887e-11
GO:0043231	intracellular membrane-bound organelle	1.30194602817798e-10
GO:0006955	immune response	3.39802702451023e-10
GO:0004674	protein serine/threonine kinase activity	8.69936814223141e-10
GO:0016043	cellular component organization and biogenesis	1.73376669626815e-09
GO:0050794	regulation of cellular process	1.82680086375628e-09
GO:0001816	cytokine production	7.49599132013846e-09
GO:0045087	innate immune response	8.2988231132907e-09
GO:0043226	organelle	8.90891577650755e-09
GO:0043066	negative regulation of apoptosis	1.1348732510678e-08
GO:0006366	transcription from RNA polymerase II promoter	1.14571224699502e-08
GO:0043069	negative regulation of programmed cell death	1.36712346560301e-08
GO:0043229	intracellular organelle	1.44804535625172e-08
GO:0042221	response to chemical stimulus	3.17902881772514e-08
GO:0006464	protein modification process	3.56527372285036e-08
GO:0048522	positive regulation of cellular process	3.56527372285036e-08
GO:0043687	post-translational protein modification	3.59860419209216e-08
GO:0030036	actin cytoskeleton organization and biogenesis	4.21987174972899e-08
GO:0002250	adaptive immune response	5.25485933906375e-08
GO:0002460	adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	5.25485933906375e-08
GO:0045321	leukocyte activation	7.13617488655799e-08
GO:0030029	actin filament-based process	9.51583661415444e-08
GO:0001775	cell activation	1.00470138746343e-07
GO:0000074	regulation of progression through cell cycle	1.22075889019874e-07
GO:0006512	ubiquitin cycle	1.53729399747906e-07
GO:0051726	regulation of cell cycle	2.00933992315588e-07
GO:0008047	enzyme activator activity	2.22024391949892e-07
GO:0030695	GTPase regulator activity	2.56329182083249e-07
GO:0043412	biopolymer modification	2.81440393036738e-07
GO:0048856	anatomical structure development	2.81440393036738e-07
GO:0045786	negative regulation of progression through cell cycle	2.81440393036738e-07
GO:0005634	nucleus	3.02101488965551e-07
GO:0009607	response to biotic stimulus	4.77729790936277e-07
GO:0065008	regulation of biological quality	6.79608815123395e-07
GO:0009966	regulation of signal transduction	7.72012816372328e-07
GO:0050776	regulation of immune response	7.83195376909534e-07
GO:0002682	regulation of immune system process	9.71854813245851e-07
GO:0016020	membrane	1.43394114318094e-06
GO:0002467	germinal center formation	1.54806276020501e-06
GO:0005886	plasma membrane	2.36025001158794e-06
GO:0019538	protein metabolic process	2.78360310437701e-06
GO:0050790	regulation of catalytic activity	2.93575361530114e-06
GO:0008134	transcription factor binding	3.44332806529627e-06
GO:0008104	protein localization	3.72323964797527e-06
GO:0008283	cell proliferation	9.51630512223467e-06
GO:0048731	system development	9.71205435558929e-06
GO:0044260	cellular macromolecule metabolic process	1.25379744376044e-05
GO:0051240	positive regulation of multicellular organismal process	1.28994795855984e-05
GO:0051707	response to other organism	1.31834484433513e-05
GO:0042226	interleukin-6 biosynthetic process	1.40637468618215e-05
GO:0050778	positive regulation of immune response	1.40637468618215e-05
GO:0051246	regulation of protein metabolic process	1.42290576868954e-05
GO:0002684	positive regulation of immune system process	1.53342023952661e-05
GO:0045184	establishment of protein localization	1.54201292486783e-05
GO:0051704	multi-organism process	1.64486562329149e-05
GO:0009893	positive regulation of metabolic process	1.65703289280465e-05
GO:0033036	macromolecule localization	1.8297649351406e-05
GO:0016064	immunoglobulin mediated immune response	1.93857933250456e-05
GO:0043170	macromolecule metabolic process	1.93857933250456e-05
GO:0019222	regulation of metabolic process	2.07373405119266e-05
GO:0019724	B cell mediated immunity	2.19225889979397e-05
GO:0051239	regulation of multicellular organismal process	2.19225889979397e-05
GO:0002253	activation of immune response	2.42472631391152e-05
GO:0031325	positive regulation of cellular metabolic process	2.52028844850619e-05
GO:0007249	I-kappaB kinase/NF-kappaB cascade	2.6113260313665e-05
GO:0016044	membrane organization and biogenesis	2.96291024406554e-05
GO:0007275	multicellular organismal development	3.28162269880261e-05
GO:0044238	primary metabolic process	3.30120973243395e-05
GO:0006468	protein amino acid phosphorylation	3.43684116914692e-05
GO:0016310	phosphorylation	3.61440829059196e-05
GO:0044425	membrane part	3.8344408130855e-05
GO:0032635	interleukin-6 production	4.06180374127075e-05
GO:0044267	cellular protein metabolic process	5.12387297454074e-05
GO:0019992	diacylglycerol binding	5.21396798691282e-05
GO:0045859	regulation of protein kinase activity	5.78441588151654e-05
GO:0042035	regulation of cytokine biosynthetic process	5.82866992933787e-05
GO:0005096	GTPase activator activity	6.62777686415129e-05
GO:0005887	integral to plasma membrane	6.62777686415129e-05
GO:0043549	regulation of kinase activity	7.20219961431365e-05
GO:0004672	protein kinase activity	8.20552133082211e-05
GO:0006357	regulation of transcription from RNA polymerase II promoter	8.62560274787019e-05
GO:0051338	regulation of transferase activity	8.99759037782292e-05
GO:0009889	regulation of biosynthetic process	9.19901748557854e-05
GO:0043122	regulation of I-kappaB kinase/NF-kappaB cascade	9.19901748557854e-05
GO:0031226	intrinsic to plasma membrane	9.2052245191411e-05
GO:0016773	phosphotransferase activity, alcohol group as acceptor	0.000106845638766849
GO:0042089	cytokine biosynthetic process	0.000123205026030262
GO:0043065	positive regulation of apoptosis	0.000131717537270196
GO:0044237	cellular metabolic process	0.000134442765175178
GO:0042107	cytokine metabolic process	0.000134442765175178
