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Coexpression cluster:C1446

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Full id: C1446_CD14_Mast_CD14CD16_Basophils_Melanocyte_Neutrophils_immature



Phase1 CAGE Peaks

Hg19::chr18:74826350..74826370,-p@chr18:74826350..74826370
-
Hg19::chr18:74843480..74843491,+p@chr18:74843480..74843491
+
Hg19::chr18:74844048..74844062,-p16@MBP
Hg19::chr18:74844167..74844184,+p@chr18:74844167..74844184
+
Hg19::chr2:43764398..43764438,-p@chr2:43764398..43764438
-
Hg19::chr2:43767323..43767344,-p@chr2:43767323..43767344
-


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Cell Type
Ontology termp-valuen
myeloid leukocyte1.02e-10272
granulocyte monocyte progenitor cell1.44e-9167
defensive cell7.29e-8948
phagocyte7.29e-8948
macrophage dendritic cell progenitor7.27e-8861
classical monocyte1.50e-8642
CD14-positive, CD16-negative classical monocyte1.50e-8642
myeloid lineage restricted progenitor cell2.74e-8666
monopoietic cell3.70e-8459
monocyte3.70e-8459
monoblast3.70e-8459
promonocyte3.70e-8459
myeloid cell2.48e-74108
common myeloid progenitor2.48e-74108
leukocyte6.20e-72136
hematopoietic stem cell1.35e-59168
angioblastic mesenchymal cell1.35e-59168
stuff accumulating cell3.57e-5887
hematopoietic cell1.55e-55177
hematopoietic lineage restricted progenitor cell4.56e-55120
hematopoietic oligopotent progenitor cell1.51e-53161
hematopoietic multipotent progenitor cell1.51e-53161
nongranular leukocyte2.40e-52115
motile cell1.79e-20386
intermediate monocyte3.50e-209
CD14-positive, CD16-positive monocyte3.50e-209
mesenchymal cell3.45e-19354
connective tissue cell2.00e-18361
granulocyte1.70e-138
multi fate stem cell1.68e-12427
somatic stem cell4.69e-12433
stem cell1.75e-11441
blood cell1.88e-0911
non-classical monocyte6.25e-083
CD14-low, CD16-positive monocyte6.25e-083
basophil9.54e-083
neutrophil1.69e-073
somatic cell3.06e-07588
single nucleate cell4.05e-073
mononuclear cell4.05e-073
light melanocyte5.66e-073
melanocyte9.66e-0710
melanoblast9.66e-0710
Uber Anatomy
Ontology termp-valuen
bone marrow7.45e-7976
hematopoietic system2.27e-7798
blood island2.27e-7798
bone element6.50e-7282
hemolymphoid system1.48e-68108
skeletal element4.34e-6490
immune system6.68e-6493
skeletal system4.65e-56100
lateral plate mesoderm4.22e-28203
musculoskeletal system4.39e-27167
connective tissue2.18e-17371
mesoderm2.60e-13315
mesoderm-derived structure2.60e-13315
presumptive mesoderm2.60e-13315


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.12.14318
MA0004.10.558729
MA0006.11.01439
MA0007.10.539222
MA0009.11.03681
MA0014.10.108006
MA0017.10.432438
MA0019.10.7124
MA0024.10.929647
MA0025.11.17262
MA0027.12.65688
MA0028.10.408079
MA0029.10.949428
MA0030.10.937696
MA0031.10.871496
MA0038.10.665566
MA0040.10.955415
MA0041.11.41501
MA0042.10.544748
MA0043.11.03713
MA0046.11.02569
MA0048.10.152639
MA0050.10.545671
MA0051.10.661179
MA0052.10.959373
MA0055.10.0586456
MA0056.10
MA0057.10.147053
MA0058.10.458909
MA0059.10.457555
MA0060.10.267412
MA0061.10.23892
MA0063.10
MA0066.10.66601
MA0067.11.35893
MA0068.10.578694
MA0069.11.02175
MA0070.11.01032
MA0071.10.625297
MA0072.11.00572
MA0073.11.53717
MA0074.10.660398
MA0076.10.475586
MA0077.10.997832
MA0078.10.763954
MA0081.10.457725
MA0083.11.04447
MA0084.11.5477
MA0087.11.00322
MA0088.11.09824
MA0089.10
MA0090.10.490736
MA0091.10.561458
MA0092.10.522012
MA0093.11.02138
MA0095.10
MA0098.10
MA0100.10.679972
MA0101.10.397846
MA0103.10.381434
MA0105.12.61648
MA0106.10.70837
MA0107.10.320267
MA0108.20.868347
MA0109.10
MA0111.11.25994
MA0113.10.725375
MA0114.10.314898
MA0115.11.28169
MA0116.10.323925
MA0117.11.07516
MA0119.10.440684
MA0122.11.10154
MA0124.11.23968
MA0125.11.15445
MA0130.10
MA0131.10.782708
MA0132.10
MA0133.10
MA0135.11.06778
MA0136.10.672893
MA0139.10.226048
MA0140.10.622527
MA0141.10.455728
MA0142.10.838805
MA0143.10.725558
MA0144.10.299851
MA0145.10.707171
MA0146.10.441872
MA0147.10.87383
MA0148.10.584698
MA0149.10.612449
MA0062.20.23336
MA0035.20.621793
MA0039.20.200862
MA0138.20.765223
MA0002.20.709311
MA0137.20.414885
MA0104.20.735746
MA0047.20.695777
MA0112.20.101413
MA0065.20.718489
MA0150.10.484557
MA0151.10
MA0152.10.629368
MA0153.11.13732
MA0154.11.92418
MA0155.10.318517
MA0156.10.417278
MA0157.10.810597
MA0158.10
MA0159.10.328286
MA0160.10.600559
MA0161.10
MA0162.10.62636
MA0163.11.60684
MA0164.10.738243
MA0080.20.394469
MA0018.20.709805
MA0099.20.629739
MA0079.20.983809
MA0102.21.58513
MA0258.10.289793
MA0259.10.336472
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
POLR2A#543062.147453176558070.01019570676818780.038032338708578



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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