Coexpression cluster:C13
From FANTOM5_SSTAR
Full id: C13_Neutrophils_Eosinophils_CD14_Monocytederived_Whole_Peripheral_CD4
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
| p.value | FDR | nGenes | nPathway | Name |
|---|---|---|---|---|
| 0.0018405173547374 | 0.0173887684410265 | 3 | 49 | Lysine degradation (KEGG):00310 |
| 0.00220738681258641 | 0.0202503746719884 | 6 | 268 | MAPK signaling pathway (KEGG):04010 |
| 4.75696612601041e-06 | 0.000143388550369742 | 8 | 189 | Chemokine signaling pathway (KEGG):04062 |
| 0.000544972812093181 | 0.00627214163736333 | 6 | 204 | Endocytosis (KEGG):04144 |
| 0.000129151376253141 | 0.00199397124800582 | 6 | 156 | Phagosome (KEGG):04145 |
| 0.000477873723519282 | 0.00570743522618312 | 5 | 130 | Axon guidance (KEGG):04360 |
| 0.000555448880078327 | 0.00627855609088538 | 4 | 76 | VEGF signaling pathway (KEGG):04370 |
| 0.00379144781430769 | 0.0311686554085295 | 4 | 128 | Osteoclast differentiation (KEGG):04380 |
| 6.38563537105438e-05 | 0.00112280755274373 | 7 | 200 | Focal adhesion (KEGG):04510 |
| 0.00470126286392068 | 0.0381525563187409 | 4 | 136 | Cell adhesion molecules (CAMs) (KEGG):04514 |
| 0.000476640489844645 | 0.00570743522618312 | 4 | 73 | Adherens junction (KEGG):04520 |
| 2.50238958708191e-06 | 0.000113143757758775 | 6 | 78 | Antigen processing and presentation (KEGG):04612 |
| 0.00313298878550628 | 0.0268445654528105 | 3 | 59 | NOD-like receptor signaling pathway (KEGG):04621 |
| 4.24213640246652e-07 | 2.44115667523755e-05 | 8 | 137 | Natural killer cell mediated cytotoxicity (KEGG):04650 |
| 0.000202935328796993 | 0.00298739681694179 | 5 | 108 | T cell receptor signaling pathway (KEGG):04660 |
| 0.000528223360008896 | 0.00619195160899317 | 4 | 75 | B cell receptor signaling pathway (KEGG):04662 |
| 4.60074460211976e-05 | 0.000832077523754802 | 5 | 79 | Fc epsilon RI signaling pathway (KEGG):04664 |
| 2.45504413162327e-08 | 2.2200613361679e-06 | 8 | 95 | Fc gamma R-mediated phagocytosis (KEGG):04666 |
| 2.6027562062418e-05 | 0.000531466025339051 | 6 | 117 | Leukocyte transendothelial migration (KEGG):04670 |
| 0.00368687673083986 | 0.0307078022450215 | 4 | 127 | Neurotrophin signaling pathway (KEGG):04722 |
| 1.17977344757862e-05 | 0.000276591330487875 | 8 | 214 | Regulation of actin cytoskeleton (KEGG):04810 |
| 0.000363495604710622 | 0.00479359828712133 | 4 | 68 | Epithelial cell signaling in Helicobacter pylori infection (KEGG):05120 |
| 0.00360581559816889 | 0.0304330836485454 | 3 | 62 | Shigellosis (KEGG):05131 |
| 0.00570081622960004 | 0.0434773093173111 | 3 | 73 | Leishmaniasis (KEGG):05140 |
| 8.54068010170417e-06 | 0.000225260437682447 | 5 | 56 | Staphylococcus aureus infection (KEGG):05150 |
| 3.59938972250457e-06 | 0.000130303329693828 | 8 | 182 | Tuberculosis (KEGG):05152 |
| 0.000248504129258276 | 0.00357507076864747 | 6 | 176 | Influenza A (KEGG):05164 |
| 3.78884120324693e-05 | 0.000726768630804638 | 9 | 327 | Pathways in cancer (KEGG):05200 |
| 0.00507154967491869 | 0.0396332215336238 | 3 | 70 | Renal cell carcinoma (KEGG):05211 |
| 0.00100604412657952 | 0.0106137655354139 | 4 | 89 | Prostate cancer (KEGG):05215 |
| 0.000452243654198215 | 0.00561314182563667 | 4 | 72 | Viral myocarditis (KEGG):05416 |
| 0.000384395796239585 | 0.00486645078039314 | 4 | 69 | IL-5 Signaling Pathway (Wikipathways):WP127 |
| 1.83855981047397e-06 | 8.95237200023094e-05 | 7 | 116 | Androgen Receptor Signaling Pathway (Wikipathways):WP138 |
| 0.000669270369221152 | 0.00743242357398227 | 5 | 140 | Regulation of toll-like receptor signaling pathway (Wikipathways):WP1449 |
| 0.00163153868388462 | 0.0158886767215225 | 3 | 47 | Energy Metabolism (Wikipathways):WP1541 |
| 1.12506608720223e-05 | 0.000273910320461158 | 6 | 101 | Integrin-mediated cell adhesion (Wikipathways):WP185 |
| 0.00134706607943366 | 0.0137531101335727 | 3 | 44 | IL-7 Signaling Pathway (Wikipathways):WP205 |
| 0.00622640640872304 | 0.046368414784961 | 2 | 24 | IL-9 Signaling Pathway (Wikipathways):WP22 |
| 8.05516149998604e-09 | 1.01978344589823e-06 | 10 | 161 | B Cell Receptor Signaling Pathway (Wikipathways):WP23 |
| 0.000353729092570809 | 0.00476405352334728 | 6 | 188 | TNF-alpha/NF-kB Signaling Pathway (Wikipathways):WP231 |
| 5.04956713370177e-06 | 0.000145289817983328 | 7 | 135 | Adipogenesis (Wikipathways):WP236 |
| 0.00548612407591146 | 0.0423502017079507 | 3 | 72 | Peptide GPCRs (Wikipathways):WP24 |
| 0.00487160358359413 | 0.0385465633551886 | 3 | 69 | Alpha6-Beta4 Integrin Signaling Pathway (Wikipathways):WP244 |
| 4.3026432980935e-08 | 3.02619245299243e-06 | 8 | 102 | IL-3 Signaling Pathway (Wikipathways):WP286 |
| 0.000384395796239585 | 0.00486645078039314 | 4 | 69 | Kit Receptor Signaling Pathway (Wikipathways):WP304 |
| 4.31933965208029e-05 | 0.000804159411696125 | 7 | 188 | Focal Adhesion (Wikipathways):WP306 |
| 2.08795739019065e-05 | 0.000440559009330226 | 4 | 33 | Signaling of Hepatocyte Growth Factor Receptor (Wikipathways):WP313 |
