Coexpression cluster:C104

Full id: C104_Mast_Basophils_immature_CD14_CD34_eye_Natural

Phase1 CAGE Peaks

Hg19::chr10:119008587..119008609,+	p@chr10:119008587..119008609 +
Hg19::chr10:22629327..22629380,+	p@chr10:22629327..22629380 +
Hg19::chr10:22629385..22629413,+	p@chr10:22629385..22629413 +
Hg19::chr10:70091066..70091074,+	p41@HNRNPH3
Hg19::chr10:70845215..70845221,+	p@chr10:70845215..70845221 +
Hg19::chr10:75670452..75670464,+	p15@PLAU
Hg19::chr10:75670497..75670502,+	p27@PLAU
Hg19::chr10:75670546..75670555,+	p25@PLAU
Hg19::chr10:80827832..80827858,+	p@chr10:80827832..80827858 +
Hg19::chr11:11140283..11140298,+	p@chr11:11140283..11140298 +
Hg19::chr11:114042361..114042371,+	p@chr11:114042361..114042371 +
Hg19::chr11:123950597..123950605,-	p@chr11:123950597..123950605 -
Hg19::chr11:123986579..123986582,+	p8@VWA5A
Hg19::chr11:18913178..18913190,-	p@chr11:18913178..18913190 -
Hg19::chr11:35060106..35060117,-	p@chr11:35060106..35060117 -
Hg19::chr11:66035836..66035852,+	p5@RAB1B
Hg19::chr11:68049932..68049949,+	p@chr11:68049932..68049949 +
Hg19::chr12:109221132..109221142,+	p@chr12:109221132..109221142 +
Hg19::chr12:123355673..123355677,+	p@chr12:123355673..123355677 +
Hg19::chr12:123367928..123367963,+	p@chr12:123367928..123367963 +
Hg19::chr12:123373444..123373465,-	p3@AK022083
Hg19::chr12:2027058..2027073,+	p2@ENST00000544163
Hg19::chr12:49595765..49595807,-	p@chr12:49595765..49595807 -
Hg19::chr12:52405627..52405641,+	p@chr12:52405627..52405641 +
Hg19::chr12:52406753..52406758,+	p@chr12:52406753..52406758 +
Hg19::chr12:69309135..69309157,+	p@chr12:69309135..69309157 +
Hg19::chr12:9926395..9926410,+	p@chr12:9926395..9926410 +
Hg19::chr13:102107644..102107646,+	p@chr13:102107644..102107646 +
Hg19::chr13:110320109..110320114,-	p@chr13:110320109..110320114 -
Hg19::chr13:33858530..33858557,+	p@chr13:33858530..33858557 +
Hg19::chr14:107253174..107253177,+	p@chr14:107253174..107253177 +
Hg19::chr14:107254686..107254688,+	p@chr14:107254686..107254688 +
Hg19::chr14:25042788..25042795,-	p@chr14:25042788..25042795 -
Hg19::chr14:25043949..25043954,-	p@chr14:25043949..25043954 -
Hg19::chr14:25464405..25464415,-	p@chr14:25464405..25464415 -
Hg19::chr14:75988851..75988862,+	p3@BATF
Hg19::chr14:75990204..75990207,-	p@chr14:75990204..75990207 -
Hg19::chr14:75990216..75990238,-	p@chr14:75990216..75990238 -
Hg19::chr14:75990393..75990403,+	p@chr14:75990393..75990403 +
Hg19::chr14:76011156..76011159,+	p@chr14:76011156..76011159 +
Hg19::chr14:76093618..76093623,+	p@chr14:76093618..76093623 +
Hg19::chr14:93118081..93118090,+	p33@RIN3
Hg19::chr15:50555987..50555996,-	p4@HDC
Hg19::chr15:74285218..74285223,+	p@chr15:74285218..74285223 +
Hg19::chr15:86124935..86124950,+	p47@AKAP13
Hg19::chr15:86126058..86126070,+	p14@AKAP13
Hg19::chr16:1306063..1306088,+	p1@TPSD1
Hg19::chr16:1309001..1309007,-	p@chr16:1309001..1309007 -
Hg19::chr16:27254686..27254705,-	p@chr16:27254686..27254705 -
Hg19::chr16:27297536..27297559,+	p@chr16:27297536..27297559 +
Hg19::chr16:27297597..27297620,+	p@chr16:27297597..27297620 +
Hg19::chr16:27341974..27341981,-	p@chr16:27341974..27341981 -
Hg19::chr17:35848660..35848677,+	p@chr17:35848660..35848677 +
Hg19::chr17:38498236..38498251,+	p24@RARA
Hg19::chr17:57914836..57914848,-	p@chr17:57914836..57914848 -
Hg19::chr17:80217542..80217565,+	p@chr17:80217542..80217565 +
Hg19::chr17:80225355..80225360,-	p@chr17:80225355..80225360 -
Hg19::chr17:8050682..8050689,-	p@chr17:8050682..8050689 -
Hg19::chr17:8053906..8053911,-	p16@PER1
Hg19::chr17:8055163..8055196,-	p@chr17:8055163..8055196 -
Hg19::chr18:72919862..72919879,+	p@chr18:72919862..72919879 +
