Coexpression cluster:C26

Full id: C26_Eosinophils_Neutrophils_CD14_CD14CD16_Basophils_Monocytederived_Whole

Phase1 CAGE Peaks

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Hg19::chr10:104402064..104402122,+	p@chr10:104402064..104402122 +
Hg19::chr10:104952377..104952445,+	p@chr10:104952377..104952445 +
Hg19::chr10:104953009..104953061,-	p1@NT5C2
Hg19::chr10:109449332..109449361,+	p@chr10:109449332..109449361 +
Hg19::chr10:120553339..120553353,+	p@chr10:120553339..120553353 +
Hg19::chr10:121154941..121154959,-	p@chr10:121154941..121154959 -
Hg19::chr10:125853048..125853095,-	p2@CHST15
Hg19::chr10:129848000..129848023,-	p@chr10:129848000..129848023 -
Hg19::chr10:20105531..20105546,+	p3@PLXDC2
Hg19::chr10:20105553..20105560,+	p7@PLXDC2
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Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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p.value	FDR	nGenes	nPathway	Name
0.00210270397278665	0.0283643277689648	3	25	Nicotinate and nicotinamide metabolism (KEGG):00760
2.19470554783533e-05	0.000771804784322091	12	265	Cytokine-cytokine receptor interaction (KEGG):04060
0.00016032408551047	0.00338283820427091	9	189	Chemokine signaling pathway (KEGG):04062
0.000265683255398174	0.00509628789900134	7	121	Lysosome (KEGG):04142
9.41979212788425e-09	1.19254568339015e-06	13	156	Phagosome (KEGG):04145
0.00138780438603381	0.0204297715432419	4	47	Notch signaling pathway (KEGG):04330
1.38355162575075e-15	4.37894089550111e-13	18	128	Osteoclast differentiation (KEGG):04380
0.0041386555775396	0.0451684306996994	5	102	Toll-like receptor signaling pathway (KEGG):04620
0.00321584695640288	0.0391467523731351	4	59	NOD-like receptor signaling pathway (KEGG):04621
0.00021429850188657	0.00423909224044372	8	155	Jak-STAT signaling pathway (KEGG):04630
2.01409574227168e-08	1.59758257887329e-06	12	137	Natural killer cell mediated cytotoxicity (KEGG):04650
0.0010733031461005	0.0167141974071038	5	75	B cell receptor signaling pathway (KEGG):04662
0.000167841842169932	0.00342722213205054	6	79	Fc epsilon RI signaling pathway (KEGG):04664
5.8343161504992e-05	0.00175862958250762	7	95	Fc gamma R-mediated phagocytosis (KEGG):04666
0.0017726751998801	0.0249356311449801	8	214	Regulation of actin cytoskeleton (KEGG):04810
0.00217108722785528	0.0286312128173415	4	53	Amyotrophic lateral sclerosis (ALS) (KEGG):05014
6.29137107331061e-08	4.42493098822846e-06	9	73	Leishmaniasis (KEGG):05140
0.0044944671353932	0.0475224096999027	5	104	Chagas disease (American trypanosomiasis) (KEGG):05142
7.41536578885903e-05	0.0019030767731606	8	133	Toxoplasmosis (KEGG):05145
0.000116879046210597	0.00264230129468957	7	106	Amoebiasis (KEGG):05146
1.06512111842637e-07	6.74221667963894e-06	8	56	Staphylococcus aureus infection (KEGG):05150
3.49983290919671e-16	2.21539423152152e-13	21	182	Tuberculosis (KEGG):05152
7.81674503983818e-05	0.0019030767731606	8	134	Measles (KEGG):05162
9.34287433017998e-05	0.00219038498185331	9	176	Influenza A (KEGG):05164
0.00265478867993691	0.0336096246880012	5	92	Rheumatoid arthritis (KEGG):05323
5.58414603213884e-07	3.21342221667626e-05	8	69	IL-5 Signaling Pathway (Wikipathways):WP127
0.000752338728751996	0.0125323793500004	4	40	NOD pathway (Wikipathways):WP1433
0.0010825941448519	0.0167141974071038	3	20	Eicosanoid Synthesis (Wikipathways):WP167
7.11797888184495e-06	0.000300378708813857	10	161	B Cell Receptor Signaling Pathway (Wikipathways):WP23
0.0012799549587713	0.0192907497357675	4	46	Notch Signaling Pathway (Wikipathways):WP268
0.0041386555775396	0.0451684306996994	5	102	IL-3 Signaling Pathway (Wikipathways):WP286
0.000734767934485199	0.0125323793500004	5	69	Kit Receptor Signaling Pathway (Wikipathways):WP304
0.00346235995346592	0.0413523368027156	7	188	Focal Adhesion (Wikipathways):WP306
7.59006461325607e-05	0.0019030767731606	7	99	IL-6 Signaling Pathway (Wikipathways):WP364
0.00162222970345282	0.0233379864155826	4	49	Diurnally regulated genes with circadian orthologs (Wikipathways):WP410
0.000752338728751996	0.0125323793500004	4	40	G13 Signaling Pathway (Wikipathways):WP524
1.23152256122436e-05	0.000487221113284388	6	50	Type II interferon signaling (IFNG) (Wikipathways):WP619
1.44160653729474e-08	1.52089489684595e-06	12	133	T Cell Receptor Signaling Pathway (Wikipathways):WP69
0.0041386555775396	0.0451684306996994	5	102	Toll-like receptor signaling pathway (Wikipathways):WP75
1.93492498359097e-14	4.08269171537694e-12	30	511	Signaling in Immune system (Reactome):REACT_6900
0.00210604013450449	0.0283643277689648	8	220	Signalling by NGF (Reactome):REACT_11061
2.0190617110563e-08	1.59758257887329e-06	21	466	Hemostasis (Reactome):REACT_604
0.000295725248406183	0.00550570830120924	13	401	Transmembrane transport of small molecules (Reactome):REACT_15518
0.000880837521100879	0.0142966705347912	19	816	TGF beta receptor up reg. targets (Netpath):NetPath_7
3.03208345042419e-06	0.000147639140316808	23	740	TGF beta receptor down reg. targets (Netpath):NetPath_7
2.49214619662143e-05	0.000830278180242824	21	728	TNF alpha/NF-kB up reg. targets (Netpath):NetPath_9
6.6679280793151e-09	1.05519961855161e-06	16	246	B Cell Receptor up reg. targets (Netpath):NetPath_12
0.00289477132790361	0.0359292205992742	7	182	B Cell Receptor down reg. targets (Netpath):NetPath_12
7.26424414660834e-05	0.0019030767731606	6	68	T Cell Receptor down reg. targets (Netpath):NetPath_11
3.03130027733277e-06	0.000147639140316808	17	433	IL-2 up reg. targets (Netpath):NetPath_14
1.33593498908399e-05	0.000497439322405979	13	295	IL-2 down reg. targets (Netpath):NetPath_14
6.66379624582048e-05	0.0019030767731606	8	131	IL-5 up reg. targets (Netpath):NetPath_17
0.00357361785137221	0.0418907425910854	3	30	{FYN,30} (Static Module):NA
5.65840095958621e-06	0.000255840557672719	16	406	{GRB2,414} (Static Module):NA
0.00066068764862038	0.0119490080450486	3	17	{HCLS1,17} (Static Module):NA
3.06943049964634e-05	0.000971474753138067	7	86	{JUN,88} (Static Module):NA
0.000122995274538997	0.00268468995804087	3	10	{SPI1,10} (Static Module):NA
0.00450449381041732	0.0475224096999027	2	10	{TLE1,10} (Static Module):NA
0.00241230155738467	0.0311629976698876	5	90	{TRAF2,90} (Static Module):NA
0.00384805504905189	0.0442876153827245	4	62	{VAMP2,63} (Static Module):NA

