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Coexpression cluster:C4514: Difference between revisions

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|tf_chipseq_enrich=CTCF#10664;3:5.36025637307503:0.006492509252767:0.0280960957093616!E2F1#1869;3:4.90738921487932:0.00846098534723939:0.0327219718081961!EGR1#1958;3:4.98817909481014:0.00805648813738344:0.0322108400803993!MYC#4609;3:5.2222818716094:0.00702084375574015:0.0295736831897131!NRF1#4899;3:12.2102794477109:0.000549217240102001:0.00472952666053866!ZEB1#6935;3:16.8884320175439:0.000207548691732758:0.00243607302943105!ZNF263#10127;3:8.22184163701068:0.00179904392556587:0.0109935257470115
|tf_chipseq_enrich=CTCF#10664;3:5.36025637307503:0.006492509252767:0.0280960957093616!E2F1#1869;3:4.90738921487932:0.00846098534723939:0.0327219718081961!EGR1#1958;3:4.98817909481014:0.00805648813738344:0.0322108400803993!MYC#4609;3:5.2222818716094:0.00702084375574015:0.0295736831897131!NRF1#4899;3:12.2102794477109:0.000549217240102001:0.00472952666053866!ZEB1#6935;3:16.8884320175439:0.000207548691732758:0.00243607302943105!ZNF263#10127;3:8.22184163701068:0.00179904392556587:0.0109935257470115
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}}
}}

Revision as of 16:47, 26 November 2012


Full id: C4514_nasal_immature_Prostate_cervical_amniotic_Intestinal_colon



Phase1 CAGE Peaks

Hg19::chr5:68788365..68788387,+p2@OCLN
Hg19::chr5:68788394..68788432,+p3@OCLN
Hg19::chr5:68788435..68788460,+p4@OCLN


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>


Cell Type
Ontology termp-valuen
epithelial cell1.86e-22253
endodermal cell1.08e-1858
endo-epithelial cell1.08e-1442
epithelial cell of alimentary canal1.45e-1020
Uber Anatomy
Ontology termp-valuen
endoderm-derived structure6.43e-23160
endoderm6.43e-23160
presumptive endoderm6.43e-23160
digestive system8.52e-20145
digestive tract8.52e-20145
primitive gut8.52e-20145
subdivision of digestive tract6.41e-19118
endo-epithelium5.98e-1482
trunk region element6.89e-13101
organ system subdivision9.80e-13223
immaterial anatomical entity1.86e-12117
foregut1.03e-1187
adult organism3.11e-11114
organ2.44e-10503
anatomical space3.13e-0995
gastrointestinal system4.83e-0925
subdivision of trunk6.24e-09112
respiratory system7.19e-0874
multi-tissue structure8.01e-08342
reproductive structure1.60e-0759
reproductive system1.60e-0759
epithelial bud1.62e-0737
gut epithelium1.65e-0754
organ part1.79e-07218
multi-cellular organism3.74e-07656
orifice4.77e-0736
embryo5.58e-07592
reproductive organ5.71e-0748
intestine6.98e-0717
abdomen element7.75e-0754
abdominal segment element7.75e-0754
Disease
Ontology termp-valuen
carcinoma6.55e-26106
cell type cancer4.35e-17143
adenocarcinoma2.94e-1225
squamous cell carcinoma3.78e-1114
cancer6.98e-07235
disease of cellular proliferation7.56e-07239


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CTCF#1066435.360256373075030.0064925092527670.0280960957093616
E2F1#186934.907389214879320.008460985347239390.0327219718081961
EGR1#195834.988179094810140.008056488137383440.0322108400803993
MYC#460935.22228187160940.007020843755740150.0295736831897131
NRF1#4899312.21027944771090.0005492172401020010.00472952666053866
ZEB1#6935316.88843201754390.0002075486917327580.00243607302943105
ZNF263#1012738.221841637010680.001799043925565870.0109935257470115



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.