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Coexpression cluster:C151

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Full id: C151_CD14_Natural_Basophils_CD8_Eosinophils_CD4_Mast



Phase1 CAGE Peaks

Hg19::chr10:17553392..17553414,-p@chr10:17553392..17553414
-
Hg19::chr10:17553468..17553477,-p@chr10:17553468..17553477
-
Hg19::chr10:3799978..3799981,+p@chr10:3799978..3799981
+
Hg19::chr10:3825575..3825583,-p@chr10:3825575..3825583
-
Hg19::chr10:3825586..3825604,+p@chr10:3825586..3825604
+
Hg19::chr10:3825673..3825701,+p@chr10:3825673..3825701
+
Hg19::chr10:3827371..3827386,-p2@KLF6
Hg19::chr10:3847590..3847615,+p@chr10:3847590..3847615
+
Hg19::chr10:3847617..3847639,+p@chr10:3847617..3847639
+
Hg19::chr10:3894565..3894585,-p@chr10:3894565..3894585
-
Hg19::chr10:3894940..3894969,+p@chr10:3894940..3894969
+
Hg19::chr10:3930116..3930153,-p@chr10:3930116..3930153
-
Hg19::chr10:3930230..3930262,+p@chr10:3930230..3930262
+
Hg19::chr10:99408822..99408843,-p@chr10:99408822..99408843
-
Hg19::chr11:108338193..108338213,-p2@C11orf65
Hg19::chr11:58341454..58341467,+p@chr11:58341454..58341467
+
Hg19::chr11:9482158..9482185,-p1@LOC644656
Hg19::chr12:47785018..47785030,+p@chr12:47785018..47785030
+
Hg19::chr12:62997510..62997571,-p1@C12orf61
Hg19::chr12:64616313..64616329,-p2@C12orf66
Hg19::chr12:64845781..64845792,+p5@TBK1
Hg19::chr12:92270910..92270924,-p@chr12:92270910..92270924
-
Hg19::chr12:96793507..96793519,+p@chr12:96793507..96793519
+
Hg19::chr13:114894670..114894687,+p@chr13:114894670..114894687
+
Hg19::chr13:52378012..52378023,+p5@ENST00000456688
Hg19::chr13:52378405..52378429,+p3@ENST00000456688
Hg19::chr13:71865578..71865595,+p@chr13:71865578..71865595
+
Hg19::chr13:99935844..99935865,-p@chr13:99935844..99935865
-
Hg19::chr14:102414353..102414415,-p@chr14:102414353..102414415
-
Hg19::chr14:23790136..23790163,-p@chr14:23790136..23790163
-
Hg19::chr14:81636804..81636835,+p@chr14:81636804..81636835
+
Hg19::chr14:81685834..81685853,+p@chr14:81685834..81685853
+
Hg19::chr15:85525866..85525879,-p@chr15:85525866..85525879
-
Hg19::chr16:20912122..20912137,-p3@DCUN1D3
Hg19::chr17:26926162..26926194,+p1@SPAG5-AS1
Hg19::chr17:33569446..33569460,+p@chr17:33569446..33569460
+
Hg19::chr17:33570565..33570588,-p@chr17:33570565..33570588
-
Hg19::chr17:38255699..38255715,+p@chr17:38255699..38255715
+
Hg19::chr17:38476516..38476528,-p@chr17:38476516..38476528
-
Hg19::chr17:38477491..38477543,-p@chr17:38477491..38477543
-
Hg19::chr18:11851262..11851282,-p@chr18:11851262..11851282
-
Hg19::chr18:3448924..3448950,-p@chr18:3448924..3448950
-
Hg19::chr18:60829037..60829058,-p@chr18:60829037..60829058
-
Hg19::chr18:711915..711927,+p@chr18:711915..711927
+
Hg19::chr19:11201287..11201316,+p9@LDLR
Hg19::chr19:14480830..14480845,+p@chr19:14480830..14480845
+
Hg19::chr19:2504035..2504041,+p@chr19:2504035..2504041
+
Hg19::chr19:45959099..45959131,-p@chr19:45959099..45959131
-
Hg19::chr1:171455486..171455504,+p@chr1:171455486..171455504
+
Hg19::chr1:184942941..184942967,-p@chr1:184942941..184942967
-
Hg19::chr1:206753511..206753542,+p@chr1:206753511..206753542
+
Hg19::chr1:221885672..221885702,-p@chr1:221885672..221885702
-
Hg19::chr1:221915746..221915770,+p@chr1:221915746..221915770
+
