Coexpression cluster:C108

Full id: C108_breast_hepatoblastoma_MCF7_parotid_salivary_submaxillary_prostate

Phase1 CAGE Peaks

Hg19::chr10:37451700..37451715,+	p@chr10:37451700..37451715 +
Hg19::chr10:37451725..37451728,+	p@chr10:37451725..37451728 +
Hg19::chr10:37485037..37485044,+	p@chr10:37485037..37485044 +
Hg19::chr10:37485774..37485794,+	p@chr10:37485774..37485794 +
Hg19::chr10:37555522..37555528,+	p@chr10:37555522..37555528 +
Hg19::chr10:37555579..37555584,+	p@chr10:37555579..37555584 +
Hg19::chr10:37601250..37601252,+	p@chr10:37601250..37601252 +
Hg19::chr10:37637623..37637627,+	p1@VN1R53P
Hg19::chr10:37656774..37656778,+	p@chr10:37656774..37656778 +
Hg19::chr10:37679189..37679193,+	p@chr10:37679189..37679193 +
Hg19::chr10:37685495..37685497,+	p@chr10:37685495..37685497 +
Hg19::chr10:9062678..9062682,-	p@chr10:9062678..9062682 -
Hg19::chr10:9102477..9102481,-	p@chr10:9102477..9102481 -
Hg19::chr10:9107734..9107754,-	p@chr10:9107734..9107754 -
Hg19::chr11:113212368..113212375,+	p9@TTC12
Hg19::chr11:120110546..120110551,-	p@chr11:120110546..120110551 -
Hg19::chr11:67436996..67437009,-	p@chr11:67436996..67437009 -
Hg19::chr11:67437863..67437876,-	p@chr11:67437863..67437876 -
Hg19::chr11:72493645..72493661,-	p23@STARD10
Hg19::chr11:72493668..72493679,-	p22@STARD10
Hg19::chr11:7618413..7618427,+	p6@PPFIBP2
Hg19::chr11:7618431..7618436,+	p34@PPFIBP2
Hg19::chr11:7618437..7618448,+	p20@PPFIBP2
Hg19::chr11:827914..827930,+	p15@EFCAB4A
Hg19::chr11:827941..827978,+	p10@EFCAB4A
Hg19::chr11:828104..828109,+	p32@EFCAB4A
Hg19::chr11:828151..828163,+	p14@EFCAB4A
Hg19::chr11:829412..829430,+	p11@EFCAB4A
Hg19::chr11:829495..829500,+	p23@EFCAB4A
Hg19::chr11:829538..829547,+	p17@EFCAB4A
Hg19::chr11:829560..829573,+	p13@EFCAB4A
Hg19::chr11:830434..830484,+	p1@EFCAB4A
Hg19::chr11:831114..831132,+	p@chr11:831114..831132 +
Hg19::chr12:49453217..49453224,+	p@chr12:49453217..49453224 +
Hg19::chr12:90313394..90313420,+	p1@ENST00000549551
Hg19::chr12:93806120..93806155,-	p@chr12:93806120..93806155 -
Hg19::chr14:46389767..46389768,+	p@chr14:46389767..46389768 +
Hg19::chr14:76447439..76447452,-	p18@TGFB3
Hg19::chr14:76447469..76447487,-	p12@TGFB3
Hg19::chr14:92302549..92302564,-	p9@TC2N
Hg19::chr15:69854027..69854040,+	p1@LOC145837
Hg19::chr15:69857515..69857518,+	p3@ENST00000559477
Hg19::chr15:69857547..69857555,+	p1@ENST00000559477
Hg19::chr15:69857557..69857562,+	p2@ENST00000559477
Hg19::chr16:48281411..48281419,-	p5@ABCC11
Hg19::chr16:48281444..48281451,-	p2@ABCC11
Hg19::chr16:54972581..54972585,-	p1@ENST00000558156 p1@ENST00000559802
Hg19::chr17:12935401..12935405,-	p@chr17:12935401..12935405 -
Hg19::chr17:61514114..61514119,-	p@chr17:61514114..61514119 -
Hg19::chr17:61514163..61514170,-	p@chr17:61514163..61514170 -
Hg19::chr17:61514195..61514205,-	p@chr17:61514195..61514205 -
Hg19::chr17:61514208..61514213,-	p@chr17:61514208..61514213 -
Hg19::chr17:65990349..65990362,-	p@chr17:65990349..65990362 -
Hg19::chr17:65990378..65990389,-	p@chr17:65990378..65990389 -
Hg19::chr17:65990392..65990397,-	p@chr17:65990392..65990397 -
Hg19::chr17:65990543..65990553,-	p@chr17:65990543..65990553 -
Hg19::chr17:72968809..72968834,-	p1@C17orf28
