MCL coexpression mm9:33
From FANTOM5_SSTAR
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
| GO ID | GO name | FDR corrected p-value |
|---|---|---|
| GO:0001772 | immunological synapse | 2.99783538433605e-11 |
| GO:0042110 | T cell activation | 7.04819708463535e-09 |
| GO:0045321 | leukocyte activation | 8.72590786767768e-09 |
| GO:0001775 | cell activation | 1.57848975591422e-08 |
| GO:0046649 | lymphocyte activation | 2.96797349047148e-08 |
| GO:0002376 | immune system process | 3.83248281841986e-08 |
| GO:0007242 | intracellular signaling cascade | 3.83248281841986e-08 |
| GO:0042101 | T cell receptor complex | 3.83248281841986e-08 |
| GO:0042105 | alpha-beta T cell receptor complex | 8.57599784927289e-07 |
| GO:0051239 | regulation of multicellular organismal process | 1.19398090832422e-06 |
| GO:0050852 | T cell receptor signaling pathway | 1.8294209328212e-06 |
| GO:0050870 | positive regulation of T cell activation | 4.73100989334206e-06 |
| GO:0043235 | receptor complex | 4.73100989334206e-06 |
| GO:0006955 | immune response | 6.23148382852215e-06 |
| GO:0048518 | positive regulation of biological process | 7.09843147316181e-06 |
| GO:0050851 | antigen receptor-mediated signaling pathway | 1.14387444260065e-05 |
| GO:0030098 | lymphocyte differentiation | 1.88529070359754e-05 |
| GO:0050848 | regulation of calcium-mediated signaling | 1.88529070359754e-05 |
| GO:0050850 | positive regulation of calcium-mediated signaling | 1.88529070359754e-05 |
| GO:0002429 | immune response-activating cell surface receptor signaling pathway | 2.23825675513156e-05 |
| GO:0030217 | T cell differentiation | 2.36003365417723e-05 |
| GO:0051251 | positive regulation of lymphocyte activation | 2.36003365417723e-05 |
| GO:0002768 | immune response-regulating cell surface receptor signaling pathway | 2.62622071547099e-05 |
| GO:0050863 | regulation of T cell activation | 2.62622071547099e-05 |
| GO:0009966 | regulation of signal transduction | 2.75500539890309e-05 |
| GO:0009967 | positive regulation of signal transduction | 2.92357979986028e-05 |
| GO:0002757 | immune response-activating signal transduction | 3.05546783946035e-05 |
| GO:0002764 | immune response-regulating signal transduction | 3.89219096520578e-05 |
| GO:0045058 | T cell selection | 4.04925148963563e-05 |
| GO:0002682 | regulation of immune system process | 4.55610779762465e-05 |
| GO:0032943 | mononuclear cell proliferation | 5.13953715085872e-05 |
| GO:0046651 | lymphocyte proliferation | 5.13953715085872e-05 |
| GO:0051240 | positive regulation of multicellular organismal process | 5.23387364811454e-05 |
| GO:0019722 | calcium-mediated signaling | 8.54018733502857e-05 |
| GO:0002521 | leukocyte differentiation | 8.54018733502857e-05 |
| GO:0051249 | regulation of lymphocyte activation | 8.97993411921825e-05 |
| GO:0050865 | regulation of cell activation | 0.000107538028930487 |
| GO:0007165 | signal transduction | 0.00014426066591897 |
| GO:0005886 | plasma membrane | 0.000152434036677986 |
| GO:0042098 | T cell proliferation | 0.000176641003652872 |
| GO:0042102 | positive regulation of T cell proliferation | 0.0001930012953993 |
| GO:0031325 | positive regulation of cellular metabolic process | 0.0001930012953993 |
| GO:0030097 | hemopoiesis | 0.0001930012953993 |
| GO:0002684 | positive regulation of immune system process | 0.0001930012953993 |
| GO:0050856 | regulation of T cell receptor signaling pathway | 0.000196410979729113 |
| GO:0007154 | cell communication | 0.00021925579436586 |
| GO:0009893 | positive regulation of metabolic process | 0.000282476194491058 |
