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Coexpression cluster:C516: Difference between revisions

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|ontology_enrichment_disease=DOID:305!1.60e-15!106;DOID:0050687!4.55e-12!143;DOID:1749!1.91e-09!14;DOID:299!4.66e-07!25
|ontology_enrichment_disease=DOID:305!1.60e-15!106;DOID:0050687!4.55e-12!143;DOID:1749!1.91e-09!14;DOID:299!4.66e-07!25
|ontology_enrichment_uberon=UBERON:0006554!1.55e-10!44;UBERON:0001008!5.03e-10!45;UBERON:0000064!9.09e-09!219;UBERON:0000481!4.11e-08!347;UBERON:0004119!4.41e-08!169;UBERON:0000925!4.41e-08!169;UBERON:0006595!4.41e-08!169;UBERON:0001893!4.86e-08!34;UBERON:0002020!5.67e-08!34;UBERON:0003528!5.67e-08!34;UBERON:0001869!9.14e-08!32;UBERON:0002791!1.01e-07!33;UBERON:0001017!1.98e-07!82;UBERON:0000344!4.09e-07!12;UBERON:0005743!6.69e-07!86;UBERON:0001007!9.38e-07!155;UBERON:0001555!9.38e-07!155;UBERON:0007026!9.38e-07!155
|ontology_enrichment_uberon=UBERON:0006554!1.55e-10!44;UBERON:0001008!5.03e-10!45;UBERON:0000064!9.09e-09!219;UBERON:0000481!4.11e-08!347;UBERON:0004119!4.41e-08!169;UBERON:0000925!4.41e-08!169;UBERON:0006595!4.41e-08!169;UBERON:0001893!4.86e-08!34;UBERON:0002020!5.67e-08!34;UBERON:0003528!5.67e-08!34;UBERON:0001869!9.14e-08!32;UBERON:0002791!1.01e-07!33;UBERON:0001017!1.98e-07!82;UBERON:0000344!4.09e-07!12;UBERON:0005743!6.69e-07!86;UBERON:0001007!9.38e-07!155;UBERON:0001555!9.38e-07!155;UBERON:0007026!9.38e-07!155
|tf_chipseq_enrich=ESR1#2099;5:8.5468342489318:0.000217524100570887:0.00248937097737484
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2,0.320562,0.937727,0.182735,0.47483,0.774031,0.214645,0.308574,0.63263,0.185435,0.499229,0.503087,0.837701,0.159801,0.951569,0.0690662,0.211589,0.422522,0.00507097,0.606778,0.257551,0.183229,0.71767,0.569618,0.354097,0.802847,0.601932,0.0827385,0.314132,0.401036,0.701952,0.442866,0.616682,0.599545,0.0992326,0.597186,0.428223,0.891694,0.602205,0.252299,0.450163,0.281822,0.574933,0.38344,0.500313,0.562062,0.570699,0.99255,0.871698,0.2734,0.13126,0.265077,0.318145,0.37568,0.445667,0.239771,0.187529,0.0790404,0.579412,0.418045,0.456141,0.183613,0.607116,0.533106,0.722709,0.115318,0.991456,0.0501013,0.253653,0.949969,0.313952,0.685432,0.631863,0.358506,0.781428,0.154673,0.195384,0.553066,0.110885,0.976535,0.999732,0.750293,0.771651,0.497219,0.341862,0.152602,0.262149,0.453683,0.748926,0.375958,0.244499,0.503741,0.354161,0.785282,0.264113,0.205881,0.574149,0.241402,0.282895,0.517064,0.117111,0.67875,0.485849,0.777635,0.297565,0.475641,0.377588,0.868466,0.261254,0.373545,0.771789,0.136214,0.686443,0.680044,0.242768,0.0778162,0.321823,0.364017,0.25139,0.922915,0.638083,0.360861,0.439211,0.311174,0.240361,0.624525,0.459217,0.636046,0.103667,0.370144,0.587519,0.0725683,0.824099,0.604413,0.532516,0.408856,0.694998,0.513464,0.511834,0.351591,0.684185,0.450032,0.84115,0.820664,0.596934,0.467764,0.832569,0.140888,0.162761,0.143867,0.668089,0.434597,0.280436,0.665825,0.714737,0.399122,0.0361602,0.639215,0.38865,0.80301,0.306133,0.818177,0.692392,0.771716,0.467462,0.820566,0.687855,0.197893,0.617603,0.569631,0.234019,0.577076,0.630272,0.300345,0.479785,0.0985867,0.211352,0