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0002376	immune system process	1.20118765244635e-23
GO:0005515	protein binding	1.09182905839681e-19
GO:0006955	immune response	2.029161774243e-19
GO:0006952	defense response	1.57236611920896e-17
GO:0005887	integral to plasma membrane	3.56951470544992e-16
GO:0031226	intrinsic to plasma membrane	6.58892987557053e-16
GO:0005886	plasma membrane	5.00885807174355e-14
GO:0051707	response to other organism	5.26086446105106e-13
GO:0016020	membrane	3.34784429214969e-12
GO:0044459	plasma membrane part	9.09884578843473e-12
GO:0005737	cytoplasm	3.2477965828267e-11
GO:0044464	cell part	8.02708375563169e-11
GO:0009607	response to biotic stimulus	1.48101209081076e-10
GO:0001816	cytokine production	4.86036389190393e-10
GO:0007154	cell communication	1.14911911228074e-09
GO:0051704	multi-organism process	1.43405977852945e-09
GO:0045184	establishment of protein localization	1.68319336975749e-09
GO:0007165	signal transduction	1.89103188637165e-09
GO:0007242	intracellular signaling cascade	4.18546939172051e-09
GO:0044425	membrane part	5.3916656987842e-09
GO:0008104	protein localization	7.16002997453345e-09
GO:0009611	response to wounding	8.62140678502574e-09
GO:0009605	response to external stimulus	1.01206693116221e-08
GO:0033036	macromolecule localization	4.46744067389888e-08
GO:0006954	inflammatory response	6.713796191904e-08
GO:0008219	cell death	9.24553325759189e-08
GO:0016265	death	9.24553325759189e-08
GO:0002224	toll-like receptor signaling pathway	1.83829980638352e-07
GO:0002221	pattern recognition receptor signaling pathway	1.83829980638352e-07
GO:0015031	protein transport	1.83829980638352e-07
GO:0048518	positive regulation of biological process	1.95055140581875e-07
GO:0002757	immune response-activating signal transduction	2.02315113322484e-07
GO:0006968	cellular defense response	2.05300331420288e-07
GO:0004871	signal transducer activity	2.05300331420288e-07
GO:0060089	molecular transducer activity	2.05300331420288e-07
GO:0031224	intrinsic to membrane	2.17191454593406e-07
GO:0002764	immune response-regulating signal transduction	2.20650733110649e-07
GO:0045089	positive regulation of innate immune response	2.63106641089538e-07
GO:0016021	integral to membrane	3.82799220987116e-07
GO:0045088	regulation of innate immune response	4.55401929819083e-07
GO:0002218	activation of innate immune response	6.47712420688381e-07
GO:0002758	innate immune response-activating signal transduction	6.47712420688381e-07
GO:0048519	negative regulation of biological process	6.86070417659224e-07
GO:0050778	positive regulation of immune response	6.96647715698022e-07
GO:0002684	positive regulation of immune system process	7.55780107013146e-07
GO:0048523	negative regulation of cellular process	1.29406789978908e-06
GO:0048869	cellular developmental process	1.3567904047578e-06
GO:0030154	cell differentiation	1.3567904047578e-06
GO:0010324	membrane invagination	1.40595791697428e-06
GO:0006897	endocytosis	1.40595791697428e-06
GO:0016044	membrane organization and biogenesis	1.4693502251562e-06
GO:0044424	intracellular part	1.98066256929885e-06
GO:0050776	regulation of immune response	1.99125449206432e-06
GO:0009615	response to virus	1.99125449206432e-06
GO:0065008	regulation of biological quality	2.06335561628644e-06
GO:0002253	activation of immune response	2.10149708532329e-06
GO:0002682	regulation of immune system process	2.25044970328901e-06
GO:0001775	cell activation	2.32009246701787e-06
GO:0051240	positive regulation of multicellular organismal process	3.32325264158938e-06
GO:0009617	response to bacterium	3.54760547615533e-06
GO:0045321	leukocyte activation	4.11892626337132e-06
GO:0065007	biological regulation	4.50924138179558e-06
GO:0004872	receptor activity	4.57775819453697e-06
GO:0051239	regulation of multicellular organismal process	6.28479497352412e-06
GO:0012501	programmed cell death	6.8279559675677e-06
GO:0051179	localization	9.98301549557246e-06
GO:0032760	positive regulation of tumor necrosis factor production	1.08826606128751e-05
GO:0048468	cell development	1.29710139430562e-05
GO:0048522	positive regulation of cellular process	1.30046162066149e-05
GO:0001817	regulation of cytokine production	1.56700106360984e-05
GO:0001819	positive regulation of cytokine production	1.734346092045e-05
GO:0016192	vesicle-mediated transport	2.54008652693375e-05
GO:0051234	establishment of localization	3.71545828986038e-05
GO:0006915	apoptosis	3.78567362327851e-05
GO:0005773	vacuole	4.32524305198211e-05
GO:0032640	tumor necrosis factor production	4.87897918495313e-05
GO:0005622	intracellular	5.77263174891412e-05
GO:0045087	innate immune response	5.89359435272415e-05
GO:0007264	small GTPase mediated signal transduction	6.03929003349644e-05
GO:0002429	immune response-activating cell surface receptor signaling pathway	6.24164023815124e-05
GO:0002768	immune response-regulating cell surface receptor signaling pathway	7.30463586104659e-05
GO:0005764	lysosome	7.31162264981264e-05
GO:0032502	developmental process	7.40252369562258e-05
GO:0000323	lytic vacuole	7.45976380675629e-05
GO:0032680	regulation of tumor necrosis factor production	8.28681065709088e-05
GO:0019961	interferon binding	8.28681065709088e-05
GO:0004904	interferon receptor activity	8.28681065709088e-05
GO:0050878	regulation of body fluid levels	0.000103917413123012
GO:0032501	multicellular organismal process	0.000166433145305134
GO:0006950	response to stress	0.00017107320303156
GO:0006810	transport	0.000186794483038511