| GO:0050854 | regulation of antigen receptor-mediated signaling pathway | 0.000353971813074002 |
| GO:0050776 | regulation of immune response | 0.000353971813074002 |
| GO:0048534 | hemopoietic or lymphoid organ development | 0.000371628981410534 |
| GO:0051247 | positive regulation of protein metabolic process | 0.000487000525487249 |
| GO:0050671 | positive regulation of lymphocyte proliferation | 0.00051006031548629 |
| GO:0032946 | positive regulation of mononuclear cell proliferation | 0.00051006031548629 |
| GO:0002520 | immune system development | 0.00056422082637471 |
| GO:0019932 | second-messenger-mediated signaling | 0.00056422082637471 |
| GO:0002253 | activation of immune response | 0.000657411883649913 |
| GO:0045061 | thymic T cell selection | 0.000659888924177137 |
| GO:0048522 | positive regulation of cellular process | 0.000844700323544027 |
| GO:0042129 | regulation of T cell proliferation | 0.000844700323544027 |
| GO:0005515 | protein binding | 0.000844700323544027 |
| GO:0050789 | regulation of biological process | 0.000844700323544027 |
| GO:0065007 | biological regulation | 0.00118977625869821 |
| GO:0008283 | cell proliferation | 0.00143484492394102 |
| GO:0003705 | RNA polymerase II transcription factor activity, enhancer binding | 0.00153653105332945 |
| GO:0050778 | positive regulation of immune response | 0.00162667199622183 |
| GO:0001816 | cytokine production | 0.00182568081393974 |
| GO:0032944 | regulation of mononuclear cell proliferation | 0.00182568081393974 |
| GO:0005089 | Rho guanyl-nucleotide exchange factor activity | 0.00182568081393974 |
| GO:0050670 | regulation of lymphocyte proliferation | 0.00182568081393974 |
| GO:0035023 | regulation of Rho protein signal transduction | 0.00223165829853142 |
| GO:0005088 | Ras guanyl-nucleotide exchange factor activity | 0.00269552029983079 |
| GO:0033077 | T cell differentiation in the thymus | 0.00317239499202463 |
| GO:0044459 | plasma membrane part | 0.00439932371219049 |
| GO:0042108 | positive regulation of cytokine biosynthetic process | 0.00649057593105132 |
| GO:0006357 | regulation of transcription from RNA polymerase II promoter | 0.00740243397161587 |
| GO:0045086 | positive regulation of interleukin-2 biosynthetic process | 0.00796707338806494 |
| GO:0007266 | Rho protein signal transduction | 0.00797609674285202 |
| GO:0005622 | intracellular | 0.0081965425153586 |
| GO:0007265 | Ras protein signal transduction | 0.010493138724542 |
| GO:0050794 | regulation of cellular process | 0.0108992317658478 |
| GO:0045727 | positive regulation of translation | 0.0113541057150638 |
| GO:0042127 | regulation of cell proliferation | 0.0113541057150638 |
| GO:0007159 | leukocyte adhesion | 0.0116484252852234 |
| GO:0005737 | cytoplasm | 0.0126565985125951 |
| GO:0006366 | transcription from RNA polymerase II promoter | 0.0126565985125951 |
| GO:0044464 | cell part | 0.0128456748123895 |
| GO:0005623 | cell | 0.0128456748123895 |
| GO:0043170 | macromolecule metabolic process | 0.01290639511985 |
| GO:0031328 | positive regulation of cellular biosynthetic process | 0.01290639511985 |
| GO:0019222 | regulation of metabolic process | 0.0153973630460122 |
| GO:0046578 | regulation of Ras protein signal transduction | 0.0155140027921792 |
| GO:0045076 | regulation of interleukin-2 biosynthetic process | 0.0180389444757243 |
| GO:0008284 | positive regulation of cell proliferation | 0.018096984897661 |
| GO:0042035 | regulation of cytokine biosynthetic process | 0.0189258409044981 |
| GO:0005643 | nuclear pore | 0.0198257683009723 |
| GO:0005070 | SH3/SH2 adaptor activity | 0.0198959906764414 |
