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{{Coexpression_clusters
{
|full_id=C1637_CD19_Basophils_CD14_CD14CD16_Peripheral_Mast_CD4
 

Latest revision as of 11:49, 17 September 2013


Full id: C1637_CD19_Basophils_CD14_CD14CD16_Peripheral_Mast_CD4



Phase1 CAGE Peaks

Hg19::chr11:60157065..60157091,-p@chr11:60157065..60157091
-
Hg19::chr17:7036237..7036263,-p@chr17:7036237..7036263
-
Hg19::chr3:42108875..42108907,-p@chr3:42108875..42108907
-
Hg19::chr6:25006945..25006954,-p@chr6:25006945..25006954
-
Hg19::chr9:27572810..27572824,+p@chr9:27572810..27572824
+


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Cell Type
Ontology termp-valuen
classical monocyte4.18e-8342
CD14-positive, CD16-negative classical monocyte4.18e-8342
leukocyte2.19e-72136
defensive cell2.20e-7148
phagocyte2.20e-7148
myeloid leukocyte4.05e-6172
nongranular leukocyte4.72e-60115
granulocyte monocyte progenitor cell2.90e-5967
hematopoietic lineage restricted progenitor cell4.62e-59120
hematopoietic stem cell6.50e-58168
angioblastic mesenchymal cell6.50e-58168
myeloid lineage restricted progenitor cell4.44e-5766
macrophage dendritic cell progenitor4.21e-5661
monopoietic cell5.52e-5559
monocyte5.52e-5559
monoblast5.52e-5559
promonocyte5.52e-5559
hematopoietic cell3.28e-54177
hematopoietic oligopotent progenitor cell2.89e-50161
hematopoietic multipotent progenitor cell2.89e-50161
myeloid cell4.11e-43108
common myeloid progenitor4.11e-43108
stuff accumulating cell1.14e-3487
intermediate monocyte3.38e-269
CD14-positive, CD16-positive monocyte3.38e-269
mesenchymal cell1.64e-19354
connective tissue cell7.77e-19361
motile cell1.85e-16386
stem cell3.64e-14441
multi fate stem cell1.47e-13427
somatic stem cell3.70e-13433
basophil4.45e-103
non-classical monocyte9.47e-103
CD14-low, CD16-positive monocyte9.47e-103
single nucleate cell1.30e-093
mononuclear cell1.30e-093
B cell2.87e-0914
lymphoid lineage restricted progenitor cell5.13e-0852
lymphocyte8.39e-0853
common lymphoid progenitor8.39e-0853
nucleate cell2.12e-0755
Uber Anatomy
Ontology termp-valuen
bone marrow7.94e-5476
hematopoietic system1.17e-5398
blood island1.17e-5398
bone element4.31e-4982
hemolymphoid system1.49e-47108
immune system3.61e-4493
skeletal element9.37e-4490
skeletal system2.81e-38100
lateral plate mesoderm1.53e-19203
musculoskeletal system1.61e-18167
connective tissue6.47e-18371
mesoderm4.96e-09315
mesoderm-derived structure4.96e-09315
presumptive mesoderm4.96e-09315


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.00991994
MA0004.10.626788
MA0006.10.452993
MA0007.11.47524
MA0009.11.11255
MA0014.10.161847
MA0017.10.496101
MA0019.10.784036
MA0024.11.00439
MA0025.11.24931
MA0027.12.73598
MA0028.10.470679
MA0029.11.02437
MA0030.11.01252
MA0031.10.945567
MA0038.10.736268
MA0040.11.03042
MA0041.11.55893
MA0042.12.52778
MA0043.11.11288
MA0046.11.10134
MA0048.10.195817
MA0050.10.613347
MA0051.10.731787
MA0052.11.03442
MA0055.10.0853006
MA0056.10
MA0057.10.189508
MA0058.10.523638
MA0059.10.522232
MA0060.10.860776
MA0061.10.791444
MA0063.10
MA0066.10.736721
MA0067.11.43651
MA0068.10.247962
MA0069.11.09737
MA0070.11.08584
MA0071.10.695094
MA0072.11.0812
MA0073.10.00220137
MA0074.10.730989
MA0076.10.540943
MA0077.11.07324
MA0078.10.836493
MA0081.11.2972
MA0083.11.12028
MA0084.11.62584
MA0087.11.07867
MA0088.10.132006
MA0089.10
MA0090.10.556637
MA0091.10.629594
MA0092.10.588959
MA0093.10.456342
MA0095.10
MA0098.10
MA0100.10.750974
MA0101.10.459973
MA0103.10.442769
MA0105.10.175503
MA0106.10.779931
MA0107.10.985964
MA0108.20.94238
MA0109.10
MA0111.10.5713
MA0113.10.797251
MA0114.10.372523
MA0115.11.35895
MA0116.10.382106
MA0117.11.1512
MA0119.10.504689
MA0122.11.17777
MA0124.11.31673
MA0125.11.23103
MA0130.10
MA0131.10.855546
MA0132.10
MA0133.10
MA0135.11.14377
MA0136.10.743749
MA0139.10.277033
MA0140.10.692258
MA0141.10.520334
MA0142.12.10746
MA0143.11.87149
MA0144.10.356507
MA0145.10.143698
MA0146.10.0359558
MA0147.10.386018
MA0148.10.653474
MA0149.10.681935
MA0062.20.284987
MA0035.20.691506
MA0039.20.0118463
MA0138.20.837782
MA0002.20.83106
MA0137.20.47779
MA0104.20.320919
MA0047.20.767096
MA0112.20.136971
MA0065.20.146576
MA0150.10.550239
MA0151.10
MA0152.10.69926
MA0153.11.21379
MA0154.10.514087
MA0155.10.130813
MA0156.10.480289
MA0157.10.883854
MA0158.10
MA0159.10.386729
MA0160.10.669748
MA0161.10
MA0162.10.0592265
MA0163.10.0439995
MA0164.10.810347
MA0080.21.15604
MA0018.20.781393
MA0099.20.699641
MA0079.23.83292e-05
MA0102.21.66336
MA0258.10.345771
MA0259.10.395396
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
MEF2A#4205414.99458472771523.876195075647e-050.000727842390337103
MEF2C#4208216.52454179704960.005579850077982050.0252383699564473
POU2F2#545235.463674434645510.01115650094469780.0410027026837206
SPI1#668846.563458806818180.0009957429636454020.00714002055476568



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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