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Coexpression cluster:C1976: Difference between revisions

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|ontology_enrichment_uberon=UBERON:0002390!1.52e-30!98;UBERON:0003061!1.52e-30!98;UBERON:0002193!4.07e-29!108;UBERON:0002405!2.30e-20!93;UBERON:0002371!1.49e-17!76;UBERON:0001474!6.93e-16!82;UBERON:0004765!3.84e-13!90;UBERON:0001434!5.09e-11!100;UBERON:0000178!5.11e-11!15;UBERON:0000179!5.11e-11!15;UBERON:0000463!5.11e-11!15;UBERON:0002384!7.57e-09!371;UBERON:0003081!5.02e-08!203;UBERON:0007023!6.49e-08!114
|ontology_enrichment_uberon=UBERON:0002390!1.52e-30!98;UBERON:0003061!1.52e-30!98;UBERON:0002193!4.07e-29!108;UBERON:0002405!2.30e-20!93;UBERON:0002371!1.49e-17!76;UBERON:0001474!6.93e-16!82;UBERON:0004765!3.84e-13!90;UBERON:0001434!5.09e-11!100;UBERON:0000178!5.11e-11!15;UBERON:0000179!5.11e-11!15;UBERON:0000463!5.11e-11!15;UBERON:0002384!7.57e-09!371;UBERON:0003081!5.02e-08!203;UBERON:0007023!6.49e-08!114
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}}
}}

Revision as of 15:13, 26 November 2012


Full id: C1976_Neutrophils_Whole_Eosinophils_CD8_CD19_CD4_blood



Phase1 CAGE Peaks

Hg19::chr6:24851973..24851977,-p@chr6:24851973..24851977
-
Hg19::chr6:24923083..24923087,-p@chr6:24923083..24923087
-
Hg19::chr6:24936170..24936199,-p1@FAM65B
Hg19::chr6:31548877..31548898,+p2@AK095821
Hg19::chr8:101963707..101963755,-p8@YWHAZ


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
leukocyte9.42e-70136
nongranular leukocyte2.27e-62115
hematopoietic lineage restricted progenitor cell1.15e-57120
hematopoietic stem cell6.31e-57168
angioblastic mesenchymal cell6.31e-57168
hematopoietic oligopotent progenitor cell1.15e-53161
hematopoietic multipotent progenitor cell1.15e-53161
hematopoietic cell5.73e-52177
lymphocyte6.09e-3953
common lymphoid progenitor6.09e-3953
lymphoid lineage restricted progenitor cell3.57e-3852
nucleate cell8.19e-3755
myeloid leukocyte7.41e-2772
classical monocyte3.31e-2142
CD14-positive, CD16-negative classical monocyte3.31e-2142
granulocyte monocyte progenitor cell6.52e-2167
macrophage dendritic cell progenitor1.22e-2061
monopoietic cell1.37e-2059
monocyte1.37e-2059
monoblast1.37e-2059
promonocyte1.37e-2059
myeloid lineage restricted progenitor cell2.76e-2066
myeloid cell1.47e-18108
common myeloid progenitor1.47e-18108
lymphocyte of B lineage1.68e-1824
pro-B cell1.68e-1824
mature alpha-beta T cell1.80e-1818
alpha-beta T cell1.80e-1818
immature T cell1.80e-1818
mature T cell1.80e-1818
immature alpha-beta T cell1.80e-1818
defensive cell3.59e-1848
phagocyte3.59e-1848
T cell5.57e-1825
pro-T cell5.57e-1825
B cell8.11e-1414
CD8-positive, alpha-beta T cell6.30e-1311
mesenchymal cell1.03e-10354
connective tissue cell6.48e-10361
motile cell1.65e-07386
granulocyte2.63e-078
CD4-positive, alpha-beta T cell6.77e-076
Uber Anatomy
Ontology termp-valuen
hematopoietic system1.52e-3098
blood island1.52e-3098
hemolymphoid system4.07e-29108
immune system2.30e-2093
bone marrow1.49e-1776
bone element6.93e-1682
skeletal element3.84e-1390
skeletal system5.09e-11100
blood5.11e-1115
haemolymphatic fluid5.11e-1115
organism substance5.11e-1115
connective tissue7.57e-09371
lateral plate mesoderm5.02e-08203
adult organism6.49e-08114


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

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ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.