Hg19::chr17:72968837..72968868,-	p2@C17orf28
Hg19::chr17:73389834..73389850,-	p4@GRB2
Hg19::chr18:20911185..20911195,-	p6@TMEM241
Hg19::chr19:15674405..15674438,+	p@chr19:15674405..15674438 +
Hg19::chr19:15674459..15674486,+	p@chr19:15674459..15674486 +
Hg19::chr19:48010224..48010231,-	p@chr19:48010224..48010231 -
Hg19::chr19:5217451..5217456,-	p@chr19:5217451..5217456 -
Hg19::chr1:11139818..11139830,-	p6@EXOSC10
Hg19::chr1:153940716..153940739,+	p4@CREB3L4
Hg19::chr1:153940741..153940751,+	p7@CREB3L4
Hg19::chr1:164559541..164559546,+	p52@PBX1
Hg19::chr1:164559556..164559568,+	p21@PBX1
Hg19::chr1:164559583..164559590,+	p50@PBX1
Hg19::chr1:189493099..189493102,-	p@chr1:189493099..189493102 -
Hg19::chr1:190446662..190446678,-	p6@FAM5C
Hg19::chr1:190446698..190446710,-	p10@FAM5C
Hg19::chr1:190447673..190447683,-	p@chr1:190447673..190447683 -
Hg19::chr1:233750790..233750823,-	p@chr1:233750790..233750823 -
Hg19::chr1:236686445..236686452,+	p18@LGALS8
Hg19::chr1:236686501..236686513,+	p8@LGALS8
Hg19::chr1:31882617..31882630,+	p4@SERINC2
Hg19::chr1:40598486..40598500,+	p1@ENST00000430724
Hg19::chr1:47366146..47366153,-	p1@CYP4Z2P
Hg19::chr1:51763556..51763631,-	p2@TTC39A
Hg19::chr1:53559544..53559570,-	p@chr1:53559544..53559570 -
Hg19::chr1:53559600..53559623,-	p@chr1:53559600..53559623 -
Hg19::chr1:86889165..86889168,+	p@chr1:86889165..86889168 +
Hg19::chr1:86889531..86889552,+	p4@CLCA2
Hg19::chr1:86911063..86911068,+	p@chr1:86911063..86911068 +
Hg19::chr1:94080063..94080068,-	p23@BCAR3
Hg19::chr1:94080175..94080205,-	p@chr1:94080175..94080205 -
Hg19::chr20:31781321..31781329,+	p2@BPIFA4P
Hg19::chr20:34380919..34380924,+	p@chr20:34380919..34380924 +
Hg19::chr20:60803269..60803302,+	p@chr20:60803269..60803302 +
Hg19::chr20:62173412..62173437,-	p@chr20:62173412..62173437 -
Hg19::chr21:36729875..36729891,+	p@chr21:36729875..36729891 +
Hg19::chr21:37505138..37505151,-	p@chr21:37505138..37505151 -
Hg19::chr21:43540870..43540878,+	p10@UMODL1
Hg19::chr21:43540892..43540907,+	p4@UMODL1
Hg19::chr21:43540912..43540915,+	p15@UMODL1
Hg19::chr21:47704051..47704065,-	p11@MCM3AP
Hg19::chr21:47704085..47704094,-	p18@MCM3AP
Hg19::chr22:24990735..24990742,+	p8@GGT2 p9@GGT1
Hg19::chr22:46283597..46283636,-	p1@ENST00000451118
Hg19::chr2:142889034..142889073,-	p4@LRP1B
Hg19::chr2:142889081..142889086,-	p11@LRP1B
Hg19::chr2:142895398..142895426,-	p1@ENST00000436132
Hg19::chr2:149863976..149863986,+	p@chr2:149863976..149863986 +
Hg19::chr2:149864004..149864021,+	p@chr2:149864004..149864021 +
Hg19::chr2:242674815..242674830,-	p3@ENST00000400768
Hg19::chr2:242680762..242680768,+	p@chr2:242680762..242680768 +
Hg19::chr2:242680772..242680783,+	p@chr2:242680772..242680783 +
Hg19::chr2:242680789..242680804,+	p@chr2:242680789..242680804 +
Hg19::chr2:242681835..242681844,+	p5@D2HGDH
Hg19::chr3:141174789..141174790,-	p8@AK129571
Hg19::chr3:14833061..14833093,+	p@chr3:14833061..14833093 +
Hg19::chr3:149002564..149002570,+	p1@ENST00000489011
Hg19::chr3:169587753..169587760,-	p3@LRRC31
Hg19::chr3:169756594..169756605,+	p9@GPR160
Hg19::chr3:169756638..169756645,+	p15@GPR160
Hg19::chr3:169756667..169756675,+	p14@GPR160
Hg19::chr3:169756689..169756695,+	p13@GPR160