GO:0006793	phosphorus metabolic process	0.000134968609987214
GO:0006796	phosphate metabolic process	0.000134968609987214
GO:0009653	anatomical structure morphogenesis	0.000135832433009582
GO:0043068	positive regulation of programmed cell death	0.000137682657937617
GO:0010324	membrane invagination	0.000142524951185541
GO:0006897	endocytosis	0.000142524951185541
GO:0048513	organ development	0.000148748215308577
GO:0006916	anti-apoptosis	0.000158600669124775
GO:0002260	lymphocyte homeostasis	0.000161971248557648
GO:0045408	regulation of interleukin-6 biosynthetic process	0.000161971248557648
GO:0007049	cell cycle	0.000168455338725797
GO:0005764	lysosome	0.000169040310560079
GO:0000323	lytic vacuole	0.000175879890986852
GO:0005773	vacuole	0.000175879890986852
GO:0000902	cell morphogenesis	0.000175879890986852
GO:0032989	cellular structure morphogenesis	0.000175879890986852
GO:0043283	biopolymer metabolic process	0.000175879890986852
GO:0051090	regulation of transcription factor activity	0.000178779809974693
GO:0002449	lymphocyte mediated immunity	0.000178779809974693
GO:0006606	protein import into nucleus	0.000199194718536622
GO:0004871	signal transducer activity	0.000199194718536622
GO:0060089	molecular transducer activity	0.000199194718536622
GO:0032501	multicellular organismal process	0.000199194718536622
GO:0031323	regulation of cellular metabolic process	0.000199194718536622
GO:0002224	toll-like receptor signaling pathway	0.000199194718536622
GO:0002221	pattern recognition receptor signaling pathway	0.000199194718536622
GO:0001782	B cell homeostasis	0.000199194718536622
GO:0019899	enzyme binding	0.000209670156622561
GO:0044459	plasma membrane part	0.000220746902180751
GO:0033157	regulation of intracellular protein transport	0.000220746902180751
GO:0042306	regulation of protein import into nucleus	0.000220746902180751
GO:0051170	nuclear import	0.000220746902180751
GO:0042110	T cell activation	0.000220746902180751
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade	0.000238168079240672
GO:0000267	cell fraction	0.000260244692140042
GO:0006417	regulation of translation	0.000287464837479106
GO:0002443	leukocyte mediated immunity	0.000287464837479106
GO:0046649	lymphocyte activation	0.000289090338790022
GO:0032386	regulation of intracellular transport	0.000406928694899644
GO:0001817	regulation of cytokine production	0.000406928694899644
GO:0051235	maintenance of localization	0.000406928694899644
GO:0042108	positive regulation of cytokine biosynthetic process	0.000406928694899644
GO:0032640	tumor necrosis factor production	0.000425388916911271
GO:0042113	B cell activation	0.000436519458042769
GO:0002218	activation of innate immune response	0.000436519458042769
GO:0002758	innate immune response-activating signal transduction	0.000436519458042769
GO:0045185	maintenance of protein localization	0.000477595373883177
GO:0051247	positive regulation of protein metabolic process	0.000504554501252737
GO:0002252	immune effector process	0.000505616072729594
GO:0042127	regulation of cell proliferation	0.00053030865526599
GO:0009595	detection of biotic stimulus	0.000558035046025798
GO:0001776	leukocyte homeostasis	0.000558035046025798
GO:0002274	myeloid leukocyte activation	0.000559144771840552
GO:0031326	regulation of cellular biosynthetic process	0.000561209676122636
GO:0003712	transcription cofactor activity	0.000615689089228685
GO:0051223	regulation of protein transport	0.00066067970855473
GO:0010468	regulation of gene expression	0.00066067970855473
GO:0048534	hemopoietic or lymphoid organ development	0.00070671054586468
GO:0048872	homeostasis of number of cells	0.00072291227930451
GO:0016021	integral to membrane	0.000739522995320113
GO:0046822	regulation of nucleocytoplasmic transport	0.000767310905370015
GO:0005085	guanyl-nucleotide exchange factor activity	0.000767310905370015
GO:0007010	cytoskeleton organization and biogenesis	0.000809856938063797
GO:0005057	receptor signaling protein activity	0.000840895505733988
GO:0043405	regulation of MAP kinase activity	0.000876264081011511
GO:0002455	humoral immune response mediated by circulating immunoglobulin	0.000885788773056769
GO:0031224	intrinsic to membrane	0.000918567875049023
GO:0015031	protein transport	0.000928566903816074
GO:0006917	induction of apoptosis	0.000951574335387679
GO:0012502	induction of programmed cell death	0.000990062321748732
GO:0017038	protein import	0.0010079216383447
GO:0016564	transcription repressor activity	0.00101970487408215
GO:0005794	Golgi apparatus	0.00101970487408215
GO:0002520	immune system development	0.00102457075488619
GO:0009967	positive regulation of signal transduction	0.00111553253922731
GO:0002757	immune response-activating signal transduction	0.00115990563039756
GO:0002764	immune response-regulating signal transduction	0.00134385879823729
GO:0043085	positive regulation of catalytic activity	0.0013860620179607
GO:0050871	positive regulation of B cell activation	0.0013999877127062
GO:0008289	lipid binding	0.0013999877127062
GO:0006350	transcription	0.0013999877127062
GO:0045727	positive regulation of translation	0.00143220607608904
GO:0007050	cell cycle arrest	0.00143220607608904
GO:0031324	negative regulation of cellular metabolic process	0.00149477289682098
GO:0008285	negative regulation of cell proliferation	0.00154075920568224
GO:0022402	cell cycle process	0.00155147037861787
GO:0030099	myeloid cell differentiation	0.00157379104853228
GO:0030097	hemopoiesis	0.0015904493236356
GO:0006928	cell motility	0.0015904493236356
GO:0051674	localization of cell	0.0015904493236356
GO:0009620	response to fungus	0.0016638172949723
GO:0019864	IgG binding	0.00182892753792743