GO:0019955	cytokine binding	0.000201945177289229
GO:0009620	response to fungus	0.000208518076822058
GO:0043235	receptor complex	0.000393614568367592
GO:0046649	lymphocyte activation	0.00046295469679559
GO:0050789	regulation of biological process	0.000463748905889363
GO:0008283	cell proliferation	0.000463748905889363
GO:0045934	negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	0.000632316496660832
GO:0050854	regulation of antigen receptor-mediated signaling pathway	0.000841095174793124
GO:0002237	response to molecule of bacterial origin	0.000841095174793124
GO:0042221	response to chemical stimulus	0.000850493647253148
GO:0008047	enzyme activator activity	0.000850493647253148
GO:0019964	interferon-gamma binding	0.000904235788854328
GO:0002238	response to molecule of fungal origin	0.000904235788854328
GO:0032765	positive regulation of mast cell cytokine production	0.000904235788854328
GO:0002755	MyD88-dependent toll-like receptor signaling pathway	0.000904235788854328
GO:0004906	interferon-gamma receptor activity	0.000904235788854328
GO:0051091	positive regulation of transcription factor activity	0.00118882322638526
GO:0016481	negative regulation of transcription	0.00131876519881436
GO:0043227	membrane-bound organelle	0.00139139368469882
GO:0007249	I-kappaB kinase/NF-kappaB cascade	0.00148346196141786
GO:0042110	T cell activation	0.00159795366421067
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade	0.00167538647739106
GO:0007596	blood coagulation	0.00175557783622935
GO:0019899	enzyme binding	0.00183680570260926
GO:0005829	cytosol	0.00185812970643557
GO:0050817	coagulation	0.0019080314001248
GO:0009892	negative regulation of metabolic process	0.00201920236851201
GO:0001776	leukocyte homeostasis	0.00209623465111779
GO:0007599	hemostasis	0.0021817209423024
GO:0007243	protein kinase cascade	0.00219179762744337
GO:0042089	cytokine biosynthetic process	0.00219179762744337
GO:0043231	intracellular membrane-bound organelle	0.00219179762744337
GO:0044444	cytoplasmic part	0.00221579715088772
GO:0042107	cytokine metabolic process	0.00231016553811391
GO:0000267	cell fraction	0.00233132503894854
GO:0031324	negative regulation of cellular metabolic process	0.00233132503894854
GO:0009967	positive regulation of signal transduction	0.00233132503894854
GO:0043122	regulation of I-kappaB kinase/NF-kappaB cascade	0.00233132503894854
GO:0030029	actin filament-based process	0.00233132503894854
GO:0004896	hematopoietin/interferon-class (D200-domain) cytokine receptor activity	0.00233132503894854
GO:0032635	interleukin-6 production	0.00233132503894854
GO:0048872	homeostasis of number of cells	0.00233132503894854
GO:0050794	regulation of cellular process	0.00261900285596442
GO:0009893	positive regulation of metabolic process	0.00276099271238151
GO:0030048	actin filament-based movement	0.00276993141392856
GO:0019865	immunoglobulin binding	0.00276993141392856
GO:0006909	phagocytosis	0.00321999849278881
GO:0022603	regulation of anatomical structure morphogenesis	0.00346256585009687
GO:0008360	regulation of cell shape	0.00346256585009687
GO:0022604	regulation of cell morphogenesis	0.00346256585009687
GO:0001726	ruffle	0.00376833921483665
GO:0051649	establishment of cellular localization	0.00387925819966616
GO:0043226	organelle	0.00387925819966616
GO:0032762	mast cell cytokine production	0.00393631980094903
GO:0032763	regulation of mast cell cytokine production	0.00393631980094903
GO:0006366	transcription from RNA polymerase II promoter	0.00490785082406937
GO:0050663	cytokine secretion	0.00510372768786045
GO:0051247	positive regulation of protein metabolic process	0.00549265797319925
GO:0031982	vesicle	0.00568668973622424
GO:0042060	wound healing	0.00568668973622424
GO:0051641	cellular localization	0.00568668973622424
GO:0009966	regulation of signal transduction	0.00568668973622424
GO:0031325	positive regulation of cellular metabolic process	0.00570935644568082
GO:0043229	intracellular organelle	0.0058600453291888
GO:0030036	actin cytoskeleton organization and biogenesis	0.00692056459963043
GO:0051090	regulation of transcription factor activity	0.00708762945419995
GO:0030595	leukocyte chemotaxis	0.00725700204255904
GO:0051092	activation of NF-kappaB transcription factor	0.00725700204255904
GO:0005768	endosome	0.00757070727003222
GO:0042742	defense response to bacterium	0.00844434905875339
GO:0002720	positive regulation of cytokine production during immune response	0.00867303804046271
GO:0002702	positive regulation of production of molecular mediator of immune response	0.00867303804046271
GO:0050856	regulation of T cell receptor signaling pathway	0.00867303804046271
GO:0016043	cellular component organization and biogenesis	0.00969188158235719
GO:0042127	regulation of cell proliferation	0.0101616641858054
GO:0050851	antigen receptor-mediated signaling pathway	0.0110922639012538
GO:0002274	myeloid leukocyte activation	0.0110922639012538
GO:0042035	regulation of cytokine biosynthetic process	0.011310648108726
GO:0005123	death receptor binding	0.0116549966605453
GO:0008154	actin polymerization and/or depolymerization	0.0118921896988637
GO:0045941	positive regulation of transcription	0.0137133861946189
GO:0005794	Golgi apparatus	0.0139341140580002
GO:0042325	regulation of phosphorylation	0.0139791191987268
GO:0042981	regulation of apoptosis	0.0143637554832046
GO:0002252	immune effector process	0.0143637554832046
GO:0051246	regulation of protein metabolic process	0.0143637554832046
GO:0019864	IgG binding	0.0143637554832046