Hg19::chr3:189026705..189026726,+	p@chr3:189026705..189026726 +
Hg19::chr3:189438863..189438865,+	p@chr3:189438863..189438865 +
Hg19::chr3:4722258..4722271,+	p@chr3:4722258..4722271 +
Hg19::chr3:4722283..4722286,+	p@chr3:4722283..4722286 +
Hg19::chr3:4722301..4722324,+	p@chr3:4722301..4722324 +
Hg19::chr3:60761167..60761179,+	p@chr3:60761167..60761179 +
Hg19::chr3:60761181..60761194,+	p@chr3:60761181..60761194 +
Hg19::chr3:9956047..9956079,+	p@chr3:9956047..9956079 +
Hg19::chr4:14879181..14879226,-	p@chr4:14879181..14879226 -
Hg19::chr4:160605526..160605546,-	p@chr4:160605526..160605546 -
Hg19::chr4:160605585..160605628,-	p@chr4:160605585..160605628 -
Hg19::chr4:776378..776392,+	p@chr4:776378..776392 +
Hg19::chr5:111755562..111755580,-	p@chr5:111755562..111755580 -
Hg19::chr5:111755583..111755641,-	p@chr5:111755583..111755641 -
Hg19::chr5:148231224..148231235,+	p@chr5:148231224..148231235 +
Hg19::chr5:148231243..148231244,+	p@chr5:148231243..148231244 +
Hg19::chr5:153666993..153667004,+	p9@GALNT10
Hg19::chr5:153667008..153667036,+	p3@GALNT10
Hg19::chr5:176513895..176513924,+	p1@FGFR4
Hg19::chr5:176513938..176513951,+	p3@FGFR4
Hg19::chr5:176514238..176514245,+	p18@FGFR4
Hg19::chr5:176518002..176518011,+	p19@FGFR4
Hg19::chr5:176519127..176519154,+	p@chr5:176519127..176519154 +
Hg19::chr5:180022690..180022710,-	p@chr5:180022690..180022710 -
Hg19::chr6:10141294..10141304,+	p@chr6:10141294..10141304 +
Hg19::chr6:34524093..34524135,-	p1@SPDEF
Hg19::chr6:44013424..44013453,-	p@chr6:44013424..44013453 -
Hg19::chr6:50785214..50785224,+	p@chr6:50785214..50785224 +
Hg19::chr6:50785279..50785289,+	p@chr6:50785279..50785289 +
Hg19::chr6:50786414..50786426,+	p7@TFAP2B
Hg19::chr6:50786479..50786490,+	p6@TFAP2B
Hg19::chr6:50786509..50786527,+	p5@TFAP2B
Hg19::chr6:50786529..50786540,+	p8@TFAP2B
Hg19::chr6:50789717..50789729,+	p4@TFAP2B
Hg19::chr6:50789737..50789746,+	p10@TFAP2B
Hg19::chr6:50836577..50836581,+	p@chr6:50836577..50836581 +
Hg19::chr7:157285832..157285841,+	p@chr7:157285832..157285841 +
Hg19::chr7:42429365..42429366,-	p@chr7:42429365..42429366 -
Hg19::chr7:42429373..42429374,-	p@chr7:42429373..42429374 -
Hg19::chr7:42429377..42429382,-	p@chr7:42429377..42429382 -
Hg19::chr7:94277045..94277057,-	p@chr7:94277045..94277057 -
Hg19::chr8:116684676..116684688,-	p@chr8:116684676..116684688 -
Hg19::chr8:30584492..30584503,-	p10@GSR
Hg19::chr8:30584507..30584514,-	p13@GSR
Hg19::chr8:30584524..30584529,-	p14@GSR
Hg19::chr8:30584533..30584543,-	p9@GSR
Hg19::chr8:58943424..58943435,+	p@chr8:58943424..58943435 +
Hg19::chr8:58943437..58943442,+	p@chr8:58943437..58943442 +
Hg19::chr9:117379097..117379106,+	p3@AB528759
Hg19::chr9:131870403..131870416,-	p@chr9:131870403..131870416 -
Hg19::chr9:131871258..131871269,-	p3@CRAT
Hg19::chr9:131871491..131871519,+	p@chr9:131871491..131871519 +
Hg19::chr9:140506839..140506847,+	p9@ARRDC1
Hg19::chr9:140506865..140506902,+	p5@ARRDC1
Hg19::chrX:153603404..153603411,-	p127@FLNA
Hg19::chrX:153603415..153603426,-	p119@FLNA
Hg19::chrX:153603428..153603446,-	p104@FLNA
Hg19::chrX:153603570..153603573,-	p@chrX:153603570..153603573 -
Hg19::chrX:66763970..66763981,+	p7@AR