GO:0042534	regulation of tumor necrosis factor biosynthetic process	0.00182892753792743
GO:0042533	tumor necrosis factor biosynthetic process	0.00182892753792743
GO:0016045	detection of bacterium	0.00182892753792743
GO:0009617	response to bacterium	0.00188565647270838
GO:0050663	cytokine secretion	0.00199921374353912
GO:0009306	protein secretion	0.00200656163015759
GO:0040008	regulation of growth	0.0021781854385877
GO:0004438	phosphatidylinositol-3-phosphatase activity	0.00222333512173573
GO:0033256	I-kappaB/NF-kappaB complex	0.00222333512173573
GO:0051896	regulation of protein kinase B signaling cascade	0.00222333512173573
GO:0002634	regulation of germinal center formation	0.00222333512173573
GO:0002266	follicular dendritic cell activation	0.00222333512173573
GO:0002268	follicular dendritic cell differentiation	0.00222333512173573
GO:0046696	lipopolysaccharide receptor complex	0.00222333512173573
GO:0002902	regulation of B cell apoptosis	0.00222333512173573
GO:0002903	negative regulation of B cell apoptosis	0.00222333512173573
GO:0033257	Bcl3/NF-kappaB2 complex	0.00222333512173573
GO:0016607	nuclear speck	0.00226952078661409
GO:0042990	regulation of transcription factor import into nucleus	0.00228400400131031
GO:0042991	transcription factor import into nucleus	0.00228400400131031
GO:0045860	positive regulation of protein kinase activity	0.00248361208409688
GO:0031328	positive regulation of cellular biosynthetic process	0.00248361208409688
GO:0042834	peptidoglycan binding	0.00248361208409688
GO:0008361	regulation of cell size	0.00249997916701087
GO:0009892	negative regulation of metabolic process	0.00251292657462567
GO:0003704	specific RNA polymerase II transcription factor activity	0.00251292657462567
GO:0019219	regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	0.00264895407238468
GO:0000060	protein import into nucleus, translocation	0.00266781112286974
GO:0016192	vesicle-mediated transport	0.00277155439822717
GO:0006935	chemotaxis	0.00277155439822717
GO:0042330	taxis	0.00277155439822717
GO:0033674	positive regulation of kinase activity	0.00277155439822717
GO:0042592	homeostatic process	0.00277155439822717
GO:0006909	phagocytosis	0.00308979829212634
GO:0001819	positive regulation of cytokine production	0.00310217522664878
GO:0051347	positive regulation of transferase activity	0.00318277979495032
GO:0045089	positive regulation of innate immune response	0.00329975516094788
GO:0002237	response to molecule of bacterial origin	0.00329975516094788
GO:0007626	locomotory behavior	0.00340222093393801
GO:0009719	response to endogenous stimulus	0.00346253883669758
GO:0006886	intracellular protein transport	0.00346253883669758
GO:0032507	maintenance of cellular protein localization	0.00356478571220302
GO:0005100	Rho GTPase activator activity	0.00356478571220302
GO:0016481	negative regulation of transcription	0.00372607278399943
GO:0043406	positive regulation of MAP kinase activity	0.00380319940307587
GO:0030155	regulation of cell adhesion	0.00380319940307587
GO:0007610	behavior	0.00405769825019489
GO:0050864	regulation of B cell activation	0.00406786771277168
GO:0051651	maintenance of cellular localization	0.00406786771277168
GO:0031347	regulation of defense response	0.00406786771277168
GO:0050727	regulation of inflammatory response	0.00406786771277168
GO:0006913	nucleocytoplasmic transport	0.00420493472130453
GO:0045088	regulation of innate immune response	0.00421898565002408
GO:0051101	regulation of DNA binding	0.00421898565002408
GO:0007266	Rho protein signal transduction	0.00431344681394228
GO:0007166	cell surface receptor linked signal transduction	0.00432388266846493
GO:0043285	biopolymer catabolic process	0.0043485995176637
GO:0044444	cytoplasmic part	0.00445199977952222
GO:0051169	nuclear transport	0.00449855735965538
GO:0006351	transcription, DNA-dependent	0.00449855735965538
GO:0032774	RNA biosynthetic process	0.00470757709268044
GO:0016301	kinase activity	0.00472793550449719
GO:0009891	positive regulation of biosynthetic process	0.00490357246070419
GO:0002440	production of molecular mediator of immune response	0.00525579452535207
GO:0008329	pattern recognition receptor activity	0.00530596839859969
GO:0042088	T-helper 1 type immune response	0.00530596839859969
GO:0042577	lipid phosphatase activity	0.00530596839859969
GO:0001783	B cell apoptosis	0.00533052027451271
GO:0001530	lipopolysaccharide binding	0.00533052027451271
GO:0046477	glycosylceramide catabolic process	0.00533052027451271
GO:0008339	MP kinase activity	0.00533052027451271
GO:0042536	negative regulation of tumor necrosis factor biosynthetic process	0.00533052027451271
GO:0006958	complement activation, classical pathway	0.0058706079836588
GO:0044428	nuclear part	0.00602396649121175
GO:0045449	regulation of transcription	0.00645900719813096
GO:0006020	inositol metabolic process	0.00661053066566868
GO:0030183	B cell differentiation	0.00663889512614563
GO:0016049	cell growth	0.00666454022393828
GO:0006959	humoral immune response	0.00669490893657115
GO:0031981	nuclear lumen	0.00701167784539665
GO:0051251	positive regulation of lymphocyte activation	0.00721865019066037
GO:0051091	positive regulation of transcription factor activity	0.00740554367868296
GO:0002429	immune response-activating cell surface receptor signaling pathway	0.00740554367868296
GO:0045941	positive regulation of transcription	0.00740554367868296
GO:0045934	negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	0.00753510545326577
GO:0002768	immune response-regulating cell surface receptor signaling pathway	0.00833584181326916
GO:0002526	acute inflammatory response	0.00856200825930765
GO:0016604	nuclear body	0.00856200825930765