Hg19::chr1:221916350..221916370,+p@chr1:221916350..221916370
+
Hg19::chr1:221916408..221916416,+p@chr1:221916408..221916416
+
Hg19::chr1:224033536..224033567,-p4@TP53BP2
Hg19::chr1:226867811..226867833,-p@chr1:226867811..226867833
-
Hg19::chr1:226891331..226891354,+p@chr1:226891331..226891354
+
Hg19::chr1:226891361..226891380,+p@chr1:226891361..226891380
+
Hg19::chr1:234746616..234746632,-p@chr1:234746616..234746632
-
Hg19::chr1:24286129..24286138,-p@chr1:24286129..24286138
-
Hg19::chr1:37944377..37944382,-p@chr1:37944377..37944382
-
Hg19::chr1:59249927..59249963,+p@chr1:59249927..59249963
+
Hg19::chr22:36782241..36782263,+p@chr22:36782241..36782263
+
Hg19::chr22:42929620..42929624,+p@chr22:42929620..42929624
+
Hg19::chr2:135810133..135810145,-p@chr2:135810133..135810145
-
Hg19::chr2:178077129..178077179,-p@chr2:178077129..178077179
-
Hg19::chr2:178129611..178129638,+p@chr2:178129611..178129638
+
Hg19::chr2:178129685..178129703,+p@chr2:178129685..178129703
+
Hg19::chr2:191979419..191979439,+p@chr2:191979419..191979439
+
Hg19::chr2:192015854..192015875,+p@chr2:192015854..192015875
+
Hg19::chr2:232258341..232258363,-p@chr2:232258341..232258363
-
Hg19::chr2:241564662..241564674,-p@chr2:241564662..241564674
-
Hg19::chr2:48133949..48133962,+p2@ENST00000417692
Hg19::chr2:61991361..61991380,-p@chr2:61991361..61991380
-
Hg19::chr2:61991387..61991406,-p@chr2:61991387..61991406
-
Hg19::chr2:70370094..70370116,+p@chr2:70370094..70370116
+
Hg19::chr2:88927395..88927420,+p2@uc002std.1
Hg19::chr2:88927653..88927687,-p@chr2:88927653..88927687
-
Hg19::chr3:11331017..11331048,+p@chr3:11331017..11331048
+
Hg19::chr3:113933266..113933281,+p2@ENST00000493033
p2@uc003ebe.1
Hg19::chr3:5026037..5026052,+p@chr3:5026037..5026052
+
Hg19::chr3:5048654..5048681,+p@chr3:5048654..5048681
+
Hg19::chr4:103436594..103436605,+p@chr4:103436594..103436605
+
Hg19::chr4:139936151..139936155,-p@chr4:139936151..139936155
-
Hg19::chr4:139938135..139938140,+p@chr4:139938135..139938140
+
Hg19::chr4:170541477..170541493,-p@chr4:170541477..170541493
-
Hg19::chr4:2748210..2748233,+p@chr4:2748210..2748233
+
Hg19::chr5:142784911..142784925,-p15@NR3C1
Hg19::chr5:1521157..1521164,+p@chr5:1521157..1521164
+
Hg19::chr5:75843262..75843275,-p@chr5:75843262..75843275
-
Hg19::chr6:138028841..138028852,-p@chr6:138028841..138028852
-
Hg19::chr6:28105422..28105451,-p1@uc003nkl.1
p1@uc010jqw.1
p2@uc003nkk.1
Hg19::chr6:29617855..29617871,-p@chr6:29617855..29617871
-
Hg19::chr6:33281942..33281963,+p@chr6:33281942..33281963
+
Hg19::chr6:33386279..33386304,+p@chr6:33386279..33386304
+
Hg19::chr7:12727041..12727066,-p@chr7:12727041..12727066
-
Hg19::chr7:130626444..130626463,+p@chr7:130626444..130626463
+
Hg19::chr7:151722642..151722676,-p@chr7:151722642..151722676
-
Hg19::chr7:30634289..30634301,-p@chr7:30634289..30634301
-
Hg19::chr7:44673697..44673718,+p@chr7:44673697..44673718
+
Hg19::chr7:44925415..44925438,+p@chr7:44925415..44925438
+
Hg19::chr7:66093620..66093638,-p@chr7:66093620..66093638
-
Hg19::chr8:101964395..101964441,+p@chr8:101964395..101964441
+
Hg19::chr8:141475127..141475140,+p@chr8:141475127..141475140
+
Hg19::chr8:141601516..141601544,-p@chr8:141601516..141601544
-
Hg19::chr9:132891288..132891326,-p@chr9:132891288..132891326
-