.693733,0.457789,0.0627622,0.647168,0.47923,0.73287,0.584602,0.0202577,0.818821,0.781969,0.59577,0.424672,0.00820699,0.64656,0.948665,0.11252,0.598241,0.277038,0.647518,0.930902,0.983159,0.202699,0.93295,0.827231,0.561256,0.86597,0.923039,0.526825,0.984388,0.870889,0.292238,0.975936,0.869589,0.963696,0.747264,0.914508,0.891911,0.534841,0.869259,0.235769,0.999878,0.797142,0.996885,0.967982,0.0911851,0.997782,0.946758,0.587996,0.999303,0.769993,0.998993,0.900268,0.810019,0.988649,0.940497,0.744508,0.388179,0.401542,0.0666169,0.00983673,0.42636,0.92402,0.785432,0.270993,0.0652049,0.617077,0.454764,0.394684,0.927854,0.658198,0.792519,0.53631,0.325073,0.552243,0.394665,0.699128,0.051765,0.980009,0.353411,0.822121,0.0341347,0.676805,0.881414,0.0412123,0.920713,0.79156,0.935645,0.85133,0.491386,0.192775,0.960581,0.108871,0.975943,0.956402,0.761531,0.747185,0.157754,0.592235,0.990652,0.299375,0.381166,0.406909,0.665152,0.751622,0.685157,0.911881,0.532019,0.820639,0.610461,0.513547,0.836399,0.571059,0.287611,0.0809244,0.744635,0.570854,0.537094,0.284036,0.731561,0.305027,0.407743,0.374794,0.231096,0.766475,0.644797,0.638534,0.392581,0.337497,0.797117,0.82339,0.168224,0.307703,0.923005,0.189284,0.926235,0.0447313,0.364499,0.513945,0.646514,0.378156,0.713566,0.864658,0.130773,0.535188,0.195027,0.30041,0.519534,0.304449,0.333247,0.746867,0.74594,0.0139282,0.3811,0.918868,0.562553,0.437528,0.659174,0.0221221,0.719828,0.74832,0.687875,0.385297,0.133089,0.400802,0.185981,0.134185,0.268668,0.355893,0.360982,0.84219,0.655096,0.719738,0.656304,0.773807,0.753221,0.432404,0.451923,0.663792,0.254325,0.777691,0.829733,0.406648,0.149928,0.00739755,0.725021,0.776362,0.194602,0.458339,0.0264757,0.433934,0.735119,0.710818,0.546023,0.0118353,0.180297,0.11788,0.548272,0.695747,0.456739,0.135796,0.415306,0.00024383,0.053947,0.508871,0.778821,0.0665089,0.754074,0.554755,0.513289,0.611261,0.790648,0.654051,0.462069,0.0264065,0.20985,0.336557,0.275056,0.244013,0.0423107,0.391097,0.26158,0.635815,0.536216,0.000468316,0.497844,0.308198,0.428543,0.00422954,0.775352,0.728313,0.548777,0.835303,0.0253119,0.697339,0.648411,0.532604,0.624798,0.183311,0.547862,0.345446,0.127054,0.362671,0.83378,0.54332,0.745202,0.763881,0.406725,0.600675,0.368499,0.820737,0.169682,0.782599,0.505205,0.680147,0.388018,0.594826,0.146875,0.0265665,0.639739,0.569592,0.531803,0.0672,0.678071,0.325508,0.457605,0.742029,0.385293,0.58825,0.185312,0.402439,0.155587,0.491991,0.281488,0.282255,0.0772178,0.0863966,0.220774,0.282081,0.407481,0.543273,0.759361,0.71279,0.797398,0.359321,0.398723,0.0250965,0.328182,0.184057,0.326996,0.48466,0.337521,0.378673,0.56258,0.500235,0.237135,0.340182,0.430665,0.201185,0.216542,0.746375,0.878019,0.0551261,0.72428,0.0656872,0.546704,0.830335,0.152114,0.458329,0.880698,0.82696,0.690759,0.0527899,0.28079,0.208459,0.650351,0.749886,0.0464767,0.601711,0.221504,0.90554,0.522191,0.771405,0.781357,0.520448,0.0432298,0.363115,0.31938,0.322755,0.821957,0.2934,0.197101,0.445395,0.217442,0.784583,0.752806,0.453778,0.102276,0.665994,0.0280269,0.645799,0.295944,0.357633,0.0435336,0.472167,0.0669542,0.323245,0.00408539,0.180642,0.009098,0.749347,0.0560261
}}
}}