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	0.00895330076114232
GO:0044265	cellular macromolecule catabolic process	0.00919147312744725
GO:0005829	cytosol	0.00934445881406469
GO:0006511	ubiquitin-dependent protein catabolic process	0.00934445881406469
GO:0006355	regulation of transcription, DNA-dependent	0.00934445881406469
GO:0045935	positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	0.00934445881406469
GO:0043632	modification-dependent macromolecule catabolic process	0.00934445881406469
GO:0019941	modification-dependent protein catabolic process	0.00934445881406469
GO:0001890	placenta development	0.00934445881406469
GO:0001565	phorbol ester receptor activity	0.00934445881406469
GO:0004697	protein kinase C activity	0.00934445881406469
GO:0032762	mast cell cytokine production	0.00934445881406469
GO:0019432	triacylglycerol biosynthetic process	0.00934445881406469
GO:0004681	casein kinase I activity	0.00934445881406469
GO:0042832	defense response to protozoan	0.00934445881406469
GO:0032763	regulation of mast cell cytokine production	0.00934445881406469
GO:0001975	response to amphetamine	0.00934445881406469
GO:0001892	embryonic placenta development	0.00934445881406469
GO:0014075	response to amine stimulus	0.00934445881406469
GO:0046514	ceramide catabolic process	0.00934445881406469
GO:0048536	spleen development	0.00934445881406469
GO:0051603	proteolysis involved in cellular protein catabolic process	0.00947450313935781
GO:0044257	cellular protein catabolic process	0.0100103033010618
GO:0000187	activation of MAPK activity	0.0108350148414493
GO:0045637	regulation of myeloid cell differentiation	0.0108857719829047
GO:0043433	negative regulation of transcription factor activity	0.0110384389471148
GO:0019865	immunoglobulin binding	0.0110384389471148
GO:0009887	organ morphogenesis	0.0110722832033106
GO:0007399	nervous system development	0.0116890920193093
GO:0048583	regulation of response to stimulus	0.0119662257172445
GO:0000165	MAPKKK cascade	0.0123229474835794
GO:0051046	regulation of secretion	0.0123459537611952
GO:0045893	positive regulation of transcription, DNA-dependent	0.0126556008439957
GO:0051048	negative regulation of secretion	0.012981943555186
GO:0008277	regulation of G-protein coupled receptor protein signaling pathway	0.0131100094153854
GO:0060090	molecular adaptor activity	0.0131508350132592
GO:0006996	organelle organization and biogenesis	0.0140251682503365
GO:0008632	apoptotic program	0.0140251682503365
GO:0051457	maintenance of protein localization in nucleus	0.0143533537491886
GO:0001562	response to protozoan	0.0143533537491886
GO:0031401	positive regulation of protein modification process	0.0143533537491886
GO:0043491	protein kinase B signaling cascade	0.0143533537491886
GO:0045064	T-helper 2 cell differentiation	0.0143533537491886
GO:0045410	positive regulation of interleukin-6 biosynthetic process	0.0143533537491886
GO:0046521	sphingoid catabolic process	0.0143533537491886
GO:0002521	leukocyte differentiation	0.0145026035080263
GO:0010033	response to organic substance	0.0147339835509124
GO:0045638	negative regulation of myeloid cell differentiation	0.0147497066996684
GO:0002377	immunoglobulin production	0.0147497066996684
GO:0043233	organelle lumen	0.01490594205667
GO:0031974	membrane-enclosed lumen	0.01490594205667
GO:0051641	cellular localization	0.0162637245259618
GO:0030098	lymphocyte differentiation	0.0166453266974832
GO:0007259	JAK-STAT cascade	0.0166453266974832
GO:0006956	complement activation	0.0166453266974832
GO:0002541	activation of plasma proteins during acute inflammatory response	0.0166453266974832
GO:0005625	soluble fraction	0.0167623315410622
GO:0048503	GPI anchor binding	0.0173836267822387
GO:0035023	regulation of Rho protein signal transduction	0.017665184263463
GO:0001558	regulation of cell growth	0.0183002469971962
GO:0043167	ion binding	0.0184272063446712
GO:0031625	ubiquitin protein ligase binding	0.0193886096320649
GO:0042542	response to hydrogen peroxide	0.0193886096320649
GO:0001568	blood vessel development	0.0195140859974698
GO:0051020	GTPase binding	0.0199926444987049
GO:0016909	SAP kinase activity	0.0199926444987049
GO:0042119	neutrophil activation	0.0199926444987049
GO:0008354	germ cell migration	0.0199926444987049
GO:0045892	negative regulation of transcription, DNA-dependent	0.0205661016105646
GO:0001944	vasculature development	0.0206732510589604
GO:0042060	wound healing	0.020843442772185
GO:0040014	regulation of multicellular organism growth	0.0217780768316378
GO:0006801	superoxide metabolic process	0.0217780768316378
GO:0051174	regulation of phosphorus metabolic process	0.0217928288822071
GO:0019220	regulation of phosphate metabolic process	0.0217928288822071
GO:0051649	establishment of cellular localization	0.0220698353604131
GO:0001726	ruffle	0.0225295920369183
GO:0007204	elevation of cytosolic calcium ion concentration	0.0229481913434765
GO:0051480	cytosolic calcium ion homeostasis	0.0229481913434765
GO:0007265	Ras protein signal transduction	0.0237767981550979
GO:0031252	leading edge	0.0257714455900923
GO:0006800	oxygen and reactive oxygen species metabolic process	0.0262374214180816
GO:0046460	neutral lipid biosynthetic process	0.0263351924920615
GO:0046463	acylglycerol biosynthetic process	0.0263351924920615
GO:0001953	negative regulation of cell-matrix adhesion	0.0263351924920615
GO:0019377	glycolipid catabolic process	0.0263351924920615
GO:0031543	peptidyl-proline dioxygenase activity	0.0263351924920615
GO:0016070	RNA metabolic process	0.0263351924920615
GO:0009968	negative regulation of signal transduction	0.0265227587828139
GO:0051092	activation of NF-kappaB transcription factor	0.0271446694828396