GO:0032606	interferon type I production	0.0143637554832046
GO:0045576	mast cell activation	0.0143637554832046
GO:0005031	tumor necrosis factor receptor activity	0.0143637554832046
GO:0016045	detection of bacterium	0.0143637554832046
GO:0045351	interferon type I biosynthetic process	0.0143637554832046
GO:0031988	membrane-bound vesicle	0.0145142797470331
GO:0043067	regulation of programmed cell death	0.014938936187726
GO:0045893	positive regulation of transcription, DNA-dependent	0.0149752432356112
GO:0050900	leukocyte migration	0.0149752432356112
GO:0008285	negative regulation of cell proliferation	0.0155648488558152
GO:0045935	positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	0.0155648488558152
GO:0051174	regulation of phosphorus metabolic process	0.016822618890774
GO:0019220	regulation of phosphate metabolic process	0.016822618890774
GO:0030218	erythrocyte differentiation	0.0170693884444353
GO:0002700	regulation of production of molecular mediator of immune response	0.0170693884444353
GO:0043120	tumor necrosis factor binding	0.0170693884444353
GO:0002367	cytokine production during immune response	0.0170693884444353
GO:0042834	peptidoglycan binding	0.0170693884444353
GO:0002718	regulation of cytokine production during immune response	0.0170693884444353
GO:0015629	actin cytoskeleton	0.0172406774977119
GO:0003779	actin binding	0.0173168803048573
GO:0031252	leading edge	0.0187829569235703
GO:0005057	receptor signaling protein activity	0.0201930820884009
GO:0005095	GTPase inhibitor activity	0.0204015098784014
GO:0002260	lymphocyte homeostasis	0.0204015098784014
GO:0043621	protein self-association	0.0204015098784014
GO:0005035	death receptor activity	0.0204015098784014
GO:0007626	locomotory behavior	0.0220165075837084
GO:0006928	cell motility	0.022634251627448
GO:0051674	localization of cell	0.022634251627448
GO:0045646	regulation of erythrocyte differentiation	0.0237670833948128
GO:0008367	bacterial binding	0.0237670833948128
GO:0030228	lipoprotein receptor activity	0.0237670833948128
GO:0004185	serine carboxypeptidase activity	0.0237670833948128
GO:0002699	positive regulation of immune effector process	0.0237670833948128
GO:0005041	low-density lipoprotein receptor activity	0.0237670833948128
GO:0002526	acute inflammatory response	0.0244857410857003
GO:0007266	Rho protein signal transduction	0.0253186650100781
GO:0004715	non-membrane spanning protein tyrosine kinase activity	0.0269755922369315
GO:0008329	pattern recognition receptor activity	0.0274791503579048
GO:0042226	interleukin-6 biosynthetic process	0.0274791503579048
GO:0030593	neutrophil chemotaxis	0.0274791503579048
GO:0051605	protein maturation via proteolysis	0.0274791503579048
GO:0042108	positive regulation of cytokine biosynthetic process	0.0282916980507276
GO:0042592	homeostatic process	0.029620540858432
GO:0030866	cortical actin cytoskeleton organization and biogenesis	0.0317709787102618
GO:0019222	regulation of metabolic process	0.0317709787102618
GO:0006461	protein complex assembly	0.0349472916140101
GO:0030865	cortical cytoskeleton organization and biogenesis	0.0360677869904019
GO:0051604	protein maturation	0.0360677869904019
GO:0009595	detection of biotic stimulus	0.0360677869904019
GO:0005624	membrane fraction	0.0360677869904019
GO:0006935	chemotaxis	0.0360677869904019
GO:0042330	taxis	0.0360677869904019
GO:0045121	lipid raft	0.0371754496588662
GO:0003924	GTPase activity	0.0371754496588662
GO:0005096	GTPase activator activity	0.0383148415908638
GO:0031410	cytoplasmic vesicle	0.0383148415908638
GO:0002697	regulation of immune effector process	0.0383148415908638
GO:0050707	regulation of cytokine secretion	0.0383148415908638
GO:0030695	GTPase regulator activity	0.0383148415908638
GO:0046942	carboxylic acid transport	0.0383148415908638
GO:0008092	cytoskeletal protein binding	0.0383148415908638
GO:0016064	immunoglobulin mediated immune response	0.0383148415908638
GO:0015849	organic acid transport	0.0383148415908638
GO:0046983	protein dimerization activity	0.0383148415908638
GO:0050852	T cell receptor signaling pathway	0.0383148415908638
GO:0030169	low-density lipoprotein binding	0.0383148415908638
GO:0005637	nuclear inner membrane	0.0383148415908638
GO:0030130	clathrin coat of trans-Golgi network vesicle	0.0383148415908638
GO:0019724	B cell mediated immunity	0.0383148415908638
GO:0032403	protein complex binding	0.0383148415908638
GO:0007166	cell surface receptor linked signal transduction	0.0383148415908638
GO:0033032	regulation of myeloid cell apoptosis	0.0383148415908638
GO:0045554	regulation of TRAIL biosynthetic process	0.0383148415908638
GO:0033371	T cell secretory granule organization and biogenesis	0.0383148415908638
GO:0017001	antibiotic catabolic process	0.0383148415908638
GO:0004567	beta-mannosidase activity	0.0383148415908638
GO:0008917	lipopolysaccharide N-acetylglucosaminyltransferase activity	0.0383148415908638
GO:0006050	mannosamine metabolic process	0.0383148415908638
GO:0033367	protein localization in mast cell secretory granule	0.0383148415908638
GO:0033025	regulation of mast cell apoptosis	0.0383148415908638
GO:0008457	beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity	0.0383148415908638
GO:0009169	purine ribonucleoside monophosphate catabolic process	0.0383148415908638
GO:0009158	ribonucleoside monophosphate catabolic process	0.0383148415908638
GO:0009125	nucleoside monophosphate catabolic process	0.0383148415908638
GO:0030653	beta-lactam antibiotic metabolic process	0.0383148415908638
