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Coexpression cluster:C1402

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Full id: C1402_hippocampus_occipital_medial_pineal_temporal_parietal_amygdala



Phase1 CAGE Peaks

Hg19::chr14:93651186..93651265,-p1@MOAP1
Hg19::chr18:32621351..32621421,+p1@MAPRE2
Hg19::chr18:54318893..54318941,+p@chr18:54318893..54318941
+
Hg19::chr2:99061298..99061377,+p1@INPP4A
Hg19::chr3:14989138..14989151,+p6@NR2C2
Hg19::chr5:156693092..156693150,+p1@CYFIP2


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


GO IDGO nameFDR corrected p-value
GO:0016316phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity0.0367928413934545



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
leukocyte1.12e-34140
hematopoietic stem cell1.06e-31172
angioblastic mesenchymal cell1.06e-31172
hematopoietic cell2.86e-29182
nongranular leukocyte1.00e-28119
hematopoietic oligopotent progenitor cell1.48e-28165
hematopoietic multipotent progenitor cell1.48e-28165
hematopoietic lineage restricted progenitor cell1.15e-27124
lymphocyte1.73e-1653
common lymphoid progenitor1.73e-1653
lymphoid lineage restricted progenitor cell2.48e-1652
myeloid leukocyte2.46e-1576
CD14-positive, CD16-negative classical monocyte9.88e-1442
myeloid cell6.34e-13112
common myeloid progenitor6.34e-13112
granulocyte monocyte progenitor cell1.17e-1271
classical monocyte1.81e-1245
myeloid lineage restricted progenitor cell8.55e-1270
macrophage dendritic cell progenitor1.64e-1165
monopoietic cell2.40e-1163
monocyte2.40e-1163
monoblast2.40e-1163
promonocyte2.40e-1163
T cell3.99e-1125
pro-T cell3.99e-1125
mature alpha-beta T cell3.66e-1018
alpha-beta T cell3.66e-1018
immature T cell3.66e-1018
mature T cell3.66e-1018
immature alpha-beta T cell3.66e-1018
Uber Anatomy
Ontology termp-valuen
adult organism5.27e-36115
neural tube2.04e-2757
neural rod2.04e-2757
future spinal cord2.04e-2757
neural keel2.04e-2757
central nervous system6.98e-2582
regional part of nervous system7.35e-2494
nervous system7.35e-2494
regional part of forebrain3.32e-2341
forebrain3.32e-2341
future forebrain3.32e-2341
anterior neural tube4.28e-2342
regional part of brain7.33e-2359
brain1.37e-2169
future brain1.37e-2169
gray matter5.19e-2034
brain grey matter5.19e-2034
telencephalon5.87e-2034
cerebral hemisphere2.43e-1932
regional part of telencephalon2.64e-1933
neural plate1.04e-1886
presumptive neural plate1.04e-1886
neurectoderm1.60e-1890
hematopoietic system2.85e-16102
blood island2.85e-16102
regional part of cerebral cortex6.47e-1622
cerebral cortex2.92e-1525
pallium2.92e-1525
pre-chordal neural plate8.42e-1561
neocortex1.21e-1420
hemolymphoid system1.26e-14112
bone marrow3.65e-1080
bone element8.94e-1086
anterior region of body7.34e-09129
craniocervical region7.34e-09129
immune system2.29e-08115
head1.74e-07123
skeletal element6.88e-07101
skeletal system6.88e-07101


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.