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Coexpression cluster:C4042: Difference between revisions

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|tf_chipseq_enrich=ELK4#2005;2:10.823787772312:0.0109128471951648:0.0402005872179399!SPI1#6688;3:8.20432350852273:0.00181059318941052:0.0109184446047026!USF1#7391;3:6.36149927720796:0.0038840405729056:0.0190595927920729
|tf_chipseq_enrich=ELK4#2005;2:10.823787772312:0.0109128471951648:0.0402005872179399!SPI1#6688;3:8.20432350852273:0.00181059318941052:0.0109184446047026!USF1#7391;3:6.36149927720796:0.0038840405729056:0.0190595927920729
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}}
}}

Revision as of 16:30, 26 November 2012


Full id: C4042_large_ductal_prostate_Neutrophils_Eosinophils_Whole_colon



Phase1 CAGE Peaks

Hg19::chr20:44420982..44420997,+p11@DNTTIP1
Hg19::chr20:44421093..44421108,+p4@DNTTIP1
Hg19::chr20:44421137..44421162,+p3@DNTTIP1


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
classical monocyte1.04e-3842
CD14-positive, CD16-negative classical monocyte1.04e-3842
defensive cell2.00e-3648
phagocyte2.00e-3648
myeloid leukocyte8.76e-3572
macrophage dendritic cell progenitor7.83e-3461
myeloid cell1.93e-32108
common myeloid progenitor1.93e-32108
monopoietic cell1.75e-3159
monocyte1.75e-3159
monoblast1.75e-3159
promonocyte1.75e-3159
granulocyte monocyte progenitor cell6.85e-3167
myeloid lineage restricted progenitor cell5.19e-2866
leukocyte2.93e-22136
hematopoietic stem cell2.34e-21168
angioblastic mesenchymal cell2.34e-21168
hematopoietic cell3.29e-19177
hematopoietic oligopotent progenitor cell1.28e-18161
hematopoietic multipotent progenitor cell1.28e-18161
stuff accumulating cell6.20e-1887
nongranular leukocyte3.18e-15115
hematopoietic lineage restricted progenitor cell4.63e-14120
intermediate monocyte1.68e-109
CD14-positive, CD16-positive monocyte1.68e-109
Langerhans cell7.55e-075
granulocyte8.96e-078
Uber Anatomy
Ontology termp-valuen
hematopoietic system3.85e-4098
blood island3.85e-4098
hemolymphoid system1.10e-35108
bone marrow3.63e-2876
bone element5.39e-2882
immune system1.68e-2693
skeletal element4.32e-2490
skeletal system3.97e-20100
lateral plate mesoderm2.43e-11203
blood1.21e-1015
haemolymphatic fluid1.21e-1015
organism substance1.21e-1015
musculoskeletal system4.28e-08167


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

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ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
ELK4#2005210.8237877723120.01091284719516480.0402005872179399
SPI1#668838.204323508522730.001810593189410520.0109184446047026
USF1#739136.361499277207960.00388404057290560.0190595927920729



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.