GO:0002752	cell surface pattern recognition receptor signaling pathway	0.0383148415908638
GO:0005350	pyrimidine transmembrane transporter activity	0.0383148415908638
GO:0001802	type III hypersensitivity	0.0383148415908638
GO:0045556	positive regulation of TRAIL biosynthetic process	0.0383148415908638
GO:0045545	syndecan binding	0.0383148415908638
GO:0015855	pyrimidine transport	0.0383148415908638
GO:0033024	mast cell apoptosis	0.0383148415908638
GO:0002905	regulation of mature B cell apoptosis	0.0383148415908638
GO:0001875	lipopolysaccharide receptor activity	0.0383148415908638
GO:0006051	N-acetylmannosamine metabolic process	0.0383148415908638
GO:0032498	detection of muramyl dipeptide	0.0383148415908638
GO:0030655	beta-lactam antibiotic catabolic process	0.0383148415908638
GO:0051076	Gram-positive bacterial binding	0.0383148415908638
GO:0045553	TRAIL biosynthetic process	0.0383148415908638
GO:0001866	NK T cell proliferation	0.0383148415908638
GO:0033026	negative regulation of mast cell apoptosis	0.0383148415908638
GO:0001787	natural killer cell proliferation	0.0383148415908638
GO:0009128	purine nucleoside monophosphate catabolic process	0.0383148415908638
GO:0030347	syntaxin-2 binding	0.0383148415908638
GO:0050855	regulation of B cell receptor signaling pathway	0.0383148415908638
GO:0032733	positive regulation of interleukin-10 production	0.0383148415908638
GO:0004051	arachidonate 5-lipoxygenase activity	0.0383148415908638
GO:0033375	protease localization in T cell secretory granule	0.0383148415908638
GO:0045127	N-acetylglucosamine kinase activity	0.0383148415908638
GO:0032639	TRAIL production	0.0383148415908638
GO:0030882	lipid antigen binding	0.0383148415908638
GO:0006196	AMP catabolic process	0.0383148415908638
GO:0033377	maintenance of protein localization in T cell secretory granule	0.0383148415908638
GO:0008800	beta-lactamase activity	0.0383148415908638
GO:0033028	myeloid cell apoptosis	0.0383148415908638
GO:0033365	protein localization in organelle	0.0383148415908638
GO:0032500	muramyl dipeptide binding	0.0383148415908638
GO:0033370	maintenance of protein localization in mast cell secretory granule	0.0383148415908638
GO:0015288	porin activity	0.0383148415908638
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I	0.0383148415908638
GO:0030884	exogenous lipid antigen binding	0.0383148415908638
GO:0001805	positive regulation of type III hypersensitivity	0.0383148415908638
GO:0033366	protein localization in secretory granule	0.0383148415908638
GO:0042892	chloramphenicol transport	0.0383148415908638
GO:0008513	secondary active organic cation transmembrane transporter activity	0.0383148415908638
GO:0033382	maintenance of granzyme B localization in T cell secretory granule	0.0383148415908638
GO:0033373	maintenance of protease localization in mast cell secretory granule	0.0383148415908638
GO:0033380	granzyme B localization in T cell secretory granule	0.0383148415908638
GO:0033379	maintenance of protease localization in T cell secretory granule	0.0383148415908638
GO:0033033	negative regulation of myeloid cell apoptosis	0.0383148415908638
GO:0005896	interleukin-6 receptor complex	0.0383148415908638
GO:0048006	antigen processing and presentation, endogenous lipid antigen via MHC class Ib	0.0383148415908638
GO:0002906	negative regulation of mature B cell apoptosis	0.0383148415908638
GO:0033364	mast cell secretory granule organization and biogenesis	0.0383148415908638
GO:0004218	cathepsin S activity	0.0383148415908638
GO:0001803	regulation of type III hypersensitivity	0.0383148415908638
GO:0033368	protease localization in mast cell secretory granule	0.0383148415908638
GO:0042891	antibiotic transport	0.0383148415908638
GO:0032490	detection of molecule of bacterial origin	0.0383148415908638
GO:0050861	positive regulation of B cell receptor signaling pathway	0.0383148415908638
GO:0032495	response to muramyl dipeptide	0.0383148415908638
GO:0030348	syntaxin-3 binding	0.0383148415908638
GO:0015734	taurine transport	0.0383148415908638
GO:0032499	detection of peptidoglycan	0.0383148415908638
GO:0033374	protein localization in T cell secretory granule	0.0383148415908638
GO:0002901	mature B cell apoptosis	0.0383148415908638
GO:0032494	response to peptidoglycan	0.0383148415908638
GO:0030881	beta-2-microglobulin binding	0.0383148415908638
GO:0033023	mast cell homeostasis	0.0383148415908638
GO:0008434	vitamin D3 receptor activity	0.0383148415908638
GO:0004187	carboxypeptidase D activity	0.0383148415908638
GO:0002431	Fc receptor mediated stimulatory signaling pathway	0.0383148415908638
GO:0006886	intracellular protein transport	0.0383148415908638
GO:0032943	mononuclear cell proliferation	0.0383148415908638
GO:0045727	positive regulation of translation	0.0383148415908638
GO:0030131	clathrin adaptor complex	0.0383148415908638
GO:0046651	lymphocyte proliferation	0.0383148415908638
GO:0030097	hemopoiesis	0.0393055798470624
GO:0030119	AP-type membrane coat adaptor complex	0.0399478438347448
GO:0006516	glycoprotein catabolic process	0.0399478438347448
GO:0019209	kinase activator activity	0.0399478438347448
GO:0012510	trans-Golgi network transport vesicle membrane	0.0399478438347448
GO:0008305	integrin complex	0.0416939217740311
GO:0046982	protein heterodimerization activity	0.0417941675612297
GO:0019905	syntaxin binding	0.0440391752151675
GO:0009306	protein secretion	0.0455905431133296
GO:0046903	secretion	0.0459302065463414
GO:0050793	regulation of developmental process	0.0463991328541862