Hg19::chr9:135991340..135991361,+p@chr9:135991340..135991361
+
Hg19::chr9:26892877..26892898,+p@chr9:26892877..26892898
+
Hg19::chr9:34989341..34989353,-p@chr9:34989341..34989353
-
Hg19::chr9:91933623..91933645,-p@chr9:91933623..91933645
-
Hg19::chr9:99417081..99417092,+p@chr9:99417081..99417092
+
Hg19::chrX:70752106..70752119,+p@chrX:70752106..70752119
+


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0030229very-low-density lipoprotein receptor activity0.0155274932297186
GO:0004883glucocorticoid receptor activity0.0155274932297186
GO:0065007biological regulation0.0214504329188226
GO:0045192low-density lipoprotein catabolic process0.0228181386588504
GO:0004871signal transducer activity0.0228181386588504
GO:0060089molecular transducer activity0.0228181386588504
GO:0042159lipoprotein catabolic process0.0266107250734418
GO:0030299cholesterol absorption0.0275930581833342
GO:0044241lipid digestion0.0275930581833342
GO:0050892intestinal absorption0.0284503157301035
GO:0005041low-density lipoprotein receptor activity0.0284503157301035
GO:0030228lipoprotein receptor activity0.0284503157301035
GO:0042632cholesterol homeostasis0.0286397731579021
GO:0055092sterol homeostasis0.0286397731579021
GO:0030169low-density lipoprotein binding0.0286397731579021
GO:0055088lipid homeostasis0.0286397731579021
GO:0015918sterol transport0.0286397731579021
GO:0051059NF-kappaB binding0.0286397731579021
GO:0030301cholesterol transport0.0286397731579021
GO:0022600digestive system process0.0286397731579021
GO:0006952defense response0.0286397731579021
GO:0007530sex determination0.0296085113281691
GO:0050794regulation of cellular process0.0315335977428127
GO:0030183B cell differentiation0.0356404869340457
GO:0008034lipoprotein binding0.0356404869340457
GO:0006493protein amino acid O-linked glycosylation0.0356404869340457
GO:0050789regulation of biological process0.0356404869340457
GO:0005905coated pit0.0475738017393153



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Cell Type
Ontology termp-valuen
leukocyte6.69e-85136
classical monocyte5.77e-7342
CD14-positive, CD16-negative classical monocyte5.77e-7342
hematopoietic lineage restricted progenitor cell2.11e-67120
nongranular leukocyte1.38e-66115
hematopoietic stem cell4.36e-66168
angioblastic mesenchymal cell4.36e-66168
hematopoietic cell6.54e-65177
defensive cell4.40e-6248
phagocyte4.40e-6248
myeloid leukocyte9.83e-6072
hematopoietic oligopotent progenitor cell9.81e-59161
hematopoietic multipotent progenitor cell9.81e-59161
granulocyte monocyte progenitor cell4.74e-5467
macrophage dendritic cell progenitor1.99e-5261
myeloid lineage restricted progenitor cell5.49e-5066
monopoietic cell2.52e-4959
monocyte2.52e-4959
monoblast2.52e-4959
promonocyte2.52e-4959
myeloid cell3.81e-41108
common myeloid progenitor3.81e-41108
stuff accumulating cell3.63e-2887
mesenchymal cell1.06e-20354
connective tissue cell7.44e-20361
motile cell7.01e-17386
intermediate monocyte5.07e-169
CD14-positive, CD16-positive monocyte5.07e-169
lymphoid lineage restricted progenitor cell1.91e-1552
lymphocyte5.10e-1553
common lymphoid progenitor5.10e-1553
nucleate cell3.24e-1455
stem cell1.89e-13441
multi fate stem cell2.79e-13427
somatic stem cell8.68e-13433
CD4-positive, alpha-beta T cell8.96e-126