Hg19::chr19:13943041..13943045,-	p@chr19:13943041..13943045 -
Hg19::chr1:194021410..194021419,+	p@chr1:194021410..194021419 +
Hg19::chr1:204433825..204433835,-	p@chr1:204433825..204433835 -
Hg19::chr1:208040829..208040861,-	p@chr1:208040829..208040861 -
Hg19::chr1:208041790..208041810,+	p@chr1:208041790..208041810 +
Hg19::chr1:211500017..211500028,+	p4@TRAF5
Hg19::chr1:211665830..211665832,-	p5@RD3
Hg19::chr1:234746113..234746135,-	p@chr1:234746113..234746135 -
Hg19::chr1:234746222..234746233,-	p@chr1:234746222..234746233 -
Hg19::chr1:26394211..26394222,-	p2@TRIM63
Hg19::chr1:51442887..51442897,+	p@chr1:51442887..51442897 +
Hg19::chr1:8585424..8585441,+	p@chr1:8585424..8585441 +
Hg19::chr1:87652214..87652226,+	p@chr1:87652214..87652226 +
Hg19::chr20:46239342..46239384,-	p@chr20:46239342..46239384 -
Hg19::chr20:47527269..47527280,+	p@chr20:47527269..47527280 +
Hg19::chr20:47527319..47527327,+	p@chr20:47527319..47527327 +
Hg19::chr20:61546414..61546426,-	p@chr20:61546414..61546426 -
Hg19::chr20:62711742..62711760,-	p16@RGS19
Hg19::chr21:44876530..44876542,-	p@chr21:44876530..44876542 -
Hg19::chr21:46291662..46291669,+	p@chr21:46291662..46291669 +
Hg19::chr22:46440393..46440404,+	p@chr22:46440393..46440404 +
Hg19::chr2:102890300..102890303,-	p@chr2:102890300..102890303 -
Hg19::chr2:102890553..102890560,+	p@chr2:102890553..102890560 +
Hg19::chr2:102918664..102918670,+	p@chr2:102918664..102918670 +
Hg19::chr2:102921765..102921775,-	p@chr2:102921765..102921775 -
Hg19::chr2:129198690..129198730,+	p@chr2:129198690..129198730 +
Hg19::chr2:191334654..191334665,-	p@chr2:191334654..191334665 -
Hg19::chr2:192712167..192712178,+	p@chr2:192712167..192712178 +
Hg19::chr2:203971678..203971694,+	p@chr2:203971678..203971694 +
Hg19::chr2:219434730..219434737,-	p@chr2:219434730..219434737 -
Hg19::chr2:232476642..232476652,-	p@chr2:232476642..232476652 -
Hg19::chr2:240158723..240158738,+	p@chr2:240158723..240158738 +
Hg19::chr2:43439913..43439961,+	p@chr2:43439913..43439961 +
Hg19::chr2:43452693..43452706,-	p@chr2:43452693..43452706 -
Hg19::chr2:43494674..43494682,-	p@chr2:43494674..43494682 -
Hg19::chr2:74408903..74408905,+	p@chr2:74408903..74408905 +
Hg19::chr3:148673507..148673511,+	p@chr3:148673507..148673511 +
Hg19::chr3:194379490..194379494,+	p@chr3:194379490..194379494 +
Hg19::chr3:194382239..194382248,-	p@chr3:194382239..194382248 -
Hg19::chr3:32426693..32426725,+	p@chr3:32426693..32426725 +
Hg19::chr3:37494463..37494467,-	p@chr3:37494463..37494467 -
Hg19::chr3:39217751..39217754,+	p@chr3:39217751..39217754 +
Hg19::chr3:39544357..39544362,-	p@chr3:39544357..39544362 -
Hg19::chr3:52143667..52143678,-	p@chr3:52143667..52143678 -
Hg19::chr3:63965180..63965183,+	p@chr3:63965180..63965183 +
Hg19::chr3:63965199..63965211,+	p@chr3:63965199..63965211 +
Hg19::chr3:63965367..63965410,+	p@chr3:63965367..63965410 +
Hg19::chr3:63967092..63967120,+	p@chr3:63967092..63967120 +
Hg19::chr3:71256933..71256980,-	p@chr3:71256933..71256980 -
Hg19::chr3:71257632..71257638,-	p@chr3:71257632..71257638 -
Hg19::chr4:102210033..102210054,-	p@chr4:102210033..102210054 -
Hg19::chr4:102267113..102267120,-	p4@BC038734
Hg19::chr4:164479989..164479993,-	p@chr4:164479989..164479993 -
Hg19::chr4:175441901..175441909,-	p@chr4:175441901..175441909 -
Hg19::chr4:175441997..175442010,-	p@chr4:175441997..175442010 -
Hg19::chr4:55531069..55531072,+	p@chr4:55531069..55531072 +
Hg19::chr4:55589865..55589867,+	p@chr4:55589865..55589867 +
Hg19::chr4:55598235..55598239,+	p@chr4:55598235..55598239 +
Hg19::chr4:6910966..6910998,+	p11@TBC1D14
Hg19::chr4:6912718..6912721,-	p@chr4:6912718..6912721 -
Hg19::chr4:6918766..6918775,+	p@chr4:6918766..6918775 +