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

---

Cell Type

Ontology term	p-value	n
myeloid leukocyte	2.28e-77	72
granulocyte monocyte progenitor cell	5.22e-67	67
macrophage dendritic cell progenitor	3.77e-66	61
monopoietic cell	5.79e-64	59
monocyte	5.79e-64	59
monoblast	5.79e-64	59
promonocyte	5.79e-64	59
leukocyte	6.85e-64	136
myeloid lineage restricted progenitor cell	1.71e-63	66
defensive cell	3.34e-62	48
phagocyte	3.34e-62	48
myeloid cell	1.49e-58	108
common myeloid progenitor	1.49e-58	108
classical monocyte	1.34e-55	42
CD14-positive, CD16-negative classical monocyte	1.34e-55	42
hematopoietic stem cell	2.44e-53	168
angioblastic mesenchymal cell	2.44e-53	168
hematopoietic cell	5.55e-49	177
hematopoietic oligopotent progenitor cell	3.68e-48	161
hematopoietic multipotent progenitor cell	3.68e-48	161
hematopoietic lineage restricted progenitor cell	5.71e-47	120
nongranular leukocyte	5.32e-46	115
stuff accumulating cell	5.20e-26	87
intermediate monocyte	4.47e-12	9
CD14-positive, CD16-positive monocyte	4.47e-12	9
granulocyte	6.62e-12	8
dendritic cell	7.08e-11	10
mesenchymal cell	6.31e-10	354
connective tissue cell	2.94e-09	361
conventional dendritic cell	4.82e-09	8
blood cell	4.75e-08	11
macrophage	8.07e-08	6
immature conventional dendritic cell	2.81e-07	5
common dendritic progenitor	2.81e-07	5
motile cell	5.46e-07	386

Uber Anatomy

Ontology term	p-value	n
hematopoietic system	3.31e-70	98
blood island	3.31e-70	98
hemolymphoid system	8.57e-65	108
bone marrow	2.05e-58	76
immune system	1.23e-53	93
bone element	1.79e-52	82
skeletal element	8.46e-46	90
skeletal system	5.53e-39	100
lateral plate mesoderm	7.21e-25	203
adult organism	2.78e-18	114
musculoskeletal system	9.86e-16	167
blood	4.71e-11	15
haemolymphatic fluid	4.71e-11	15
organism substance	4.71e-11	15
mesoderm	7.82e-11	315
mesoderm-derived structure	7.82e-11	315
presumptive mesoderm	7.82e-11	315
connective tissue	9.00e-09	371
tissue	9.31e-07	773