| 3.40102496999233e-08 | 2.69106100750643e-06 | 8 | 99 | IL-6 Signaling Pathway (Wikipathways):WP364 |
| 0.00128626211862013 | 0.0133476052637138 | 5 | 162 | MAPK signaling pathway (Wikipathways):WP382 |
| 1.65159599828503e-05 | 0.00036050354031532 | 5 | 64 | IL-4 signaling Pathway (Wikipathways):WP395 |
| 0.0018405173547374 | 0.0173887684410265 | 3 | 49 | Diurnally regulated genes with circadian orthologs (Wikipathways):WP410 |
| 3.18211748645181e-06 | 0.000126155147371127 | 8 | 179 | EGFR1 Signaling Pathway (Wikipathways):WP437 |
| 0.000158684934282218 | 0.00239160865239628 | 6 | 162 | Insulin Signaling (Wikipathways):WP481 |
| 4.57915386150178e-09 | 7.24651098582656e-07 | 8 | 77 | IL-2 Signaling Pathway (Wikipathways):WP49 |
| 8.08190344501322e-06 | 0.000222428038291016 | 7 | 145 | Regulation of Actin Cytoskeleton (Wikipathways):WP51 |
| 0.000282192468742205 | 0.00396950739364035 | 3 | 26 | EPO Receptor Signaling (Wikipathways):WP581 |
| 1.06496489622608e-05 | 0.000269649111724443 | 4 | 28 | Interferon type I (Wikipathways):WP585 |
| 1.27731658450251e-13 | 4.04270698995043e-11 | 13 | 133 | T Cell Receptor Signaling Pathway (Wikipathways):WP69 |
| 0.000810294146516502 | 0.0088433826680163 | 4 | 84 | DNA damage response (only ATM dependent) (Wikipathways):WP710 |
| 8.90315433193457e-16 | 5.63569669211458e-13 | 23 | 511 | Signaling in Immune system (Reactome):REACT_6900 |
| 0.000128448803996245 | 0.00199397124800582 | 4 | 52 | Signaling by EGFR (Reactome):REACT_9417 |
| 0.00481489011429591 | 0.0385465633551886 | 5 | 220 | Signalling by NGF (Reactome):REACT_11061 |
| 3.705307953379e-06 | 0.000130303329693828 | 12 | 466 | Hemostasis (Reactome):REACT_604 |
| 0.00138489869458035 | 0.0139149345026883 | 4 | 97 | Cell junction organization (Reactome):REACT_20676 |
| 0.00208674702189166 | 0.0194251597773151 | 6 | 265 | Axon guidance (Reactome):REACT_18266 |
| 3.18875569974414e-06 | 0.000126155147371127 | 5 | 46 | Interactions of the immunoglobulin superfamily (IgSF) member proteins (Reactome):REACT_23853 |
| 0.0014383578317433 | 0.014226257929586 | 4 | 98 | EGFR1 down reg. targets (Netpath):NetPath_4 |
| 2.26356649343929e-08 | 2.2200613361679e-06 | 19 | 816 | TGF beta receptor up reg. targets (Netpath):NetPath_7 |
| 4.15328696291227e-06 | 0.000131451532376173 | 15 | 740 | TGF beta receptor down reg. targets (Netpath):NetPath_7 |
| 6.88721406633646e-05 | 0.00117827202810567 | 13 | 728 | TNF alpha/NF-kB up reg. targets (Netpath):NetPath_9 |
| 0.006145163808536 | 0.0463081987000391 | 3 | 75 | Kit Receptor up reg. targets (Netpath):NetPath_6 |
| 3.2429120465427e-07 | 2.05276332546153e-05 | 9 | 182 | B Cell Receptor down reg. targets (Netpath):NetPath_12 |
| 1.0834361410196e-06 | 5.71512564387841e-05 | 8 | 155 | IL-1 up reg. targets (Netpath):NetPath_13 |
| 0.000314063200171219 | 0.0043217827327909 | 9 | 433 | IL-2 up reg. targets (Netpath):NetPath_14 |
| 2.60123119844324e-10 | 5.48859782871524e-08 | 14 | 295 | IL-2 down reg. targets (Netpath):NetPath_14 |
| 0.000106343822457922 | 0.00177146420041749 | 7 | 217 | IL-4 up reg. targets (Netpath):NetPath_16 |
| 4.13810866964249e-06 | 0.000131451532376173 | 7 | 131 | IL-5 up reg. targets (Netpath):NetPath_17 |
| 0.00674604731973775 | 0.0490833098091264 | 2 | 25 | IL-9 up reg. targets (Netpath):NetPath_20 |
| 1.39908131026856e-05 | 0.000316292310499999 | 9 | 288 | {ACTB,297} (Static Module):NA |
| 0.00674604731973775 | 0.0490833098091264 | 2 | 25 | {BCLAF1,25} (Static Module):NA |
| 3.5829366915091e-05 | 0.000708749664289145 | 10 | 406 | {GRB2,414} (Static Module):NA |
| 0.00313822724092887 | 0.0268445654528105 | 2 | 17 | {HCLS1,17} (Static Module):NA |
| 0.000119022266074925 | 0.00193182293398532 | 4 | 51 | {HLA-A,53} (Static Module):NA |
| 0.00274682664308726 | 0.0244893135925948 | 4 | 117 | {MAPK14,123} (Static Module):NA |
| 0.00313822724092887 | 0.0268445654528105 | 2 | 17 | {RARA,17} (Static Module):NA |
| 0.000924157004303776 | 0.00991510819871679 | 4 | 87 | {SP1,88} (Static Module):NA |
| 0.00256491107916644 | 0.0231941244730337 | 3 | 55 | {TRAF6,55} (Static Module):NA |
Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data
| GO ID | GO name | FDR corrected p-value |
|---|---|---|
| GO:0005515 | protein binding | 1.84262744873468e-22 |
| GO:0007242 | intracellular signaling cascade | 1.22264422542866e-12 |
| GO:0007165 | signal transduction | 1.12813612362486e-08 |
| GO:0065007 | biological regulation | 1.12813612362486e-08 |
| GO:0044424 | intracellular part | 1.14132096489891e-08 |
| GO:0007243 | protein kinase cascade | 4.06771338954035e-08 |
| GO:0002376 | immune system process | 4.06771338954035e-08 |
| GO:0016043 | cellular component organization and biogenesis | 4.57425031243648e-08 |
| GO:0007154 | cell communication | 4.57425031243648e-08 |
| GO:0006952 | defense response | 1.10572205609874e-07 |
| GO:0005887 | integral to plasma membrane | 1.1344529093615e-07 |
| GO:0031226 | intrinsic to plasma membrane | 1.44797888781427e-07 |