Hg19::chr4:89615287..89615307,+	p@chr4:89615287..89615307 +
Hg19::chr4:89615318..89615326,+	p@chr4:89615318..89615326 +
Hg19::chr4:95260150..95260154,+	p@chr4:95260150..95260154 +
Hg19::chr4:95275784..95275794,-	p@chr4:95275784..95275794 -
Hg19::chr5:102880097..102880102,-	p@chr5:102880097..102880102 -
Hg19::chr5:102880115..102880126,-	p@chr5:102880115..102880126 -
Hg19::chr5:102880145..102880156,-	p@chr5:102880145..102880156 -
Hg19::chr5:102880238..102880241,-	p@chr5:102880238..102880241 -
Hg19::chr5:108747424..108747436,-	p@chr5:108747424..108747436 -
Hg19::chr5:149267445..149267449,+	p@chr5:149267445..149267449 +
Hg19::chr5:150794473..150794487,+	p@chr5:150794473..150794487 +
Hg19::chr5:173285551..173285555,-	p@chr5:173285551..173285555 -
Hg19::chr5:179476329..179476356,-	p@chr5:179476329..179476356 -
Hg19::chr5:179507817..179507822,-	p@chr5:179507817..179507822 -
Hg19::chr5:179517526..179517567,-	p@chr5:179517526..179517567 -
Hg19::chr5:86707965..86707982,+	p@chr5:86707965..86707982 +
Hg19::chr6:138190841..138190851,+	p@chr6:138190841..138190851 +
Hg19::chr6:138200103..138200115,+	p@chr6:138200103..138200115 +
Hg19::chr6:138202233..138202243,+	p@chr6:138202233..138202243 +
Hg19::chr6:157137665..157137709,-	p@chr6:157137665..157137709 -
Hg19::chr6:157154072..157154094,+	p@chr6:157154072..157154094 +
Hg19::chr6:163833586..163833600,+	p@chr6:163833586..163833600 +
Hg19::chr6:170125256..170125267,-	p@chr6:170125256..170125267 -
Hg19::chr6:35510078..35510095,+	p@chr6:35510078..35510095 +
Hg19::chr6:35510165..35510177,+	p@chr6:35510165..35510177 +
Hg19::chr6:35515792..35515827,+	p@chr6:35515792..35515827 +
Hg19::chr6:5431321..5431328,+	p@chr6:5431321..5431328 +
Hg19::chr7:107875966..107875974,+	p@chr7:107875966..107875974 +
Hg19::chr7:117371534..117371545,-	p@chr7:117371534..117371545 -
Hg19::chr7:117371907..117371913,+	p@chr7:117371907..117371913 +
Hg19::chr7:117432550..117432557,+	p@chr7:117432550..117432557 +
Hg19::chr7:117499585..117499593,+	p@chr7:117499585..117499593 +
Hg19::chr7:138643448..138643459,-	p@chr7:138643448..138643459 -
Hg19::chr7:138648579..138648581,-	p@chr7:138648579..138648581 -
Hg19::chr7:138650425..138650430,+	p@chr7:138650425..138650430 +
Hg19::chr7:138650434..138650440,+	p@chr7:138650434..138650440 +
Hg19::chr7:138665870..138665905,-	p4@KIAA1549
Hg19::chr7:138665915..138665946,-	p3@KIAA1549
Hg19::chr7:29232648..29232659,+	p@chr7:29232648..29232659 +
Hg19::chr7:37394629..37394635,+	p@chr7:37394629..37394635 +
Hg19::chr8:134013990..134014000,+	p@chr8:134013990..134014000 +
Hg19::chr8:134087711..134087720,-	p14@SLA
Hg19::chr8:27256513..27256546,+	p@chr8:27256513..27256546 +
Hg19::chr8:28223655..28223659,+	p@chr8:28223655..28223659 +
Hg19::chr8:29107560..29107569,-	p@chr8:29107560..29107569 -
Hg19::chr8:29172479..29172484,+	p@chr8:29172479..29172484 +
Hg19::chr8:91014165..91014183,+	p@chr8:91014165..91014183 +
Hg19::chr8:91014202..91014207,+	p@chr8:91014202..91014207 +
Hg19::chr9:100264166..100264193,+	p@chr9:100264166..100264193 +
Hg19::chr9:116113276..116113282,-	p@chr9:116113276..116113282 -
Hg19::chr9:127040669..127040685,+	p@chr9:127040669..127040685 +
Hg19::chr9:139595662..139595702,+	p@chr9:139595662..139595702 +
Hg19::chr9:73036504..73036509,-	p@chr9:73036504..73036509 -
Hg19::chr9:73100454..73100458,+	p@chr9:73100454..73100458 +
Hg19::chr9:74979223..74979257,-	p8@ZFAND5
Hg19::chr9:74980687..74980701,-	p@chr9:74980687..74980701 -
Hg19::chrX:124097601..124097611,-	p5@ODZ1
Hg19::chrX:48819077..48819118,+	p@chrX:48819077..48819118 +
Hg19::chrX:55186081..55186097,-	p6@FAM104B
Hg19::chrX:55186101..55186116,-	p@chrX:55186101..55186116 -