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0006606	protein import into nucleus	0.0214404100491165
GO:0051170	nuclear import	0.0214404100491165
GO:0006749	glutathione metabolic process	0.0214404100491165
GO:0017038	protein import	0.0229499729418118
GO:0006913	nucleocytoplasmic transport	0.0314709153876722
GO:0051169	nuclear transport	0.0314709153876722
GO:0001655	urogenital system development	0.0320263746614859
GO:0051990	(R)-2-hydroxyglutarate dehydrogenase activity	0.0320263746614859
GO:0004092	carnitine O-acetyltransferase activity	0.0320263746614859
GO:0032025	response to cobalt ion	0.0320263746614859
GO:0010042	response to manganese ion	0.0320263746614859
GO:0004362	glutathione-disulfide reductase activity	0.0320263746614859
GO:0048702	embryonic neurocranium morphogenesis	0.0320263746614859
GO:0006605	protein targeting	0.0355748464990184
GO:0043565	sequence-specific DNA binding	0.0367617866652938
GO:0018685	alkane 1-monooxygenase activity	0.0499155661978534
GO:0042221	response to chemical stimulus	0.0499155661978534
GO:0006732	coenzyme metabolic process	0.0499155661978534
GO:0007167	enzyme linked receptor protein signaling pathway	0.0499155661978534
GO:0030850	prostate gland development	0.0499155661978534
GO:0015038	glutathione disulfide oxidoreductase activity	0.0499155661978534
GO:0015037	peptide disulfide oxidoreductase activity	0.0499155661978534
GO:0016413	O-acetyltransferase activity	0.0499155661978534
GO:0045817	positive regulation of global transcription from RNA polymerase II promoter	0.0499155661978534
GO:0000176	nuclear exosome (RNase complex)	0.0499155661978534