| GO:0044464 | cell part | 1.44797888781427e-07 |
| GO:0005622 | intracellular | 1.57391985100704e-07 |
| GO:0050789 | regulation of biological process | 1.69473593906004e-07 |
| GO:0044459 | plasma membrane part | 2.55875056804847e-07 |
| GO:0050794 | regulation of cellular process | 3.41040805344107e-07 |
| GO:0032502 | developmental process | 3.41040805344107e-07 |
| GO:0043229 | intracellular organelle | 4.2556551024474e-07 |
| GO:0043226 | organelle | 4.2556551024474e-07 |
| GO:0005634 | nucleus | 1.02939648773538e-06 |
| GO:0048731 | system development | 1.48491407089361e-06 |
| GO:0006915 | apoptosis | 1.61652568947051e-06 |
| GO:0012501 | programmed cell death | 1.74280139657553e-06 |
| GO:0043227 | membrane-bound organelle | 2.99673716296919e-06 |
| GO:0008219 | cell death | 3.26745920063044e-06 |
| GO:0016265 | death | 3.26745920063044e-06 |
| GO:0048869 | cellular developmental process | 3.92266031912764e-06 |
| GO:0030154 | cell differentiation | 3.92266031912764e-06 |
| GO:0009605 | response to external stimulus | 6.28542973466932e-06 |
| GO:0043231 | intracellular membrane-bound organelle | 7.19847457654459e-06 |
| GO:0005737 | cytoplasm | 1.20078696789179e-05 |
| GO:0005886 | plasma membrane | 1.93530797550935e-05 |
| GO:0006955 | immune response | 2.36861361662294e-05 |
| GO:0006950 | response to stress | 3.24389759425993e-05 |
| GO:0043233 | organelle lumen | 3.24389759425993e-05 |
| GO:0031974 | membrane-enclosed lumen | 3.24389759425993e-05 |
| GO:0044428 | nuclear part | 3.7321407539547e-05 |
| GO:0048468 | cell development | 3.84888240213538e-05 |
| GO:0007275 | multicellular organismal development | 4.29317967553265e-05 |
| GO:0006935 | chemotaxis | 4.29317967553265e-05 |
| GO:0042330 | taxis | 4.29317967553265e-05 |
| GO:0048856 | anatomical structure development | 4.29317967553265e-05 |
| GO:0048513 | organ development | 4.79743269405076e-05 |
| GO:0006954 | inflammatory response | 5.33495258267e-05 |
| GO:0006928 | cell motility | 6.15409949332808e-05 |
| GO:0051674 | localization of cell | 6.15409949332808e-05 |
| GO:0031981 | nuclear lumen | 6.65162746272407e-05 |
| GO:0048518 | positive regulation of biological process | 7.76982785461788e-05 |
| GO:0048522 | positive regulation of cellular process | 9.52862128812495e-05 |
| GO:0005654 | nucleoplasm | 0.000128588693663112 |
| GO:0009611 | response to wounding | 0.000133725078278206 |
| GO:0044422 | organelle part | 0.000139278993908166 |
| GO:0007626 | locomotory behavior | 0.000151987965746328 |
| GO:0008134 | transcription factor binding | 0.000151987965746328 |
| GO:0044451 | nucleoplasm part | 0.000221251510725771 |
| GO:0048519 | negative regulation of biological process | 0.000255606649396761 |
| GO:0042221 | response to chemical stimulus | 0.000368347857325151 |
| GO:0016607 | nuclear speck | 0.00037134787502976 |
| GO:0044446 | intracellular organelle part | 0.000400006721529906 |
| GO:0009893 | positive regulation of metabolic process | 0.000422306573492724 |
| GO:0016568 | chromatin modification | 0.000456145202705162 |
| GO:0006351 | transcription, DNA-dependent | 0.000500497434674178 |
| GO:0032774 | RNA biosynthetic process | 0.000511083231310546 |
| GO:0008283 | cell proliferation | 0.000567867890665101 |
| GO:0048523 | negative regulation of cellular process | 0.000567867890665101 |
| GO:0043405 | regulation of MAP kinase activity | 0.000567867890665101 |
| GO:0045859 | regulation of protein kinase activity | 0.000678589140495389 |
| GO:0006996 | organelle organization and biogenesis | 0.000678589140495389 |
| GO:0043549 | regulation of kinase activity | 0.000763450336580879 |
| GO:0015440 | peptide-transporting ATPase activity | 0.00077901622395267 |
| GO:0015433 | peptide antigen-transporting ATPase activity | 0.00077901622395267 |
| GO:0004871 | signal transducer activity | 0.000810914730933035 |
| GO:0060089 | molecular transducer activity | 0.000810914730933035 |
| GO:0051338 | regulation of transferase activity | 0.000810914730933035 |
| GO:0006355 | regulation of transcription, DNA-dependent | 0.000832661682729396 |
| GO:0009966 | regulation of signal transduction | 0.000964614818783044 |
| GO:0031323 | regulation of cellular metabolic process | 0.000987099628522861 |
| GO:0016604 | nuclear body | 0.000987099628522861 |
| GO:0019222 | regulation of metabolic process | 0.00117199322082277 |
| GO:0001816 | cytokine production | 0.00119408448748778 |
| GO:0042127 | regulation of cell proliferation | 0.00127966313612629 |
| GO:0031325 | positive regulation of cellular metabolic process | 0.00127966313612629 |
| GO:0046977 | TAP binding | 0.00128619338684924 |
| GO:0046979 | TAP2 binding | 0.00128619338684924 |
| GO:0042824 | MHC class I peptide loading complex | 0.00128619338684924 |
| GO:0046978 | TAP1 binding | 0.00128619338684924 |
| GO:0010468 | regulation of gene expression | 0.00150374071157884 |
