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Coexpression cluster:C3761

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Full id: C3761_Basophils_Eosinophils_CD4_blood_CD19_CD8_CD14CD16



Phase1 CAGE Peaks

Hg19::chr19:16435625..16435682,+p1@KLF2
Hg19::chr19:16436712..16436718,+p@chr19:16436712..16436718
+
Hg19::chr19:16436783..16436796,+p@chr19:16436783..16436796
+


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
leukocyte5.31e-22136
nongranular leukocyte2.18e-20115
hematopoietic lineage restricted progenitor cell1.21e-17120
classical monocyte4.99e-1542
CD14-positive, CD16-negative classical monocyte4.99e-1542
mature alpha-beta T cell2.06e-1418
alpha-beta T cell2.06e-1418
immature T cell2.06e-1418
mature T cell2.06e-1418
immature alpha-beta T cell2.06e-1418
myeloid leukocyte1.30e-1272
hematopoietic stem cell3.89e-12168
angioblastic mesenchymal cell3.89e-12168
defensive cell4.87e-1248
phagocyte4.87e-1248
hematopoietic oligopotent progenitor cell1.50e-11161
hematopoietic multipotent progenitor cell1.50e-11161
lymphocyte1.56e-1153
common lymphoid progenitor1.56e-1153
lymphoid lineage restricted progenitor cell2.01e-1152
hematopoietic cell6.86e-11177
nucleate cell1.37e-1055
T cell6.10e-1025
pro-T cell6.10e-1025
CD8-positive, alpha-beta T cell1.07e-0911
monopoietic cell3.60e-0859
monocyte3.60e-0859
monoblast3.60e-0859
promonocyte3.60e-0859
myeloid lineage restricted progenitor cell4.92e-0866
granulocyte monocyte progenitor cell1.01e-0767
macrophage dendritic cell progenitor1.67e-0761
mesenchymal cell1.79e-07354
intermediate monocyte3.06e-079
CD14-positive, CD16-positive monocyte3.06e-079
granulocyte4.83e-078
connective tissue cell6.56e-07361
Uber Anatomy
Ontology termp-valuen
hemolymphoid system1.93e-13108
lateral plate mesoderm2.50e-12203
hematopoietic system2.59e-1298
blood island2.59e-1298
immune system3.70e-0993
adult organism1.83e-08114
bone marrow3.16e-0776
bone element6.60e-0782


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.