GO:0006461	protein complex assembly	0.0285169091043676
GO:0009057	macromolecule catabolic process	0.0301509643917555
GO:0003714	transcription corepressor activity	0.0301509643917555
GO:0007167	enzyme linked receptor protein signaling pathway	0.0303015660173156
GO:0035264	multicellular organism growth	0.0303015660173156
GO:0006605	protein targeting	0.0304948554869333
GO:0051249	regulation of lymphocyte activation	0.0311060052260318
GO:0010467	gene expression	0.0311060052260318
GO:0030163	protein catabolic process	0.0313473053448635
GO:0001666	response to hypoxia	0.0316229277055235
GO:0051093	negative regulation of developmental process	0.0325448676104552
GO:0007264	small GTPase mediated signal transduction	0.0325448676104552
GO:0043506	regulation of JNK activity	0.0325448676104552
GO:0045937	positive regulation of phosphate metabolic process	0.0325448676104552
GO:0051241	negative regulation of multicellular organismal process	0.0325448676104552
GO:0045885	positive regulation of survival gene product activity	0.0325448676104552
GO:0045414	regulation of interleukin-8 biosynthetic process	0.0325448676104552
GO:0030279	negative regulation of ossification	0.0325448676104552
GO:0004680	casein kinase activity	0.0325448676104552
GO:0004908	interleukin-1 receptor activity	0.0325448676104552
GO:0046504	glycerol ether biosynthetic process	0.0325448676104552
GO:0006677	glycosylceramide metabolic process	0.0325448676104552
GO:0045017	glycerolipid biosynthetic process	0.0325448676104552
GO:0017022	myosin binding	0.0325448676104552
GO:0005070	SH3/SH2 adaptor activity	0.0328152215133495
GO:0000287	magnesium ion binding	0.0331592620783585
GO:0006974	response to DNA damage stimulus	0.0339857307778434
GO:0046872	metal ion binding	0.0340843194335913
GO:0048514	blood vessel morphogenesis	0.0345620099906766
GO:0009581	detection of external stimulus	0.0348449683767451
GO:0005624	membrane fraction	0.0349513423291501
GO:0016563	transcription activator activity	0.0351476911150477
GO:0050708	regulation of protein secretion	0.0355780392891336
GO:0019888	protein phosphatase regulator activity	0.036119034018545
GO:0050865	regulation of cell activation	0.036119034018545
GO:0003713	transcription coactivator activity	0.0365247810243425
GO:0044451	nucleoplasm part	0.0369271087799732
GO:0042995	cell projection	0.0380168597849864
GO:0050851	antigen receptor-mediated signaling pathway	0.0388206435412315
GO:0000302	response to reactive oxygen species	0.0388206435412315
GO:0019208	phosphatase regulator activity	0.0388206435412315
GO:0002700	regulation of production of molecular mediator of immune response	0.0388206435412315
GO:0042994	cytoplasmic sequestering of transcription factor	0.0388206435412315
GO:0042228	interleukin-8 biosynthetic process	0.0388206435412315
GO:0002367	cytokine production during immune response	0.0388206435412315
GO:0050777	negative regulation of immune response	0.0388206435412315
GO:0002718	regulation of cytokine production during immune response	0.0388206435412315
GO:0031348	negative regulation of defense response	0.0388206435412315
GO:0042116	macrophage activation	0.0388206435412315
GO:0050728	negative regulation of inflammatory response	0.0388206435412315
GO:0045191	regulation of isotype switching	0.0388206435412315
GO:0030890	positive regulation of B cell proliferation	0.0388206435412315
GO:0005089	Rho guanyl-nucleotide exchange factor activity	0.0390399174762732
GO:0016772	transferase activity, transferring phosphorus-containing groups	0.0399937144638436
GO:0046651	lymphocyte proliferation	0.0402344846430698
GO:0032943	mononuclear cell proliferation	0.0402344846430698
GO:0051098	regulation of binding	0.0414296497374927
GO:0031267	small GTPase binding	0.0439801697447111
GO:0050793	regulation of developmental process	0.0442528033564641
GO:0006664	glycolipid metabolic process	0.0449153411911552
GO:0007163	establishment and/or maintenance of cell polarity	0.0449153411911552
GO:0008092	cytoskeletal protein binding	0.0449153411911552
GO:0051220	cytoplasmic sequestering of protein	0.0449153411911552
GO:0002683	negative regulation of immune system process	0.0449153411911552
GO:0001818	negative regulation of cytokine production	0.0449153411911552
GO:0031399	regulation of protein modification process	0.0449153411911552
GO:0002263	cell activation during immune response	0.0449153411911552
GO:0002294	CD4-positive, alpha-beta T cell differentiation during immune response	0.0449153411911552
GO:0002285	lymphocyte activation during immune response	0.0449153411911552
GO:0022408	negative regulation of cell-cell adhesion	0.0449153411911552
GO:0050854	regulation of antigen receptor-mediated signaling pathway	0.0449153411911552
GO:0002292	T cell differentiation during immune response	0.0449153411911552
GO:0030888	regulation of B cell proliferation	0.0449153411911552
GO:0042092	T-helper 2 type immune response	0.0449153411911552
GO:0042093	T-helper cell differentiation	0.0449153411911552
GO:0002366	leukocyte activation during immune response	0.0449153411911552
GO:0017053	transcriptional repressor complex	0.0449153411911552
GO:0050702	interleukin-1 beta secretion	0.0449153411911552
GO:0019966	interleukin-1 binding	0.0449153411911552
GO:0002286	T cell activation during immune response	0.0449153411911552
GO:0002293	alpha-beta T cell differentiation during immune response	0.0449153411911552
GO:0031575	G1/S transition checkpoint	0.0449153411911552
GO:0043086	negative regulation of catalytic activity	0.0458411256007982
GO:0050671	positive regulation of lymphocyte proliferation	0.0473015148732841
GO:0032946	positive regulation of mononuclear cell proliferation	0.0473015148732841