| GO:0043406 | positive regulation of MAP kinase activity | 0.00175416738534898 |
| GO:0007610 | behavior | 0.00200250634886722 |
| GO:0051707 | response to other organism | 0.00202210308918571 |
| GO:0000389 | nuclear mRNA 3'-splice site recognition | 0.00202210308918571 |
| GO:0007204 | elevation of cytosolic calcium ion concentration | 0.00208832239458626 |
| GO:0051480 | cytosolic calcium ion homeostasis | 0.00208832239458626 |
| GO:0003712 | transcription cofactor activity | 0.00223717139630057 |
| GO:0006366 | transcription from RNA polymerase II promoter | 0.00236671322977424 |
| GO:0002460 | adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains | 0.00275403169654034 |
| GO:0002250 | adaptive immune response | 0.00275403169654034 |
| GO:0045860 | positive regulation of protein kinase activity | 0.00276474495811126 |
| GO:0016070 | RNA metabolic process | 0.00288514496413255 |
| GO:0033674 | positive regulation of kinase activity | 0.00298818754751718 |
| GO:0043066 | negative regulation of apoptosis | 0.00307151716335223 |
| GO:0065009 | regulation of a molecular function | 0.00319275776762726 |
| GO:0051347 | positive regulation of transferase activity | 0.00319275776762726 |
| GO:0043069 | negative regulation of programmed cell death | 0.0031957394480737 |
| GO:0006350 | transcription | 0.0031957394480737 |
| GO:0032501 | multicellular organismal process | 0.0035306863540627 |
| GO:0045449 | regulation of transcription | 0.00394153802693509 |
| GO:0051641 | cellular localization | 0.00442051820834764 |
| GO:0030036 | actin cytoskeleton organization and biogenesis | 0.00446912707081442 |
| GO:0015197 | peptide transporter activity | 0.0046577760375652 |
| GO:0030674 | protein binding, bridging | 0.00480455293926072 |
| GO:0051179 | localization | 0.00509319164276725 |
| GO:0019219 | regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process | 0.00522707068233443 |
| GO:0004715 | non-membrane spanning protein tyrosine kinase activity | 0.00537387442104823 |
| GO:0043009 | chordate embryonic development | 0.00537387442104823 |
| GO:0009792 | embryonic development ending in birth or egg hatching | 0.00537387442104823 |
| GO:0009887 | organ morphogenesis | 0.00537387442104823 |
| GO:0030029 | actin filament-based process | 0.00541637313920974 |
| GO:0006606 | protein import into nucleus | 0.0054799776659082 |
| GO:0042288 | MHC class I protein binding | 0.0054799776659082 |
| GO:0051235 | maintenance of localization | 0.00550949546437534 |
| GO:0051170 | nuclear import | 0.00570055348062042 |
| GO:0009615 | response to virus | 0.00570055348062042 |
| GO:0042110 | T cell activation | 0.00570055348062042 |
| GO:0002474 | antigen processing and presentation of peptide antigen via MHC class I | 0.00657581068391102 |
| GO:0045321 | leukocyte activation | 0.00659915376473326 |
| GO:0009968 | negative regulation of signal transduction | 0.00696322506792375 |
| GO:0048002 | antigen processing and presentation of peptide antigen | 0.00710686025933866 |
| GO:0048771 | tissue remodeling | 0.00710686025933866 |
| GO:0045941 | positive regulation of transcription | 0.00711465004812667 |
| GO:0003714 | transcription corepressor activity | 0.00751217091511505 |
| GO:0001666 | response to hypoxia | 0.0080426070213927 |
| GO:0045935 | positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process | 0.00828594108934803 |
| GO:0009607 | response to biotic stimulus | 0.00828594108934803 |
| GO:0005070 | SH3/SH2 adaptor activity | 0.0083550101418975 |
| GO:0009897 | external side of plasma membrane | 0.00861854157373779 |
| GO:0001701 | in utero embryonic development | 0.00861854157373779 |
| GO:0043542 | endothelial cell migration | 0.00861854157373779 |
| GO:0042088 | T-helper 1 type immune response | 0.00861854157373779 |
| GO:0015629 | actin cytoskeleton | 0.00897497222342482 |
| GO:0051649 | establishment of cellular localization | 0.00922709412012321 |
| GO:0006874 | cellular calcium ion homeostasis | 0.00930695676064902 |
| GO:0055074 | calcium ion homeostasis | 0.00930695676064902 |
| GO:0006376 | mRNA splice site selection | 0.0098098836361281 |
| GO:0042277 | peptide binding | 0.0109551780411168 |
| GO:0017038 | protein import | 0.0109899586528098 |
| GO:0001775 | cell activation | 0.0110388023274176 |
| GO:0006875 | cellular metal ion homeostasis | 0.0110998112957131 |
| GO:0055065 | metal ion homeostasis | 0.0110998112957131 |
| GO:0035257 | nuclear hormone receptor binding | 0.0111049864874675 |
| GO:0000187 | activation of MAPK activity | 0.0115368019501498 |
| GO:0051427 | hormone receptor binding | 0.0115368019501498 |
| GO:0043283 | biopolymer metabolic process | 0.0116992954001711 |
| GO:0016564 | transcription repressor activity | 0.0116992954001711 |
| GO:0001890 | placenta development | 0.0122135427281653 |
| GO:0042981 | regulation of apoptosis | 0.0128762391084492 |
| GO:0060090 | molecular adaptor activity | 0.0128762391084492 |