T cell2.37e-1125
pro-T cell2.37e-1125
mature alpha-beta T cell5.84e-1118
alpha-beta T cell5.84e-1118
immature T cell5.84e-1118
mature T cell5.84e-1118
immature alpha-beta T cell5.84e-1118
granulocyte1.29e-088
blood cell6.15e-0811
natural killer cell1.50e-073
pro-NK cell1.50e-073
circulating cell1.97e-076
basophil4.47e-073
dendritic cell7.89e-0710
Uber Anatomy
Ontology termp-valuen
bone marrow5.36e-4876
hematopoietic system1.95e-4698
blood island1.95e-4698
bone element2.13e-4382
hemolymphoid system1.36e-40108
immune system4.66e-4093
skeletal element3.18e-3890
skeletal system6.29e-33100
connective tissue1.06e-18371
lateral plate mesoderm1.26e-15203
musculoskeletal system4.34e-14167


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
ATF3#467254.969728877435572.66467314316163e-113.13396169367857e-09
BATF#10538306.46667304220451.78853175422964e-163.55118760228117e-14
BCL11A#53335225.5232567458356.95516102941178e-117.6704336087723e-09
BCL3#602103.05726573484410.001698830845581860.0106133992152733
BCLAF1#9774122.299396206384620.006123377207064820.0270868018690658
BRCA1#672234.108294732691567.05821815684309e-095.48885514581188e-07
CCNT2#905402.242903213084122.72979303212699e-071.40303570119247e-05
CEBPB#1051402.821645177283123.93737605036592e-103.88672606166509e-08
CHD2#1106272.471580677178367.91815342052214e-060.000223443400455529
CTCF#10664341.612820501633190.002234365881386610.0128343932618048
E2F1#1869482.08455471074528.25544338046805e-084.92117723294921e-06
E2F4#1874283.138988396707654.17937700915703e-082.75214347704509e-06
E2F6#1876492.175580804010371.31376188976336e-089.67616205959067e-07
EBF1#1879413.231549917781672.95693619281385e-123.93400584765969e-10
EGR1#1958522.295445247169274.5236953710125e-104.40718489601842e-08
ELF1#1997562.110207837993121.50435047935138e-091.33485862118079e-07
EP300#2033543.237104895717289.13461812603964e-171.84171888506844e-14
ETS1#2113292.49676165260062.70068542736109e-069.41444877664103e-05
FOS#2353524.140652000553181.11873731240395e-202.92831594411419e-18
FOSL1#806182.811580864875970.00797685585004890.0322517458914969
FOSL2#2355243.595794818667973.97259582102482e-082.62757400222933e-06
FOXA1#3169201.961313229979730.002660798006733480.0146822572528788
GABPB1#2553352.189105612976783.72692965840947e-060.000121979569600322
GATA1#2623354.200095442770051.33491818158606e-132.06238934861933e-11
GATA2#2624313.496397201240484.77408719987822e-104.63814784249378e-08
GATA3#2625133.133404536669720.0002717762413345660.00290077045158311
GTF2B#2959185.088397688653421.60268193608411e-081.16887219778414e-06
GTF2F1#2962303.382210852236542.14376572639155e-091.83669194994756e-07
HEY1#23462562.002178924016991.13798507624104e-088.54421447717744e-07
HMGN3#9324292.098919327231577.27131734507085e-050.00114231214230123
HSF1#329745.8155988200590.005204334282971130.024116401995706
IRF1#3659322.162736638177391.46675799887184e-050.000348547755731913
IRF3#366193.741925397375280.0007289877444173080.00581181305642743
IRF4#3662244.654409774175742.66844518639816e-102.71892435924134e-08
JUN#3725424.650786071487844.61058878097027e-181.02234667026699e-15
JUNB#3726184.876029981210453.04894406944946e-082.06236185018933e-06
JUND#3727503.094984045075681.57466873110116e-142.67844996103378e-12