| GO:0051092 | activation of NF-kappaB transcription factor | 0.0198959906764414 |
| GO:0044424 | intracellular part | 0.01994171957689 |
| GO:0009891 | positive regulation of biosynthetic process | 0.0212478928141761 |
| GO:0042094 | interleukin-2 biosynthetic process | 0.0217609137144639 |
| GO:0000059 | protein import into nucleus, docking | 0.0217609137144639 |
| GO:0004697 | protein kinase C activity | 0.0217609137144639 |
| GO:0031323 | regulation of cellular metabolic process | 0.0225440284046253 |
| GO:0046930 | pore complex | 0.0235599913653708 |
| GO:0006468 | protein amino acid phosphorylation | 0.0235599913653708 |
| GO:0032623 | interleukin-2 production | 0.0238537132630127 |
| GO:0045944 | positive regulation of transcription from RNA polymerase II promoter | 0.0256303808209819 |
| GO:0005085 | guanyl-nucleotide exchange factor activity | 0.025966892294461 |
| GO:0045580 | regulation of T cell differentiation | 0.025966892294461 |
| GO:0001565 | phorbol ester receptor activity | 0.025966892294461 |
| GO:0042089 | cytokine biosynthetic process | 0.026996997198834 |
| GO:0042107 | cytokine metabolic process | 0.0277911690663867 |
| GO:0044453 | nuclear membrane part | 0.0277911690663867 |
| GO:0051056 | regulation of small GTPase mediated signal transduction | 0.0278540160198996 |
| GO:0043234 | protein complex | 0.0283394973162875 |
| GO:0031965 | nuclear membrane | 0.0296583651185824 |
| GO:0051091 | positive regulation of transcription factor activity | 0.0337772330446337 |
| GO:0009897 | external side of plasma membrane | 0.0352124189702825 |
| GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation | 0.0352124189702825 |
| GO:0001920 | negative regulation of receptor recycling | 0.0352124189702825 |
| GO:0031045 | dense core granule | 0.0352124189702825 |
| GO:0004294 | tripeptidyl-peptidase II activity | 0.0352124189702825 |
| GO:0021542 | dentate gyrus development | 0.0352124189702825 |
| GO:0050862 | positive regulation of T cell receptor signaling pathway | 0.0352124189702825 |
| GO:0030338 | CMP-N-acetylneuraminate monooxygenase activity | 0.0352124189702825 |
| GO:0002639 | positive regulation of immunoglobulin production | 0.0352124189702825 |
| GO:0032127 | dense core granule membrane | 0.0352124189702825 |
| GO:0045937 | positive regulation of phosphate metabolic process | 0.0370057851207591 |
| GO:0042327 | positive regulation of phosphorylation | 0.0370057851207591 |
| GO:0006793 | phosphorus metabolic process | 0.0377934744610867 |
| GO:0006796 | phosphate metabolic process | 0.0377934744610867 |
| GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 0.0381119084067437 |
| GO:0016310 | phosphorylation | 0.0381927530601523 |
| GO:0045619 | regulation of lymphocyte differentiation | 0.038891919616813 |
| GO:0051246 | regulation of protein metabolic process | 0.039069924265652 |
| GO:0003702 | RNA polymerase II transcription factor activity | 0.0427498761853349 |
| GO:0045893 | positive regulation of transcription, DNA-dependent | 0.0428345608353504 |
| GO:0003700 | transcription factor activity | 0.0432385141556203 |
| GO:0007264 | small GTPase mediated signal transduction | 0.0432385141556203 |
| GO:0051090 | regulation of transcription factor activity | 0.0432385141556203 |
| GO:0030674 | protein binding, bridging | 0.0432385141556203 |
| GO:0001707 | mesoderm formation | 0.0432385141556203 |
| GO:0005083 | small GTPase regulator activity | 0.0432464818492326 |
| GO:0004672 | protein kinase activity | 0.0447916571168891 |
| GO:0048332 | mesoderm morphogenesis | 0.0457247249566859 |
| GO:0001934 | positive regulation of protein amino acid phosphorylation | 0.0472676852032728 |