| GO:0042035 | regulation of cytokine biosynthetic process | 0.0128762391084492 |
| GO:0043067 | regulation of programmed cell death | 0.0132495113248071 |
| GO:0002483 | antigen processing and presentation of endogenous peptide antigen | 0.0132495113248071 |
| GO:0030048 | actin filament-based movement | 0.0132495113248071 |
| GO:0019885 | antigen processing and presentation of endogenous peptide antigen via MHC class I | 0.0132495113248071 |
| GO:0045893 | positive regulation of transcription, DNA-dependent | 0.0132495113248071 |
| GO:0005856 | cytoskeleton | 0.0133584039364792 |
| GO:0007399 | nervous system development | 0.0133992214044442 |
| GO:0006325 | establishment and/or maintenance of chromatin architecture | 0.013401314080748 |
| GO:0008285 | negative regulation of cell proliferation | 0.0134490563505068 |
| GO:0051704 | multi-organism process | 0.0136306802472682 |
| GO:0006323 | DNA packaging | 0.01418615925078 |
| GO:0006461 | protein complex assembly | 0.0149527019550057 |
| GO:0005681 | spliceosome | 0.015034197989807 |
| GO:0007249 | I-kappaB kinase/NF-kappaB cascade | 0.015034197989807 |
| GO:0016477 | cell migration | 0.015034197989807 |
| GO:0008284 | positive regulation of cell proliferation | 0.015034197989807 |
| GO:0005102 | receptor binding | 0.0152710871734914 |
| GO:0009790 | embryonic development | 0.0153949146803293 |
| GO:0042605 | peptide antigen binding | 0.0153949146803293 |
| GO:0019883 | antigen processing and presentation of endogenous antigen | 0.0153949146803293 |
| GO:0042089 | cytokine biosynthetic process | 0.0155639383529718 |
| GO:0055082 | cellular chemical homeostasis | 0.0155639383529718 |
| GO:0006873 | cellular ion homeostasis | 0.0155639383529718 |
| GO:0008092 | cytoskeletal protein binding | 0.0157208472398865 |
| GO:0042107 | cytokine metabolic process | 0.0158711184915856 |
| GO:0050790 | regulation of catalytic activity | 0.0158711184915856 |
| GO:0016192 | vesicle-mediated transport | 0.0159469662208784 |
| GO:0051270 | regulation of cell motility | 0.016351894059097 |
| GO:0043170 | macromolecule metabolic process | 0.0164478806101929 |
| GO:0046907 | intracellular transport | 0.0175954514904003 |
| GO:0000165 | MAPKKK cascade | 0.0178862580855057 |
| GO:0040012 | regulation of locomotion | 0.0178862580855057 |
| GO:0006968 | cellular defense response | 0.0178862580855057 |
| GO:0002449 | lymphocyte mediated immunity | 0.0178862580855057 |
| GO:0040011 | locomotion | 0.0185056350013201 |
| GO:0006913 | nucleocytoplasmic transport | 0.0193659325674853 |
| GO:0046649 | lymphocyte activation | 0.0195842152546191 |
| GO:0043065 | positive regulation of apoptosis | 0.0195842152546191 |
| GO:0043085 | positive regulation of catalytic activity | 0.0195842152546191 |
| GO:0051169 | nuclear transport | 0.0195842152546191 |
| GO:0043068 | positive regulation of programmed cell death | 0.0195842152546191 |
| GO:0050681 | androgen receptor binding | 0.0195842152546191 |
| GO:0000060 | protein import into nucleus, translocation | 0.0195842152546191 |
| GO:0002443 | leukocyte mediated immunity | 0.0195842152546191 |
| GO:0030097 | hemopoiesis | 0.0195842152546191 |
| GO:0002526 | acute inflammatory response | 0.0195842152546191 |
| GO:0042287 | MHC protein binding | 0.0195842152546191 |
| GO:0005158 | insulin receptor binding | 0.0195842152546191 |
| GO:0050801 | ion homeostasis | 0.0195842152546191 |
| GO:0006494 | protein amino acid terminal glycosylation | 0.0195842152546191 |
| GO:0033371 | T cell secretory granule organization and biogenesis | 0.0195842152546191 |
| GO:0001667 | ameboidal cell migration | 0.0195842152546191 |
| GO:0006496 | protein amino acid terminal N-glycosylation | 0.0195842152546191 |
| GO:0004409 | homoaconitate hydratase activity | 0.0195842152546191 |
| GO:0002335 | mature B cell differentiation | 0.0195842152546191 |
| GO:0033367 | protein localization in mast cell secretory granule | 0.0195842152546191 |
| GO:0050822 | peptide stabilization | 0.0195842152546191 |
| GO:0060057 | apoptosis involved in mammary gland involution | 0.0195842152546191 |
| GO:0060054 | positive regulation of epithelial cell proliferation involved in wound healing | 0.0195842152546191 |
| GO:0030112 | glycocalyx | 0.0195842152546191 |
| GO:0051898 | negative regulation of protein kinase B signaling cascade | 0.0195842152546191 |
| GO:0004883 | glucocorticoid receptor activity | 0.0195842152546191 |
| GO:0032027 | myosin light chain binding | 0.0195842152546191 |
| GO:0033375 | protease localization in T cell secretory granule | 0.0195842152546191 |
| GO:0050823 | peptide antigen stabilization | 0.0195842152546191 |
| GO:0001891 | phagocytic cup | 0.0195842152546191 |
| GO:0033377 | maintenance of protein localization in T cell secretory granule | 0.0195842152546191 |
| GO:0033365 | protein localization in organelle | 0.0195842152546191 |
| GO:0033370 | maintenance of protein localization in mast cell secretory granule | 0.0195842152546191 |