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

---

Cell Type

Ontology term	p-value	n
classical monocyte	7.41e-113	42
CD14-positive, CD16-negative classical monocyte	7.41e-113	42
myeloid leukocyte	1.78e-97	72
defensive cell	2.64e-97	48
phagocyte	2.64e-97	48
macrophage dendritic cell progenitor	6.23e-80	61
monopoietic cell	2.92e-79	59
monocyte	2.92e-79	59
monoblast	2.92e-79	59
promonocyte	2.92e-79	59
granulocyte monocyte progenitor cell	3.46e-75	67
myeloid lineage restricted progenitor cell	4.35e-73	66
myeloid cell	2.24e-63	108
common myeloid progenitor	2.24e-63	108
leukocyte	2.38e-63	136
nongranular leukocyte	4.85e-50	115
hematopoietic stem cell	1.18e-48	168
angioblastic mesenchymal cell	1.18e-48	168
stuff accumulating cell	1.55e-48	87
hematopoietic cell	1.80e-45	177
hematopoietic oligopotent progenitor cell	2.75e-45	161
hematopoietic multipotent progenitor cell	2.75e-45	161
hematopoietic lineage restricted progenitor cell	7.69e-45	120
granulocyte	1.44e-24	8
intermediate monocyte	2.82e-24	9
CD14-positive, CD16-positive monocyte	2.82e-24	9
blood cell	2.00e-17	11
mesenchymal cell	1.08e-15	354
connective tissue cell	4.08e-15	361
motile cell	4.36e-13	386
multi fate stem cell	1.29e-10	427
neutrophil	1.53e-10	3
stem cell	1.75e-10	441
somatic stem cell	2.81e-10	433
basophil	8.23e-10	3
single nucleate cell	2.28e-09	3
mononuclear cell	2.28e-09	3
natural killer cell	2.28e-08	3
pro-NK cell	2.28e-08	3
non-classical monocyte	2.47e-08	3
CD14-low, CD16-positive monocyte	2.47e-08	3
eosinophil	1.20e-07	2

Uber Anatomy

Ontology term	p-value	n
hematopoietic system	1.46e-81	98
blood island	1.46e-81	98
hemolymphoid system	8.31e-73	108
bone marrow	5.43e-65	76
bone element	2.01e-59	82
immune system	1.63e-53	93
skeletal element	3.82e-53	90
skeletal system	1.07e-46	100
lateral plate mesoderm	1.92e-32	203
musculoskeletal system	2.26e-23	167
blood	1.80e-20	15
haemolymphatic fluid	1.80e-20	15
organism substance	1.80e-20	15
mesoderm	6.21e-17	315
mesoderm-derived structure	6.21e-17	315
presumptive mesoderm	6.21e-17	315
connective tissue	2.49e-14	371

