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{{Coexpression_clusters
{
|coexpression_dpi_cluster_scores_median=0,0,0

Latest revision as of 12:05, 17 September 2013


Full id: C2401_serous_Renal_renal_signet_mesothelioma_kidney_clear



Phase1 CAGE Peaks

Hg19::chr17:36065029..36065045,-p@chr17:36065029..36065045
-
Hg19::chr17:36105042..36105060,-p1@HNF1B
Hg19::chr17:36105163..36105191,+p1@ENST00000558143
Hg19::chr18:3456189..3456200,+p@chr18:3456189..3456200
+


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0001822kidney development0.0276698457553279
GO:0001655urogenital system development0.0276698457553279



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

Uber Anatomy
Ontology termp-valuen
urinary system structure2.41e-2347
renal system1.08e-2248
nephron tubule epithelium8.59e-2210
excretory tube1.61e-2116
kidney epithelium1.61e-2116
kidney2.16e-2126
kidney mesenchyme2.16e-2126
upper urinary tract2.16e-2126
kidney rudiment2.16e-2126
kidney field2.16e-2126
abdomen element3.96e-2054
abdominal segment element3.96e-2054
nephron epithelium1.00e-1915
renal tubule1.00e-1915
nephron tubule1.00e-1915
nephron1.00e-1915
uriniferous tubule1.00e-1915
nephrogenic mesenchyme1.00e-1915
cavitated compound organ4.17e-1931
abdominal segment of trunk2.53e-1760
abdomen2.53e-1760
subdivision of digestive tract9.70e-16118
trunk region element1.01e-15101
endoderm-derived structure3.69e-14160
endoderm3.69e-14160
presumptive endoderm3.69e-14160
cortex of kidney6.53e-1412
renal parenchyma6.53e-1412
digestive system1.57e-12145
digestive tract1.57e-12145
primitive gut1.57e-12145
larynx1.17e-119
cortex1.08e-1015
parenchyma1.08e-1015
subdivision of trunk2.33e-10112
gastrointestinal system4.25e-1025
duct4.65e-0919
foregut1.13e-0887
endo-epithelium3.55e-0882
trunk4.25e-08199
renal cortex tubule1.10e-073
region of nephron tubule1.10e-073
proximal tubule1.10e-073
intestine1.13e-0717
epithelium of foregut-midgut junction1.57e-0725
anatomical boundary1.57e-0725
hepatobiliary system1.57e-0725
foregut-midgut junction1.57e-0725
septum transversum1.57e-0725
gut epithelium2.67e-0754
mesenchyme3.58e-07160
entire embryonic mesenchyme3.58e-07160
small intestine5.06e-074
multi-tissue structure5.66e-07342
mesonephric epithelium8.34e-078
mesonephric tubule8.34e-078
nephric duct8.34e-078
renal duct8.34e-078
mesonephric duct8.34e-078
pronephric duct8.34e-078
Disease
Ontology termp-valuen
carcinoma1.92e-13106
adenocarcinoma2.27e-1325
cell type cancer2.08e-08143


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.443649
MA0004.10.71247
MA0006.10.532262
MA0007.10.6918
MA0009.11.20602
MA0014.10.244769
MA0017.10.577281
MA0019.10.873355
MA0024.11.09684
MA0025.11.34373
MA0027.12.83281
MA0028.10.550763
MA0029.11.11704
MA0030.11.10506
MA0031.11.03735
MA0038.10.824639
MA0040.11.12314
MA0041.10.732902
MA0042.10.697662
MA0043.11.20635
MA0046.11.19471
MA0048.10.25531
MA0050.10.69864
MA0051.10.820063
MA0052.11.12718
MA0055.10.125954
MA0056.10
MA0057.11.28333
MA0058.10.605914
MA0059.10.604454
MA0060.10.393285
MA0061.10.360128
MA0063.10
MA0066.10.825101
MA0067.11.53181
MA0068.10.313194
MA0069.11.19071
MA0070.11.17908
MA0071.10.782546
MA0072.11.1744
MA0073.10.599068
MA0074.11.91637
MA0076.10.623864
MA0077.11.16637
MA0078.10.926725
MA0081.10.604638
MA0083.12.71961
MA0084.11.72172
MA0087.11.17185
MA0088.10.182167
MA0089.10
MA0090.10.640115
MA0091.10.715356
MA0092.10.673508
MA0093.10.535768
MA0095.10
MA0098.10
MA0100.10.83965
MA0101.11.33363
MA0103.10.521546
MA0105.10.656404
MA0106.10.869173
MA0107.10.453492
MA0108.21.03412
MA0109.10
MA0111.10.655276
MA0113.10.886811
MA0114.10.447443
MA0115.11.45393
MA0116.10.457606
MA0117.11.24497
MA0119.10.586221
MA0122.11.27173
MA0124.11.41151
MA0125.11.32534
MA0130.10
MA0131.10.94608
MA0132.10
MA0133.10
MA0135.11.23748
MA0136.10.832277
MA0139.10.344952
MA0140.10.779643
MA0141.10.602484
MA0142.11.00381
MA0143.10.887001
MA0144.10.430413
MA0145.10.195821
MA0146.10.061409
MA0147.10.46175
MA0148.10.739888
MA0149.10.769072
MA0062.20.353589
MA0035.20.778873
MA0039.20.0247757
MA0138.22.1393
MA0002.20.379056
MA0137.20.558189
MA0104.20.392359
MA0047.20.856092
MA0112.20.187982
MA0065.20.199162
MA0150.10.633493
MA0151.10
MA0152.10.78681
MA0153.11.30799
MA0154.10.649108
MA0155.10.533581
MA0156.10.560797
MA0157.10.97481
MA0158.10
MA0159.10.462502
MA0160.10.756582
MA0161.10
MA0162.10.0928415
MA0163.10.253219
MA0164.10.90014
MA0080.20.535868
MA0018.20.870662
MA0099.20.7872
MA0079.20.657636
MA0102.21.75932
MA0258.10.418966
MA0259.10.471671
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
BCL11A#53335214.18472755180350.007108328585298740.0296208246865904
HNF4A#3172211.56614518147680.01057585681762490.039068050020371
HNF4G#3174214.37671126322340.006924169980439180.0293035654666945



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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