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

---

Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
MA0003.1	14.3372
MA0004.1	0.448195
MA0006.1	1.39987
MA0007.1	0.444383
MA0009.1	0.0719156
MA0014.1	23.7838
MA0017.1	3.34936
MA0019.1	0.151122
MA0024.1	1.09473
MA0025.1	0.0502716
MA0027.1	0.657459
MA0028.1	2.2288
MA0029.1	0.0370449
MA0030.1	0.00272261
MA0031.1	0.0168047
MA0038.1	0.199097
MA0040.1	0.0212868
MA0041.1	6.63922e-05
MA0042.1	0.018191
MA0043.1	1.29594
MA0046.1	0.107133
MA0048.1	4.81925
MA0050.1	1.64223
MA0051.1	0.296848
MA0052.1	0.00150872
MA0055.1	6.56545
MA0056.1	0
MA0057.1	3.84194
MA0058.1	0.841012
MA0059.1	0.373819
MA0060.1	0.0284865
MA0061.1	1.40079
MA0063.1	0
MA0066.1	0.255903
MA0067.1	2.23643
MA0068.1	3.49831
MA0069.1	0.345033
MA0070.1	0.011639
MA0071.1	0.0078878
MA0072.1	0.0107326
MA0073.1	20.4529
MA0074.1	0.853706
MA0076.1	4.76635
MA0077.1	0.0421342
MA0078.1	0.101676
MA0081.1	8.13026
MA0083.1	0.0204166
MA0084.1	0.0173799
MA0087.1	0.0102636
MA0088.1	3.92358
MA0089.1	0
MA0090.1	0.537049
MA0091.1	0.00929968
MA0092.1	0.692594
MA0093.1	0.775214
MA0095.1	0
MA0098.1	0
MA0100.1	0.197827
MA0101.1	1.01036
MA0103.1	0.133264
MA0105.1	3.89085
MA0106.1	1.07508
MA0107.1	1.48801
MA0108.2	0.242816
MA0109.1	0
MA0111.1	1.09384
MA0113.1	0.0477034
MA0114.1	2.1366
MA0115.1	1.34977
MA0116.1	7.6267
MA0117.1	0.276281
MA0119.1	0.405509
MA0122.1	0.346003
MA0124.1	0.0166422
MA0125.1	0.149531
MA0130.1	0
MA0131.1	0.631761
MA0132.1	0
MA0133.1	0
MA0135.1	0.666145
MA0136.1	4.64887
MA0139.1	0.725492
MA0140.1	0.00118701
MA0141.1	0.627785
MA0142.1	0.0160025
MA0143.1	0.00604814
MA0144.1	1.63302
MA0145.1	4.55527
MA0146.1	17.0876
MA0147.1	0.91309
MA0148.1	0.000443285
MA0149.1	0.536195
MA0062.2	16.1149
MA0035.2	0.000261355
MA0039.2	52.0531
MA0138.2	1.04274
MA0002.2	0.310354
MA0137.2	1.84299
MA0104.2	1.30302
MA0047.2	0.0369471
MA0112.2	5.57784
MA0065.2	3.31186
MA0150.1	1.0109
MA0151.1	0
MA0152.1	0.0711417
MA0153.1	0.0329986
MA0154.1	5.70037
MA0155.1	2.83355
MA0156.1	8.28396
MA0157.1	0.00175787
MA0158.1	0
MA0159.1	2.78221
MA0160.1	0.530669
MA0161.1	0
MA0162.1	17.7572
MA0163.1	16.0399
MA0164.1	0.0625253
MA0080.2	14.7161
MA0018.2	0.692575
MA0099.2	0.58072
MA0079.2	68.6377
MA0102.2	1.49634
MA0258.1	1.52998
MA0259.1	1.01007
MA0442.1	0