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

---

Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
MA0003.1	3.00624
MA0004.1	0.81623
MA0006.1	0.0573594
MA0007.1	0.200994
MA0009.1	1.21969
MA0014.1	0.0932167
MA0017.1	1.9955
MA0019.1	1.13235
MA0024.1	0.014489
MA0025.1	4.89923
MA0027.1	0.286244
MA0028.1	5.85577
MA0029.1	0.0307475
MA0030.1	5.80198
MA0031.1	5.46364
MA0038.1	0.56218
MA0040.1	0.119868
MA0041.1	1.31974e-05
MA0042.1	0.0654446
MA0043.1	19.3312
MA0046.1	9.32918e-06
MA0048.1	0.182251
MA0050.1	0.429027
MA0051.1	0.386939
MA0052.1	0.000130269
MA0055.1	1.04079
MA0056.1	0
MA0057.1	4.61562
MA0058.1	1.4129
MA0059.1	2.65455
MA0060.1	9.64327e-16
MA0061.1	70.3086
MA0063.1	0
MA0066.1	5.89145
MA0067.1	3.81898
MA0068.1	0.270068
MA0069.1	1.1245
MA0070.1	6.86408e-05
MA0071.1	1.39827
MA0072.1	0.0597634
MA0073.1	0.190376
MA0074.1	1.20535
MA0076.1	8.51514
MA0077.1	0.0170488
MA0078.1	1.01211
MA0081.1	26.5265
MA0083.1	1.36735
MA0084.1	0.0655347
MA0087.1	0.0218834
MA0088.1	0.519552
MA0089.1	0
MA0090.1	0.0261158
MA0091.1	0.179124
MA0092.1	0.0621574
MA0093.1	1.30796
MA0095.1	0
MA0098.1	0
MA0100.1	0.881144
MA0101.1	49.0652
MA0103.1	0.110103
MA0105.1	37.335
MA0106.1	0.0688737
MA0107.1	69.5108
MA0108.2	0.000187498
MA0109.1	0
MA0111.1	0.609879
MA0113.1	1.00411
MA0114.1	1.12064
MA0115.1	0.385337
MA0116.1	3.32342
MA0117.1	2.60158
MA0119.1	0.375057
MA0122.1	0.934205
MA0124.1	0.00667389
MA0125.1	0.00471843
MA0130.1	0
MA0131.1	0.330199
MA0132.1	0
MA0133.1	0
MA0135.1	0.00296207
MA0136.1	40.6715
MA0139.1	0.410921
MA0140.1	2.05459e-05
MA0141.1	6.50755
MA0142.1	0.0049029
MA0143.1	0.0796893
MA0144.1	8.62831
MA0145.1	1.7831
MA0146.1	4.6581
MA0147.1	0.444758
MA0148.1	0.765552
MA0149.1	0.00792609
MA0062.2	38.9521
MA0035.2	0.00250007
MA0039.2	6.4619
MA0138.2	0.00431808
MA0002.2	31.0719
MA0137.2	6.03159
MA0104.2	0.677711
MA0047.2	0.443672
MA0112.2	3.25054
MA0065.2	4.93337
MA0150.1	34.4168
MA0151.1	0
MA0152.1	1.20235e-05
MA0153.1	3.02474e-05
MA0154.1	8.94257
MA0155.1	9.17214
MA0156.1	51.2671
MA0157.1	2.18887
MA0158.1	0
MA0159.1	6.774
MA0160.1	5.65509
MA0161.1	0
MA0162.1	0.000271406
MA0163.1	3.10941
MA0164.1	0.922326
MA0080.2	120.336
MA0018.2	11.4506
MA0099.2	10.6584
MA0079.2	12.8702
MA0102.2	11.7688
MA0258.1	1.88993
MA0259.1	0.150615
MA0442.1	0