| GO:0060055 | angiogenesis involved in wound healing | 0.0195842152546191 |
| GO:0033366 | protein localization in secretory granule | 0.0195842152546191 |
| GO:0002312 | B cell activation during immune response | 0.0195842152546191 |
| GO:0016046 | detection of fungus | 0.0195842152546191 |
| GO:0033382 | maintenance of granzyme B localization in T cell secretory granule | 0.0195842152546191 |
| GO:0046856 | phosphoinositide dephosphorylation | 0.0195842152546191 |
| GO:0030874 | nucleolar chromatin | 0.0195842152546191 |
| GO:0033373 | maintenance of protease localization in mast cell secretory granule | 0.0195842152546191 |
| GO:0060058 | positive regulation of apoptosis involved in mammary gland involution | 0.0195842152546191 |
| GO:0033380 | granzyme B localization in T cell secretory granule | 0.0195842152546191 |
| GO:0033379 | maintenance of protease localization in T cell secretory granule | 0.0195842152546191 |
| GO:0051642 | centrosome localization | 0.0195842152546191 |
| GO:0032996 | Bcl3-Bcl10 complex | 0.0195842152546191 |
| GO:0033364 | mast cell secretory granule organization and biogenesis | 0.0195842152546191 |
| GO:0008383 | manganese superoxide dismutase activity | 0.0195842152546191 |
| GO:0004218 | cathepsin S activity | 0.0195842152546191 |
| GO:0033368 | protease localization in mast cell secretory granule | 0.0195842152546191 |
| GO:0051800 | phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity | 0.0195842152546191 |
| GO:0002313 | mature B cell differentiation during immune response | 0.0195842152546191 |
| GO:0002378 | immunoglobulin biosynthetic process | 0.0195842152546191 |
| GO:0005731 | nucleolus organizer region | 0.0195842152546191 |
| GO:0051717 | inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity | 0.0195842152546191 |
| GO:0046855 | inositol phosphate dephosphorylation | 0.0195842152546191 |
| GO:0060046 | regulation of acrosome reaction | 0.0195842152546191 |
| GO:0033374 | protein localization in T cell secretory granule | 0.0195842152546191 |
| GO:0002315 | marginal zone B cell differentiation | 0.0195842152546191 |
| GO:0004468 | lysine N-acetyltransferase activity | 0.0206624903730258 |
| GO:0004402 | histone acetyltransferase activity | 0.0206624903730258 |
| GO:0005884 | actin filament | 0.0206624903730258 |
| GO:0051247 | positive regulation of protein metabolic process | 0.0213803152382462 |
| GO:0048534 | hemopoietic or lymphoid organ development | 0.0220713072828972 |
| GO:0045185 | maintenance of protein localization | 0.0220713072828972 |
| GO:0051276 | chromosome organization and biogenesis | 0.0225151249880667 |
| GO:0010467 | gene expression | 0.022936814377073 |
| GO:0001503 | ossification | 0.022936814377073 |
| GO:0031214 | biomineral formation | 0.022936814377073 |
| GO:0014706 | striated muscle development | 0.022936814377073 |
| GO:0016044 | membrane organization and biogenesis | 0.0230226932232316 |
| GO:0002521 | leukocyte differentiation | 0.024238047899317 |
| GO:0030005 | cellular di-, tri-valent inorganic cation homeostasis | 0.0245306160476434 |
| GO:0048754 | branching morphogenesis of a tube | 0.0246891163155832 |
| GO:0002520 | immune system development | 0.0253118380822166 |
| GO:0055066 | di-, tri-valent inorganic cation homeostasis | 0.0257075204638059 |
| GO:0006417 | regulation of translation | 0.0261065821235635 |
| GO:0006357 | regulation of transcription from RNA polymerase II promoter | 0.0271951748819693 |
| GO:0003713 | transcription coactivator activity | 0.0274237502124997 |
| GO:0035258 | steroid hormone receptor binding | 0.0274552103647454 |
| GO:0000245 | spliceosome assembly | 0.0274552103647454 |
| GO:0002455 | humoral immune response mediated by circulating immunoglobulin | 0.0274552103647454 |
| GO:0007167 | enzyme linked receptor protein signaling pathway | 0.0276754729405831 |
| GO:0046849 | bone remodeling | 0.0277499763019194 |
| GO:0048878 | chemical homeostasis | 0.0282434003362857 |
| GO:0030054 | cell junction | 0.0282445479216886 |
| GO:0050900 | leukocyte migration | 0.0287570441271378 |
| GO:0007264 | small GTPase mediated signal transduction | 0.0290182553154888 |
| GO:0001763 | morphogenesis of a branching structure | 0.0302762894015435 |
| GO:0008286 | insulin receptor signaling pathway | 0.0302762894015435 |
| GO:0016563 | transcription activator activity | 0.0303902120321727 |
| GO:0003779 | actin binding | 0.030498723930092 |
| GO:0008289 | lipid binding | 0.0307547152246479 |
| GO:0032403 | protein complex binding | 0.0308212818739032 |
| GO:0010324 | membrane invagination | 0.0309494433170335 |
| GO:0006897 | endocytosis | 0.0309494433170335 |
| GO:0031326 | regulation of cellular biosynthetic process | 0.0310313695148337 |
| GO:0006066 | alcohol metabolic process | 0.0310313695148337 |
| GO:0030003 | cellular cation homeostasis | 0.0310313695148337 |
| GO:0005764 | lysosome | 0.0310313695148337 |
| GO:0030521 | androgen receptor signaling pathway | 0.0310313695148337 |