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n
epithelial cell	3.46e-28	254
endodermal cell	3.93e-10	59
endo-epithelial cell	6.84e-08	43
kidney cell	5.90e-07	18
kidney epithelial cell	5.90e-07	18

Uber Anatomy

Ontology term	p-value	n
anatomical conduit	1.04e-24	241
multi-tissue structure	4.11e-24	347
anatomical cluster	7.13e-24	286
multi-cellular organism	1.53e-23	659
adult organism	2.17e-22	115
embryo	5.44e-22	612
cell layer	8.59e-22	312
epithelium	1.04e-21	309
organ part	7.51e-20	219
organism subdivision	1.37e-19	365
tube	2.41e-19	194
embryonic structure	4.41e-19	605
developing anatomical structure	4.41e-19	605
germ layer	8.86e-19	604
embryonic tissue	8.86e-19	604
presumptive structure	8.86e-19	604
epiblast (generic)	8.86e-19	604
anatomical system	1.23e-18	625
anatomical group	1.24e-18	626
endoderm-derived structure	2.97e-17	169
endoderm	2.97e-17	169
presumptive endoderm	2.97e-17	169
trunk region element	1.28e-16	107
subdivision of trunk	4.37e-16	113
subdivision of digestive tract	6.04e-16	129
endodermal part of digestive tract	6.04e-16	129
organ	3.18e-15	511
digestive system	3.33e-15	155
digestive tract	3.33e-15	155
primitive gut	3.33e-15	155
ectoderm	3.63e-15	173
presumptive ectoderm	3.63e-15	173
immaterial anatomical entity	4.73e-15	126
ectoderm-derived structure	5.11e-15	169
regional part of nervous system	8.46e-15	94
nervous system	8.46e-15	94
central nervous system	1.93e-14	82
neural plate	3.04e-14	86
presumptive neural plate	3.04e-14	86
neurectoderm	3.12e-14	90
neural tube	5.66e-14	57
neural rod	5.66e-14	57
future spinal cord	5.66e-14	57
neural keel	5.66e-14	57
head	1.84e-13	123
anterior region of body	4.55e-13	129
craniocervical region	4.55e-13	129
mixed endoderm/mesoderm-derived structure	7.55e-13	130
regional part of brain	9.91e-13	59
brain	1.47e-12	69
future brain	1.47e-12	69
anatomical space	3.63e-12	104
pre-chordal neural plate	3.43e-11	61
renal system	1.23e-10	45
abdomen element	1.33e-10	55
abdominal segment element	1.33e-10	55
anterior neural tube	1.84e-10	42
urinary system structure	2.63e-10	44
cavitated compound organ	3.85e-10	32
mesenchyme	4.10e-10	238
entire embryonic mesenchyme	4.10e-10	238
foregut	4.40e-10	98
regional part of forebrain	6.23e-10	41
forebrain	6.23e-10	41
future forebrain	6.23e-10	41
organ segment	9.75e-10	97
kidney	3.47e-09	27
kidney mesenchyme	3.47e-09	27
kidney rudiment	3.47e-09	27
kidney field	3.47e-09	27
abdominal segment of trunk	3.55e-09	61
abdomen	3.55e-09	61
gray matter	4.35e-09	34
brain grey matter	4.35e-09	34
endo-epithelium	4.47e-09	82
telencephalon	9.70e-09	34
trunk	1.19e-08	216
regional part of telencephalon	1.55e-08	33
cerebral hemisphere	2.91e-08	32
intermediate mesoderm	6.21e-08	37
mesonephros	8.11e-08	18
pronephros	8.11e-08	18
nephrogenic cord	8.11e-08	18
pronephric mesoderm	8.11e-08	18
rostral part of nephrogenic cord	8.11e-08	18
presumptive pronephric mesoderm	8.11e-08	18
respiratory system	8.33e-08	72
duct	9.31e-08	26
thoracic segment of trunk	1.10e-07	52
primordium	1.25e-07	168
thoracic segment organ	2.30e-07	35
excretory tube	3.20e-07	17
mesonephric epithelium	3.20e-07	17
mesonephric tubule	3.20e-07	17

Disease

Ontology term	p-value	n

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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