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

---

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF	#promoters	Enrichment	p-value	q-value
BATF#10538	52	1.87367706094643	1.54636341751571e-05	0.00036251548588535
BCL11A#53335	49	2.0563658285159	2.43194992322331e-06	8.60109779991598e-05
BCLAF1#9774	52	1.66558827770168	0.000286690479205936	0.00304811839130498
BHLHE40#8553	33	2.19048793942345	3.28884967345976e-05	0.000654255563898026
BRCA1#672	53	1.58249145575571	0.000806555028198336	0.00615938875329088
CCNT2#905	191	1.79025813786962	1.57866835322314e-16	3.15851617130788e-14
CEBPB#1051	155	1.82770396745983	6.20710992178318e-14	9.97329774032483e-12
CHD2#1106	91	1.39246461228496	0.000862316567567634	0.00643741815583961
E2F1#1869	205	1.48818755776666	5.91403814521128e-10	5.67698740668861e-08
E2F4#1874	78	1.4616992671482	0.000542140281982163	0.0046828706401402
E2F6#1876	232	1.72186409726893	1.44418977877068e-18	3.30043186663088e-16
EBF1#1879	177	2.33201868615786	3.19158563225624e-27	1.12610139137571e-24
EGR1#1958	254	1.8742566421328	4.80041523149933e-26	1.59665785465783e-23
ELF1#1997	332	2.09125521053861	1.03530930866577e-47	7.06710254168266e-45
ELK4#2005	80	1.92138244478912	2.4290588599316e-08	1.6980487166827e-06
EP300#2033	129	1.29266047734141	0.00126105872948115	0.00846696963344791
ETS1#2113	127	1.82774058745517	2.1539303939277e-11	2.57679652246753e-09
FOS#2353	98	1.30443730809416	0.00399859413967487	0.0191748552896599
FOXA1#3169	84	1.3769811522905	0.00187981564613415	0.0110793491121109
GABPB1#2553	186	1.94465857031048	9.74387868171527e-20	2.42873734042879e-17
GATA1#2623	82	1.64488944939591	7.66855195877937e-06	0.000218346755186194
GTF2F1#2962	86	1.62072608787154	7.83860945829634e-06	0.000222159167765268
HEY1#23462	288	1.72123074025805	2.30282725100496e-24	7.13664615037706e-22
HMGN3#9324	158	1.91155405368253	7.0512798781119e-16	1.33896112580023e-13
IRF1#3659	171	1.93188609742519	1.0166877895145e-17	2.18931661956917e-15
IRF4#3662	55	1.78298549966113	3.37963181268807e-05	0.000670654316711627
JUN#3725	72	1.33272736959795	0.00832307680932835	0.0327871838748281
JUNB#3726	38	1.72071603709054	0.00104274089909976	0.00737324419506294
JUND#3727	120	1.24165632104219	0.00707152950286164	0.02949219190757
MAFK#7975	39	1.5635038348748	0.00463588054761611	0.0218881884499313
MAX#4149	204	1.94722089325067	5.58900308789575e-22	1.5483021047659e-19
MEF2A#4205	63	1.74678039542541	1.65708338639354e-05	0.000382293200334779
MEF2C#4208	31	1.89445560543098	0.000670531616815779	0.00541354758260846
MXI1#4601	105	1.54728553405285	5.23959618430048e-06	0.000160380476521734
MYC#4609	217	1.67638338186278	7.3774067462014e-16	1.39581337530168e-13
NFE2#4778	25	2.85518715427622	4.28223037103312e-06	0.000135565885941294
NFKB1#4790	254	2.06208300258171	1.65999614938745e-32	7.3773760785479e-30
NFYA#4800	53	1.44460913770861	0.00526184000387674	0.0243720644032678
NR4A1#3164	3	12.2423606817981	0.00196075867965753	0.0115148265713424
NRF1#4899	81	1.4630660284979	0.000410513768897813	0.00391254312008749
PAX5#5079	193	1.90418069159367	1.45229023986933e-19	3.56046338877262e-17
POLR2A#5430	523	1.66141717653827	1.79761492789014e-60	1.73834356901776e-57
POLR3A#11128	7	3.51172303349438	0.00429854155493133	0.0204098645869919
POU2F2#5452	165	2.22264862356141	5.1263137974855e-23	1.50389631094266e-20
REST#5978	114	1.62737170656597	1.62007122772451e-07	8.9665404850196e-06
RFX5#5993	98	1.7465906228774	5.77189556131038e-08	3.60317394218586e-06
RXRA#6256	49	1.45511278079516	0.00628292248522301	0.0277174174805359
SIN3A#25942	210	1.68027484117038	2.23402239620308e-15	4.05772287020963e-13
SMARCA4#6597	14	3.24663113359531	0.000148283045175576	0.00191309857382236
SMARCB1#6598	61	1.64706458971983	0.000116163630689233	0.00157886692159719
SMARCC1#6599	30	1.93772304672921	0.0005708790823646	0.00486591369322423
SP1#6667	185	1.55946827656223	1.5437686984365e-10	1.63022911118311e-08
SPI1#6688	272	3.30114792058903	4.33598280307696e-76	5.26564776709947e-73
SRF#6722	81	1.65321218821833	7.31122776764995e-06	0.000210525866232587
STAT1#6772	49	1.50092128308101	0.00355486574071877	0.018020027330725
STAT2#6773	22	2.12396888476582	0.00096151387080055	0.00691689951457079
STAT3#6774	118	1.83623797287604	9.89663580573054e-11	1.0733071099841e-08
TAF1#6872	346	1.71108582081046	5.21232125811661e-31	2.16880326644e-28
TAF7#6879	78	1.31920031595276	0.0077610291996911	0.0319178629094916
TAL1#6886	36	1.59063639110628	0.00491787909582783	0.0229858301583872
TBP#6908	308	1.68888368583681	3.04506410823267e-25	9.75532056440833e-23
TCF12#6938	128	2.01362649035483	2.14958440841342e-14	3.62682465315492e-12
TFAP2C#7022	80	1.27919865205446	0.0142386254380363	0.0499418257026826
USF1#7391	164	1.54332230985518	5.55596542269572e-09	4.42608293501845e-07
USF2#7392	95	1.8258265555941	1.19821575532817e-08	8.9386039479085e-07
YY1#7528	223	1.62010514381274	1.0154489678866e-14	1.75583567478657e-12
ZBTB7A#51341	179	1.94673338181921	5.78061036482001e-19	1.36588499070461e-16
ZEB1#6935	83	2.07357967079311	4.09053624419563e-10	4.02270729573962e-08

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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FF samples	Score

FF samples	Score
Eosinophils, donor3 CNhs12549	1.07
Neutrophils, donor3 CNhs11905	1.06
Eosinophils, donor2 CNhs12548	1.05
CD14+ monocytes - treated with Group A streptococci, donor1 CNhs13469	1.02
CD14+ monocytes - treated with Salmonella, donor1 CNhs13471	1.01
CD14+ monocytes - treated with Group A streptococci, donor3 CNhs13492	0.99
CD14+ monocytes - treated with BCG, donor1 CNhs13465	0.97
CD14+ monocytes - treated with Candida, donor1 CNhs13473	0.97
Neutrophils, donor1 CNhs10862	0.97
CD14+ monocytes - treated with BCG, donor3 CNhs13543	0.96

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