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{{Coexpression_clusters
{
|coexpression_dpi_cluster_scores_median=0,0

Latest revision as of 11:47, 17 September 2013


Full id: C1577_Mast_CD4_CD34_CD8_Natural_CD14_immature



Phase1 CAGE Peaks

Hg19::chr10:3916381..3916422,+p@chr10:3916381..3916422
+
Hg19::chr11:66384629..66384643,+p6@RBM14
Hg19::chr3:107941436..107941490,+p@chr3:107941436..107941490
+
Hg19::chr3:32543733..32543758,+p@chr3:32543733..32543758
+
Hg19::chr5:672925..672969,-p@chr5:672925..672969
-


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Cell Type
Ontology termp-valuen
leukocyte4.12e-43136
hematopoietic lineage restricted progenitor cell1.24e-35120
hematopoietic stem cell5.29e-35168
angioblastic mesenchymal cell5.29e-35168
hematopoietic cell2.20e-33177
hematopoietic oligopotent progenitor cell6.46e-32161
hematopoietic multipotent progenitor cell6.46e-32161
nongranular leukocyte4.00e-31115
lymphoid lineage restricted progenitor cell9.49e-2152
nucleate cell9.75e-2155
lymphocyte3.41e-2053
common lymphoid progenitor3.41e-2053
myeloid leukocyte2.53e-1572
granulocyte monocyte progenitor cell3.04e-1467
T cell6.56e-1425
pro-T cell6.56e-1425
mature alpha-beta T cell9.55e-1418
alpha-beta T cell9.55e-1418
immature T cell9.55e-1418
mature T cell9.55e-1418
immature alpha-beta T cell9.55e-1418
myeloid lineage restricted progenitor cell3.14e-1366
myeloid cell3.55e-13108
common myeloid progenitor3.55e-13108
classical monocyte3.63e-1342
CD14-positive, CD16-negative classical monocyte3.63e-1342
CD4-positive, alpha-beta T cell1.64e-126
intermediate monocyte3.27e-129
CD14-positive, CD16-positive monocyte3.27e-129
macrophage dendritic cell progenitor4.47e-1161
defensive cell8.40e-1148
phagocyte8.40e-1148
mesenchymal cell6.75e-10354
monopoietic cell2.20e-0959
monocyte2.20e-0959
monoblast2.20e-0959
promonocyte2.20e-0959
connective tissue cell2.37e-09361
Langerhans cell5.77e-095
motile cell8.76e-09386
natural killer cell3.53e-073
pro-NK cell3.53e-073
naive T cell7.23e-073
basophil7.66e-073
histamine secreting cell9.33e-075
biogenic amine secreting cell9.33e-075
granulocytopoietic cell9.33e-075
mast cell9.33e-075
mast cell progenitor9.33e-075
basophil mast progenitor cell9.33e-075
Uber Anatomy
Ontology termp-valuen
hematopoietic system2.51e-1598
blood island2.51e-1598
hemolymphoid system5.89e-13108
bone marrow9.38e-1376
immune system1.71e-1193
bone element3.08e-1182
skeletal element1.50e-0990
connective tissue1.29e-08371
skeletal system7.42e-08100


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.0497246
MA0004.10.626788
MA0006.10.452993
MA0007.10.606704
MA0009.11.11255
MA0014.10.369468
MA0017.10.496101
MA0019.10.784036
MA0024.11.00439
MA0025.11.24931
MA0027.12.73598
MA0028.10.470679
MA0029.11.02437
MA0030.11.01252
MA0031.10.945567
MA0038.10.736268
MA0040.11.03042
MA0041.10.64667
MA0042.11.48719
MA0043.11.11288
MA0046.11.10134
MA0048.10.195817
MA0050.10.613347
MA0051.10.731787
MA0052.11.03442
MA0055.10.0853006
MA0056.10
MA0057.10.189508
MA0058.10.523638
MA0059.10.522232
MA0060.10.321781
MA0061.10.291022
MA0063.10
MA0066.10.736721
MA0067.11.43651
MA0068.10.247962
MA0069.11.09737
MA0070.11.08584
MA0071.10.695094
MA0072.11.0812
MA0073.10.111822
MA0074.10.730989
MA0076.10.540943
MA0077.11.07324
MA0078.10.836493
MA0081.10.522409
MA0083.11.12028
MA0084.11.62584
MA0087.11.07867
MA0088.10.132006
MA0089.10
MA0090.10.556637
MA0091.10.629594
MA0092.10.588959
MA0093.10.456342
MA0095.10
MA0098.10
MA0100.10.750974
MA0101.10.459973
MA0103.10.442769
MA0105.10.175503
MA0106.10.779931
MA0107.10.378225
MA0108.20.94238
MA0109.10
MA0111.11.40074
MA0113.10.797251
MA0114.10.372523
MA0115.11.35895
MA0116.10.382106
MA0117.11.1512
MA0119.11.25946
MA0122.11.17777
MA0124.11.31673
MA0125.11.23103
MA0130.10
MA0131.10.855546
MA0132.10
MA0133.10
MA0135.11.14377
MA0136.10.743749
MA0139.10.277033
MA0140.10.692258
MA0141.10.520334
MA0142.10.912455
MA0143.10.797437
MA0144.10.356507
MA0145.10.143698
MA0146.10.143081
MA0147.10.386018
MA0148.11.57313
MA0149.10.681935
MA0062.20.284987
MA0035.20.691506
MA0039.20.527987
MA0138.20.837782
MA0002.20.30855
MA0137.20.47779
MA0104.20.320919
MA0047.20.767096
MA0112.20.839774
MA0065.20.146576
MA0150.10.550239
MA0151.10
MA0152.10.69926
MA0153.11.21379
MA0154.10.172764
MA0155.10.130813
MA0156.10.480289
MA0157.10.883854
MA0158.10
MA0159.10.386729
MA0160.10.669748
MA0161.10
MA0162.10.21472
MA0163.10.382496
MA0164.10.810347
MA0080.20.456437
MA0018.20.781393
MA0099.20.699641
MA0079.20.0850863
MA0102.21.66336
MA0258.10.914277
MA0259.10.395396
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
FOXA1#316936.648851849631270.006389025166568720.0278038001321418
FOXA2#3170314.77827825159910.0006289192851194480.0051727595856505
MAX#414945.16204440720570.002526309009485180.0139941225544512
MXI1#460135.976942977255580.008653004889366880.032938882404162



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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