Coexpression cluster:C625

Full id: C625_CD14_Neutrophils_Basophils_CD14CD16_Peripheral_Eosinophils_Macrophage

Phase1 CAGE Peaks

Hg19::chr12:133065321..133065365,+	p@chr12:133065321..133065365 +
Hg19::chr12:69742296..69742328,-	p@chr12:69742296..69742328 -
Hg19::chr12:69747672..69747700,-	p2@ENST00000548626
Hg19::chr12:69747723..69747752,-	p1@ENST00000548900
Hg19::chr17:7077743..7077758,-	p@chr17:7077743..7077758 -
Hg19::chr17:7077765..7077789,-	p@chr17:7077765..7077789 -
Hg19::chr1:10057107..10057116,+	p5@RBP7
Hg19::chr22:41418135..41418155,+	p@chr22:41418135..41418155 +
Hg19::chr7:36764004..36764059,-	p1@AOAH
Hg19::chr7:36764062..36764124,-	p2@AOAH
Hg19::chr7:36764142..36764157,-	p6@AOAH
Hg19::chrX:152086373..152086414,+	p3@ZNF185
Hg19::chrX:152086415..152086444,+	p5@ZNF185
Hg19::chrX:152086449..152086473,+	p4@ZNF185

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

---

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

---

GO ID	GO name	FDR corrected p-value
GO:0050528	acyloxyacyl hydrolase activity	0.00468032497350759
GO:0004465	lipoprotein lipase activity	0.00842260114111378
GO:0031348	negative regulation of defense response	0.00842260114111378
GO:0019841	retinol binding	0.00842260114111378
GO:0050728	negative regulation of inflammatory response	0.00842260114111378
GO:0016918	retinal binding	0.00883645061134167
GO:0008653	lipopolysaccharide metabolic process	0.00883645061134167
GO:0005501	retinoid binding	0.00883645061134167
GO:0019840	isoprenoid binding	0.00883645061134167
GO:0050727	regulation of inflammatory response	0.0106295889560112
GO:0031347	regulation of defense response	0.0106295889560112
GO:0048583	regulation of response to stimulus	0.0136372896623196
GO:0044264	cellular polysaccharide metabolic process	0.0286786892116701
GO:0005976	polysaccharide metabolic process	0.0286786892116701
GO:0016298	lipase activity	0.0438139912943119

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

---

Cell Type

Ontology term	p-value	n
monopoietic cell	2.33e-70	59
monocyte	2.33e-70	59
monoblast	2.33e-70	59
promonocyte	2.33e-70	59
macrophage dendritic cell progenitor	9.43e-70	61
defensive cell	4.51e-69	48
phagocyte	4.51e-69	48
myeloid leukocyte	1.41e-66	72
granulocyte monocyte progenitor cell	4.13e-64	67
myeloid lineage restricted progenitor cell	7.57e-61	66
classical monocyte	1.21e-60	42
CD14-positive, CD16-negative classical monocyte	1.21e-60	42
myeloid cell	1.65e-49	108
common myeloid progenitor	1.65e-49	108
leukocyte	3.25e-43	136
nongranular leukocyte	9.40e-42	115
hematopoietic stem cell	1.43e-39	168
angioblastic mesenchymal cell	1.43e-39	168
hematopoietic cell	3.09e-36	177
hematopoietic lineage restricted progenitor cell	1.18e-35	120
hematopoietic oligopotent progenitor cell	2.47e-34	161
hematopoietic multipotent progenitor cell	2.47e-34	161
stuff accumulating cell	3.94e-30	87
intermediate monocyte	3.23e-15	9
CD14-positive, CD16-positive monocyte	3.23e-15	9
macrophage	1.62e-09	6
mesenchymal cell	7.39e-08	354
connective tissue cell	2.54e-07	361

Uber Anatomy

Ontology term	p-value	n
hematopoietic system	1.03e-69	98
blood island	1.03e-69	98
hemolymphoid system	8.74e-65	108
bone marrow	2.65e-56	76
immune system	1.88e-52	93
bone element	1.05e-50	82
skeletal element	2.06e-44	90
skeletal system	5.59e-38	100
lateral plate mesoderm	1.65e-25	203
musculoskeletal system	1.16e-16	167
adult organism	2.49e-16	114
blood	2.64e-12	15
haemolymphatic fluid	2.64e-12	15
organism substance	2.64e-12	15
mesoderm	7.15e-12	315
mesoderm-derived structure	7.15e-12	315
presumptive mesoderm	7.15e-12	315
connective tissue	5.48e-07	371

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

---

Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

---

No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

---

This analysis result is provided for C0 - C305 clusters.