| GO:0033240 | positive regulation of amine metabolic process | 0.0472676852032728 |
| GO:0045764 | positive regulation of amino acid metabolic process | 0.0472676852032728 |
| GO:0005925 | focal adhesion | 0.0472676852032728 |
| GO:0001704 | formation of primary germ layer | 0.0472676852032728 |
| GO:0042100 | B cell proliferation | 0.0472676852032728 |
| GO:0019538 | protein metabolic process | 0.0475865655395633 |
Relative expression of the co-expression cluster over median <br>Analyst:
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>
TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
| Motifs | -log10(p-value) |
|---|---|
| MA0003.1 | 1.35491e-10 |
| MA0004.1 | 0.478166 |
| MA0006.1 | 0.000834106 |
| MA0007.1 | 0.307528 |
| MA0009.1 | 0.481254 |
| MA0014.1 | 2.91781e-10 |
| MA0017.1 | 0.334061 |
| MA0019.1 | 0.67883 |
| MA0024.1 | 0.347667 |
| MA0025.1 | 0.0347463 |
| MA0027.1 | 0.839619 |
| MA0028.1 | 0.0250576 |
| MA0029.1 | 0.0609157 |
| MA0030.1 | 0.602073 |
| MA0031.1 | 1.50073 |
| MA0038.1 | 0.0645122 |
| MA0040.1 | 0.0320741 |
| MA0041.1 | 1.78143 |
| MA0042.1 | 1.385 |
| MA0043.1 | 0.00852032 |
| MA0046.1 | 0.428171 |
| MA0048.1 | 0.628074 |
| MA0050.1 | 2.2323 |
| MA0051.1 | 0.424946 |
| MA0052.1 | 0.0123507 |
| MA0055.1 | 0.241593 |
| MA0056.1 | 0 |
| MA0057.1 | 0.242501 |
| MA0058.1 | 0.329702 |
| MA0059.1 | 0.220296 |
| MA0060.1 | 0.00254971 |
| MA0061.1 | 0.115494 |
| MA0063.1 | 0 |
| MA0066.1 | 0.553924 |
| MA0067.1 | 0.0791948 |
| MA0068.1 | 0.122624 |
| MA0069.1 | 0.150071 |
| MA0070.1 | 0.232666 |
| MA0071.1 | 0.106919 |
| MA0072.1 | 1.41057 |
| MA0073.1 | 1.092 |
| MA0074.1 | 0.0139697 |
| MA0076.1 | 0.142606 |
| MA0077.1 | 0.420617 |
| MA0078.1 | 0.594374 |
| MA0081.1 | 2.49083 |
| MA0083.1 | 0.271856 |
| MA0084.1 | 0.110204 |
| MA0087.1 | 0.0503979 |
| MA0088.1 | 0.00820617 |
| MA0089.1 | 0 |
| MA0090.1 | 0.168604 |
| MA0091.1 | 0.570602 |
| MA0092.1 | 0.521737 |
| MA0093.1 | 0.403893 |
| MA0095.1 | 0 |
| MA0098.1 | 0 |
| MA0100.1 | 0.315471 |
| MA0101.1 | 0.0917077 |
| MA0103.1 | 1.8552 |
| MA0105.1 | 0.00375567 |
| MA0106.1 | 0.00689599 |
| MA0107.1 | 0.037757 |
| MA0108.2 | 0.0633308 |
| MA0109.1 | 0 |
| MA0111.1 | 0.436468 |
| MA0113.1 | 0.0571135 |
| MA0114.1 | 0.106409 |
| MA0115.1 | 0.867992 |
| MA0116.1 | 0.446722 |
| MA0117.1 | 0.0584373 |
| MA0119.1 | 0.013174 |
| MA0122.1 | 0.145131 |
| MA0124.1 | 0.301032 |
| MA0125.1 | 0.195251 |
| MA0130.1 | 0 |
| MA0131.1 | 0.124044 |
| MA0132.1 | 0 |
| MA0133.1 | 0 |
| MA0135.1 | 0.106144 |
| MA0136.1 | 5.48559 |
| MA0139.1 | 0.0615496 |
| MA0140.1 | 0.508675 |
| MA0141.1 | 0.0845914 |
| MA0142.1 | 1.13993 |
| MA0143.1 | 1.69309 |
| MA0144.1 | 0.82532 |
| MA0145.1 | 0.00121222 |
| MA0146.1 | 7.61009e-12 |
| MA0147.1 | 0.258991 |
| MA0148.1 | 0.838466 |
| MA0149.1 | 6.59377 |
| MA0062.2 | 1.08697 |
| MA0035.2 | 0.659403 |
| MA0039.2 | 1.42944e-07 |
| MA0138.2 | 0.000867434 |
| MA0002.2 | 1.71303 |
| MA0137.2 | 0.988241 |
| MA0104.2 | 0.0662386 |
| MA0047.2 | 2.18835 |
| MA0112.2 | 0.00766538 |
| MA0065.2 | 0.0605416 |
| MA0150.1 | 0.00348823 |
| MA0151.1 | 0 |
| MA0152.1 | 0.0637712 |
| MA0153.1 | 0.231513 |
| MA0154.1 | 0.100553 |
| MA0155.1 | 0.0202833 |
| MA0156.1 | 10.8092 |
| MA0157.1 | 1.13515 |
| MA0158.1 | 0 |
| MA0159.1 | 0.890889 |
| MA0160.1 | 0.146027 |
| MA0161.1 | 0 |
| MA0162.1 | 9.28803e-05 |
| MA0163.1 | 0.00497909 |
| MA0164.1 | 0.204396 |
| MA0080.2 | 8.95769 |
| MA0018.2 | 0.00723405 |
| MA0099.2 | 0.160334 |
| MA0079.2 | 0.0886611 |
| MA0102.2 | 0.134447 |
| MA0258.1 | 0.232663 |
| MA0259.1 | 0.00513144 |
| MA0442.1 | 0 |