| GO:0000323 | lytic vacuole | 0.0310313695148337 |
| GO:0002268 | follicular dendritic cell differentiation | 0.0310313695148337 |
| GO:0004438 | phosphatidylinositol-3-phosphatase activity | 0.0310313695148337 |
| GO:0042629 | mast cell granule | 0.0310313695148337 |
| GO:0046696 | lipopolysaccharide receptor complex | 0.0310313695148337 |
| GO:0004910 | interleukin-1, Type II, blocking receptor activity | 0.0310313695148337 |
| GO:0033256 | I-kappaB/NF-kappaB complex | 0.0310313695148337 |
| GO:0051896 | regulation of protein kinase B signaling cascade | 0.0310313695148337 |
| GO:0046967 | cytosol to ER transport | 0.0310313695148337 |
| GO:0004572 | mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity | 0.0310313695148337 |
| GO:0016314 | phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity | 0.0310313695148337 |
| GO:0045415 | negative regulation of interleukin-8 biosynthetic process | 0.0310313695148337 |
| GO:0033257 | Bcl3/NF-kappaB2 complex | 0.0310313695148337 |
| GO:0060056 | mammary gland involution | 0.0310313695148337 |
| GO:0033363 | secretory granule organization and biogenesis | 0.0310313695148337 |
| GO:0019968 | interleukin-1, Type II, blocking binding | 0.0310313695148337 |
| GO:0005988 | lactose metabolic process | 0.0310313695148337 |
| GO:0002266 | follicular dendritic cell activation | 0.0310313695148337 |
| GO:0046351 | disaccharide biosynthetic process | 0.0310313695148337 |
| GO:0042975 | peroxisome proliferator activated receptor binding | 0.0310313695148337 |
| GO:0046838 | phosphorylated carbohydrate dephosphorylation | 0.0310313695148337 |
| GO:0017158 | regulation of calcium ion-dependent exocytosis | 0.0310313695148337 |
| GO:0001315 | age-dependent response to reactive oxygen species | 0.0310313695148337 |
| GO:0005989 | lactose biosynthetic process | 0.0310313695148337 |
| GO:0055080 | cation homeostasis | 0.0311196817475937 |
| GO:0008047 | enzyme activator activity | 0.0324822145202512 |
| GO:0043122 | regulation of I-kappaB kinase/NF-kappaB cascade | 0.033142004853316 |
| GO:0065003 | macromolecular complex assembly | 0.0339324668854299 |
| GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | 0.0345236620980173 |
| GO:0002252 | immune effector process | 0.0345236620980173 |
| GO:0006917 | induction of apoptosis | 0.0354513145653319 |
| GO:0012502 | induction of programmed cell death | 0.0359160070756013 |
| GO:0005083 | small GTPase regulator activity | 0.0380357419318679 |
| GO:0009889 | regulation of biosynthetic process | 0.0380357419318679 |
| GO:0042098 | T cell proliferation | 0.038162162366814 |
| GO:0007259 | JAK-STAT cascade | 0.038162162366814 |
| GO:0006605 | protein targeting | 0.0382871957777362 |
| GO:0016197 | endosome transport | 0.0397262737011969 |
| GO:0035295 | tube development | 0.0397262737011969 |
| GO:0042592 | homeostatic process | 0.0398408343875746 |
| GO:0042108 | positive regulation of cytokine biosynthetic process | 0.0409559580800493 |
| GO:0030217 | T cell differentiation | 0.0409559580800493 |
| GO:0005096 | GTPase activator activity | 0.0409559580800493 |
| GO:0008380 | RNA splicing | 0.0409559580800493 |
| GO:0018193 | peptidyl-amino acid modification | 0.0409559580800493 |
| GO:0018108 | peptidyl-tyrosine phosphorylation | 0.0409559580800493 |
| GO:0045136 | development of secondary sexual characteristics | 0.0409559580800493 |
| GO:0018076 | N-terminal peptidyl-lysine acetylation | 0.0409559580800493 |
| GO:0008339 | MP kinase activity | 0.0409559580800493 |
| GO:0045084 | positive regulation of interleukin-12 biosynthetic process | 0.0409559580800493 |
| GO:0045082 | positive regulation of interleukin-10 biosynthetic process | 0.0409559580800493 |
| GO:0004461 | lactose synthase activity | 0.0409559580800493 |
| GO:0010225 | response to UV-C | 0.0409559580800493 |
| GO:0003831 | beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity | 0.0409559580800493 |
| GO:0001530 | lipopolysaccharide binding | 0.0409559580800493 |
| GO:0045730 | respiratory burst | 0.0409559580800493 |
| GO:0045074 | regulation of interleukin-10 biosynthetic process | 0.0409559580800493 |
| GO:0001915 | negative regulation of T cell mediated cytotoxicity | 0.0409559580800493 |
| GO:0051895 | negative regulation of focal adhesion formation | 0.0409559580800493 |
| GO:0004944 | C5a anaphylatoxin receptor activity | 0.0409559580800493 |
| GO:0001911 | negative regulation of leukocyte mediated cytotoxicity | 0.0409559580800493 |
| GO:0042091 | interleukin-10 biosynthetic process | 0.0409559580800493 |
| GO:0042825 | TAP complex | 0.0409559580800493 |
| GO:0018394 | peptidyl-lysine acetylation | 0.0409559580800493 |
| GO:0019730 | antimicrobial humoral response | 0.0409559580800493 |
| GO:0046980 | tapasin binding | 0.0409559580800493 |
| GO:0042536 | negative regulation of tumor necrosis factor biosynthetic process | 0.0409559580800493 |