Revision as of 12:32, 5 September 2012


Full id: C516_endometrioid_clear_serous_anaplastic_malignant_oral_uterus



Phase1 CAGE Peaks

Hg19::chr14:33147559..33147570,+p@chr14:33147559..33147570
+
Hg19::chr14:33403217..33403226,+p@chr14:33403217..33403226
+
Hg19::chr14:33403278..33403307,+p@chr14:33403278..33403307
+
Hg19::chr19:28782435..28782439,+p@chr19:28782435..28782439
+
Hg19::chr1:46651830..46651834,-p@chr1:46651830..46651834
-
Hg19::chr4:19457174..19457178,+p3@ENST00000511431
Hg19::chr4:95680517..95680526,-p@chr4:95680517..95680526
-
Hg19::chr4:95680536..95680545,-p@chr4:95680536..95680545
-
Hg19::chr4:95680548..95680553,-p@chr4:95680548..95680553
-
Hg19::chr6:134327986..134327991,-p@chr6:134327986..134327991
-
Hg19::chr6:20541194..20541205,+p@chr6:20541194..20541205
+
Hg19::chr6:31097301..31097322,+p@chr6:31097301..31097322
+
Hg19::chr6:52837931..52837938,-p@chr6:52837931..52837938
-
Hg19::chr6:52837942..52837955,-p@chr6:52837942..52837955
-
Hg19::chr7:27208949..27208981,+p4@ENST00000523790
Hg19::chr7:6312923..6312932,-p@chr7:6312923..6312932
-
Hg19::chr8:145578301..145578317,+p5@GPR172A
Hg19::chr9:124877971..124877982,+p@chr9:124877971..124877982
+


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

Cell Type
Ontology termp-valuen
epithelial cell2.14e-15254
endo-epithelial cell7.90e-1443
endodermal cell8.75e-1159
epithelial cell of alimentary canal8.15e-0721
Uber Anatomy
Ontology termp-valuen
urinary system structure1.55e-1044
renal system5.03e-1045
organ part9.09e-09219
multi-tissue structure4.11e-08347
endoderm-derived structure4.41e-08169
endoderm4.41e-08169
presumptive endoderm4.41e-08169
telencephalon4.86e-0834
gray matter5.67e-0834
brain grey matter5.67e-0834
cerebral hemisphere9.14e-0832
regional part of telencephalon1.01e-0733
central nervous system1.98e-0782
mucosa4.09e-0712
digestive system9.38e-07155
digestive tract9.38e-07155
primitive gut9.38e-07155
Disease
Ontology termp-valuen
carcinoma1.60e-15106
cell type cancer4.55e-12143
squamous cell carcinoma1.91e-0914
adenocarcinoma4.66e-0725


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
ESR1#209958.54683424893180.0002175241005708870.00248937097737484



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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