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

---

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF	#promoters	Enrichment	p-value	q-value
BATF#10538	603	3.11379149475495	1.57450732966158e-135	3.91523740482203e-132
BCL11A#53335	600	3.6085802548578	1.7539085174532e-164	5.23361290440843e-161
BCL3#602	346	2.53408894850402	6.05193242653807e-55	4.93795133355632e-52
BCLAF1#9774	280	1.28529602095275	1.50620806988876e-05	0.000356785812227517
BHLHE40#8553	157	1.49350746806772	7.36771583678697e-07	3.27019496080831e-05
BRCA1#672	340	1.45487352526947	6.13280611088516e-12	7.8879819878662e-10
BRF2#55290	10	2.27809112019366	0.0134254500753273	0.0474337138165462
CCNT2#905	1044	1.40237321313313	3.35039193431519e-31	1.41093380333848e-28
CEBPB#1051	1337	2.25936493019457	2.22371263468074e-189	8.2943687090508e-186
CHD2#1106	607	1.33110490996585	2.977003912083e-13	4.43531114941564e-11
CTCF#10664	998	1.13409706600146	5.86039447614214e-06	0.000175978648273091
E2F1#1869	1041	1.08301720854131	0.00199368428172762	0.0115940972603904
E2F6#1876	1159	1.23275036952242	1.94068477717669e-15	3.555845218308e-13
EBF1#1879	1437	2.71329083284284	1.36179324670294e-287	1.09403326840314e-283
EGR1#1958	1441	1.52384271266089	2.17716608576368e-67	2.22922596893209e-64
ELF1#1997	1913	1.72689026822108	3.12712755085306e-153	8.59458090219849e-150
ELK4#2005	427	1.46971296759929	2.04680239803888e-15	3.7371677560976e-13
EP300#2033	1266	1.81806449552651	3.81367172443084e-105	6.8671734694454e-102
ESR1#2099	211	1.37633565730095	2.99094460745262e-06	0.000101419241512255
ETS1#2113	629	1.29730562223135	9.16878026526434e-12	1.14955371203354e-09
FOS#2353	948	1.80836583269703	5.69591666213972e-74	6.60973155863566e-71
FOSL1#8061	272	2.29003470062613	1.03497121068419e-35	5.19669991695415e-33
FOSL2#2355	528	1.8950913545068	6.61121943980273e-45	4.2886282426929e-42
FOXA1#3169	658	1.54580754613009	3.08137116510974e-29	1.18751041739076e-26
FOXA2#3170	338	1.76491345100718	1.62438904422278e-23	4.9031666875602e-21
GABPB1#2553	1005	1.50583469479819	1.20523810925413e-41	7.19279216527957e-39
GATA1#2623	519	1.49200761641561	7.19198994091569e-20	1.80125716412301e-17
GATA2#2624	610	1.64816797911129	3.33704384871586e-34	1.58417055689107e-31
GATA3#2625	232	1.33959546213097	6.13019466523317e-06	0.000182039067569601
GTF2F1#2962	497	1.34229625943366	1.76061918351437e-11	2.13314741191481e-09
HDAC2#3066	575	1.63535756541448	2.57796644930424e-31	1.09447251219059e-28
HEY1#23462	1385	1.18625265946606	1.65937826835444e-13	2.53739102443146e-11
HMGN3#9324	839	1.45469610767249	3.09089087428406e-29	1.18679982360056e-26
HNF4A#3172	321	1.57419232701042	2.00083193867761e-15	3.65963024244397e-13
HNF4G#3174	248	1.51173389581488	1.64350318369824e-10	1.72681920525413e-08
HSF1#3297	48	1.67181513673945	0.000500088293566223	0.00441158216840635
IRF1#3659	795	1.28716243037594	4.1218181619148e-14	6.7579052906157e-12
IRF4#3662	585	2.71782699210204	2.33611858567745e-106	4.43603434490123e-103
JUN#3725	835	2.21501216357872	3.78173320072402e-106	6.92913041667397e-103
JUNB#3726	317	2.0571487286757	6.0464863066957e-33	2.73371854279218e-30
JUND#3727	1201	1.78091825189466	5.87643584149747e-93	8.6440715894388e-90
MAFF#23764	159	1.8982704434813	3.75546300092429e-14	6.17664252525247e-12
MAFK#7975	373	2.14300900157103	1.74674627873169e-42	1.06683295090327e-39
MAX#4149	1375	1.88091240722595	1.04639285824948e-127	2.32519624941952e-124
MEF2A#4205	581	2.30863200307466	2.31509690146235e-78	2.87840958680745e-75
MEF2C#4208	251	2.1982510022575	2.32016721266587e-30	9.46546654389106e-28
MXI1#4601	575	1.21431072430286	7.08980540470073e-07	3.17518090335137e-05
MYC#4609	1327	1.46914734865925	6.62704644947947e-52	5.1268304010162e-49
NFE2#4778	126	2.06227196143847	6.52615168015856e-14	1.04537539160135e-11
NFKB1#4790	1820	2.11750592156726	1.02153647160843e-242	6.66801547239458e-239
NR3C1#2908	551	1.74902180527376	2.57373470365063e-37	1.37141978936004e-34
NR4A1#3164	7	4.09376374434801	0.00160289278772352	0.0100961654820009
PAX5#5079	1394	1.97103547815601	1.45015979591561e-146	3.88341638270847e-143
PBX3#5090	347	1.61211276283659	4.6379070491652e-18	1.02622536929611e-15
POLR2A#5430	3172	1.44407917660424	7.64891108489399e-185	2.66281541598415e-181
POU2F2#5452	985	1.90153321960492	7.85761097650533e-89	1.09418804370032e-85
PPARGC1A#10891	33	2.44894795420818	3.31905107199618e-06	0.000110924279970627
PRDM1#639	62	1.73277915162234	3.15908825919016e-05	0.000634484651349156
RAD21#5885	599	1.31495978447707	3.48076630385273e-12	4.60744932836597e-10
RDBP#7936	47	1.53084693396887	0.00321966187353143	0.0166852709973577
REST#5978	599	1.22543294487189	1.24592755643261e-07	7.14571268897668e-06
RFX5#5993	589	1.50439251160015	2.32187696368891e-23	6.94826671090849e-21
RXRA#6256	414	1.76190194945965	1.47506845600046e-28	5.46293171901532e-26
SIN3A#25942	1180	1.35308119093531	1.30735431580436e-29	5.17192338592012e-27
SIRT6#51548	66	2.14969994982863	1.13429751671312e-08	8.5226545574102e-07
SMARCA4#6597	47	1.56200921252295	0.00220645797214348	0.0127083364116634
SMARCB1#6598	419	1.62134575202564	4.16785690146597e-22	1.16698875853138e-19
SMARCC1#6599	263	2.43448452428728	7.02829969366191e-39	3.90440740269338e-36
SMARCC2#6601	89	1.77651649862071	2.56542729496186e-07	1.3316633263346e-05
SMC3#9126	516	1.64578871061805	1.17837180247296e-28	4.42690549203143e-26
SP1#6667	1363	1.64657490320247	3.09344823308663e-84	4.03845800019169e-81
SPI1#6688	1702	2.96030498441927	0	0
SRF#6722	542	1.58534462965761	2.28210834159033e-26	7.71330463065867e-24
STAT1#6772	383	1.68128535328117	7.24824770574766e-23	2.09115950867564e-20
STAT2#6773	134	1.85400579584122	1.81710135662243e-11	2.19394507033861e-09
STAT3#6774	1127	2.51334260160967	4.29422400436023e-190	1.66105355848659e-186
TAF1#6872	1904	1.34940854951432	3.95245633301336e-54	3.19992703072544e-51
TAL1#6886	270	1.70967277992556	2.96363250111955e-17	6.14124632508778e-15
TBP#6908	1834	1.44121633244324	1.57269067473311e-72	1.78532871063534e-69
TCF12#6938	936	2.11020969863186	2.56674074467777e-108	4.96421919691484e-105
TCF7L2#6934	557	1.27178044215974	2.99607175048545e-09	2.51330712890723e-07
TFAP2A#7020	443	1.55135786034745	7.06405102223501e-20	1.77346736709424e-17
TFAP2C#7022	677	1.55137752149149	1.49422482961671e-30	6.11981752864077e-28
TRIM28#10155	291	1.146882083564	0.0090742872402377	0.0343472559105242
USF1#7391	1044	1.40797228013676	7.65550924098737e-32	3.30385838685735e-29
USF2#7392	612	1.68565291491681	5.1376258072146e-37	2.70994192767518e-34
WRNIP1#56897	99	2.30489219219594	5.18797406898318e-14	8.41345999674742e-12
YY1#7528	1266	1.31811366744011	1.65106811120892e-27	5.9256323871666e-25
ZBTB7A#51341	980	1.52742656809802	5.97324943734373e-43	3.69136211826475e-40
ZEB1#6935	412	1.47509730575113	3.91279852011059e-15	6.94980892248011e-13

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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FF samples	Score

FF samples	Score
Eosinophils, donor3 CNhs12549	1.39
Eosinophils, donor2 CNhs12548	1.34
Neutrophils, donor3 CNhs11905	1.22
Neutrophils, donor1 CNhs10862	1.09
Neutrophils, donor2 CNhs11959	0.84
CD14+ Monocytes, donor1 CNhs10852	0.60
CD14+ monocytes - treated with Candida, donor3 CNhs13494	0.57
CD14+ Monocytes, donor2 CNhs11954	0.56
CD14+ Monocytes, donor3 CNhs11997	0.56
CD14+ monocytes - treated with Group A streptococci, donor3 CNhs13492	0.55

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