| GO:0042770 | DNA damage response, signal transduction | 0.0420003752033478 |
| GO:0005773 | vacuole | 0.0435332580147788 |
| GO:0046777 | protein amino acid autophosphorylation | 0.0435332580147788 |
| GO:0018212 | peptidyl-tyrosine modification | 0.0435332580147788 |
| GO:0048503 | GPI anchor binding | 0.0441535757273857 |
| GO:0022607 | cellular component assembly | 0.0447512379991805 |
| GO:0001525 | angiogenesis | 0.0466323365824604 |
| GO:0030198 | extracellular matrix organization and biogenesis | 0.0466323365824604 |
| GO:0045121 | lipid raft | 0.0466323365824604 |
| GO:0016540 | protein autoprocessing | 0.0466323365824604 |
| GO:0019725 | cellular homeostasis | 0.049216123872577 |
| GO:0007049 | cell cycle | 0.049216123872577 |
| GO:0001960 | negative regulation of cytokine and chemokine mediated signaling pathway | 0.049216123872577 |
| GO:0007341 | penetration of zona pellucida | 0.049216123872577 |
| GO:0042090 | interleukin-12 biosynthetic process | 0.049216123872577 |
| GO:0001892 | embryonic placenta development | 0.049216123872577 |
| GO:0004035 | alkaline phosphatase activity | 0.049216123872577 |
| GO:0000303 | response to superoxide | 0.049216123872577 |
| GO:0042832 | defense response to protozoan | 0.049216123872577 |
| GO:0003945 | N-acetyllactosamine synthase activity | 0.049216123872577 |
| GO:0050710 | negative regulation of cytokine secretion | 0.049216123872577 |
| GO:0030502 | negative regulation of bone mineralization | 0.049216123872577 |
| GO:0015379 | potassium:chloride symporter activity | 0.049216123872577 |
| GO:0048008 | platelet-derived growth factor receptor signaling pathway | 0.049216123872577 |
| GO:0001914 | regulation of T cell mediated cytotoxicity | 0.049216123872577 |
| GO:0045075 | regulation of interleukin-12 biosynthetic process | 0.049216123872577 |
| GO:0048662 | negative regulation of smooth muscle cell proliferation | 0.049216123872577 |
| GO:0002467 | germinal center formation | 0.049216123872577 |
| GO:0004942 | anaphylatoxin receptor activity | 0.049216123872577 |
| GO:0000085 | G2 phase of mitotic cell cycle | 0.049216123872577 |
| GO:0004992 | platelet activating factor receptor activity | 0.049216123872577 |
| GO:0051893 | regulation of focal adhesion formation | 0.049216123872577 |
| GO:0004062 | aryl sulfotransferase activity | 0.049216123872577 |
| GO:0000138 | Golgi trans cisterna | 0.049216123872577 |
| GO:0007184 | SMAD protein nuclear translocation | 0.049216123872577 |
| GO:0048536 | spleen development | 0.049216123872577 |
| GO:0051319 | G2 phase | 0.049216123872577 |
| GO:0042788 | polysomal ribosome | 0.049216123872577 |
| GO:0001913 | T cell mediated cytotoxicity | 0.049216123872577 |
| GO:0043169 | cation binding | 0.049216123872577 |
| GO:0033036 | macromolecule localization | 0.0496114207343618 |
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>
| Ontology term | p-value | n |
|---|---|---|
| leukocyte | 1.48e-50 | 140 |
| hematopoietic stem cell | 3.94e-44 | 172 |
| angioblastic mesenchymal cell | 3.94e-44 | 172 |
| hematopoietic oligopotent progenitor cell | 2.22e-42 | 165 |
| hematopoietic multipotent progenitor cell | 2.22e-42 | 165 |
| nongranular leukocyte | 3.00e-41 | 119 |
| hematopoietic lineage restricted progenitor cell | 1.49e-40 | 124 |
| hematopoietic cell | 1.25e-39 | 182 |
| myeloid leukocyte | 8.43e-34 | 76 |
| granulocyte monocyte progenitor cell | 2.11e-28 | 71 |
| myeloid cell | 4.93e-28 | 112 |
| common myeloid progenitor | 4.93e-28 | 112 |
| macrophage dendritic cell progenitor | 7.03e-28 | 65 |
| myeloid lineage restricted progenitor cell | 4.82e-27 | 70 |
| monopoietic cell | 6.42e-27 | 63 |
| monocyte | 6.42e-27 | 63 |
| monoblast | 6.42e-27 | 63 |
| promonocyte | 6.42e-27 | 63 |
| CD14-positive, CD16-negative classical monocyte | 9.59e-27 | 42 |
| classical monocyte | 5.28e-25 | 45 |
| lymphocyte | 1.14e-12 | 53 |
| common lymphoid progenitor | 1.14e-12 | 53 |
| lymphoid lineage restricted progenitor cell | 2.39e-12 | 52 |
| mesenchymal cell | 3.03e-08 | 358 |
| connective tissue cell | 4.72e-07 | 365 |
| T cell | 7.56e-07 | 25 |
| pro-T cell | 7.56e-07 | 25 |
| Ontology term | p-value | n |
|---|---|---|
| hematopoietic system | 1.32e-31 | 102 |
| blood island | 1.32e-31 | 102 |
| hemolymphoid system | 2.78e-29 | 112 |
| bone marrow | 5.99e-23 | 80 |
| bone element | 5.89e-20 | 86 |
| immune system | 1.60e-17 | 115 |
| skeletal element | 3.39e-14 | 101 |
| skeletal system | 3.39e-14 | 101 |
| adult organism | 2.46e-13 | 115 |
| blood | 8.32e-08 | 15 |
| haemolymphatic fluid | 8.32e-08 | 15 |
| organism substance | 8.32e-08 | 15 |
Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
| Motifs | -log10(p-value) |
|---|---|
|
{{{tfbs_overrepresentation_jaspar}}} |
ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data
No analysis results for this cluster
Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data
"{{{coexpression_dpi_cluster_scores_median}}}" is not a number.