MAFK#7975102.398294967949550.009184688775860730.0347386995640502
MAX#4149372.112783662241274.0391830074391e-060.00013028049231437
MEF2A#4205284.644340402389686.57314347228091e-128.42322124050977e-10
MEF2C#4208145.118220910590596.76449638682922e-073.0623200613093e-05
MXI1#4601302.644665034183885.15462307509125e-072.40869655185438e-05
MYC#4609462.12588465569941.02375377015787e-075.99326345299986e-06
NANOG#79923123.105640192673910.000510768811138660.00443131615438699
NFKB1#4790783.788220770682473.69176964866529e-321.62685540226563e-29
NFYA#4800233.750339434478783.76520743942639e-082.49672698264287e-06
NFYB#4801213.114651843577573.19693126773653e-060.000107635172363358
NR3C1#2908182.385083362487740.0005058725216919290.00443377142438598
PAX5#5079553.246248709865313.39068642342045e-177.01227523516055e-15
PBX3#5090142.715072368269180.0006555844727749180.00536798014520891
POLR2A#5430971.843389009965783.54610992376171e-187.89663484707353e-16
POU2F2#5452493.948673263976851.89972792138008e-184.2852199650327e-16
PRDM1#63944.666582505396840.01105683307715370.0406693171002625
RAD21#5885201.832749362027670.005701289473952280.0257041645314095
REST#5978252.134962105338060.0002001048270637130.00240160285379305
RFX5#5993333.518416436260529.30893924055347e-111.01272531806684e-08
RXRA#6256142.487120707503240.001511460460112370.009651814062591
SETDB1#986982.854515127646760.007315906403366760.0302588392087926
SIN3A#25942492.345445589503919.93910696295933e-109.23514583722873e-08
SIX5#147912162.419357926436670.0009177863444959130.00667730324157496
SMARCB1#6598172.745983790085630.0001454253002017150.00187947938717571
SMARCC2#660154.166167010039720.007343129231577390.0303654210412065
SP1#6667552.773548458387163.49835029250443e-145.78107921200745e-12
SP2#6668133.008813242654690.0003994310599470580.00390053113322214
SPI1#6688342.46855751583873.50947156535219e-071.73380180138986e-05
SREBF1#6720135.407752590498659.5226189052277e-074.06928312538084e-05
SREBF2#6721519.33377267306857.02435613897748e-060.000202768582310301
SRF#6722323.907165525569651.339630289454e-111.65377834279298e-09
STAT3#6774312.885870928422844.42424132863666e-082.89876624919375e-06
TAF1#6872732.159667069552272.84227679809916e-144.71930916560696e-12
TAF7#6879232.327084923126110.0001080502839088670.0015040202054056
TAL1#6886112.907564455326040.001488240585563730.00951750404235447
TBP#6908782.558655872509011.52483061793185e-203.97136620713678e-18
TCF12#6938323.0115298838059.03457520958592e-096.90748170068773e-07
TCF7L2#6934292.764027613548523.39933605809316e-071.68737290195433e-05
TFAP2C#7022242.295765368465899.16183333387457e-050.00133508122164996
THAP1#55145113.053633545410310.00100812219744410.00721837886870045
TRIM28#10155182.961322573581643.45147705808527e-050.000677318324820307
USF1#7391452.533340420127066.26621038400348e-105.98752741349441e-08
USF2#7392313.564231141036792.98657280119873e-103.02242903860847e-08
YY1#7528552.390392842849221.77009623719073e-112.14214462243294e-09
ZBTB7A#51341271.756650896572120.002213519682961390.012727951449034
ZNF263#10127271.964510833622020.0004062057445107080.00390677979104464



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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