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0050789	regulation of biological process	0.0117611210674096
GO:0007165	signal transduction	0.0117611210674096
GO:0065007	biological regulation	0.0117611210674096
GO:0007154	cell communication	0.0117611210674096
GO:0050794	regulation of cellular process	0.0117611210674096
GO:0030695	GTPase regulator activity	0.0187433768986224
GO:0004398	histidine decarboxylase activity	0.0187433768986224
GO:0031432	titin binding	0.0187433768986224
GO:0009966	regulation of signal transduction	0.0219531518181022
GO:0005096	GTPase activator activity	0.0219531518181022
GO:0007264	small GTPase mediated signal transduction	0.0256806715861687
GO:0008047	enzyme activator activity	0.0395456422424184
GO:0004871	signal transducer activity	0.0398203207331036
GO:0060089	molecular transducer activity	0.0398203207331036
GO:0030019	tryptase activity	0.039955865136738
GO:0009649	entrainment of circadian clock	0.0440579443643909
GO:0008243	plasminogen activator activity	0.0440579443643909
GO:0007242	intracellular signaling cascade	0.0449662500481875
GO:0048519	negative regulation of biological process	0.0449662500481875

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
hematopoietic stem cell	8.36e-40	172
angioblastic mesenchymal cell	8.36e-40	172
hematopoietic cell	3.86e-37	182
hematopoietic oligopotent progenitor cell	1.69e-36	165
hematopoietic multipotent progenitor cell	1.69e-36	165
leukocyte	1.91e-36	140
myeloid cell	9.70e-30	112
common myeloid progenitor	9.70e-30	112
hematopoietic lineage restricted progenitor cell	2.08e-29	124
myeloid leukocyte	4.50e-26	76
nongranular leukocyte	1.56e-25	119
CD14-positive, CD16-negative classical monocyte	1.06e-23	42
granulocyte monocyte progenitor cell	2.67e-23	71
myeloid lineage restricted progenitor cell	2.45e-22	70
classical monocyte	1.03e-20	45
macrophage dendritic cell progenitor	9.97e-20	65
monopoietic cell	1.56e-18	63
monocyte	1.56e-18	63
monoblast	1.56e-18	63
promonocyte	1.56e-18	63
mesenchymal cell	8.68e-08	358
lymphoid lineage restricted progenitor cell	3.51e-07	52
lymphocyte	6.91e-07	53
common lymphoid progenitor	6.91e-07	53
connective tissue cell	8.51e-07	365

Uber Anatomy

Ontology term	p-value	n
hematopoietic system	2.74e-27	102
blood island	2.74e-27	102
hemolymphoid system	1.01e-24	112
bone marrow	2.11e-21	80
bone element	2.51e-18	86
immune system	8.09e-16	115
adult organism	5.39e-14	115
skeletal element	1.06e-11	101
skeletal system	1.06e-11	101
lateral plate mesoderm	1.19e-09	216

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF	#promoters	Enrichment	p-value	q-value
GATA1#2623	38	2.83127312892537	4.78191682440238e-09	3.85949467715426e-07
GATA2#2624	49	3.43132777441838	1.18635036802646e-14	2.044575017926e-12
JUN#3725	26	1.78754702747662	0.00283707764860148	0.0153826992286517
NR3C1#2908	36	2.96169692264961	4.14717299369646e-09	3.39175098111719e-07
SMARCA4#6597	5	4.30675558538154	0.00652942205494645	0.0279535277719431
TAL1#6886	18	2.95403901205453	4.60944866978425e-05	0.000809766542680567

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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